CN106345051A - Miniature injection needle and integrated device thereof - Google Patents
Miniature injection needle and integrated device thereof Download PDFInfo
- Publication number
- CN106345051A CN106345051A CN201611056980.2A CN201611056980A CN106345051A CN 106345051 A CN106345051 A CN 106345051A CN 201611056980 A CN201611056980 A CN 201611056980A CN 106345051 A CN106345051 A CN 106345051A
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- China
- Prior art keywords
- microneedle
- pin
- medicine
- needle head
- medicament
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- Pending
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Classifications
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61M2210/06—Head
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
- A61N2005/066—Radiation therapy using light characterised by the wavelength of light used infrared far infrared
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to a miniature injection needle and an integrated device thereof. The miniature needle comprises a needle and a body, wherein the needle comprises a slant part with the outer slant wall, a perfectly straight part with the outer perfectly-straight wall and a groove with the certain depth along the outer slant wall or the outer perfectly-straight wall; the body is coupled to the needle to move or support the needle, the body comprises a cylindrical part and a conical part the body connected to the needle part with the reduced diameter, and a plurality of V-shaped grooves are formed in the surface of the cylindrical part of the body in an etched mode in the axial direction of the body, The invention also relates to a miniature needle head and miniature needle device which are integrated with the miniature needle. The miniature needle and integrated device thereof have the advantages shown in the specification.
Description
Technical field
The application is related to a kind of micro-injection pin and a kind of integrating device of micro-injection pin, relates more particularly to a kind of tool
The drug delivery efficiency being improved and the micro-injection pin of resistance to fracture, a kind of for the epidemic disease of active immunity will be used for through skin
Seedling or the skin elasticity conditioning liquid for skin care are more efficiently injected in human body and maximize ultrared biological activity
The micro-injection pin integrating device of effect.
Background technology
Medicine for the active immunity such as conditioning liquid or vaccine (hereafter can be referred to as medicine) or medicine pass through oral or
Injection delivery is entered in human body.However, when by oral delivery medicine, the effect of the digestive enzyme in digestive tract can stop medicine quilt
Directly it is absorbed in blood flow, or drug modified can be made thus destroying its desired effects.When by injection delivery medicine, they lead to
Cross skin or vein to be directly absorbed in blood flow.Therefore, from oral different it is therefore prevented that medicine is changed by the digestive enzyme in digestive tract
Property.However, in injection process needle-penetration dermis of skin, this can cause pain or infection.
In order to solve to inject and these oral limitations, actively have studied for drug delivery being entered local group through skin
Knit or whole blood circulation transdermal delivery approach.This transdermal delivery approach can with for example include there is the micro- of multiple microneedle
The microneedle devices of type syringe needle are used together.The microneedle of microneedle devices painlessly can pass through injection of skin medicine, and thing
Reason pierces through the epidermis including keratodermatitis, supplies the diffusion velocity to corium for the position to improve medicine from medicine.This miniature
Pin is also commonly referred to as micro-injection pin.When using typical non die-casting type microneedle injection medicine, medicine is along non die-casting type
The smooth outer wall of microneedle is transported to skin.However, at this moment, substantial amounts of medicine is stopped by skin, very small amount of medicine note
Inject skin.In addition, when had using the heart wherein the hollow type pin of hollow space by drug injection to skin when, in these
Void type pin easy fracture, and the air of hollow space can enter skin before the injection.Additionally, typical microneedle devices do not include
For loosening the device of the skin with shrinkable at low temperature pore or sclereid tissue.Therefore, when at low temperature or
When drug injection being entered by microneedle the epidermis including keratodermatitis in winter, by the drug absorption efficiency of epidermis or
The transfer efficiency that medicine enters corium is high-fall low.Result can reduce the injection efficiency of medicine.Additionally, typical microneedle devices are not
Have before or after medicine is injected from micro needle head, prevent medicine to be supplied from supplying position from microneedle leakage by medicine
Device.Therefore, when inject medicine before or after microneedle devices movement with using or storage microneedle devices when or
When micro needle head is rocked, medicine can be leaked by microneedle.In addition, when skin pore shrinks or cell tissue at low temperature
During hardening, the performance of typical microneedle devices significantly deteriorates.Even if that is, miniature needle-penetration includes at low temperature or in winter
The epidermis of keratodermatitis, medicine can be reduced by the absorption efficiency of epidermis or the efficiency of transmission of medicine entrance corium, thus dropping
The normal healing efficiency of low hypodermal cell.Further, since these micro-injection stylus it is trickle, avoiding bending, before fracture
Put, these micro-injection pins must closely be coordinated with the corresponding component of the device of these micro-injection pins integrated.But shape
The device of these micro-injection pins is become the use of synthetic resin to be preferred for material.However it has been found that some drugses are using
During the device of this kind of integrated micro injection needle, have drug solution and flow out not smooth problem.
Therefore, this area is still expected to have and is overcome said one or multiple problem and the device to dermal delivery of drugs.
Content of the invention
The purpose of the application is to provide a kind of micro-injection pin and its integrating device, and expects this micro-injection pin
And its integrating device can overcome the problem of one or more aspects of prior art.Have been surprisingly found that by this
Bright design can realize this purpose of one or more aspects.The present invention is based on this and finds and be accomplished.
One embodiment of the present invention is to provide a kind of microneedle, and it is used for through the groove being arranged in microneedle outer wall
Drug injection is entered skin, thus improves the drug delivery efficiency of microneedle, and prevent microneedle from rupturing.
One embodiment of the present invention is to provide a kind of microneedle devices, and it heats skin to expand skin when injecting medicine
Skin pore, or stimulate skin by means of infrared ray and/or far infrared, thus improving drug delivery efficiency.
One embodiment of the present invention is to provide a kind of microneedle devices, and it is by inside infrared emitting to skin and table
Skin, thus makes ultrared effect maximize.
Specifically, first aspect present invention provides a kind of microneedle, comprising:
Pin, it includes having the rake of inclined outer wall, has the straight portion of straight outer wall and along outside described inclination
Wall or described straight outer wall have the groove of certain depth；And
Body, it is couple to described pin with the mobile or described pin of support.
According to above-mentioned design, described microneedle has the drug delivery efficiency of raising, and can Resisting fractre.
Microneedle according to a first aspect of the present invention, wherein, described groove has the straight straight line extending along described pin
Shape, and the recessed certain depth in center towards described pin.
Microneedle according to a first aspect of the present invention, wherein, described groove is set to three or more along the outer wall of described pin
Multiple, or it is set to four with constant space along described outer wall at upper side, downside, left surface and right flank.
Microneedle according to a first aspect of the present invention, wherein, described groove extends to institute from the one end of described rake
State a part or the end of straight portion, and there are multiple branch shape.
Microneedle according to a first aspect of the present invention, wherein, described groove have cross (+) shape or flat (-) shape.
Microneedle according to a first aspect of the present invention, wherein, described groove have along described pin outer wall clockwise or
The screw thread form extending counterclockwise.
Microneedle according to a first aspect of the present invention, wherein, described body has cylindrical shape and described being connected to
The conical by its shape that at the part of pin, diameter reduces.
Microneedle according to a first aspect of the present invention, wherein, on the surface of the cylindrical shape branch of described body, along
It is axially etched with a plurality of v shape groove, and the depth of this v shape groove is 1/50～1/15 (such as 1/40～1/15) of body radius.
Microneedle according to a first aspect of the present invention, wherein, in the radial section of the cylindrical shape branch of described body,
Described a plurality of v shape groove covers 1/8～1/5 region (such as 1/7～1/5 region) of body radial surface.
Microneedle according to a first aspect of the present invention, wherein, described a plurality of v shape groove is at the conical by its shape of body along this
The other end axially extending to body of body.
Further, second aspect present invention provides a kind of microneedle devices, comprising:
Medicament storage portion, it is used for storing medicine；
Micro needle head, it includes being connected to the drug channel in described medicament storage portion and multiple has from described miniature
The microneedle of the leading section that syringe needle projects, wherein, when described microneedle is pressed towards skin, described miniature needle-penetration dermis of skin
So that medicine to be transported to dermis of skin from described drug channel；And
Heating part, it is used for heating skin by described micro needle head.
Microneedle devices according to a second aspect of the present invention, wherein, described medicament storage portion pass through medicament storage chamber and
Medicine supply pipe is connected to each other and is formed.
Microneedle devices according to a second aspect of the present invention, wherein, described medicament storage chamber includes medicament reservoir, medicine
Chamber, medicament selection device and at least two are along longitudinally isolation to receive the drug unit of multi-medicament.
Microneedle devices according to a second aspect of the present invention, wherein, described medicament selection device includes:
Hollow housing, described hollow housing allows that described medicament storage portion rotates in it；
Baffle plate, described baffle plate setting is in the lower end of described housing, and includes and one of multiple described drug units
Export corresponding selecting hole；
Rotor, described rotor is arranged on the upper end in described medicament storage portion；And
Upper lid, described upper lid closes the top in described medicament storage portion, and supports described rotor and allow that described rotor turns
It is dynamic,
Wherein, described rotor rotates to rotate described medicament storage portion in described housing.
Microneedle devices according to a second aspect of the present invention, wherein, described medicament selection device includes:
Hollow housing, described hollow housing allows that described medicament storage portion rotates in it；
Multiple drug units, the plurality of drug unit include flexible member within positioned at described medicament storage portion and
Opening/closing ball；
Baffle plate, described baffle plate setting is in the lower end of described housing, and includes the outlet with one of described drug unit
Corresponding selecting hole；
Rotor, described rotor is arranged on the upper end in described medicament storage portion；And
Upper lid, described upper lid closes the top in described medicament storage portion, and supports described rotor and allow described rotor
Rotate,
Wherein, described rotor rotates to rotate described medicament storage portion in described housing.
Microneedle devices according to a second aspect of the present invention, wherein, described medicament selection device includes:
Flap shutter, described flap shutter is arranged on the lower end in described medicament storage portion, and can be blocked up with rotating manner
Fill in the bottom of described drug unit, described flap shutter includes the corresponding choosing in bottom with one of multiple described drug units
Select hole；
Rotor, described rotor is arranged on the upper end in described medicament storage portion, and can block described medicine with rotating manner
The upper end of thing unit；And
Rotating bar, described rotating bar passes through described medicament storage portion, and described flap shutter is connected to described rotor,
Wherein, when described rotor rotates, described flap shutter and described rotating bar unitary rotation.
Microneedle devices according to a second aspect of the present invention, wherein, described micro needle head includes:
Fixing body, described fixing body described drug channel formed therein that；
Pin fixed plate, described pin fixed plate fixes described microneedle；And
Pin covers, and described pin capping forms medicament distribution space with described drug channel even together with described pin fixed plate
Logical, and include pin hole hole, described microneedle is externally exposed through described pin hole hole；
Wherein, each of described pin hole hole is respectively provided with the internal diameter more bigger than the external diameter of described microneedle, with from described
Medicament distribution space is along described microneedle discharge medicine.
Microneedle devices according to a second aspect of the present invention, wherein, described micro needle head also includes medicine choking portion, described
Medicine choking portion includes:
Bott stick, described bott stick is arranged on inside described drug channel, when described micro needle head contact skin, described
Bott stick opens described drug channel, and when described micro needle head is spaced apart with skin, described bott stick is closed described medicine and led to
Road, wherein said bott stick is being used for opening the primary importance of described drug channel and for closing the second of described drug channel
Can move between position；And
Spring, described spring ground supports described bott stick so that described bott stick is maintained at the described second position.
Microneedle devices according to a second aspect of the present invention, wherein, described bott stick includes:
Pressure end, when described pressure end is located at the described second position, described pressure end is than described microneedle
Leading section is more projected into outside；
Spring base, described spring base supports the spring being located between described drug channel and described spring base；And
Blocking end, described blocking end blocks described drug channel in the described second position.
Microneedle devices according to a second aspect of the present invention, wherein, the fixing body of described micro needle head, pin fixed plate and
Pin capping is made up of synthetic resin (such as polymethyl methacrylate or Merlon etc.) or lucite.
Microneedle devices according to a second aspect of the present invention, the arbitrary enforcement of wherein said microneedle such as first aspect present invention
Described in scheme.
Microneedle devices according to a second aspect of the present invention, the described a plurality of v shape groove in wherein said microneedle is from body
Conical by its shape at along body axially extending at least in the medicament distribution space of described micro needle head.
Microneedle devices according to a second aspect of the present invention, wherein, described heating part be arranged on described medicament storage portion with
Between described micro needle head, and it is located at the position with the spaced apart segment distance of described micro needle head and contacts described micro needle head
One of position place.
Microneedle devices according to a second aspect of the present invention, wherein, described heating part include infrared generator portion and
At least one of infrared generator portion, wherein said infrared generator portion is couple to described heater and by means of next
Give birth to far infrared from the delivery in hot weather of described heater, described infrared generator portion produces infrared ray.
Microneedle devices according to a second aspect of the present invention, wherein, described infrared generator portion includes producing infrared ray
Lamp and one of light emitting diode.
Further, third aspect present invention provides a kind of micro needle head, comprising:
Fixing body, described fixing body described drug channel formed therein that；
Pin fixed plate, is fixed with microneedle thereon；And
Pin covers, and described pin capping forms medicament distribution space with described drug channel even together with described pin fixed plate
Logical, and include pin hole hole, described microneedle is externally exposed through described pin hole hole；
Wherein, each of described pin hole hole is respectively provided with the internal diameter more bigger than the external diameter of described microneedle, with from described
Medicament distribution space is along described microneedle discharge medicine.
Micro needle head according to a third aspect of the present invention, it also includes medicine choking portion, and described medicine choking portion includes:
Bott stick, described bott stick is arranged on inside described drug channel, when described micro needle head contact skin, described
Bott stick opens described drug channel, and when described micro needle head is spaced apart with skin, described bott stick is closed described medicine and led to
Road, wherein said bott stick is being used for opening the primary importance of described drug channel and for closing the second of described drug channel
Can move between position；And
Spring, described spring ground supports described bott stick so that described bott stick is maintained at the described second position.
Micro needle head according to a third aspect of the present invention, wherein, described bott stick includes:
Pressure end, when described pressure end is located at the described second position, described pressure end is than described microneedle
Leading section is more projected into outside；
Spring base, described spring base supports the spring being located between described drug channel and described spring base；And
Blocking end, described blocking end blocks described drug channel in the described second position.
Micro needle head according to a third aspect of the present invention, wherein, described fixing body, pin fixed plate and pin capping are by closing
Resin (such as polymethyl methacrylate or Merlon etc.) or lucite are made.
Micro needle head according to a third aspect of the present invention, the arbitrary embodiment party of wherein said microneedle such as first aspect present invention
Described in case.
Micro needle head according to a third aspect of the present invention, the described a plurality of v shape groove in wherein said microneedle is from body
At conical by its shape along body axially extending at least in the medicament distribution space of described micro needle head.
Further, fourth aspect present invention is related to a kind of microneedle injection device, comprising:
Micro needle head, it is as described in third aspect present invention any embodiment；
Block, it is used for covering the one end exposing microneedle in described micro needle head, so that this microneedle injection device is not using
When protect described microneedle；
Medicinal liquid bottle, for liquid drug, fixing body one end of the opening of this medicinal liquid bottle and described micro needle head is with can
The mode of dismounting is tightly connected.
Microneedle injection device according to a fourth aspect of the present invention, with screw socket between wherein said medicinal liquid bottle and described micro needle head
Mode is tightly connected.
Microneedle injection device according to a fourth aspect of the present invention, the material of wherein said medicinal liquid bottle is selected from glass, plastics, organic
Glass, metal.
Arbitrary technical characteristic that any embodiment of either side of the present invention or this either side has is equally applicable
Other any embodiment or any embodiment of other either side, as long as they will not be conflicting, certainly mutual
Between where applicable, if necessary can individual features be made suitably modify.Make into one with feature to various aspects of the present invention below
The description of step.
All documents recited in the present invention, their full content is incorporated herein by, and if these are civilian
When implication expressed by offering is inconsistent with the present invention, it is defined by the statement of the present invention.Additionally, the present invention use various terms and
Phrase has well known to a person skilled in the art general sense, nonetheless, the present invention remain desirable at this to these terms and
Phrase is described in more detail and explains, the term referring to and phrase if any inconsistent with common art-recognized meanings, with institute of the present invention table
The implication stated is defined.
According to the microneedle of the present invention, its have cross (+) shape, medicine can convey into skin.Further, since groove is only
It is arranged in the wall of pin side, it is thus ensured that the intensity of pin, thus prevent injection medicine hour hands from breaking in skin.
According to the microneedle of the present invention, it include having cross (+) groove of shape, therefore a certain amount of medicine is stored in
In described groove, and it is injected into skin.Therefore, the medicine being stored in described groove can be injected into skin effectively.In addition,
Because described groove is shorter in the straight portion of described pin, it is thus ensured that the intensity of described pin, thus prevent from injecting medicine hour hands
Break in skin.
According to the microneedle of the present invention, it has big volume due to the groove that the core along described pin extends, because
This can efficiently convey larger amount of medicine into skin.
According to the microneedle of the present invention, it include having flat (-) groove of shape, therefore a certain amount of medicine is stored in
In described groove, and it is injected into skin.Therefore, the medicine being stored in described groove can be injected into skin effectively.In addition, by
Shorter in the straight portion of described pin in described groove, the strength ratio of therefore described pin is larger, thus fundamentally prevents note
Penetrate medicine hour hands to break in skin.
According to the microneedle of the present invention, it is facing with each other due to described two small-sized pins, therefore can store more substantial medicine
Thing.Further, since included by the pin that two small-sized pins are constituted having flat (-) groove of shape, therefore can increase pin further
Intensity, thus prevent inject medicine hour hands break in skin.
According to the microneedle of the present invention, it includes thering is screw thread form to store the groove of a certain amount of medicine.In addition, work as will
When in pin insertion skin, the medicine from body can rotate in the circumferential along the groove with screw thread form, and lentamente notes
Inject skin.
According to the present invention, medicine passes through the groove being arranged in microneedle outer wall to be injected into skin, thus improves microneedle
Drug delivery efficiency, and prevent microneedle rupture.
In addition, being included using the integrated microneedle devices of the microneedle of these embodiments: heater, it is used in note
Penetrate and heat skin during medicine with skin expansion pore；And/or stimulated the infrared ray of skin by means of infrared ray and/or far infrared
Generator portion and/or infrared generator portion.Therefore, when injecting medicine, microneedle devices are by means of from heater
Heat and the infrared ray from infrared generator portion and/or infrared generator portion and/or far infrared stimulate Skin Cell,
By this active cell and obtain blood circulation in the skin of improvement, thermotherapy effect, suppuration effect, dampness effect, evaporation effect
Fruit and resonance effect.Therefore, medicine passes through epiderm skin along microneedle, and passes through the thin of the pore of expansion and activation
Born of the same parents reach corium, thus improve drug delivery efficiency.
According to certain embodiments of the present invention, wherein said medicament storage portion passes through medicament storage chamber and medicine supply
Pipe is connected to each other and is formed, and it is vertical that medicament storage chamber includes medicament reservoir, medicament lumen, medicament selection device and at least two edges
To isolation to receive the drug unit of multi-medicament.Therefore, medicament selection device can by multi-medicament from medicament storage portion simply
Be selectively supplied to skin.
According to certain embodiments of the present invention, wherein, when described micro needle head contact skin, medicine choking portion is opened
Drug channel, when described micro needle head is spaced apart with skin, medicine choking portion closes drug channel.Therefore, when in injection medicine
When micro needle head is spaced apart with skin before or after thing, medicine can be automatically stoped to leak by microneedle so that user
Micro needle head freely can be moved to target location, and leak from micro needle head without having to worry about medicine.
According to certain embodiments of the present invention, wherein, due to according to the microneedle devices of another embodiment from skin
External emission infrared ray, and infrared ray is fed to skin inside so that the skin that can effectively combine microneedle improves
Effect and ultrared biological activity effect.Particularly, when microneedle devices are used for head part, scalp can be by microneedle and red
Outside line stimulates, and scalp hair follicles can be stimulated and heat to improve hair quality anti-alopecia-stopping.
Brief description
Fig. 1 a to 1e is the view illustrating the microneedle according to one embodiment of the application.
Fig. 2 a to 2e is the view illustrating the microneedle according to one embodiment of the application.
Fig. 3 a to 3d is the view illustrating the microneedle according to one embodiment of the application.
Fig. 4 a to 4d is the view illustrating the microneedle according to one embodiment of the application.
Fig. 5 a to 5d is the view illustrating the microneedle according to one embodiment of the application.
Fig. 6 a to 6d is the view illustrating the microneedle according to one embodiment of the application.
Fig. 7 is the axonometric chart illustrating the microneedle devices according to one embodiment of the application.
Fig. 8 is the exploded perspective view illustrating the microneedle devices according to one embodiment of the application.
Fig. 9 is the medicament storage chamber in the medicament storage portion illustrating the microneedle devices according to one embodiment of the application
Cross-sectional view.
Figure 10 is the cross-sectional view that cutd open of line 2-2 along Fig. 9.
Figure 11 is the cross-sectional view that cutd open of line 3-3 along Fig. 9.
Figure 12 is the medicament storage chamber in the medicament storage portion illustrating the microneedle devices according to one embodiment of the application
Cross section.
Figure 13 is the cross-sectional view that cutd open of line 4-4 along Figure 12.
Figure 14 and 15 be diagram Fig. 7 and 8 the operation of microneedle devices cross-sectional view.
Figure 16 is an embodiment of microneedle injection device of the present invention.
Specific embodiment
The present invention can be conducted further description by the following examples, however, the scope of the present invention does not limit
In following embodiments.One of skill in the art is it is understood that on the premise of without departing substantially from the spirit and scope of the present invention, permissible
Various change and modification are carried out to the present invention.The present invention to test used in material and test method carry out generality
And/or specifically describe.Although for realize many materials that the object of the invention used and operational approach be it is known in the art that
But the present invention still here describes in detail as far as possible.
Describe various embodiments of the present invention with reference to the accompanying drawings in detail.
The microneedle of the application is described with reference first to Fig. 1 to Fig. 6.Each subgraph (a) to (d) in Fig. 1 to Fig. 6, is diagram root
According to the view of microneedle a of embodiment, wherein: the accompanying drawing corresponding to alphabetical a is axonometric chart；Accompanying drawing corresponding to alphabetical b is
Front view；Accompanying drawing corresponding to alphabetical c is side view；And be top view corresponding to the accompanying drawing of alphabetical d.
Referring to Fig. 1, it is microneedle a according to first embodiment of the invention, and it includes pin 1 and body 2.
Pin 1 pierces through skin to inject medicine.Body 2 is couple to pin 1 with mobile or support pin 1.Medicine is transported to from body 2
Pin 1.The conical by its shape that body 2 has generally cylindrical shape and diameter reduces at the part being connected to pin 1, pin 1 has ratio
The little diameter of the diameter of body 2.
Pin 1 includes: straight portion 20, and it has the end connecting body 2, and includes straight outer wall；And rake 10, its
Stretch out from the other end of straight portion 20, and include the inclined outer wall with the pointed end of diameter reduction.
Both rake 10 and straight portion 20 all can pierce through skin, or need only to pierce through skin by rake 10 according to user
Skin.
There is the rectilinear form extending along pin 1 groove 31 towards the recessed certain depth in pin 1 center, be arranged on inclination
In portion 10 outer wall and straight portion 20 outer wall.Groove 31 extends through its other end from the one end of straight portion 20 and reaches rake
10, and may be configured as being arranged in four with constant interval on the upside of pin 1 outer wall, downside, left side and right side, as Fig. 1 d institute
Show.Alternatively, groove 31 can be set to three or more.
When groove 31 is arranged to four, pin 1 have cross as shown in Figure 1 d (+) shape.Therefore, medicine can be along setting
The groove 31 put in pin 1 side wall efficiently conveys into skin.Further, since groove 31 is provided only in the side wall of pin 1, therefore
Can ensure that the intensity of pin 1, thus prevent injection medicine hour hands 1 from breaking in skin.
Fig. 2 a to 2d is the view illustrating the microneedle according to second embodiment.Same reference numerals indicate first and the
Similar components in two embodiments, therefore will omit the description to these similar components in the present embodiment.
Referring to Fig. 2 a to 2d, the groove 32 of cross shape is in the central part office of pin 1 rake 10 towards body 2 recessed
Depthkeeping degree.Groove 32 can extend to a part for straight portion 20 as shown in figs. 2 b and 2 c from the one end of rake 10, and has
Cross (+) shape, this cross (+) shape has four upsides towards pin 1, the branch of downside, left side and right-hand branch, such as Fig. 2 d
Shown.Although it is not shown, but observe from plane graph, groove 32 can have the shape that asterisk etc. is provided with six branches, or
There is the shape of three or more branches.
Due to groove 32 have cross as shown in Fig. 2 a to 2d (+) shape, therefore a certain amount of in groove 32 internal reservoir
Medicine.In this state, when inserting pin 1 in skin, in groove 32, the medicine of storage is injected into skin effectively.
Further, since groove 32 has shorter part in the straight portion 20 of pin 1, thus ensuring that the intensity of pin 1, thus prevent from injecting
Medicine hour hands 1 break in skin.
Fig. 3 a to 3d is the view illustrating according to the microneedle of the 3rd embodiment, and this embodiment is the of Fig. 2 a to 2d
The modification of two embodiments.Referring to Fig. 3 d, groove 33 is identical with the groove 32 of Fig. 2 a to 2d, in have four towards upside, under
The branch of side, left side and right-hand branch cross (+) shape, or in being provided with the shape of at least five branches.
However, as shown in Fig. 3 a to 3c, groove 33 not only extends fully through rake 10, and extends fully through
Straight portion 20.Therefore, pin 1 is divided into four aculeoluses so that can store relatively in the groove 33 being arranged between these aculeoluses
Substantial amounts of medicine.Although the intensity of the pin 1 of the 3rd embodiment is slightly below the intensity of the pin 1 of second embodiment, along pin 1
The volume of the groove 33 that core extends increases so that larger amount of medicine can efficiently be injected into skin.
Fig. 4 a to 4d is the view illustrating the microneedle according to the 4th embodiment.Referring to Fig. 4 a to 4d, flat pattern (-)
Groove 34 pin 1 rake 10 core towards the recessed certain depth of body 2.Groove 34 can be as illustrated in fig. 4 c from rake 10
One end extend to the part of straight portion 20, and have as shown in figure 4d towards the left side of pin 1 and right side (or upside and under
Side) branch Liang Ge branch flat (-) shape.
Due to groove 34 have as shown in Fig. 4 a to 4d flat (-) shape, therefore in groove 34 storage a certain amount of
Medicine.In this state, when inserting pin 1 in skin, the medicine being stored in groove 34 is injected in skin effectively.
Further, since groove 34 has shorter part in the straight portion 20 of pin 1, and the branch of groove 34 is more recessed than second embodiment
The branch of groove 33 is few, therefore can increase the intensity of pin 1, thus prevents injection medicine hour hands 1 to break at skin to a greater extent
Interior.
Fig. 5 a to 5d is the view illustrating according to the microneedle of the 5th embodiment, and this embodiment is the of Fig. 4 a to 4d
The modification of four embodiments.Referring to Fig. 5 d, groove 35 is identical with the groove 34 of Fig. 4 a to 4d, in having towards left side and right side
The Liang Ge branch of (or the upper side and lower side) branch flat (-) shape.
However, as shown in figures 5 a and 5 c, groove 35 not only extends fully through rake 10, and extends fully through pen
Straight portion 20.Therefore, pin 1 is divided into two aspectant aculeoluses so that can be in the groove 35 being arranged between this two aculeoluses
The interior storage medicine bigger than the medication amount of storage in the groove 34 of the 4th embodiment.Although the pin 1 of the 5th embodiment is strong
Degree is slightly below the intensity of the pin 1 of the 4th embodiment, but increases the volume of the groove 35 of the core extension along pin 1, makes
Obtain larger amount of medicine can efficiently be injected in skin.Further, since groove 35 have flat (-) shape, therefore with the 3rd
Groove 33 in embodiment is different, and the intensity of pin 1 can increase further, thus prevent injection medicine hour hands 1 and ruptures.
Fig. 6 a to 6d is the view illustrating the microneedle according to the 6th embodiment.Referring to Fig. 6, with having certain depth
Screw thread form groove 36 along pin 1 outer wall extend.Groove 36 is arranged on the whole region of straight portion 20 of pin 1 and inclines
In a part for inclined portion 10.Groove 36 can turn clockwise or rotate counterclockwise as shown in fig 6d, and has the interior table of bending
Face, the width of groove 36 can change according to design.
Therefore, according to the 6th embodiment, groove 36 can store a certain amount of medicine.In addition, work as pin 1 is inserted in skin
When, the medicine from body 2 can rotate in the circumferential along groove 36, and is lentamente injected in skin.
According to above-mentioned various embodiments, medicine is injected into skin by the groove being arranged in microneedle outer wall, thus
Improve the drug delivery efficiency of microneedle, and prevent microneedle from rupturing.
Although in said embodiment drug delivery is entered by skin by microneedle, also can be conveyed beautiful by microneedle
Hold agent.
Hereafter, with reference to the accompanying drawings, referring particularly to Fig. 7 to Figure 13 in detail, the microneedle devices according to embodiment are described in detail.
Fig. 7 and Fig. 8 is the axonometric chart illustrating microneedle devices b according to an embodiment.
Microneedle devices b are for being used for the vaccine of active immunity or be used for the skin elasticity of skin care through skin
Conditioning liquid is more efficiently injected into the transcutaneous device in body.Microneedle devices b include power supply unit 40, medicament storage portion 50, micro-
Type syringe needle 60 and heating part 70.
Power supply unit 40 includes the cylindrical body 41 with cylindrical shape.Cylindrical body 41 have for accommodate aneroid battery or
The battery space of set of cells.For example, two 1.5v aneroid battery can in this battery space arranged in series.For being selectively supplied with
The switch 42 of electric power is arranged on the outer surface of cylindrical body 41, and covers the bottom of 43 closed tube shape bodies 41.Tubular is originally
Body 41 not only act as the power supply unit 40 for accommodating aneroid battery or set of cells, and act as injecting during medicine for user folder
Hold the body of microneedle devices b.
Medicament storage portion 50 is couple to the cylindrical body 41 of power supply unit 40, and includes the medicine within positioned at medicament storage portion 50
Thing storage chamber 51 is to store medicine.Medicine supply pipe 52 is arranged on the exit in medicament storage chamber 51.Medicine supply pipe 52 extends
Hermetic it is connected to the entrance 62 of the fixing body 61 of the micro needle head 60 being hereinafter described.
Heating part 70 is arranged between medicament storage portion 50 and micro needle head 60.When drug injection is entered in skin, plus
Hot portion 70 heating skin is to expand pore, and stimulates cutaneous activation Skin Cell.For reaching this purpose, heating part 70 includes outer tube
71st, inner core 72, the heater 73 being arranged between outer tube 71 and inner core 72.
The right part of outer tube 71 is couple to the left part in medicament storage portion 50 by means of components such as screw threads.Outer tube 71 wraps
Include for heat-insulated heat insulating.Inner core 72 receives medicine supply pipe 52 and so that medicine supply pipe 52 is passed through.Similar to outer tube 71, interior
Cylinder 72 is included for protecting medicine supply pipe 52 from the photothermal heat insulating of heater 73.It is arranged on propping up on inner core 72 outside
Heater 73 is fixed on the position keeping at a certain distance away with micro needle head 60 by support member 74.Heater 73 heating micro needle head 60 with
Transmit heat to skin.For example, heater 73 includes connecting electric wire 75 side by side, for example, have the nickel filament of about 3mm width, with even
Launch the heat in the range of about 40 to 50 DEG C continuously.
As described above, heater 73 is fixed on the position separated by a distance with micro needle head 60, and indirectly heat micro-
Type syringe needle 60.Alternatively, heater 73 can directly contact micro needle head 60 and/or micro needle head 60 microneedle a, with directly plus
Hot micro needle head 60 and/or microneedle a, thus transfer heat to skin.
Far infrared and/or infrared ray can be transmitted on skin to stimulate skin so that the micro needle head 60 that is hereinafter described
Microneedle a medicine more efficiently can be transported to dermis of skin.For reaching this purpose, heating part 70 may include far infrared and sends out
Raw device 76 and/or infrared generator 77.
Although being illustrated as microneedle a in the present embodiment, present disclosure is not limited thereto, and therefore
Also can be using no around the screw thread of its side wall or the exemplary needle of groove.
Infrared generator 76 be couple to the inside of outer tube 71 with the face of heater 73 so that far-infrared engergy by means of
Produce from the heat of heater 73.For reaching this purpose, infrared generator 76 includes cylinder 78, and cylinder 78 has than outer
The little external diameter of cylinder 71 internal diameters, and it is arranged on heater 73 outside above and in outer tube 71 left part.Cylinder 78 can be by gem or pottery
Porcelain is formed.
Alternatively, infrared generator 76 may be provided between heater 73 and inner core 72.In such examples, far red
Outside line generator 76 includes cylinder (not shown), and this cylinder has the internal diameter bigger than inner core 72 external diameter, and heater 73 is by pacifying
The support member (not shown) being contained on this cylinder outside is fixed.
Infrared generator 77 is arranged between heater 73 and medicament storage portion 50, to produce infrared ray.Infrared ray is sent out
Raw device 77 includes thering is round-shaped retainer ring 79 and the ultrared infrared ray led (liquid crystal display) of multiple generation or lamp
80, the wavelength that infrared ray has for example in about 700nm to 20 μ m.Retainer ring 79 is included at position at its center
Circular hole 81, and inner core 72 coordinates in circular hole 81.The far infrared being produced by infrared generator 76 and infrared lamp 80 and
Infrared ray and the heat being produced by heater 73 are all reflected to micro needle head 60.For reaching this purpose, infrared lamp is installed
The surface of 80 retainer ring 79 may include reflecting surface.Multiple infrared lamps 80 are arranged at certain intervals around the circular hole 81 of retainer ring 79
Row.
Heater 73 and infrared lamp 80 are electrically connected to electricity by the electric wire (not shown) being arranged in medicament storage portion 50
Source portion 40.
So, the far infrared being produced by infrared generator 76 and the infrared ray being produced by infrared generator 77
Can have the effect that, during injecting, Skin Cell can be stimulated and activate；The active oxygen accumulating because of environmental pollution can be from
Body removes；The double bond of unsaturated fatty acid can be used to improve cosmetic result；Tissue because of inflammation acidifying can be alkalized.Therefore,
Blood circulation in the skin of improvement, thermotherapy effect, suppuration effect, dampness effect, evaporation effect and resonance effect can be obtained
Really.
Referring to Fig. 9 to 11, the medicament storage chamber 51 in medicament storage portion 50 is connected to medicine supply pipe 52, and includes medicine and deposit
Reservoir 51a, medicament lumen 51b, medicament selection device 51c and edge longitudinally isolate to receive at least two medicine lists of multi-medicament
First 51d.Medicament reservoir 51a is provided with housing 51e.Medicament reservoir 51a has hollow circle tube shape, and therefore can be in shell
Body 51e inner rotation.It is longitudinally empty that medicament reservoir 51a is divided at least two by the internal partitions 51f of medicament reservoir 51a
Between.As shown in Figure 10, distance piece 51f can have cross shape, and therefore the quantity of drug unit 51d can be four.However, medicine
The quantity of thing unit 51d is not limited to four, and can be therefore two or more.Multiple outlet 51h are separately positioned on many
With discharge medicine in the bottom 51g of individual drug unit 51d.
Medicament lumen 51b is arranged on below medicament reservoir 51a, to receive by exporting what 51h discharged from drug unit 51d
Medicine.That is, medicament lumen 51b is arranged between medicine supply pipe 52 and medicament reservoir 51a to be formed for temporarily depositing
The space of the medicine that storage is discharged from drug unit 51d.Medicament lumen 51b can have hollow circle tube shape, this hollow circle tube shape
Shape has the external diameter being substantially the same with the external diameter of housing 51e being hereinafter described.The medicine being stored in medicament lumen 51b passes through medicine
Supply pipe 52 is discharged to micro needle head 60.
Medicament selection device 51c is used for selecting one from multiple drug unit 51d of medicament reservoir 51a.Then, store
Medicine in a selected drug unit passes through medicament lumen 51b and medicine supply pipe 52 is discharged to micro needle head 60.Medicine
Thing selector 51c can construct in a variety of forms.
For example, medicament selection device 51c can be configured to rotate medicament reservoir 51a with the multiple medicines from medicament reservoir 51a
One is selected in thing unit 51d.
Medicament selection device 51c includes housing 51e and baffle plate 51i, and housing 51e allows that medicament reservoir 51a rotates in it,
Baffle plate 51i is arranged on the lower end of housing 51e.In bottom insertion medicament lumen 51b of housing 51e.Containment member (does not show
Go out) may be provided between baffle plate 51i and the bottom 51g of medicament reservoir 51a, to allow medicament reservoir 51a with respect to gear
Plate 51i rotates, and stops the drug leakage being stored in drug unit 51d and mixing.Referring to Fig. 9 and 11, baffle plate 51i is provided with
Outlet 51h corresponding selecting hole 51j with one of multiple drug unit 51d.Therefore, when medicament reservoir 51a rotates will be many
When the outlet 51h and selecting hole 51j of one of individual drug unit 51d match, the medicine being stored in drug unit 51d passes through choosing
Select hole 51j and be discharged to medicament lumen 51b.
Rotor 51k is arranged on so that user rotates medicament reservoir 51a on the upper end of medicament reservoir 51a, and
Extend from the capping 43 of unshowned power supply unit 40.Therefore, user can advantageously rotate medicament reservoir 51a.
Upper lid 51l is arranged on housing 51e to close the top of medicament reservoir 51a.Upper lid 51l is provided with supported hole
51m is to support support shaft 51n for rotating rotor 51k.Therefore, support shaft 51n of rotor 51k can be in the support of upper lid 51l
Rotate in the 51m of hole.When as user grip roll 51k and rotating rotor 51k according to direction of arrow x shown in Fig. 9, medicament storage
Device 51a also x rotation in the direction of the arrow in housing 51e.Therefore, when rotor 51k rotates with by one of multiple drug unit 51d's
When outlet 51h is mated with the selecting hole 51j of baffle plate 51i, the medicine being stored in drug unit 51d is discharged by selecting hole 51j
To medicament lumen 51b.
Additionally, referring to Figure 12 and 13, flexible member 51o and opening/closing ball 51p may be provided at the every of multiple drug unit 51d
In one.Therefore, user can be felt by the elasticity only by means of the flexible member 51o being arranged in drug unit 51d
Insert selecting hole 51j to opening/closing ball 51p, and just can need not be selected with the insertion of his/her eye observation opening/closing ball 51p
Select one of multiple drug unit 51d.
So, when flexible member 51o and opening/closing ball 51p is arranged on drug unit 51d inside, medicament selection device 51c bag
Include housing 51e and baffle plate 51i, housing 51e allows that medicament reservoir 51a rotates in it, and baffle plate 51i is arranged under housing 51e
End.In such examples, in bottom insertion medicament lumen 51b of housing 51e, medicament reservoir 51a can be with respect to baffle plate
51i rotates.In addition, baffle plate 51i is provided with the outlet 51h corresponding selecting hole 51j with one of multiple drug unit 51d.Referring to
Figure 13, multiple protuberance 51q around baffle plate 51i selecting hole 51j arrange, from drug unit 51d medicine from multiple protuberance 51q it
Between be discharged to medicament lumen 51b.
As described above, when user grip roll 51k and according to shown in Figure 12 direction of arrow x rotate rotor 51k when, medicine
Thing memorizer 51a also x rotation in the direction of the arrow in housing 51e.Therefore, when rotor 51k rotates with by multiple drug unit 51d
One of outlet 51h when mating with the selecting hole 51j of baffle plate 51i, be stored in medicine in drug unit 51d from around selecting hole
It is discharged to medicament lumen 51b between multiple protuberance 51q of 51j setting.
Referring next to accompanying drawing, referring particularly to Figure 14 and 15, micro needle head according to the present invention to be discussed.
Micro needle head 60 allows to painlessly penetrate skin c injection medicine, and physically puncture includes skin c horny layer
Epidermis to improve medicine by the diffusion velocity of skin c.Referring to Figure 14 and 15, micro needle head 60 includes fixing body 61, medicine
Thing choking portion 63, pin fixed plate 68 and pin capping 65.
Fixing body 61 is provided with the entrance 62 being couple to medicine supply pipe 52, and drug channel 66 is arranged on fixing body
To connect with medicine supply pipe 52 in 61.Drug channel 66 has rib gourd shape, and includes upper channel 66a, lower channel
The 66b and center-aisle 66c for upper channel 66a being connected to lower channel 66b.There is the blocking of frusto-conical shape
Seat 64a is arranged in the bottom of upper channel 66a, and is couple to the blocking end of the bott stick 64 being hereinafter described, to block medicine
Passage 66.First spring base 67a is arranged in the top of lower channel 66b to support the upper end of the spring 67 being hereinafter described.
As micro needle head 60 contact skin c, drug channel 66 is opened as shown in figure 15, as micro needle head 60 and skin c
When spaced apart, drug channel 66 is closed as shown in figure 14.For reaching this purpose, medicine choking portion 63 is arranged in drug channel 66
Portion.
Medicine choking portion 63 includes bott stick 64, bott stick 64 for open drug channel 66 primary importance (referring to
Figure 15) and removable between the second position (referring to Figure 14) of drug channel 66 for closing.Bott stick 64 includes pressure end
64b, second spring seat 64c and blocking end 64d.When bott stick 64 is arranged on the second position, pressure end 64b is sealed from pin
The prominent leading section obtaining than microneedle a of lid 65 covers 65 from pin and projects much.The lower end of second spring seat 64c support spring 67
Portion is so that spring 67 is arranged between the first spring base 63a and second spring seat 64c, and has through hole in spring 67 (not
Illustrate) with by medicine.Blocking end 64d has the corresponding shape of blocking seat 64a with drug channel 66.Therefore, work as blocking
When bar 64 is arranged on the second position, blocking end 64d is engaged with blocking seat 64a to block drug channel 66.
In order to bott stick 64 is maintained at the second position, spring 67 is arranged on the first spring base 67a of upper channel 66a and blocks up
To be elastically supported bott stick 64 between the second spring seat 64c of stopper rod 64.Spring 67 may include compression spring.
Therefore, when micro needle head 60 contacts skin c as shown in figure 15, pressure end 64b overcomes spring 67 because of skin c
Elastic force move up, bott stick 64 is moved to primary importance.Therefore, blocking end 64d is spaced apart with blocking seat 64a to beat
Open drug channel 66.On the contrary, when micro needle head 60 is spaced apart with skin c as shown in figure 14, bott stick 64 is because of the bullet of spring 67
Power and reset to the second position.Therefore, blocking end 64d contact blocking seat 64a is to close drug channel 66.
Pin fixed plate 68 fixes the upper end of microneedle a in the form of an array.Microneedle a is solid and not hollow, microneedle a
Bottom projects from pin capping 65.Therefore, when contacting skin c, microneedle a pierces through the epidermis of skin c, and from drug channel 66
The drug delivery of supply is to the corium of skin c.For example, the bottom of microneedle a can be situated between from the prominent prominent length of pin capping 65
In the range of about 200 to 500 μm.Therefore, as microneedle a contact skin c, the table of skin c is pierced through in the bottom of microneedle a
Skin efficiently to convey medicine, without stimulate skin c pain point.
Pin capping 65 and pin fixed plate 68 are fixed to fixing body 61 by means of fixing screws 65b, to form medicament distribution
Drug channel 66 between space 65a, medicament distribution space 65a and pin capping 65 and pin fixed plate 68 connects.Pin hole hole 65c sets
Put in pin capping 65.Multiple microneedle a being fixed to pin fixed plate 68 are each passed through multiple pin hole hole 65c, and are projected into pin
Outside hole 65c.
The internal diameter of pin hole hole 65c is more bigger than the external diameter of microneedle a.
The size of medicament distribution space 65a and pin hole hole 65c are sized to meet following condition: when micro needle head 60
Contact skin c and bott stick 64 is when opening drug channel 66, the medicine in the 65a of medicament distribution space passes through microneedle a and pin hole
Capillarity between the 65c of hole is along microneedle a with certain speed or a certain amount of discharge；And as micro needle head 60 and skin c
Be spaced apart and bott stick 64 close drug channel 66 when, the medicine in the 65a of medicament distribution space is stopped in microneedle a and pin
Discharge along microneedle a between hole 65c.
Fixing body 61, medicine choking portion 63, pin fixed plate 68 and pin capping 65 by such as polymethyl methacrylate,
The transparent synthetic resin material such as Merlon or lucite etc. formed so that by infrared generator 76 produce remote
Infrared ray and the infrared ray transmissive that produced by infrared generator 77 are to skin c.
After injection medicine, micro needle head 60 is sealed by syringe needle cover 90, and preserves.
Below, scheme in conjunction with each herein, particularly Fig. 1 to Fig. 2, and Figure 14 and Figure 15, the present invention is expanded on further and relates to
And microneedle another embodiment.
As shown in figure 1, according to the present invention, body 2 part of this microneedle has substantially cylindrical shape.As herein
Described, because the body 2 of this cylindrical circular shape partially passes through the in the hole footpath described pin hole hole 65c more bigger than it, such as Figure 14
As presenting with Figure 15, this pin hole hole 65c is distributed in pin capping 65 so that medicine can pass through this pin hole hole 65c and body 2
Between gap.According to the present invention, wherein constitute each component of described micro needle head 60, including fixing body 61, pin fixed plate
68th, pin capping 65, they are preferably made for material using synthetic resin or lucite.
The application has carried out the medicinal liquid osmosis test of following design: micro needle head 60 is assembled still as shown in Figure 7 and Figure 8
Do not start heating function, this assembling is the micro needle head 60 and microneedle a minimum group of reload request when using；Shown in Fig. 7
Medicament storage chamber 51 in fill drug solution；Make microneedle devices shown in the Fig. 7 assembling press to multilamellar as shown in figure 15 to inhale
Water paper, bott stick 64 opens the gap thus being advanced under medicinal liquid between pin hole hole 65c and body 2, further to pin 1 and its
In groove 31, if going out liquid and be normal, medicinal liquid can be adsorbed onto in absorbent paper, and absorbent paper tiny wetting point occurs；If gone out
No medicinal liquid in the not smooth then absorbent paper of liquid；If it is excessive to go out liquid, wetting point significantly increases, now also can be by amplification sem observation
Amount of liquid medicine in pin 1 and its groove 31, to judge whether medicinal liquid oozes out excess.
In medicinal liquid osmosis test, it has been found by the present inventors that using various synthetic resin such as polymethylacrylic acid
In the case that methyl ester, Merlon and lucite etc. cover 65 for the pin that material is made, drug solution passes through pin hole hole 65c
The ability in the gap between body 2 seems relevant with the acid-base value of solution, when the ph value of solution is less than or equal to 7, pin hole
Gap between hole 65c and body 2 is larger or smaller body in other words 2 be inserted in the 65c of pin hole hole pine some or tightlier
When, medicinal liquid can be smoothly through this gap and be discharged to pin 1 position from medicament distribution space 65a；But, when the ph value of solution
During more than 7, need to reach body 2 and be inserted in and be capable of the degree of double swerve in the 65c of pin hole hole and just can be smoothly discharged out liquid, otherwise
Only getting rid of to medicine liquid outlet direction strength just to have liquid to ooze out.This is difficult to accept because the microneedle of the present invention and its
Related device needs to be applied to the medicinal liquid of different medicinal liquids particularly different ph values.
The present inventor is found by research, when body 2 surface in microneedle a of the present invention, is axially etched with many along it
Bar v shape groove 29, the depth of this v shape groove 29 be body 2 radius 1/100～1/10, preferably 1/75～1/10, preferably 1/50～
1/15, preferably 1/40～1/15.This v shape groove 29 at the conical by its shape of body 2 along body 2 axially extending at least to medicine
In allocation space 65a, extend preferably into the other end of body 2.In an example, in body 2 radial section, these a plurality of v
Shape groove 29 covers 1/10～1/4 region of body 2 radial surface, preferably 1/8～1/5 region, such as 1/7～1/5 region.
It has been found that using design (the v shape groove too deep meeting shadow of 1/50～1/15 that the depth of v shape groove 29 is body 2 radius
Ring the structural strength of microneedle, when v shape groove is excessively shallow, do not enable its function in the present invention), the region that v shape groove 29 covers is
Requiring it may be assumed that when v shape groove 29 cover region be less than body 2 radial surface 1/10 region when it is impossible to realize ph1～
The medicinal liquid of 13 full soda acid regional extent be successfully exuded to through the gap pin hole hole 65c and body 2 pin 1 region with
Enter into groove 31 and fill up the requirement in wherein space；And the region working as v shape groove 29 covering is more than the 1/4 of body 2 radial surface
Although the medicinal liquid being capable of the full soda acid regional extent in ph1～13 successfully passes through pin hole hole 65c and body 2 during region
Between gap and be exuded to pin 1 region to enter into groove 31 and to fill up the requirement in wherein space, but occur significantly
Medicinal liquid oozes out surplus and then the microlayer model being present in outside groove 31 in pin 1 region, and the medicinal liquid that this is serious oozes out surplus,
During injection, this part medicinal liquid can be stopped by epidermis and can not enter in skin；Only find to cover in these a plurality of v shape grooves 29
During 1/8～1/5 region of body 2 radial surface, all kinds, the medicinal liquid of various ph all successfully can reach groove with desired amount
At 31.
Therefore, on body 2 surface of microneedle a, axially it is etched with a plurality of v shape groove 29, the depth of this v shape groove 29 along it
1/50～1/15 (such as 1/40～1/15) for body 2 radius；And in body 2 radial section, these a plurality of v shape grooves 29 cover
1/8～1/5 region of body 2 radial surface (such as 1/7～1/5 region).This design, for various types of medicines
(medicine of particularly full ph regional extent) is oozed with desired amount smoothly and through the gap pin hole hole 65c and body 2
Go out to pin 1 region, be extremely beneficial.
As each subgraph of Fig. 1, Fig. 1 its (a) to (c) is the axonometric chart of the application microneedle, front view, side view, at it
Body 2 surface is axially etched with a plurality of v shape groove 29 (exemplary is to be painted with 5) along it, and the depth of this v shape groove 29 is body
The 1/100～1/10 of 2 radiuses, preferably 1/75～1/10, preferably 1/50～1/15, preferably 1/40～1/15.Fig. 1 its (d) is
The top view of the application microneedle, in body 2 radial section, these a plurality of v shape grooves 29 cover the 1/10 of body 2 radial surface
～1/4 region, preferably 1/8～1/5 region, such as 1/7～1/5 region.In addition, can be easy in the top view of Fig. 1 its (d)
Understand the depth of these v shape grooves 29.Fig. 1 its (e) is the side view full figure of the application microneedle, and in figure shows this plurality of v shape groove
29 at the conical by its shape of body 2 along the other end axially extending to body 2 of body 2.
The scheme of above-mentioned v shape groove is similarly depicted in this paper Fig. 2, is different from Fig. 1, and this Fig. 2 its (e) is the application
The side view full figure of microneedle, in figure shows that this plurality of v shape groove 29 prolongs along the axial direction of body 2 at the conical by its shape of body 2
Reach the certain position of body 2, each component of this microneedle and micro needle head 60 is being included fixing body 61, pin fixed plate
68th, when pin capping 65 etc. fits together, this certain position that this plurality of v shape groove 29 extends to is at least up to micro needle head 60
In the 65a of medicament distribution space.
The scheme of above-mentioned v shape groove similarly can be embodied in the embodiment of Fig. 3 to Fig. 6 described herein；Certainly, for
For the sake of simple and clear, Fig. 3 to Fig. 6 and its each subgraph do not depict these v shape grooves.
In the medicinal liquid osmosis of the application are tested, the synthetic resin constituting each component of described micro needle head 60 adopts poly- first
Base acrylic acid methyl ester. or Merlon or during using lucite, all can obtain the conclusion being consistent with the above results.In this Shen
In medicinal liquid osmosis test please, it is respectively adopted 0.05m sodium chloride solution, 0.05m citric acid/liquor sodii citratises, 0.05m vinegar
Acid/sodium acetate solution, commercially available bullet profit brilliant cause anti-wrinkle essence, the crease-resistant light speckle brilliant white elite of commercially available face again reveal (five kinds of solution above
Adjust ph value so as to each obtain the medicinal liquid of 7 kinds of ph values with hydrochloric acid or sodium hydroxide respectively, ph1, ph3, ph5, ph7, ph9,
Ph11, ph13, if necessary filter), water for injection (ph7.2) as test medicinal liquid, investigate the application microneedle on body 2 surface
Carry out the liquid medicine flow test of v shape groove 29 design, obtain accordingly result as described in the present application.
In addition, a kind of present invention also offers microneedle injection device.Exemplary microneedle injection device is as shown in figure 16, this micropin
Syringe includes: micro needle head 60, and it can be the design as described in third aspect present invention any embodiment；Block 91,
It is used for cover the one end exposing microneedle in described micro needle head 60 so that this microneedle injection device protect when not in use described micro-
Type pin；Medicinal liquid bottle 92, for liquid drug, fixing body 61 one end of the opening of this medicinal liquid bottle 92 and described micro needle head 60
Removably it is tightly connected.One exemplary embodiment is, for the ease of micro needle head 60 and medicinal liquid bottle 92
It is tightly connected, described micro needle head 60 is provided with connection screw socket 69 near fixing body 61 one end, and the bottleneck of medicinal liquid bottle 92
Setting and the described screw thread connecting screw socket 69 cooperation.In one embodiment, described medicinal liquid bottle 92 can be glass, plastics,
The material of lucite, metal etc..
Embodiment described above is only the preferred embodiment lifted for absolutely proving the present invention, the protection model of the present invention
Enclose not limited to this.Equivalent substitute or conversion that those skilled in the art are made on the basis of the present invention, all in the present invention
Protection domain within.Protection scope of the present invention is defined by claims.
Claims (13)
1. a kind of microneedle, comprising:
Pin, it include having the rake of inclined outer wall, the straight portion with straight outer wall and along described inclined outer wall or
Described straight outer wall has the groove of certain depth；And
Body, it is couple to described pin with the mobile or described pin of support, and described body has cylindrical shape and being connected to
State the conical by its shape that at the part of pin, diameter reduces,
It is characterized in that, on the surface of the cylindrical shape branch of described body, axially it is etched with a plurality of v shape groove along it.
2. microneedle according to claim 1 it is characterised in that
In the radial section of the cylindrical shape branch of described body, described a plurality of v shape groove covers the 1/8 of body radial surface
～1/5 region (such as 1/7～1/5 region)；
The depth of described v shape groove is 1/50～1/15 (such as 1/40～1/15) of described body radius；And/or
Described a plurality of v shape groove is at the conical by its shape of body along the other end axially extending to body of body.
3. microneedle according to claim 1 it is characterised in that
Described groove has the straight rectilinear form extending along described pin, and the recessed certain depth in center towards described pin；
Described groove is set to three or more along the outer wall of described pin, or along described outer wall upper side, downside,
Left surface and right flank are sentenced constant space and are set to four；
Described groove extends to a part or the end of described straight portion from the one end of described rake, and has multiple branches
Shape；
Described groove have cross (+) shape or flat (-) shape；And/or
Described groove has the screw thread form that the outer wall along described pin extends clockwise or counterclockwise.
4. a kind of microneedle devices, comprising:
Medicament storage portion, it is used for storing medicine；
Micro needle head, it includes being connected to the drug channel in described medicament storage portion and multiple has from described micro needle head
The microneedle of prominent leading section, wherein, when described microneedle is pressed towards skin, described miniature needle-penetration dermis of skin is to incite somebody to action
Medicine is transported to dermis of skin from described drug channel；And
Heating part, it is used for heating skin by described micro needle head,
It is characterized in that, described microneedle is as described in any one of claim 1-3.
5. microneedle devices according to claim 4 it is characterised in that
Described medicament storage portion is by being connected to each other and being formed medicament storage chamber and medicine supply pipe；And/or
Described medicament storage chamber includes medicament reservoir, medicament lumen, medicament selection device and at least two along longitudinally isolation to connect
Receive the drug unit of multi-medicament.
6. microneedle devices according to claim 5 it is characterised in that
Described medicament selection device includes:
Hollow housing, described hollow housing allows that described medicament storage portion rotates in it；
Baffle plate, described baffle plate setting is in the lower end of described housing, and includes the outlet with one of multiple described drug units
Corresponding selecting hole；
Rotor, described rotor is arranged on the upper end in described medicament storage portion；And
Upper lid, described upper lid closes the top in described medicament storage portion, and supports described rotor and allow that described rotor rotates,
Wherein, described rotor rotates to rotate described medicament storage portion in described housing；Or,
Described medicament selection device includes:
Hollow housing, described hollow housing allows that described medicament storage portion rotates in it；
Multiple drug units, the plurality of drug unit includes flexible member within positioned at described medicament storage portion and opening/closing
Ball；
Baffle plate, described baffle plate setting is in the lower end of described housing, and includes corresponding with the outlet of one of described drug unit
Selecting hole；
Rotor, described rotor is arranged on the upper end in described medicament storage portion；And
Upper lid, described upper lid closes the top in described medicament storage portion, and supports described rotor and the rotation allowing described rotor,
Wherein, described rotor rotates to rotate described medicament storage portion in described housing；Or,
Described medicament selection device includes:
Flap shutter, described flap shutter is arranged on the lower end in described medicament storage portion, and can block institute with rotating manner
State the bottom of drug unit, described flap shutter includes the corresponding selection in bottom with one of multiple described drug units
Hole；
Rotor, described rotor is arranged on the upper end in described medicament storage portion, and can block described medicine list with rotating manner
The upper end of unit；And
Rotating bar, described rotating bar passes through described medicament storage portion, and described flap shutter is connected to described rotor,
Wherein, when described rotor rotates, described flap shutter and described rotating bar unitary rotation.
7. microneedle devices according to claim 5 are it is characterised in that described micro needle head includes:
Fixing body, described fixing body described drug channel formed therein that；
Pin fixed plate, described pin fixed plate fixes described microneedle；And
Pin covers, and described pin capping forms medicament distribution space to connect with described drug channel together with described pin fixed plate,
And including pin hole hole, described microneedle is externally exposed through described pin hole hole；
Wherein, each of described pin hole hole is respectively provided with the internal diameter more bigger than the external diameter of described microneedle, with from described medicine
Allocation space along described microneedle discharge medicine, or
Described micro needle head also includes medicine choking portion, and described medicine choking portion includes:
Bott stick, described bott stick is arranged on inside described drug channel, when described micro needle head contact skin, described blocking
Described drug channel opened by bar, and when described micro needle head is spaced apart with skin, described bott stick closes described drug channel, its
Described in bott stick for open the primary importance of described drug channel with for closing the second position of described drug channel
Between can move；And
Spring, described spring ground supports described bott stick so that described bott stick is maintained at the described second position, or
Described bott stick includes:
Pressure end, when described pressure end is located at the described second position, described pressure end is than the front end of described microneedle
Portion is more projected into outside；
Spring base, described spring base supports the spring being located between described drug channel and described spring base；And
Blocking end, described blocking end blocks described drug channel in the described second position, or, further
The fixing body of described micro needle head, pin fixed plate and pin capping are by synthetic resin (such as polymethyl methacrylate
Or Merlon etc.) or lucite make, or, further
Described microneedle as described in any one of claim 1-3, or, further
Described a plurality of v shape groove in described microneedle at the conical by its shape of body along body axially extending at least to described
In the medicament distribution space of micro needle head.
8. a kind of micro needle head, comprising:
Fixing body, described fixing body described drug channel formed therein that；
Pin fixed plate, is fixed with microneedle thereon；And
Pin covers, and described pin capping forms medicament distribution space to connect with described drug channel together with described pin fixed plate,
And including pin hole hole, described microneedle is externally exposed through described pin hole hole；
Wherein, each of described pin hole hole is respectively provided with the internal diameter more bigger than the external diameter of described microneedle, with from described medicine
Allocation space along described microneedle discharge medicine it is characterised in that
Described microneedle is as described in any one of claim 1-3.
9. micro needle head according to claim 8 is it is characterised in that it also includes medicine choking portion, described medicine blocking
Portion includes:
Bott stick, described bott stick is arranged on inside described drug channel, when described micro needle head contact skin, described blocking
Described drug channel opened by bar, and when described micro needle head is spaced apart with skin, described bott stick closes described drug channel, its
Described in bott stick for open the primary importance of described drug channel with for closing the second position of described drug channel
Between can move；And
Spring, described spring ground supports described bott stick so that described bott stick is maintained at the described second position.
10. micro needle head according to claim 8 is it is characterised in that its described bott stick includes:
Pressure end, when described pressure end is located at the described second position, described pressure end is than the front end of described microneedle
Portion is more projected into outside；
Spring base, described spring base supports the spring being located between described drug channel and described spring base；And
Blocking end, described blocking end blocks described drug channel in the described second position, or, further
Described fixing body, pin fixed plate and pin capping are by synthetic resin (such as polymethyl methacrylate or Merlon
Deng) or lucite make, or, further
Described a plurality of v shape groove in described microneedle at the conical by its shape of body along body axially extending at least to described
In the medicament distribution space of micro needle head.
A kind of 11. microneedle injection devices are it is characterised in that include:
Micro needle head, it is as described in any one of claim 8-10；
Block, it is used for covering the one end exposing microneedle in described micro needle head, so that this microneedle injection device is protected when not in use
Protect described microneedle；
Medicinal liquid bottle, for liquid drug, fixing body one end of the opening of this medicinal liquid bottle and described micro needle head is with detachable
Mode be tightly connected.
12. microneedle injection devices according to claim it is characterised in that between described medicinal liquid bottle and described micro needle head with
Screw socket mode is tightly connected.
13. microneedle injection devices according to claim it is characterised in that the material of described medicinal liquid bottle be selected from glass, plastics,
Lucite, metal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056980.2A CN106345051A (en) | 2016-11-25 | 2016-11-25 | Miniature injection needle and integrated device thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056980.2A CN106345051A (en) | 2016-11-25 | 2016-11-25 | Miniature injection needle and integrated device thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106345051A true CN106345051A (en) | 2017-01-25 |
Family
ID=57863151
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611056980.2A Pending CN106345051A (en) | 2016-11-25 | 2016-11-25 | Miniature injection needle and integrated device thereof |
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| CN (1) | CN106345051A (en) |
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