CN219462306U - Microneedle transdermal drug delivery device - Google Patents
Microneedle transdermal drug delivery device Download PDFInfo
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- CN219462306U CN219462306U CN202223603420.8U CN202223603420U CN219462306U CN 219462306 U CN219462306 U CN 219462306U CN 202223603420 U CN202223603420 U CN 202223603420U CN 219462306 U CN219462306 U CN 219462306U
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Abstract
The utility model provides a microneedle transdermal drug delivery device, which belongs to the technical field of transdermal drug delivery and comprises: the liquid storage component, the slow release component and the micro needle are pressed to pierce the dermis layer of human skin, the liquid medicine is input into the liquid storage component and enters the micro-passage of the liquid storage component, the liquid medicine penetrates into the slow release component through the through holes paved on the barrier layer of the micro-passage and then penetrates downwards through the porous structure of the slow release component, the liquid medicine enters the micro needle, and the liquid medicine is continuously and slowly released into the human body in multiple directions through the porous structure of the micro needle, so that the problems of single medicine injection mode and low efficiency of the micro needle in the prior art are solved.
Description
Technical Field
The utility model relates to the technical field of transdermal drug delivery, in particular to a microneedle transdermal drug delivery device.
Background
Microneedle technology has gained widespread attention in recent years in the biomedical community, and as one of the means of physical penetration promotion for transdermal drug delivery, painless accurate drug delivery can be achieved. The microneedle transdermal drug delivery can penetrate through the stratum corneum of the skin without touching pain nerves, a large amount of efficient permeation channels are formed, the permeation efficiency and absorption of macromolecular drugs are greatly improved, and the microneedle penetrates into the stratum corneum of the skin in multiple contacts on the premise of not damaging dermis, so that a channel from the stratum corneum to the lower part of the epidermis is opened, and the macromolecular drugs are finally absorbed by subcutaneous capillaries to enter the systemic circulation.
In the prior art, a microneedle transdermal drug delivery device generally adopts a thermoforming mode to manufacture microneedles, specified drugs are stored in a liquid storage tank communicated with a microneedle array, the drugs are injected transdermally through needle tracks communicated in the microneedles, sustained transdermal slow release is realized through local application, targeted drug delivery is realized, stable and effective blood concentration is maintained, pain is avoided, and patients are easier to accept.
However, in the prior art, the medicine is injected through the middle needle passage of the micro needle, the medicine injection mode is single, and the efficiency is lower.
Disclosure of Invention
Therefore, the technical problem to be solved by the utility model is that the micro-needle drug injection mode is single and the efficiency is low, so as to provide the micro-needle transdermal drug delivery device.
In order to solve the above technical problems, the present utility model provides a microneedle transdermal drug delivery device, comprising:
the liquid storage assembly is provided with a micro-channel on one surface, a blocking layer is paved on the micro-channel, a plurality of through holes communicated with the micro-channel are formed in the blocking layer, and the through holes form an outlet of the micro-channel;
the slow-release assembly is characterized in that one surface of the slow-release assembly is connected with one surface of the liquid storage assembly, which is provided with an outlet, the other surface of the slow-release assembly is connected with a plurality of micro-needles which are arranged in an array manner, and the slow-release assembly and the micro-needles are of porous structures.
Optionally, the through holes on the barrier layer are uniformly arranged.
Optionally, the device further comprises a barrier layer, wherein the barrier layer surrounds the outer side surface of the slow release component.
Optionally, the method further comprises:
one end of the liquid injection channel is communicated with the micro-channel in the liquid storage component, and the other end of the liquid injection channel is suitable for being externally connected with a pressurizing medicine injection device;
and the control valve is arranged on the liquid injection channel.
Alternatively, the microneedles are degradable microneedles.
Optionally, the liquid storage component and the slow release component are connected through bonding.
Optionally, the sustained release assembly and the microneedle are connected by an adhesive.
The technical scheme of the utility model has the following advantages:
1. when the microneedle transdermal drug delivery device provided by the utility model is used, the dermis layer of human skin is pierced by the microneedle on the pressing device, the liquid medicine is input into the liquid storage component, enters the micro-channel of the liquid storage component, permeates into the slow release component through the through holes paved on the barrier layer of the micro-channel, permeates downwards through the porous structure of the slow release component, enters the microneedle, and continuously slowly releases the liquid medicine into the human body in multiple directions through the porous structure of the microneedle, so that the problems of single drug injection mode and low efficiency of the microneedle in the prior art are solved.
2. According to the microneedle transdermal drug delivery device provided by the utility model, the through holes are uniformly formed in the barrier layer, so that the liquid medicine in the liquid storage device uniformly permeates outwards.
3. The microneedle transdermal drug delivery device provided by the utility model further comprises the impermeable layer which surrounds the outer side surface of the slow release component, so that the liquid medicine is prevented from seeping out of the outer side surface of the slow release component with the porous structure in the use process, and waste is avoided.
4. According to the microneedle transdermal drug delivery device provided by the utility model, the liquid storage component is communicated with the liquid injection channel, the other end of the liquid injection channel is externally connected with the pressurizing liquid injection device, so that different liquid medicines can be conveniently injected according to symptoms, the liquid injection channel is also provided with the control valve, and the control valve is closed after the liquid injection is completed, so that the liquid medicine is prevented from flowing back.
5. The microneedle of the transdermal drug delivery device provided by the utility model adopts the degradable microneedle, and the microneedle can be automatically degraded in the use process, so that the risk of breakage in a human body when the traditional silicon-based and metal-based microneedle is used is avoided, and the risk of injury to a human body is reduced.
6. According to the microneedle transdermal drug delivery device provided by the utility model, the liquid storage component and the slow release component are connected through bonding, so that the liquid storage component and the slow release component are connected into a whole.
7. According to the microneedle transdermal drug delivery device provided by the utility model, the slow release component and the microneedle are connected through bonding, so that the slow release component and the microneedle are connected into a whole.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic view of one embodiment of a microneedle transdermal delivery device provided in an example of the present utility model. Reference numerals illustrate:
1. a liquid storage component; 2. a slow release assembly; 3. a microneedle; 4. a micro-channel; 5. a barrier layer; 6. a through hole; 7. a liquid injection channel; 8. a control valve; 9. skin.
Detailed Description
The following description of the embodiments of the present utility model will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the utility model are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.
In addition, the technical features of the different embodiments of the present utility model described below may be combined with each other as long as they do not collide with each other.
The embodiment provides a microneedle transdermal drug delivery device for realizing subcutaneous multidirectional drug injection.
As shown in fig. 1, a specific implementation manner of an end hemming structure provided in this embodiment includes: a liquid storage component 1, a slow release component 2 and a microneedle 3; one surface of the liquid storage component 1 is provided with a micro-channel 4, a blocking layer 5 is paved on the micro-channel 4, a plurality of through holes 6 communicated with the micro-channel 4 are formed in the blocking layer 5, and the through holes 6 form an outlet of the micro-channel 4; one surface of the slow release component 2 is connected with one surface of the liquid storage component 1, which is provided with an outlet, the other surface of the slow release component 2 is connected with a plurality of micro-needles 3 which are arranged in an array, and the slow release component 2 and the micro-needles 3 are of porous structures.
When the micro-needle device is used, the micro-needle 3 on the pressing device pierces the dermis layer of human skin 9, liquid medicine is input into the liquid storage component 1 and enters the micro-channel 4 of the liquid storage component 1, the liquid medicine permeates into the slow release component 2 through the through holes 6 paved on the blocking layer 5 of the micro-channel 4 and permeates downwards through the porous structure of the slow release component 2, the liquid medicine enters the micro-needle 3, and the liquid medicine continuously slowly releases into the human body in multiple directions through the porous structure of the micro-needle 3, so that the problems of single medicine injection mode and low efficiency of the micro-needle 3 in the prior art are solved.
As shown in fig. 1, in the microneedle transdermal delivery device provided in this embodiment, the through holes 6 on the barrier layer 5 are uniformly arranged, so that the liquid medicine in the micro-channel 4 uniformly permeates outwards. In addition, as an alternative embodiment, the barrier layer 5 may also be a semi-permeable membrane, and the through holes 6 may be unevenly arranged.
As shown in fig. 1, the microneedle transdermal drug delivery device provided in this embodiment further includes an impermeable layer, where the impermeable layer surrounds the outer side surface of the sustained release assembly 2, so as to prevent the liquid medicine from leaking through the porous outer side surface of the sustained release assembly 2. Specifically, the impermeable layer is formed by brushing biological glue on the outer side surface of the slow release component 2. In addition, as an alternative embodiment, the impermeable layer may be omitted, or the outer side surface of the sustained release assembly 2 may be wrapped by a structure such as a housing.
As shown in fig. 1, in the microneedle transdermal drug delivery device provided in this embodiment, further includes: the liquid injection channel 7 is communicated with the micro-channel 4, and the other end of the liquid injection channel 7 is suitable for being externally connected with a pressurizing and drug injection device, so that the liquid medicine can be conveniently injected into the micro-channel 4 through the externally connected pressurizing and drug injection device; the control valve 8 is arranged on the upper sea of the liquid injection channel 7, and the control valve 8 is closed after liquid injection is completed, so that liquid medicine backflow is avoided. Specifically, the pressurized liquid injection device may be a micro-flow pump, or may be another pressurized liquid injection device such as a syringe, so that the liquid medicine is injected into the micro-channel in the form of droplets.
As shown in fig. 1, in the microneedle transdermal drug delivery device provided in this embodiment, the degradable microneedle 3 is used as the microneedle 3. The micro-needle 3 can be automatically degraded in the use process, so that the risk of breakage in the body when the traditional micro-needle 3 made of silicon-based and metal-based materials is used is avoided, and the risk of injury to the human body is reduced.
As shown in fig. 1, in the microneedle transdermal delivery device according to this embodiment, the reservoir assembly 1 and the sustained release assembly 2 are connected by adhesion. Specifically, the liquid storage component 1 and the sustained release component 2 are bonded together through freeze drying. In addition, as an alternative embodiment, the reservoir assembly 1 and the sustained-release assembly 2 may be bonded together using a bio-adhesive.
As shown in fig. 1, in the microneedle transdermal delivery device provided in this embodiment, the sustained release assembly 2 and the microneedle 3 are connected by adhesion. Specifically, the sustained release assembly 2 and the microneedles 3 are bonded together by freeze-drying. Additionally, as an alternative embodiment, a bio-glue may be used to bond the sustained release assembly 2 and the microneedles 3 together.
Application method
As shown in fig. 1, when the packaging machine provided in this embodiment is used, the microneedle 3 on the pressing device pierces the dermis layer of the human skin 9, the liquid medicine is input into the liquid storage component 1, enters the micro-channel 4 of the liquid storage component 1, the liquid medicine permeates into the slow release component 2 through the through hole 6 laid on the barrier layer 5 of the micro-channel 4, permeates downwards through the porous structure of the slow release component 2, and then enters the microneedle 3, and the liquid medicine continuously slowly releases into the human body in multiple directions through the porous structure of the microneedle 3, so that the problems of single medicine injection mode and low efficiency of the microneedle 3 in the prior art are solved.
In addition, the present embodiment provides a method for manufacturing a microneedle transdermal drug delivery device, for manufacturing a microneedle transdermal drug delivery device.
The specific implementation mode of the preparation method of the microneedle transdermal drug delivery device provided by the embodiment comprises the following steps:
s1: preparing a liquid storage assembly 1, arranging a micro-channel 4 on one surface of the liquid storage assembly 1, sealing the micro-channel 4 through a barrier layer 5, and arranging a plurality of through holes 6 communicated with the micro-channel 4 on the barrier layer 5;
s2: preparing a microneedle 3, injecting a microneedle 3 raw material into a template, and freeze-drying to form the microneedle 3 with a porous structure;
s3: and preparing a slow release assembly 2, injecting the raw material of the slow release assembly 2 into a template, forming the slow release assembly 2 with a porous structure through freeze-drying, and enabling the slow release assembly 2 to be respectively in adhesive connection with the micro needle 3 and the liquid storage assembly 1 through freeze-drying.
The sequence numbers "S1", "S2", "S3", etc. in the above steps are mainly for convenience of the following description, and the sequence numbers do not strictly limit the time sequence of the steps unless specifically described. For example, the microneedle 3 may be prepared after the stock solution set is prepared; alternatively, the reservoir assembly 1 may be prepared after the microneedles 3 are prepared; alternatively, the microneedle 3 may be manufactured at the same time as the reservoir assembly 1 is manufactured.
In step S1, the liquid storage assembly 1 may be manufactured by 3D printing, etching, reverse molding, and the like. The material of the liquid storage component 1 may be various polymer materials that can be molded, such as PDMS (polydimethylsiloxane), PLGA (polylactic-co-glycolic acid), PMMA (polymethyl methacrylate), and the like, and may also be materials such as silicon, metal, alloy, hydrogel, and the like. If the liquid storage component 1 needs to be transparent, the liquid storage component 1 may be made of PDMS (polydimethylsiloxane), PLGA (polylactic-co-glycolic acid), PMMA (polymethyl methacrylate), hydrogel (such as gelatin, sodium hyaluronate), or the like.
In step S2, the material of the microneedle 3 may be a degradable polymer material mixed with a small amount of hydrogel, and the degradable polymer material may be a nanomaterial such as albumin, PLGA (polylactic acid-glycolic acid copolymer), PLA (polylactic acid), PHA (polyhydroxyalkanoate), PBS (polybutylene succinate), and PCL (polycaprolactone).
In step S3, the material of the sustained release assembly 2 may be hydrogel (such as gelatin, sodium hyaluronate, etc.) mixed with a small amount of polymer material (such as albumin or PLGA, etc. nanomaterial).
Specifically, the slow release component 2 and the micro needle 3 may be freeze-dried in different molds, and then the slow release component 2 and the micro needle 3 are bonded together by freeze-drying; or the micro needle 3 is prepared firstly, the micro needle 3 is freeze-dried and formed, then the raw material of the slow release component 2 is injected into the upper layer, and freeze-dried and formed again.
In addition, as an alternative embodiment, the slow release component 2 can be adhered to the liquid storage component 1 and the micro needle 3 by brushing biological glue; bonding, in particular, means that two objects are held together by van der waals, molecular or even atomic forces. For example, the manufactured micro-needles 3 and the slow release assembly 2 may be placed in a plasma cleaning machine to be processed for a period of time, so as to ensure the cleanness and flatness of the joint surfaces of the micro-needles 3 and the slow release assembly 2, and the micro-needles 3 and the slow release assembly 2 are pressed together after the processing is completed.
The preparation method of the microneedle transdermal drug delivery device provided by the embodiment further comprises the following steps that the periphery of the connecting surface of the slow-release assembly 2 and the liquid storage assembly 1 is bonded through biological glue, so that leakage of liquid medicine from the periphery of the connecting surface of the slow-release assembly 2 and the liquid storage assembly 1 is avoided.
In the method for preparing the microneedle transdermal drug delivery device provided by the embodiment, the method further comprises the following steps of brushing biological glue on the outer side surface of the slow-release component 2 to form an impermeable layer, so that the liquid medicine is prevented from leaking from the outer side surface of the slow-release component 2.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. And obvious variations or modifications thereof are contemplated as falling within the scope of the present utility model.
Claims (7)
1. A microneedle transdermal drug delivery device, comprising:
the liquid storage assembly (1), one surface of the liquid storage assembly (1) is provided with a micro-channel (4), a blocking layer (5) is paved on the micro-channel (4), a plurality of through holes (6) communicated with the micro-channel (4) are formed in the blocking layer (5), and the through holes (6) form an outlet of the micro-channel (4);
the slow-release assembly (2), one side of slow-release assembly (2) with the one side of stock solution subassembly (1) that has the export is connected, microneedle (3) that a plurality of arrays were arranged are connected to the another side of slow-release assembly (2), slow-release assembly (2) with microneedle (3) are porous structure.
2. Microneedle transdermal delivery device according to claim 1, characterized in that the through holes (6) on the barrier layer (5) are uniformly arranged.
3. The microneedle transdermal delivery device according to claim 1, further comprising a barrier layer surrounding the outer side of the sustained release assembly (2).
4. The microneedle transdermal drug delivery device of claim 1, further comprising:
one end of the liquid injection channel (7) is communicated with the micro-channel (4) in the liquid storage assembly (1), and the other end of the liquid injection channel is suitable for being externally connected with a pressurizing medicine injection device;
and a control valve (8), wherein the control valve (8) is arranged on the liquid injection channel (7).
5. The microneedle transdermal delivery device according to any one of claims 1 to 4, wherein the microneedle (3) is a degradable microneedle (3).
6. The microneedle transdermal delivery device according to any one of claims 1 to 4, wherein the reservoir assembly (1) and the sustained release assembly (2) are connected by adhesive.
7. The microneedle transdermal delivery device according to any one of claims 1 to 4, characterized in that the slow release assembly (2) and the microneedle (3) are connected by adhesive.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223603420.8U CN219462306U (en) | 2022-12-30 | 2022-12-30 | Microneedle transdermal drug delivery device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223603420.8U CN219462306U (en) | 2022-12-30 | 2022-12-30 | Microneedle transdermal drug delivery device |
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| CN219462306U true CN219462306U (en) | 2023-08-04 |
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| CN202223603420.8U Active CN219462306U (en) | 2022-12-30 | 2022-12-30 | Microneedle transdermal drug delivery device |
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