CN103111019A - Straight inserting type self-pressing medication injecting hollow microneedle device - Google Patents
Straight inserting type self-pressing medication injecting hollow microneedle device Download PDFInfo
- Publication number
- CN103111019A CN103111019A CN2013100684694A CN201310068469A CN103111019A CN 103111019 A CN103111019 A CN 103111019A CN 2013100684694 A CN2013100684694 A CN 2013100684694A CN 201310068469 A CN201310068469 A CN 201310068469A CN 103111019 A CN103111019 A CN 103111019A
- Authority
- CN
- China
- Prior art keywords
- air
- end cap
- storage film
- oppressing
- return
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 39
- 229940079593 drug Drugs 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 4
- 239000000758 substrate Substances 0.000 claims description 23
- 238000002347 injection Methods 0.000 claims description 18
- 239000007924 injection Substances 0.000 claims description 18
- 238000003780 insertion Methods 0.000 claims description 12
- 230000037431 insertion Effects 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 5
- 239000000560 biocompatible material Substances 0.000 claims description 2
- 239000013536 elastomeric material Substances 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 2
- 230000003252 repetitive effect Effects 0.000 claims description 2
- 229910001220 stainless steel Inorganic materials 0.000 claims description 2
- 239000010935 stainless steel Substances 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 6
- 210000002615 epidermis Anatomy 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Abstract
The invention provides a straight inserting type self-pressing medication injecting hollow microneedle device which comprises a hollow needle body, a basal plate cavity, an end cover, a handle, an elastic air storage film, a check valve, an air releasing hole, a transfusion hole and the like. The hollow needle body is arranged on a basal plate cavity structure, the end cover is arranged on the handle and is connected with the basal plate cavity, the elastic air storage film is arranged between the end cover and the basal plate cavity, and the end cover is provided with the air check valve and the air releasing hole. The straight inserting type self-pressing medication injecting hollow microneedle device uses the force applied to the handle and the end cover in a drug delivery process, enables the increasing of the air pressure of the space formed between the elastic air storage film and the end cover to be achieved through the transformable end cover and the air check valve, and when the transformation of the end cover recovers, the air of the space is increased through the action of the air check valve, the air pressure recovers, the drug and the air are separated through the elastic air storage film, and the pollution to the drug by the air is avoided. The air check valve recovers the air pressure of the space formed between the elastic air storage film and the end cover timely, and the backflow of the drug is avoided.
Description
Technical field
The present invention relates to medicine controlled releasing and skin Wicresoft device, particularly direct insertion from oppressing drug injection empty micropin device.
Background technology
Traditional percutaneous dosing be medicine by the passive corium that diffuses into of epidermis passage, then enter body circulation through blood capillary.Cuticular obstruction cause the most drug molecule can't by and administration the most very little, and rate of release is difficult to reach the purpose for the treatment of too slowly, people have taked various measures to destroy horny layer to strengthen skin to the infiltration of medicine for this reason.The microneedle array that is comprised of the micropin of 10-2000 μ m is a kind of relatively new route of administration, it not only can pierce through the upper strata epidermis and create and allow the even micron-scale passage that passes through of microgranule of medicine macromole, and unlikely exciting nerve produces the damage that pain causes clinical meaning again.
Skin is divided into three layers from outside to inside: horny layer, epidermal area and skin corium.The cutin bed thickness is 10-20 μ m approximately, is that one deck is extremely organized, and there is no blood vessel and nerve, but the controlled release layer of percutaneous drug absorption; Epidermal area is positioned at outer subcutaneous approximately 50-100 μ m place, contains a small amount of living cells and nerve, does not contain blood vessel; More contain a large amount of living cells, nerve and blood vessel in the corium of depths.Micropin is the micron-sized pin of difformity, structure and the material made by Micrometer-Nanometer Processing Technology, and by producing at keratodermatitis the permeability that medicine is improved in small duct, this is a kind of administering mode between subcutaneous injection and transdermal patch.
General traditional method, active nutrient can only infiltrate through the barrier layer (being horny layer) of epidermis, and effect is remarkable (only reaching approximately 0. 3 percent effect) not.Utilize the small syringe needle chafe of micropin, make active component effectively infiltrate skin, micropin stimulates skin corium simultaneously, percutaneous self-healing ability, promote the ossein hypertrophy, can the match in excellence or beauty plastic operation of laser and filled type of the thickness hypertrophy that can make skin epidermis approximately 8 percent, its effect.And the side effect of micropin technology is extremely low, and is safe and reliable.
Summary of the invention
The purpose of this invention is to provide a kind of direct insertionly from oppressing drug injection empty micropin device, because traditional injection system can make the algesiogenic sensation of people, and be not suitable for the body local dispenser.The invention provides a kind of painless empty micropin administering mode, be convenient to patient is carried out accurate dispenser.
Hollow needle body and substrate chamber, end cap, handle, elastic air storage film, air check (non-return) valve, bleeder port, infusion hole etc.
Hollow needle body is on substrate chamber, and end cap is connected on handle, and end cap is connected with substrate chamber, is the elastic air storage film between end cap and substrate chamber, and on end cap with air check (non-return) valve and air bleeder port.
The power that during dispenser, handle opposite end lid is applied, make deformable end cap and air check (non-return) valve realize increase to the space air pressure that forms between elastic air storage film and end cap, thereby the injection of the medicine in the promotion substrate chamber, effect by the air check (non-return) valve when end cap distortion recovers increases the air in this space, air pressure recovers, and due to the effect of air check (non-return) valve 3, but top process repetitive operation.
The elastic air storage film separates air with medicine, avoided the pollution of air to medicine.
The existence of air check (non-return) valve has in time recovered to form between elastic air storage film and end cap the air pressure in space, has avoided the backflow of medicine.
Have on substrate chamber and end cap and prevent that the elastic air storage film from sliding and the groove of gas leakage, there is projection at elastic air storage film edge, the groove cooperation on projection and substrate chamber and end cap.
The air check (non-return) valve is patch form, is present in end cap inside, is perhaps other forms of check (non-return) valve.
End cap is elastomeric material.
The height of empty micropin is 0.2mm～3mm, and the outer dia of pin is 0.05mm～1mm, and inside diameter is 0.02mm～0.8mm.
The material of empty micropin is the polymer such as medical stainless steel, biocompatible material, degradable material or PMMA.
The present invention compares with background technology, and the useful effect that has is:
The power that when the present invention utilizes dispenser, handle is applied makes deformable end cap and air check (non-return) valve realize increase to elastic air storage film Air, thereby promotes the injection of the medicine in substrate chamber.The present invention has avoided the pollution of air to medicine to medicine and air separation.And due to the existence of air check (non-return) valve, avoided the backflow of medicine.
Description of drawings
Fig. 1 is the structural representation of integral body of the present invention.
Fig. 2 is the substrate chamber schematic rear view.
Fig. 3 is the substrate chamber front schematic view.
Fig. 4 is elastic air storage film schematic diagram.
Fig. 5 is the end cap connection diagram.
Fig. 6 is the handle schematic diagram.
The specific embodiment
Further illustrate below in conjunction with accompanying drawing, referring to Fig. 2, Fig. 3, Fig. 4, Fig. 5, shown in Figure 6, hollow needle body is on substrate chamber, end cap is connected on handle, end cap is connected with substrate chamber, is the elastic air storage film between end cap and substrate chamber, and on end cap with air check (non-return) valve and air bleeder port.
The power that handle applies end cap, make deformable end cap and air check (non-return) valve realize increase to the space air pressure that forms between elastic air storage film and end cap, thereby the injection of the medicine in the promotion substrate chamber, effect by the air check (non-return) valve when end cap distortion recovers increases the air in this space, air pressure recovers, and when carrying out administration, the air bleeder port is closed, when micropin was carried out perfusion, this air bleeder port was opened.
Have on substrate chamber and end cap and prevent that the elastic air storage film from sliding and the groove of gas leakage, there is projection at elastic air storage film edge, the groove cooperation on projection and substrate chamber and end cap.
Claims (10)
1. direct insertion from oppressing drug injection empty micropin device, it is characterized in that it comprises: hollow needle body 1 and substrate chamber 2, end cap 5, handle 6, elastic air storage film 8, air check (non-return) valve 3, bleeder port 7, infusion hole 4 etc.
2. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: hollow needle body 1 is on substrate chamber 2, end cap 5 is connected on handle 6, end cap 5 is connected with substrate chamber 2, be elastic air storage film 8 between end cap 5 and substrate chamber 2, and on end cap with air check (non-return) valve 3 and air bleeder port 7.
3. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: the power that during dispenser, 6 pairs of end caps 5 of handle is applied, make deformable end cap 5 and air check (non-return) valve 3 realize increase to the space air pressure that forms between elastic air storage film 7 and end cap 5, thereby promote the injection of the medicine in substrate chamber 2, effect by air check (non-return) valve 3 when end cap 5 distortion recover increases the air in this space, air pressure recovers, and due to the effect of air check (non-return) valve 3, but top process repetitive operation.
4. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: elastic air storage film 8 separates air with medicine, has avoided the pollution of air to medicine.
5. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: the existence of air check (non-return) valve 3, in time recovered to form between elastic air storage film 7 and end cap 5 air pressure in space, avoided the backflow of medicine.
6. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: have on substrate chamber 2 and end cap 5 and prevent that the elastic air storage film from sliding and the groove of gas leakage, there is projection at elastic air storage film 8 edges, and the groove on projection and substrate chamber 2 and end cap 5 coordinates.
7. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: air check (non-return) valve 3 is patch form, is present in end cap 5 inside, is perhaps other forms of check (non-return) valve.
8. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: end cap 5 is elastomeric material.
9. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: the height of empty micropin is 0.2mm～3mm, and the outer dia of pin is 0.05mm～1mm, and inside diameter is 0.02mm～0.8mm.
10. according to claim 1 direct insertion from oppressing drug injection empty micropin device, it is characterized in that: the material of empty micropin is the polymer such as medical stainless steel, biocompatible material, degradable material or PMMA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310068469.4A CN103111019B (en) | 2013-03-04 | 2013-03-04 | Straight inserting type self-pressing medication injecting hollow microneedle device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310068469.4A CN103111019B (en) | 2013-03-04 | 2013-03-04 | Straight inserting type self-pressing medication injecting hollow microneedle device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103111019A true CN103111019A (en) | 2013-05-22 |
| CN103111019B CN103111019B (en) | 2014-08-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310068469.4A Expired - Fee Related CN103111019B (en) | 2013-03-04 | 2013-03-04 | Straight inserting type self-pressing medication injecting hollow microneedle device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103111019B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108367143A (en) * | 2015-12-21 | 2018-08-03 | 美德阿利克斯株式会社 | Microneedle patch applicator and its shell |
| CN113195035A (en) * | 2018-12-21 | 2021-07-30 | 莱雅公司 | Kit using microneedle sheet and cosmetic method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1608686A (en) * | 2003-10-21 | 2005-04-27 | 中国科学院电子学研究所 | Air bag controlled micro medicine conveying executor |
| US20070161964A1 (en) * | 2006-01-10 | 2007-07-12 | Yuzhakov Vadim V | Microneedle array, patch, and applicator for transdermal drug delivery |
| CN201179077Y (en) * | 2007-12-12 | 2009-01-14 | 沈忠忠 | Fine-needle massager |
| JP2009509634A (en) * | 2005-09-30 | 2009-03-12 | Ｔｔｉ・エルビュー株式会社 | Functionalized microneedle transdermal drug delivery system, apparatus and method |
| WO2011084295A2 (en) * | 2010-01-08 | 2011-07-14 | Wisconsin Alumni Research Foundation | Bladder arrangement for microneedle-based drug delivery device |
-
2013
- 2013-03-04 CN CN201310068469.4A patent/CN103111019B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1608686A (en) * | 2003-10-21 | 2005-04-27 | 中国科学院电子学研究所 | Air bag controlled micro medicine conveying executor |
| JP2009509634A (en) * | 2005-09-30 | 2009-03-12 | Ｔｔｉ・エルビュー株式会社 | Functionalized microneedle transdermal drug delivery system, apparatus and method |
| US20070161964A1 (en) * | 2006-01-10 | 2007-07-12 | Yuzhakov Vadim V | Microneedle array, patch, and applicator for transdermal drug delivery |
| CN201179077Y (en) * | 2007-12-12 | 2009-01-14 | 沈忠忠 | Fine-needle massager |
| WO2011084295A2 (en) * | 2010-01-08 | 2011-07-14 | Wisconsin Alumni Research Foundation | Bladder arrangement for microneedle-based drug delivery device |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108367143A (en) * | 2015-12-21 | 2018-08-03 | 美德阿利克斯株式会社 | Microneedle patch applicator and its shell |
| CN113195035A (en) * | 2018-12-21 | 2021-07-30 | 莱雅公司 | Kit using microneedle sheet and cosmetic method |
| CN113195035B (en) * | 2018-12-21 | 2023-11-14 | 莱雅公司 | Package and cosmetic method using microneedle sheet |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103111019B (en) | 2014-08-20 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: NINGBO L. K. MACHINERY CO., LTD. Effective date: 20130711 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Yajun Inventor after: Cai Hengzhi Inventor after: Zhou Gang Inventor after: Zhou Wanchang Inventor after: Zhuang Jian Inventor after: Xue Ling Inventor after: Wang Xinliang Inventor after: Wang Chaohua Inventor before: Zhang Yajun Inventor before: Zhuang Jian Inventor before: Hao Junjiao Inventor before: Xue Ling Inventor before: Zhou Gang |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG YAJUN ZHUANG JIAN HAO JUNJIAO XUE LING ZHOU GANG TO: ZHANG YAJUN CAI HENGZHI ZHOU GANG ZHOU WANCHANG ZHUANG JIAN XUE LING WANG XINLIANG WANG CHAOHUA |
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| TA01 | Transfer of patent application right |
Effective date of registration: 20130711 Address after: 213164 520 Avenue, science and Education City, 801 middle Wu Road, Jiangsu, Changzhou, Changzhou Institute of advanced materials, Beijing University of Chemical Technology, block A, 211 Applicant after: Changzhou Institute of Advanced Material, Beijing University of Chemical Technology Applicant after: Ningbo Lijin Machinery Co., Ltd. Address before: 213164 520 Avenue, science and Education City, 801 middle Wu Road, Jiangsu, Changzhou, Changzhou Institute of advanced materials, Beijing University of Chemical Technology, block A, 211 Applicant before: Changzhou Institute of Advanced Material, Beijing University of Chemical Technology |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140820 Termination date: 20170304 |