CN103787914A - 一种二乙胺基水杨醛缩苯胺及其应用 - Google Patents

一种二乙胺基水杨醛缩苯胺及其应用 Download PDF

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CN103787914A
CN103787914A CN201410057768.2A CN201410057768A CN103787914A CN 103787914 A CN103787914 A CN 103787914A CN 201410057768 A CN201410057768 A CN 201410057768A CN 103787914 A CN103787914 A CN 103787914A
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diethylin
aniline
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salicylaldehyde
salicylaldehyde aniline
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CN103787914B (zh
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丁国华
江道勇
高蕊
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Guilin University of Technology
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Guilin University of Technology
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

本发明公开了一种二乙胺基水杨醛缩苯胺及其应用。二乙胺基水杨醛缩苯胺的分子结构式为：

Description

一种二乙胺基水杨醛缩苯胺及其应用
技术领域
本发明涉及一种二乙胺基水杨醛缩苯胺及其在抗菌领域的应用。
背景技术
西佛碱类化合物，在抗菌、催化、磁性、光学、电化学、非线性光学、化学传感器等领域，有广泛的用途，因此成为当前研究的热点。
发明内容
本发明的目的是提供一种二乙胺基水杨醛缩苯胺及其应用。
二乙胺基水杨醛缩苯胺的分子结构式为：
Figure 2014100577682100002DEST_PATH_IMAGE002
。
所述二乙胺基水杨醛缩苯胺应用于抗菌。
本发明的二乙胺基水杨醛缩苯胺对欧文氏草生杆菌、大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果。
具体实施方式
实施例：
(1)二乙胺基水杨醛缩苯胺的分子结构式为：
Figure 655590DEST_PATH_IMAGE002
。
(2)二乙胺基水杨醛缩苯胺的制备方法为：
取5毫摩尔4-二乙胺基水杨醛（0.9662克）置于100毫升三口烧瓶中并用25毫升乙醇溶解，另称取5毫摩尔4-羧基苯胺（0.6857克）并溶解于25毫升无水乙醇中，冰盐浴控制温度在8~10℃，将后者缓慢滴入前者，加入1.5毫升冰醋酸，半小时后出现黄色沉淀，继续反应3小时，静置后抽滤，并用无水乙醇洗涤三次，置于硅胶干燥器中干燥即制得二乙胺基水杨醛缩苯胺，MS-ESI：m/z 313.0 (MH+)；Calcd. Mr：312.37。
(3)二乙胺基水杨醛缩苯胺的应用：
通过抗菌实验，发现本实施例的二乙胺基水杨醛缩苯胺对欧文氏草生杆菌、大肠杆菌及金黄色葡萄球菌都有不同程度的抗菌效果，表1为抗菌实验数据。
表1 抗菌实验数据（抑菌圈直径，mm）
Figure 2014100577682100002DEST_PATH_IMAGE003
抑菌圈直径在7~8mm有较弱抗菌活性，在9~13mm有中等强度抗菌活性，在14~25mm有较强抗菌活性。从上表数据可以看出，本实施例的二乙胺基水杨醛缩苯胺在不同浓度下对欧文氏草生杆菌、大肠杆菌及金黄色葡萄球菌的抗菌效果不同。
实施例中所使用的化学试剂均为分析纯。

Claims (2)

1.一种二乙胺基水杨醛缩苯胺，其特征在于该二乙胺基水杨醛缩苯胺的分子结构式为：
。
2.根据权利要求1所述二乙胺基水杨醛缩苯胺的应用，其特征在于所述二乙胺基水杨醛缩苯胺应用于抗菌。
CN201410057768.2A 2014-02-20 2014-02-20 一种二乙胺基水杨醛缩苯胺及其应用 Expired - Fee Related CN103787914B (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104356024A (zh) * 2014-11-23 2015-02-18 桂林理工大学 一种二乙胺基水杨醛缩苯胺及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ISSOPOULOS, PRODROMOS B.ET AL: "Application of ternary complexes in pharmaceutical analysis. VII.Spectrophotometric determination of iron (II) in antianemic formulations,using a newly developed Schiff"s base in a micellar medium", 《BULGARIAN CHEMICAL COMMUNICATIONS》 *
KARGAR, HADI ET AL: "(E)-4-[(4-Diethylamino-2-hydroxybenzylidene)amino]benzoic acid", 《ACTA CRYSTALLOGRAPHICA》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104356024A (zh) * 2014-11-23 2015-02-18 桂林理工大学 一种二乙胺基水杨醛缩苯胺及其应用

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