CN103724225A - 一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及应用 - Google Patents

一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及应用 Download PDF

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CN103724225A
CN103724225A CN201410026165.6A CN201410026165A CN103724225A CN 103724225 A CN103724225 A CN 103724225A CN 201410026165 A CN201410026165 A CN 201410026165A CN 103724225 A CN103724225 A CN 103724225A
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dimethylaminobenzaldehyde
acid derivative
aminobenzoic acid
contracting
application
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丁国华
高蕊
江道勇
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Guilin University of Technology
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Guilin University of Technology
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Priority to CN201410026165.6A priority Critical patent/CN103724225A/zh
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

本发明公开了一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及应用。二甲氨基苯甲醛缩氨基苯甲酸衍生物的结构式为：

Description

一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及应用
技术领域
本发明涉及一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及其在抗菌上的应用。
背景技术
席夫碱衍生物，在抑菌、抗肿瘤、催化、磁性、光学、电化学、非线性光学和化学传感器等领域，有广泛的用途，因此成为当前研究的热点。
发明内容
本发明的目的是提供一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及其应用。
二甲氨基苯甲醛缩氨基苯甲酸衍生物的结构式为：
Figure 567022DEST_PATH_IMAGE001
所述二甲氨基苯甲醛缩氨基苯甲酸衍生物应用在抗菌上。
本发明的二甲氨基苯甲醛缩氨基苯甲酸衍生物对欧文氏草生杆菌，大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果。
具体实施方式
实施例：
(1) 二甲氨基苯甲醛缩氨基苯甲酸衍生物的结构式为：
Figure 899914DEST_PATH_IMAGE001
(2) 二甲氨基苯甲醛缩氨基苯甲酸衍生物的制备方法为：
将5mL溶有0.1492g（1mmol）对二甲氨基苯甲醛的无水乙醇溶液置于回流冷凝装置中，并70℃恒温水浴磁力搅拌；逐滴加入5mL溶有0.0400g(1mmol)NaOH的无水乙醇溶液；再逐滴滴加5mL溶有0.1371g(1mmol) 间氨基苯甲酸的无水乙醇溶液；恒温70℃继续反应1小时后滴加5mL溶有0.0400g（1mmol）NaOH的无水乙醇溶液；再恒温回流3小时，可见溶液有黄色沉淀生成；溶液用旋转蒸发器蒸发后得到黄色固体粉末即为二甲氨基苯甲醛缩氨基苯甲酸衍生物。
 (3) 二甲氨基苯甲醛缩氨基苯甲酸衍生物的应用：
抗菌：在抗菌实验中，发现本实施例制得的二甲氨基苯甲醛缩氨基苯甲酸衍生物对欧文氏草生杆菌，大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果。表1为抗菌实验数据。
表1.抗菌实验结果/抑菌圈(mm)
浓度(mg/mL) 大肠杆菌 金黄色葡萄球菌 草生欧文氏杆菌
0.25 2.02 0.14 4.10
0.50 3.72 1.08 4.22
1.00 5.08 2.88 4.72
1.50 6.28 4.36 6.76
2.00 9.12 8.18 11.38
(注：化合物在7~8mm有较弱抗菌活性；9~13mm有中等强度抗菌活性；14~25mm有较强抗菌活性。)
实施例中所使用的化学试剂均为分析纯。

Claims (2)

1. 一种二甲氨基苯甲醛缩氨基苯甲酸衍生物，其特征在于二甲氨基苯甲醛缩氨基苯甲酸衍生物分子结构式为：
                                                      
Figure 2014100261656100001DEST_PATH_IMAGE001
    。
2. 根据权利要求1所述的二甲氨基苯甲醛缩氨基苯甲酸衍生物的应用，其特征在于所述二甲氨基苯甲醛缩氨基苯甲酸衍生物应用在抗菌上。
CN201410026165.6A 2014-01-21 2014-01-21 一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及应用 Pending CN103724225A (zh)

Priority Applications (1)

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CN201410026165.6A CN103724225A (zh) 2014-01-21 2014-01-21 一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及应用

Applications Claiming Priority (1)

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CN201410026165.6A CN103724225A (zh) 2014-01-21 2014-01-21 一种二甲氨基苯甲醛缩氨基苯甲酸衍生物及应用

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KOLSEK, J. ET AL: "p-Dimethylaminobenzaldehyde as a reagent for characterizing primary aromatic amines", 《FRESENIUS" ZEITSCHRIFT FUER ANALYTISCHE CHEMIE》 *

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Application publication date: 20140416