CN103127502A - 使用il-21和单克隆抗体疗法治疗癌症的方法 - Google Patents

使用il-21和单克隆抗体疗法治疗癌症的方法 Download PDF

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Publication number
CN103127502A
CN103127502A CN2013100575165A CN201310057516A CN103127502A CN 103127502 A CN103127502 A CN 103127502A CN 2013100575165 A CN2013100575165 A CN 2013100575165A CN 201310057516 A CN201310057516 A CN 201310057516A CN 103127502 A CN103127502 A CN 103127502A
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cell
polypeptide
rituximab
fragment
treatment
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Chinese (zh)
Inventor
W·R·金德斯沃格尔
S·D·胡格赫斯
R·D·豪雷
C·H·克雷格
D·C·弗斯特
R·A·约翰逊
M·D·黑佩尔
P·V·斯瓦库玛
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Zymogenetics Inc
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Zymogenetics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2013100575165A 2004-05-20 2005-05-20 使用il-21和单克隆抗体疗法治疗癌症的方法 Pending CN103127502A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US57297304P 2004-05-20 2004-05-20
US60/572,973 2004-05-20
US63538004P 2004-12-10 2004-12-10
US60/635,380 2004-12-10
US67128105P 2005-04-14 2005-04-14
US60/671,281 2005-04-14
US68044705P 2005-05-12 2005-05-12
US60/680,447 2005-05-12

Related Parent Applications (1)

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CN 200580021262 Division CN101084012A (zh) 2004-05-20 2005-05-20 使用il－21和单克隆抗体疗法治疗癌症的方法

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Publication Number Publication Date
CN103127502A true CN103127502A (zh) 2013-06-05

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CN2013100575165A Pending CN103127502A (zh) 2004-05-20 2005-05-20 使用il-21和单克隆抗体疗法治疗癌症的方法
CN2011101079712A Expired - Fee Related CN102188704B (zh) 2004-05-20 2005-05-20 使用il-21和单克隆抗体疗法治疗癌症的方法

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US (8) US20050265966A1 (enExample)
EP (4) EP2431050A1 (enExample)
JP (2) JP4982373B2 (enExample)
KR (1) KR101236177B1 (enExample)
CN (2) CN103127502A (enExample)
AU (1) AU2005245031B2 (enExample)
BR (1) BRPI0511187A (enExample)
CA (1) CA2566745A1 (enExample)
CY (1) CY1113287T1 (enExample)
DK (1) DK1758610T3 (enExample)
ES (1) ES2390278T3 (enExample)
IL (1) IL179099A (enExample)
PL (1) PL1758610T3 (enExample)
PT (1) PT1758610E (enExample)
WO (1) WO2005113001A1 (enExample)

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US6307024B1 (en) * 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
WO2005113001A1 (en) * 2004-05-20 2005-12-01 Zymogenetics, Inc. Methods of treating cancer using il-21 and monoclonal antibody therapy
US20070218116A1 (en) * 2006-03-14 2007-09-20 Schwendener Reto A Compositions and methods for the treatment of tumors and tumor metastases
CN101553501A (zh) 2006-10-26 2009-10-07 诺沃-诺迪斯克有限公司 Il-21变种
KR100902340B1 (ko) * 2007-08-02 2009-06-12 한국생명공학연구원 Ｙｃ－１ 또는 ｉｌ－２１을 유효성분으로 포함하는자연살해세포 분화제 및 분화 방법
US8506933B2 (en) * 2007-11-30 2013-08-13 Msdx, Inc. Methods of detecting a neurological condition via analysis of circulating phagocytes
CA2770680A1 (en) * 2009-08-10 2011-02-17 Msdx, Inc. Methods of detecting responses to therapies using perforin levels
EP2504699A1 (en) * 2009-11-27 2012-10-03 MSDX, Inc. Methods of detecting or monitoring activity of an inflammatory or neurodegenerative condition
US8673309B2 (en) 2011-02-11 2014-03-18 Msdx, Inc. Methods for measuring high molecular weight complexes of fibrinogen with fibronectin and fibulin-1
WO2013109904A1 (en) * 2012-01-19 2013-07-25 University Of Miami Compositions, methods and kits for treatment of cancer and autoimmune diseases
WO2013169693A1 (en) 2012-05-09 2013-11-14 Bristol-Myers Squibb Company Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody
KR101453462B1 (ko) 2013-05-16 2014-10-23 앱클론(주) Her2에 특이적으로 결합하는 항체
MA39821B1 (fr) * 2014-04-08 2020-09-30 Boston Pharmaceuticals Inc Molécules de liaison spécifiques de l'il-21 et leurs utilisations
KR20160120157A (ko) * 2015-04-07 2016-10-17 주식회사 메드팩토 암 예방 또는 치료용 약학적 조성물 및 이를 이용한 방법
US20200016200A1 (en) * 2016-10-03 2020-01-16 Baylor College Of Medicine Modulating cytotoxic cell lytic granule positioning to promote diffuse killing in cellular therapies
WO2019055938A1 (en) * 2017-09-15 2019-03-21 Beckman Coulter, Inc. FLOW-BASED DOSINGS FOR THERAPEUTIC AGENTS
KR102265437B1 (ko) * 2017-11-24 2021-06-15 의료법인 성광의료재단 Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법

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WO2003103589A2 (en) * 2002-06-07 2003-12-18 Zymogenetics, Inc. Use of il-21 in cancer and other therapeutic applications

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US20070178063A1 (en) 2007-08-02
EP2428216A3 (en) 2012-05-23
EP2425847A1 (en) 2012-03-07
EP1758610A1 (en) 2007-03-07
KR20070026588A (ko) 2007-03-08
BRPI0511187A (pt) 2007-12-04
US20070122382A1 (en) 2007-05-31
EP2428216A9 (en) 2012-04-25
HK1160776A1 (en) 2012-08-17
PT1758610E (pt) 2012-10-01
US20050265966A1 (en) 2005-12-01
KR101236177B1 (ko) 2013-02-22
US20110086004A1 (en) 2011-04-14
PL1758610T3 (pl) 2012-11-30
JP2012102122A (ja) 2012-05-31
US20070048264A1 (en) 2007-03-01
JP2007538108A (ja) 2007-12-27
EP1758610B1 (en) 2012-07-04
EP2431050A1 (en) 2012-03-21
JP4982373B2 (ja) 2012-07-25
EP2428216A2 (en) 2012-03-14
DK1758610T3 (da) 2012-10-15
ES2390278T3 (es) 2012-11-08
CN102188704B (zh) 2013-04-24
EP2431050A8 (en) 2012-09-26
AU2005245031A1 (en) 2005-12-01
US20090087404A1 (en) 2009-04-02
US20090269304A1 (en) 2009-10-29
IL179099A0 (en) 2007-03-08
CY1113287T1 (el) 2016-04-13
CN102188704A (zh) 2011-09-21
IL179099A (en) 2011-03-31
AU2005245031B2 (en) 2011-08-18
CA2566745A1 (en) 2005-12-01
US20110300098A1 (en) 2011-12-08
WO2005113001A1 (en) 2005-12-01

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Application publication date: 20130605