CN103127173B - Atomizing multi-layer covering and crystallizing process for producing beer blood crystal - Google Patents
Atomizing multi-layer covering and crystallizing process for producing beer blood crystal Download PDFInfo
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- CN103127173B CN103127173B CN201310070220.7A CN201310070220A CN103127173B CN 103127173 B CN103127173 B CN 103127173B CN 201310070220 A CN201310070220 A CN 201310070220A CN 103127173 B CN103127173 B CN 103127173B
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Abstract
The invention provides an atomizing multi-layer covering and crystallizing process for producing a beer blood crystal. The atomizing multi-layer covering and crystallizing process for producing the beer blood crystal comprises the following steps of: atomizing the collected fresh beer blood; spraying at thickness of 0.5 to 1.5mm; standing the beer blood for 3 to 5 minutes at -120 to -110 DEG C under the liquid nitrogen environment; discharging the liquid nitrogen; naturally heating to reach 0 DEG C; dehumidifying to obtain the crystal; repeating the operations for three to six times; dehumidifying until the moisture in the beer blood crystal is not greater than 4wt.% at the last time; and then finishing to obtain the finished product of the beer blood. According to the atomizing multi-layer covering and crystallizing process for producing the beer blood crystal, the way of coating thin layers at a plurality of times and crystallizing at a plurality of times is carried out, thus the generated crystal particle is more regular than the beer blood crystal particle obtained by the primary crystallization; and the generated crystal particle is disintegrated in water within a short time, has good disintegrating effect, and is free from residues, great in taste and beneficial for being absorbed sufficiently by human body.
Description
Technical field
The present invention relates to a kind of manufacturing technique method of Sanguis cervi crystal, particularly relate to a kind of atomization multilamellar of producing Sanguis cervi crystal and cover crystallization processes.
Background technology
Sanguis cervi is the blood of animal in deer family, records according to Compendium of Material Medica: " the large tonifying deficiency of Sanguis cervi, benefiting essence-blood separate pox poison, poison of drug ".Sanguis cervi has irreplaceability as traditional precious Chinese medicine, and its medical value is extensively approved all the time and goed deep into exploitation, and product line is enriched constantly, and comprise deer-blood wine, fresh Sanguis cervi, Sanguis cervi crystal etc., the market value produced and demand are very huge.And wherein Sanguis cervi crystal is the product that pure fresh deer blood very obtains after Preparation process drying.The preparation method of tradition Sanguis cervi crystal is as described below, room temperature is naturally cooled to after being mixed homogeneously with anticoagulant by the fresh deer blood collected, then Sanguis cervi is poured on the glass plate after sterilization, generally to tile 1 square area with 500g fresh deer blood when toppling over, blood layer thickness is 1 ~ 2mm, then in 300,000 grades of clean rooms, Sanguis cervi is dried in the shade naturally, after Sanguis cervi bone dry, the semi-finished product Sanguis cervi crystal of its crystallization gained is scraped and adopts mechanical drying equipment conventional on market that its water content is adjusted to 5 ~ 6%.Above-mentioned production technology is easy and simple to handle, safety and sanitation, but thus technique to prepare the Sanguis cervi crystal finished product crystal grain of gained larger, when actual taking, the disintegration time of meeting water after entrance is long, occurs the not diffluent situation of crystallization even sometimes, user's mouthfeel is bad, affects trap.
Summary of the invention
In order to overcome above-mentioned the deficiencies in the prior art, the invention provides a kind of atomization multilamellar of producing Sanguis cervi crystal and cover crystallization processes, this technological operation is easy to be controlled, and the Sanguis cervi crystal finished product disintegration produced is fabulous, and take mouthfeel excellent, absorbance is high.
The present invention in order to the technical scheme solving its technical problem and adopt is:
The atomization multilamellar of producing Sanguis cervi crystal covers a crystallization processes, and comprise blood sampling, homogenizing cooling, crystallization and collection operation successively, wherein said Crystallization Procedure comprises the following steps:
(1) atomization drying crystallization first:
Fresh deer blood through homogenizing is inserted conventional atomising device under room temperature, is sprayed on the supporting plate after sterilization by this atomising device by Sanguis cervi, the quantity for spray of Sanguis cervi is that 0.5 ~ 1.5mm is as the criterion with its thickness on supporting plate;
The above-mentioned supporting plate with Sanguis cervi is put into a fully sheathed case, liquid nitrogen is injected in this fully sheathed case, the injection rate of liquid nitrogen is as the criterion at temperature in casing can be made to remain on-120 ~-110 DEG C for 3 ~ 5 minutes, leave standstill and discharge liquid nitrogen in casing after 3 ~ 5 minutes, when the temperature inside the box to be closed rises to 0 DEG C naturally, the dehumidifier utilizing the dehumidifier apparatus that fully sheathed case carries to carry out 2 ~ 3 hours, obtains the crystallization of first floor Sanguis cervi;
(2) atomization drying crystallization again:
Utilize conventional atomising device fresh deer blood to be sprayed at the upper surface of gained first floor Sanguis cervi crystallization in (1), the quantity for spray of Sanguis cervi is that 0.5 ~ 1mm is as the criterion with its thickness in the crystallization of first floor Sanguis cervi;
The above-mentioned supporting plate with the crystallization of first floor Sanguis cervi and fresh deer blood is put into fully sheathed case again, liquid nitrogen is injected in this fully sheathed case, the injection rate of liquid nitrogen is as the criterion at temperature in casing can be made to remain on-140 ~-130 DEG C for 3 ~ 5 minutes, leave standstill and discharge liquid nitrogen in casing after 3 ~ 5 minutes, the temperature inside the box to be closed carries out dehumidifier 2 ~ 3 hours when naturally rising to 0 DEG C, obtains two layers of Sanguis cervi crystallization;
(3) repeatedly atomization drying crystallization:
Two layers of Sanguis cervi crystallization of (2) middle gained repeat operation in step (2), wherein often repeat once, in the casing that in fully sheathed case, liquid nitrogen injection rate can keep, temperature all declines 20 DEG C on the basis of previous temperature, and minimum must not lower than-190 DEG C, repeat 3 ~ 6 times altogether, be evacuated to during dehumidifier in atomization drying crystallization process the last time when moisture in Sanguis cervi crystallization is not more than 4wt.% and stop dehumidifier, obtain Sanguis cervi crystal finished product.
Its further technical characteristic is:
The quantity for spray that described in step (1), step (2) and step (3), Sanguis cervi is each is that 1.0mm is as the criterion with its coating thickness.
The injection rate of liquid nitrogen described in step (1) is can make within 3 minutes, to be as the criterion in closed box, temperature remains on-120 DEG C, and time of repose is 3 minutes.
The injection rate of liquid nitrogen described in step (2) is can make within 3 minutes, to be as the criterion in closed box, temperature remains on-140 DEG C, and time of repose is 3 minutes.
Advantageous Effects of the present invention is: the atomization multilamellar of production Sanguis cervi crystal of the present invention covers crystallization processes, the spraying that thickness is 0.5 ~ 1.5mm is carried out after being atomized by the fresh deer blood collected, and discharge liquid nitrogen after this Sanguis cervi is left standstill 3 ~ 5min in liquid nitrogen environment at-120 ~-110 DEG C, and when being naturally warming up to 0 DEG C, carry out dehumidifier formation crystallization, repetition like this 3 ~ 6 times, be evacuated to during last dehumidifier when moisture is not more than 4wt.% in Sanguis cervi crystallization and terminate, obtain finished product, this kind of technology mode repeatedly thin layer sprays repeatedly crystallization, the crystal grain formed is more regular than the crystal grain of primary crystallization gained Sanguis cervi crystal, disintegration time after its water breakthrough is short, disintegrate is effective, without residue, mouthfeel is excellent and be conducive to human body and fully absorb.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Blood sampling: with people with the safety blood taking bag containing anticoagulant, confirming that healthy stag gathers Sanguis cervi by jugular vein through blood biochemical detection, evenly shaking blood taking bag inner blood and make it mix homogeneously with anticoagulant, obtain fresh deer blood.
Homogenizing cools: divided by aforementioned fresh deer blood several times to be placed on concussion instrument and carry out conventional homogenizing process, and enter cold room after naturally cooling to 25 DEG C, carry out fresh-keeping at 2 DEG C.
Safety detection: by healthy Sanguis cervi biological test standard (this standard with human blood health standards for standard), 15 are done to gained fresh deer blood and detects with the safety guaranteeing Sanguis cervi.
Produce the cleaning process of apparatus: supporting plate selects L316 rustless steel pallet.Adopt 85% degree of edible ethanol to carry out three times to the production apparatus that supplementary liquid nitrogen plan and dehumidifier apparatus etc. that conventional atomising device, L316 rustless steel pallet, fully sheathed case, fully sheathed case carry relate to disinfect.
Crystallization:
(1) atomization drying crystallization first: 25 DEG C of fresh deer bloods that also safety detection is crossed will be cooled to through homogenizing and enter in conventional atomising device in ambient temperatare, conventional nebulizers is selected in the present embodiment, to be sprayed at by Sanguis cervi in the L316 rustless steel pallet after sterilization by this conventional nebulizers, the quantity for spray of Sanguis cervi is that 1.0mm is as the criterion with its thickness on pallet; The above-mentioned pallet with Sanguis cervi is put into a fully sheathed case, this fully sheathed case is provided with temperature-detecting device, liquid nitrogen fills arranging device and dehumidifier apparatus, liquid nitrogen is injected in this fully sheathed case, the injection rate of liquid nitrogen is can make within 3 minutes, to be as the criterion in casing, temperature remains on-120 DEG C, leave standstill the liquid nitrogen of discharging after 3 minutes in closed box, when the temperature inside the box to be closed rises to 0 DEG C naturally, the dehumidifier utilizing the dehumidifier apparatus that fully sheathed case carries to carry out 3 hours, obtains the crystallization of first floor Sanguis cervi;
(2) atomization drying crystallization again: utilize aforesaid conventional nebulizers fresh deer blood to be sprayed at the upper surface of gained first floor Sanguis cervi crystallization in (1), the quantity for spray of Sanguis cervi is that 1.0mm is as the criterion with its thickness in the crystallization of first floor Sanguis cervi; The above-mentioned pallet with the crystallization of first floor Sanguis cervi and fresh deer blood is put into fully sheathed case again, liquid nitrogen is injected in this fully sheathed case, the injection rate of liquid nitrogen is as the criterion so that temperature in casing can be made to remain on-140 times 3 minutes, leave standstill and discharge liquid nitrogen in casing after 3 minutes, the temperature inside the box to be closed carries out dehumidifier 3 hours when naturally rising to 0 DEG C, obtains two layers of Sanguis cervi crystallization;
(3) repeatedly atomization drying crystallization: repeat operation in step (2) in two layers of Sanguis cervi crystallization of (2) middle gained, wherein often repeat once, in the casing that in fully sheathed case, liquid nitrogen injection rate can keep, temperature all declines 20 DEG C on the basis of previous temperature, and minimum must not lower than-190 DEG C, repeat 4 times altogether, and be evacuated to during dehumidifier in atomization drying crystallization process the last time when moisture in Sanguis cervi crystallization is not more than 4wt.% and stop dehumidifier, obtain Sanguis cervi crystal finished product.
Gather Sanguis cervi crystal finished product: dehumidifier terminates, and opens fully sheathed case chamber door, adopt to commonly use and draw together brilliant instrument collection Sanguis cervi crystal finished product.
Outside more than in operation, removing is taken a blood sample, all the other operations are all carried out in the environment of 100,000 grades of cleanliness factors.
Not special operational approach, instrument and equipment and the operation parameter thereof proposing to illustrate in the present embodiment, be conventional practices that those of ordinary skill in the art use, apparatus & equipment in common use and Common Parameters, or do not need can be known by creative work according to limited number of time experiment.
The above-mentioned Sanguis cervi crystal finished product collected is carried out disintegrate Tachistoscope.Method of testing is as described below: in 25 DEG C of environment, get Sanguis cervi crystal finished product 1g, is placed in the test tube with ground stopper that 10ml deionized water is housed, and shakes test tube 3 ~ 5 times up and down, the dissolution time of record Sanguis cervi crystal finished product, and observation has deposit-free.Test result is as shown in table 1.That wherein selects in embodiment is the Sanguis cervi crystal finished product that this process produces, and comparative example 1 selects the Sanguis cervi crystal finished product of explained hereafter described in background technology, selects other Sanguis cervi crystal finished products that existing market is sold in comparative example 2.
Table 1 crystallization processes parameter and Sanguis cervi crystal finished product disintegrate Tachistoscope result
Claims (4)
1. the atomization multilamellar of producing Sanguis cervi crystal covers a crystallization processes, comprises blood sampling, homogenizing cooling, crystallization and collection operation successively, it is characterized in that: described Crystallization Procedure comprises the following steps:
(1) atomization drying crystallization first:
Fresh deer blood through homogenizing is inserted conventional atomising device under room temperature, is sprayed on the supporting plate after sterilization by this atomising device by Sanguis cervi, the quantity for spray of Sanguis cervi is that 0.5 ~ 1.5mm is as the criterion with its thickness on supporting plate;
The above-mentioned supporting plate with Sanguis cervi is put into a fully sheathed case, liquid nitrogen is injected in this fully sheathed case, the injection rate of liquid nitrogen is as the criterion at temperature in casing can be made to remain on-120 ~-110 DEG C for 3 ~ 5 minutes, leave standstill and discharge liquid nitrogen in casing after 3 ~ 5 minutes, when the temperature inside the box to be closed rises to 0 DEG C naturally, the dehumidifier utilizing the dehumidifier apparatus that fully sheathed case carries to carry out 2 ~ 3 hours, obtains the crystallization of first floor Sanguis cervi;
(2) atomization drying crystallization again:
Utilize conventional atomising device fresh deer blood to be sprayed at the upper surface of gained first floor Sanguis cervi crystallization in (1), the quantity for spray of Sanguis cervi is that 0.5 ~ 1mm is as the criterion with its thickness in the crystallization of first floor Sanguis cervi;
The above-mentioned supporting plate with the crystallization of first floor Sanguis cervi and fresh deer blood is put into fully sheathed case again, liquid nitrogen is injected in this fully sheathed case, the injection rate of liquid nitrogen is as the criterion at temperature in casing can be made to remain on-140 ~-130 DEG C for 3 ~ 5 minutes, leave standstill and discharge liquid nitrogen in casing after 3 ~ 5 minutes, the temperature inside the box to be closed carries out dehumidifier 2 ~ 3 hours when naturally rising to 0 DEG C, obtains two layers of Sanguis cervi crystallization;
(3) repeatedly atomization drying crystallization:
Two layers of Sanguis cervi crystallization of (2) middle gained repeat operation in step (2), wherein often repeat once, in the casing that in fully sheathed case, liquid nitrogen injection rate can keep, temperature all declines 20 DEG C on the basis of previous temperature, and minimum must not lower than-190 DEG C, repeat 3 ~ 6 times altogether, be evacuated to during dehumidifier in atomization drying crystallization process the last time when moisture in Sanguis cervi crystallization is not more than 4wt.% and stop dehumidifier, obtain Sanguis cervi crystal finished product.
2. the atomization multilamellar of production Sanguis cervi crystal according to claim 1 covers crystallization processes, it is characterized in that: the quantity for spray that described in step (1), step (2) and step (3), Sanguis cervi is each is that 1.0mm is as the criterion with its coating thickness.
3. the atomization multilamellar of production Sanguis cervi crystal according to claim 1 covers crystallization processes, it is characterized in that: the injection rate of liquid nitrogen described in step (1) is can make within 3 minutes, to be as the criterion in closed box, temperature remains on-120 DEG C, and time of repose is 3 minutes.
4. the atomization multilamellar of production Sanguis cervi crystal according to claim 1 covers crystallization processes, it is characterized in that: the injection rate of liquid nitrogen described in step (2) is can make within 3 minutes, to be as the criterion in closed box, temperature remains on-140 DEG C, and time of repose is 3 minutes.
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| US5505980A (en) * | 1993-08-02 | 1996-04-09 | National Deer Horn Limited | Method of manufacturing powdered deer blood |
| RU2130314C1 (en) * | 1996-07-08 | 1999-05-20 | Открытое акционерное общество "ТФК Смирнов и К" | Remedy possessing nootropic and adaptation properties and method for producing the remedy |
| CN1429842A (en) * | 2001-12-30 | 2003-07-16 | 上海天亦医学科技有限公司 | Deer serum active polypeptide crystal preparation and its preparing method |
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| KR100503629B1 (en) * | 2002-12-31 | 2005-07-26 | 박동기 | The preparation method of the young antlers of the deer, deer blood or deer horns and the functional food using thereof |
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| US5505980A (en) * | 1993-08-02 | 1996-04-09 | National Deer Horn Limited | Method of manufacturing powdered deer blood |
| RU2130314C1 (en) * | 1996-07-08 | 1999-05-20 | Открытое акционерное общество "ТФК Смирнов и К" | Remedy possessing nootropic and adaptation properties and method for producing the remedy |
| CN1429842A (en) * | 2001-12-30 | 2003-07-16 | 上海天亦医学科技有限公司 | Deer serum active polypeptide crystal preparation and its preparing method |
| CN1894026A (en) * | 2003-12-19 | 2007-01-10 | 阿尔克-阿贝洛有限公司 | Cryogranulation and storage method for active pharmaceutical agents |
| RU2268058C2 (en) * | 2004-03-29 | 2006-01-20 | Всероссийский научно-исследовательский институт пантового оленеводства (ВНИИПО) | Method for preparing biologically active product from deer velvet antlers and blood |
| CN1803149A (en) * | 2005-01-14 | 2006-07-19 | 苏州市红冠庄国药饮片有限公司 | Traditional Chinese medicine deer blood crystal and its preparation method |
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Owner name: SUZHOU HONGGUANZHUANG TRADITIONAL CHINESE MEDICINE Free format text: FORMER NAME: HONGGUANGZHUANG CHINESE HERBAL PIECE CO., LTD., SUZHOU |
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Address after: Suzhou City, Jiangsu province 215343 Kunshan City Qiandeng Town Shipu Fumin Road No. 89, airport Oce Patentee after: SUZHOU HONGGUANZHUANG MEDICINES CO., LTD. Address before: Suzhou City, Jiangsu province 215343 Kunshan City Qiandeng Town Shipu Fumin Road No. 89, airport Oce Patentee before: Hongguangzhuang Chinese Herbal Piece Co., Ltd., Suzhou |