CN105381536A - Automatic-medicine-carrying long-time transdermal-delivery and sampling device - Google Patents
Automatic-medicine-carrying long-time transdermal-delivery and sampling device Download PDFInfo
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- CN105381536A CN105381536A CN201510968742.8A CN201510968742A CN105381536A CN 105381536 A CN105381536 A CN 105381536A CN 201510968742 A CN201510968742 A CN 201510968742A CN 105381536 A CN105381536 A CN 105381536A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150274—Manufacture or production processes or steps for blood sampling devices
- A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
- A61B5/150419—Pointed piercing elements, e.g. needles, lancets for piercing the skin comprising means for capillary action
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150503—Single-ended needles
- A61B5/150511—Details of construction of shaft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Manufacturing & Machinery (AREA)
- Anesthesiology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention provides an automatic-medicine-carrying long-time transdermal-delivery and sampling device. The automatic-medicine-carrying long-time transdermal-delivery and sampling device comprises a base plate. Microneedles are manufactured on the front face of the base plate. A storage cavity for storing medicine or sampled matter is formed in the back face of the base plate. Delivering channels communicated with the storage cavity and the front face of the base plate are formed in roots of the microneedles. At least one inwards-concave flow guide groove is formed along the surface of each microneedle. The flow guide grooves are communicated with the delivering channels and at least extend from the bottom of the storage cavity in the back face of the base plate downwards to the depth portions, punctured by the microneedles, of the skin. The automatic-medicine-carrying long-time transdermal-delivery and sampling device further comprises a cover plate with which the storage cavity in the back face of the base plate is covered. The cover plate is a flexible cover plate, or the cover plate is a rigid cover plate. A control device for medicine releasing or body fluid/blood sampling is integrated in the cover plate. By means of the automatic-medicine-carrying long-time transdermal-delivery and sampling device, medicine delivering time can be prolonged, and the number of medicine delivering times can be decreased; in addition, the limitation of the low epidermis penetration rate is broken through, and the medicine delivering effect is better.
Description
Technical field
The present invention relates to a kind of medical instruments, especially a kind of transdermal administration and sampler.
Background technology
Current microneedle devices has started to enter the application stage, micropin skin puncture epidermis, and by the Epidermal administration of medicine by puncturing spread upon on micropin, but the microneedle devices of current use exists some shortcomings;
One of shortcoming, active medicine spreads upon on the microneedle surface of microneedle devices, and micropin only wraps by the medicine of small amount, and during skin puncture administration, the persistence of effect is inadequate, cannot carry out long-time transdermal administration;
Shortcoming two, after micropin prick skin epidermis, because the self-regeneration of epiderm skin, through the time of one shorter, epiderm skin is closed by fluid passage, the place of thorn, and the medicine that surface sticks cannot realize long slow releasing.
Summary of the invention
Object of the present invention overcomes the deficiencies in the prior art, transdermal administration and sampler when a kind of medicine carrying voluntarily long be provided, in skin surface administration, make medicine with constant speed or close to constant speed, produce whole body or local therapeutic effects by skin layers by body circulation; The present invention can realize sustained release, reduces times for spraying, and breaches the low restriction of Epidermal Drug transmitance, the better effects if of administration.The technical solution used in the present invention is:
Transdermal administration and a sampler during medicine carrying voluntarily long, comprise a substrate, be manufactured with micropin in the front of substrate, the back side of substrate is provided with the storage chamber for storing medicine or sampling thing; The transmission channel being communicated with and storing chamber and substrate front side is had at micropin root;
Along the surface of micropin, have the guiding gutter of at least one indent; Described guiding gutter is communicated with transmission channel; Guiding gutter extends downward and exceedes micropin skin puncture degree of depth part bottom substrate back storage chamber.
Further, guiding gutter stores bottom chamber from substrate back and extends to micropin top.
Further, transdermal administration and sampler during described medicine carrying voluntarily long, also comprise one and cover and store cover plate above chamber at substrate back.
Further, described cover plate is flexible cover plate; Or described cover plate is rigid cover plate.
Further, the control device for drug release or body fluid/blood sampling is integrated with in described cover plate.
Further, described control device comprises direct current or pulse generator, the first electrode and the second electrode; Direct current or pulse generator are arranged in cover plate; First electrode is located at cover plate bottom surface; Second electrode is positioned at outer surface of substrate and the second electrode is positioned at substrate front side at least partly, forms loop in use with contact skin;
Direct current or pulse generator produce the direct current or pulse signal that promote that skin absorbs the drug by the first electrode and the second electrode.
Or, further, described control device comprise be arranged on cover plate bottom surface expansion module and cover plate in the electric-controlled parts of expansion module.
Or further, described control device comprises the contraction module and the interior electric-controlled parts shrinking module of cover plate that are arranged on cover plate bottom surface.
Further, the cross sectional shape of guiding gutter is that central angle is greater than 180 degree fan-shaped.
More preferably, the medicine that storage intracavity is inserted is selected from: polyglycolic acid, polylactic acid, Stereocomplex polylactic acid, plant origin polycarbonate resin, poly butylene succinate, polyvinyl alcohol, polyesteramide, polyacrylamide, polyacrylic acid, polyvinyl pyrrolidone, beta-schardinger dextrin-, Poly-L-lactic acid, xanthan gum, gelatin, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, chitin, glucosan and derivant thereof, carbomer, Chitosan-phospholipid complex, methylcellulose, carboxymethyl cellulose, the combination of one or more in sodium carboxymethyl cellulose.
The invention has the advantages that:
1) micropin skin puncture of the present invention, produces whole body or local therapeutic effects by skin layers by body circulation; The contingent liver of oral administration can be avoided to be subject to effect and gastrointestinal deactivation, to improve therapeutic effect.
2) present invention achieves and continue medication for a long time, compared to existing microneedle devices, constant blood drug level or pharmacodynamics effect can be maintained, strengthen therapeutic effect and reduce side effect; Extend administration time, reduce times for spraying, increase the medication compliance of patient.
3) micropin side is provided with guiding gutter, breaches the restriction that Epidermal Drug transmitance is low, painless, Wicresoft, and wound can self-regeneration fast after stopping administration.
4) patient can self administration, at any time interruption of the administration, easy for operation.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Fig. 2 is fragmentary bottom angle enlargement figure.
Fig. 3 is glass of the present invention or silicon wafer substrate schematic diagram.
Fig. 4 is that making of the present invention stores chamber schematic diagram.
Fig. 5 is making guiding gutter schematic diagram of the present invention.
Fig. 6 is making micropin schematic diagram of the present invention.
Fig. 7 is direct current of the present invention or pulse generator control device schematic diagram.
Fig. 8 a and Fig. 8 b is expansion module control device schematic diagram of the present invention.
Fig. 9 a and Fig. 9 b is contraction module control device schematic diagram of the present invention.
Detailed description of the invention
Below in conjunction with concrete drawings and Examples, the invention will be further described.
As depicted in figs. 1 and 2, when the invention provides a kind of medicine carrying voluntarily long, transdermal administration and sampler, comprise a substrate 1, in the front of substrate 1 (in Fig. 1, the lower surface of substrate 1 is front) be manufactured with micropin 3, the back side of substrate 1 is provided with the storage chamber 5 for storing medicine or sampling thing; Two transmission channels 2 being communicated with and storing chamber 5 and substrate 1 front are had in micropin 3 root symmetry;
Along the surface of micropin 3, have the guiding gutter 4 of two indents; Each guiding gutter 4 is communicated with corresponding transmission channel 2; Guiding gutter 4 extends downward and exceedes micropin 3 skin puncture degree of depth part bottom storage chamber, substrate 1 back side 5.Certainly, also micropin 3 top can be extended to by guiding gutter 4 bottom storage chamber, substrate 1 back side 5.
Store in chamber 5 and can insert medicine in advance, transmission channel 2 can make medicine flow to the skin of below from the storage chamber 5 of top.For traditional a small amount of medicine of micropin 3 pan coating, administration persistence of the present invention extends greatly.Show by experiment, the at least one medicine in following group is inserted in the storage chamber 5 of this device, evident in efficacy: polyglycolic acid, polylactic acid, Stereocomplex polylactic acid, plant origin polycarbonate resin, poly butylene succinate, polyvinyl alcohol, polyesteramide, polyacrylamide, polyacrylic acid, polyvinyl pyrrolidone, beta-schardinger dextrin-, Poly-L-lactic acid, xanthan gum, gelatin, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, chitin, glucosan and derivant thereof, carbomer, Chitosan-phospholipid complex, methylcellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose,
The cross sectional shape of guiding gutter 4 can design as required, the speed that subcutaneously can be discharged by the cross sectional shape controls transfer passage 2 of control guiding gutter 4, guiding gutter 5 Chinese medicine.Concave structure inside guiding gutter not only can provide the speed of mass exchange, and the fluid passage that micropin can also be made to produce exists for a long time, can not close because of the self-regeneration of epidermis.The cross sectional shape of guiding gutter 4 is preferably central angle and is greater than 180 degree fan-shaped.
Transdermal administration and sampler during above-mentioned medicine carrying voluntarily long, can be made by following technique:
Step S1, as shown in Figure 3 and Figure 4, adopt glass or silicon wafer as substrate 1, make at glass or silicon wafer (hereinafter referred disk) back side and store chamber 5, the shape of storage chamber 5 can be polygon, circle, ellipse, irregular figure etc., cavity depth is 0.02-2mm, cavity area be 20 square microns to 25 square millimeters, implementation method comprises laser ablation, sandblasting, wet etching, plasma etching etc.
The storage chamber 5 at the disk back side also can be bonded together with other materials and disk and be formed, and disk is the end of storage chamber, and the material of bonding forms the side wall storing chamber.
Step S2, as shown in Figure 5, makes guiding gutter 4, in disk storage chamber 5, makes guiding gutter 4, and because guiding gutter, storage chamber and living Epidermis carry out mass exchange, the location of guiding gutter 4 and micropin 3 needs to consider as a whole.Need for follow-up micropin technique leaves alignment mark when making guiding gutter 4.
Step S3, as shown in Figure 6, makes micropin 3, and utilize the method for etching to remove the unnecessary part in disk front, remaining part is given prominence to and forms microneedle configuration, specific implementation method can be plasma etching, wet etching, laser ablation etc.This step process will be aimed at the figure stayed in back guiding gutter manufacturing process.Store bottom chamber 5 and can make the transmission channel 2 be communicated with guiding gutter 4;
After during above-mentioned medicine carrying voluntarily long, transdermal administration and sampler make, can also install cover plate 6 above storage chamber, substrate 1 back side 5, cover plate 6 can be flexible cover plate, or described cover plate 6 is rigid cover plate.Cover plate 6 can utilize the way of bonding and storage chamber to combine.
Increased by pressing flexible cover plate and store cavity pressure, can Drug Percutaneous Absorption be promoted.Can also the integrated control device for drug release or body fluid/blood sampling in cover plate 6, control device can adopt direct current/impulse controller or pressure controller etc., if apply negative pressure at storage intracavity in addition, the present invention can also be used for painless sampling.
Present embodiments provide three kinds of control device, as described below respectively:
As shown in Figure 7, control device comprises direct current or pulse generator, the first electrode 601 and the second electrode 602 to the first control device; Switch in Fig. 7 and battery represent direct current or pulse generator; Direct current or pulse generator are arranged in cover plate 6; First electrode 601 is located at cover plate 6 bottom surface; Second electrode 602 is positioned at substrate 1 outer surface and the second electrode 602 is positioned at substrate 1 front at least partly, when micropin skin puncture, the second electrode 602 can and contact skin; Direct current or pulse generator produce the direct current or pulse signal that promote that skin absorbs the drug by the first electrode 601 and the second electrode 602.
The second control device as figures 8 a and 8 b show, control device comprise be arranged on cover plate 6 bottom surface expansion module 701 and cover plate 6 in the electric-controlled parts of expansion module 701.Battery in Fig. 8 a and switch represent the electric-controlled parts of expansion module 701.State in Fig. 8 a is before administration, and expansion module 701 is unexpanded state also.Fig. 8 b is expansion module 701 under electric-controlled parts controls, state when expanding, and can produce certain pressure in storage chamber 5, promotes that medicine subcutaneously flows along guiding gutter 4 from storage chamber 5, strengthens administering effect.
As illustrated in figures 9 a and 9b, control device comprises the contraction module 801 and the interior electric-controlled parts shrinking module 801 of cover plate 6 that are arranged on cover plate 6 bottom surface to the third control device.The electric-controlled parts of module 801 is shunk in battery case switch representative in Fig. 9 a.The initial volume shrinking module 801 is comparatively large, as illustrated in fig. 9; Cover plate 6 and substrate 1 seal in conjunction with time, when contraction module 801 is shunk under electric-controlled parts controls, then storing in chamber 5 and can produce negative pressure, impelling micropin 3 to puncture subcutaneous body fluid/blood backflow to storing intracavity, state when Fig. 9 b is contraction module 801 smaller volume; This device just can be applied to the sampling of body fluid/blood.
Claims (10)
1. transdermal administration and a sampler during medicine carrying voluntarily long, comprise a substrate (1), it is characterized in that:
Be manufactured with micropin (3) in the front of substrate (1), the back side of substrate (1) is provided with the storage chamber (5) for storing medicine or sampling thing; The transmission channel (2) being communicated with and storing chamber (5) and substrate (1) front is had at micropin (3) root;
Along the surface of micropin (3), have the guiding gutter (4) of at least one indent; Described guiding gutter (4) is communicated with transmission channel (2); Guiding gutter (4) extends downward from bottom, storage chamber, substrate 1 back side (5) and exceedes micropin (3) skin puncture degree of depth part.
2. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 1 long, is characterized in that:
Guiding gutter (4) extends to micropin (3) top from bottom, storage chamber, substrate (1) back side (5).
3. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 1 long, is characterized in that:
Also comprise a cover plate (6) covered in top, storage chamber, substrate (1) back side (5).
4. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 3 long, is characterized in that:
Described cover plate (6) is flexible cover plate, or described cover plate (6) is rigid cover plate.
5. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 3 long, is characterized in that:
The control device for drug release or body fluid/blood sampling is integrated with in described cover plate (6).
6. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 5 long, is characterized in that:
Described control device comprises direct current or pulse generator, the first electrode (601) and the second electrode (602); Direct current or pulse generator are arranged in cover plate (6); First electrode (601) is located at cover plate (6) bottom surface; Second electrode (602) is positioned at substrate (1) outer surface and the second electrode (602) is positioned at substrate (1) front at least partly;
Direct current or pulse generator produce the direct current or pulse signal that promote that skin absorbs the drug by the first electrode (601) and the second electrode (602).
7. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 5 long, is characterized in that:
Described control device comprises and is arranged on the expansion module (701) of cover plate (6) bottom surface and the electric-controlled parts of cover plate (6) interior expansion module (701).
8. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 5 long, is characterized in that:
Described control device comprises the contraction module (801) and the interior electric-controlled parts shrinking module (801) of cover plate (6) that are arranged on cover plate (6) bottom surface.
9. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 1 long, is characterized in that:
The cross sectional shape of guiding gutter (4) is that central angle is greater than 180 degree fan-shaped.
10. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 1 long, is characterized in that:
Store the medicine of inserting in chamber (5) to be selected from: polyglycolic acid, polylactic acid, Stereocomplex polylactic acid, plant origin polycarbonate resin, poly butylene succinate, polyvinyl alcohol, polyesteramide, polyacrylamide, polyacrylic acid, polyvinyl pyrrolidone, beta-schardinger dextrin-, Poly-L-lactic acid, xanthan gum, gelatin, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, chitin, glucosan and derivant thereof, carbomer, Chitosan-phospholipid complex, methylcellulose, carboxymethyl cellulose, the combination of one or more in sodium carboxymethyl cellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510968742.8A CN105381536A (en) | 2015-12-22 | 2015-12-22 | Automatic-medicine-carrying long-time transdermal-delivery and sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510968742.8A CN105381536A (en) | 2015-12-22 | 2015-12-22 | Automatic-medicine-carrying long-time transdermal-delivery and sampling device |
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|---|---|
| CN105381536A true CN105381536A (en) | 2016-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510968742.8A Pending CN105381536A (en) | 2015-12-22 | 2015-12-22 | Automatic-medicine-carrying long-time transdermal-delivery and sampling device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106345051A (en) * | 2016-11-25 | 2017-01-25 | 崔丽林 | Miniature injection needle and integrated device thereof |
| CN109475729A (en) * | 2016-07-21 | 2019-03-15 | 昂热大学 | Implantable medical device for locally injecting |
| CN111265768A (en) * | 2020-03-26 | 2020-06-12 | 中国科学技术大学 | Microneedle-based personalized intelligent drug delivery device and method |
| WO2020233604A1 (en) * | 2019-05-20 | 2020-11-26 | 上海必修福企业管理有限公司 | Electric field generating device and its use and method for making substance to be transdermal into target object |
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| WO2020233604A1 (en) * | 2019-05-20 | 2020-11-26 | 上海必修福企业管理有限公司 | Electric field generating device and its use and method for making substance to be transdermal into target object |
| CN113924142A (en) * | 2019-05-20 | 2022-01-11 | 上海必修福企业管理有限公司 | Electric field generating device, use thereof and method for introducing a substance to be permeated into a target object |
| CN111265768A (en) * | 2020-03-26 | 2020-06-12 | 中国科学技术大学 | Microneedle-based personalized intelligent drug delivery device and method |
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