CN103787940A - 一种二甲氨基苯甲醛硫脲衍生物及其应用 - Google Patents

一种二甲氨基苯甲醛硫脲衍生物及其应用 Download PDF

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CN103787940A
CN103787940A CN201410057774.8A CN201410057774A CN103787940A CN 103787940 A CN103787940 A CN 103787940A CN 201410057774 A CN201410057774 A CN 201410057774A CN 103787940 A CN103787940 A CN 103787940A
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thiourea derivative
application
dimethylaminobenzaldehyde
dimethyl aminobenzaldehyde
antibacterial
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丁国华
江道勇
高蕊
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Guilin University of Technology
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Guilin University of Technology
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

本发明公开了一种二甲氨基苯甲醛硫脲衍生物及其应用。二甲氨基苯甲醛硫脲衍生物的分子结构式为：

Description

一种二甲氨基苯甲醛硫脲衍生物及其应用
技术领域
本发明涉及一种二甲氨基苯甲醛硫脲衍生物及其在抗菌方面的应用。
背景技术
缩氨基硫脲类衍生物属于一类特殊的西佛碱，它含有R1-C=N-NH-CS-NH-R2基团。基团中氮原子、硫原子含有孤对电子，可以与过渡金属形成花样繁多的配位结构。此外，缩氨基硫脲类化合物具有的生物、催化、抗氧化、荧光、缓蚀等性质，使之在制药、生物、化工、功能材料、工业分析等领域具有广阔的应用前景。
发明内容
本发明的目的是提供一种二甲氨基苯甲醛硫脲衍生物及其应用。
二甲氨基苯甲醛硫脲衍生物的分子结构式为：
Figure 465588DEST_PATH_IMAGE001
。
所述二甲氨基苯甲醛硫脲衍生物应用于抗菌。
本发明的二甲氨基苯甲醛硫脲衍生物对欧文氏草生杆菌、大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果。
具体实施方式
实施例：
(1)二甲氨基苯甲醛硫脲衍生物的分子结构式为：
Figure 279960DEST_PATH_IMAGE001
。
(2)二甲氨基苯甲醛硫脲衍生物的制备方法为：
a.按照摩尔比1:1称取异硫氰酸苯酯与邻苯二胺，在20℃下反应生成中间体N-(2-氨基）苯基-N-苯基硫脲，抽滤并用乙醇洗涤三次，真空干燥制得白色固体。
b.取5毫摩尔（1.2165克）步骤a制得的白色固体用80毫升乙醇溶解于250毫升的三口烧瓶中，取5毫摩尔（0.746克）4-二甲氨基苯甲醛用20毫升的乙醇溶解于烧杯中，水浴升温至60℃时将后者缓慢滴入上述三口烧瓶中，再加入2.5毫升冰醋酸，回流反应3小时，冷却过夜，有橙色针状晶体析出，抽滤并用乙醇洗涤三次，真空干燥后即得二甲氨基苯甲醛硫脲衍生物，MS-ESI：m/z 374.9 (MH+)；Calcd. Mr：374.5。
(3)二甲氨基苯甲醛硫脲衍生物的应用：
通过抗菌实验，发现本实施例的二甲氨基苯甲醛硫脲衍生物对欧文氏草生杆菌、大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果，表1为抗菌实验数据。
表1 抗菌实验数据（抑菌圈直径，mm）
抑菌圈直径在7~8mm有较弱抗菌活性，在9~13mm有中等强度抗菌活性，在14~25mm有较强抗菌活性。从上表数据可以看出，本实施例的二甲氨基苯甲醛硫脲衍生物对欧文氏草生杆菌、大肠杆菌及金黄色葡萄球菌的抗菌效果中等。
实施例中所使用的化学试剂均为分析纯。

Claims (2)

1.一种二甲氨基苯甲醛硫脲衍生物，其特征在于该二甲氨基苯甲醛硫脲衍生物的分子结构式为：
Figure 2014100577748100001DEST_PATH_IMAGE001
。
2.根据权利要求1所述二甲氨基苯甲醛硫脲衍生物的应用，其特征在于所述二甲氨基苯甲醛硫脲衍生物应用于抗菌。
CN201410057774.8A 2014-02-20 2014-02-20 一种二甲氨基苯甲醛硫脲衍生物及其应用 Pending CN103787940A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610116A (zh) * 2015-02-21 2015-05-13 桂林理工大学 一种双苯基硫脲衍生物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103130695A (zh) * 2013-03-24 2013-06-05 桂林理工大学 一种硫脲席夫碱衍生物及应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103130695A (zh) * 2013-03-24 2013-06-05 桂林理工大学 一种硫脲席夫碱衍生物及应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HONG-JIA ZHANG ET AL.: "Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino)phenyl-N0-phenyl-thiourea", 《BIOORGANIC & MEDICINAL CHEMISTRY》, vol. 19, 1 July 2011 (2011-07-01), pages 5708 - 5715, XP028389435, DOI: 10.1016/j.bmc.2011.06.077 *
MEGHA K. BURGHATE ET AL.: "Synthesis of 3-Phenylimino-4-[2′-(substituted)alkyl/benzylidene amino]phenyl-5-arylimino-1,2,4-dithiazolidines and Their Antimicrobial Activity", 《ASIAN JOURNAL OF CHEMISTRY》, vol. 19, no. 5, 31 December 2007 (2007-12-31), pages 3601 - 3606 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610116A (zh) * 2015-02-21 2015-05-13 桂林理工大学 一种双苯基硫脲衍生物及其应用

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Application publication date: 20140514