CN103110859B - Traditional Chinese medicine composition for treating gastrointestinal function decline after abdominal operation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gastrointestinal function decline after abdominal operation and preparation method thereof Download PDFInfo
- Publication number
- CN103110859B CN103110859B CN201310041692.XA CN201310041692A CN103110859B CN 103110859 B CN103110859 B CN 103110859B CN 201310041692 A CN201310041692 A CN 201310041692A CN 103110859 B CN103110859 B CN 103110859B
- Authority
- CN
- China
- Prior art keywords
- parts
- parched
- brown
- fructus
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating gastrointestinal function decline after an abdominal operation and a preparation method thereof. The traditional Chinese medicine composition for treating the gastrointestinal function decline after the abdominal operation disclosed by the invention is prepared from the traditional Chinese medicine drugs in parts by weight: 10-20 parts of codonopsis pilosula, 7-17 parts of white atractylodes rhizome, 7-17 parts of Tuckahoe, 4-14 parts of stir-baked divine comedy, 4-14 parts of stir-baked hawthorn, 4-14 parts of stir-baked malt, 7-17 parts of astragalus mongholicus, 7-17 parts of dried tangerine or orange peel, 7-17 parts of immature bitter orange, 7-17 parts of semen raphani, 7-17 parts of root of red-rooted salvia, 7-17 parts of angelica sinensis, 7-17 parts of fructus cannabis and 2-10 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention has the effects of invigorating spleen and supplementing qi, and removing food retention and flatulence, and is clinically used for gastrointestinal function decline after the abdominal operation, inappetence symptom, abdominal distension, dyschizia, vomiting, diarrhea and the like.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine composition that abdominal post-operation gastrointestinal function goes down and preparation method thereof for the treatment of.
Background technology
In corrective surgery process, because of many factors such as the inhibition of anesthesia, the stimulation of interference, wound and the inflammation of operation, water and electrolyte disturbances, cause gastrointestinal function recovery after operation suppressed.There is temporary enteroparalysis in the lighter, affects the recovery of gastrointestinal function, and severe one enteric cavity inner product QI-mass liquid increases, form paralytic ileus, produce abdominal distention, affect stomach wall wound healing, even can make diaphram raise, affect respiratory function, the even generation traumatic intestinal adhesion having.Therefore, solve abdominal postoperative gastrointestinal function and go down, the recovery that promotes abdominal postoperative gastrointestinal function is one of problem of being concerned about the most of surgeon, is generally all aided with ventilation medicine and treats.The current curative for ventilating after abdominal surgery clinically, Western medicine is mainly applied anticholinergic class medicine, cisapride, neostigmine, pyridostigmine bromide etc., but this class drug side effect is larger, its pharmacological action is too strong, the strong contraction of stomach, intestinal smooth muscle often after patient takes, be higher load condition, may be spasticity what is more.Also a large amount of with Radix Raphani soup or take Chinese medicine compound decoction and carry out gastrointestinal smoother airway dysfunction disorder after iatrotechnics after operation clinically at present, there is certain curative effect, this respect also has a large amount of bibliographical informations.But often because dose is large, it is cumbersome to decoct, effective ingredient be difficult for fried, cross under chronic diarrhea the composition reason such as destructible again, add the weakness of anesthesia and postoperative body constitution, patient is difficult to swallow conventionally.
Still there is demand in the Chinese medicine preparation that therefore, people better treat the going down of abdominal postoperative gastrointestinal function, stagnation of QI abdominal fullness and distention and postoperative promotion gastrointestinal peristalsis functional rehabilitation to curative effect.
Summary of the invention
Technical problem to be solved by this invention is to avoid the existing weak point of above-mentioned prior art, and the medicine of the going down of a kind of more effective treatment treatment abdominal postoperative gastrointestinal function, stagnation of QI abdominal fullness and distention and postoperative promotion gastrointestinal peristalsis functional rehabilitation is provided.
Another technical problem to be solved by this invention is to provide dosage form of this Chinese medicine composition and preparation method thereof.
The present invention is achieved through the following technical solutions:
Treat the Chinese medicine composition that abdominal post-operation gastrointestinal function goes down, by the raw material of Chinese medicine medicine of following weight portion, made: 10～20 parts of Radix Codonopsis, 7～17 parts of the Rhizoma Atractylodis Macrocephalaes, 7～17 parts, Poria, 4～14 parts of Massa Medicata Fermentata (parched to brown), 4～14 parts of Fructus Crataegi (parched to brown)s, 4～14 parts of Fructus Hordei Germinatus (parched to brown)s, 7～17 parts of the Radixs Astragali, 7～17 parts of Pericarpium Citri Reticulataes, 7～17 parts of Fructus Aurantii Immaturuss, 7～17 parts of Semen Raphanis, 7～17 parts of Radix Salviae Miltiorrhizaes, 7～17 parts of Radix Angelicae Sinensis, 7～17 parts of Fructus Cannabiss, 2～10 parts, Radix Glycyrrhizae.
The Chinese medicine composition that above-mentioned treatment abdominal post-operation gastrointestinal function goes down, is made by the raw material of Chinese medicine medicine of following weight portion: 12～18 parts of Radix Codonopsis, 9～15 parts of the Rhizoma Atractylodis Macrocephalaes, 9～15 parts, Poria, 6～12 parts of Massa Medicata Fermentata (parched to brown), 6～12 parts of Fructus Crataegi (parched to brown)s, 6～12 parts of Fructus Hordei Germinatus (parched to brown)s, 9～15 parts of the Radixs Astragali, 9～15 parts of Pericarpium Citri Reticulataes, 9～15 parts of Fructus Aurantii Immaturuss, 9～15 parts of Semen Raphanis, 9～15 parts of Radix Salviae Miltiorrhizaes, 9～15 parts of Radix Angelicae Sinensis, 9～15 parts of Fructus Cannabiss, 3～9 parts, Radix Glycyrrhizae.
The Chinese medicine composition that above-mentioned treatment abdominal post-operation gastrointestinal function goes down, is made by the raw material of Chinese medicine medicine of following weight portion: 15 parts of Radix Codonopsis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria, 9 parts of Massa Medicata Fermentata (parched to brown), 9 parts of Fructus Crataegi (parched to brown)s, 9 parts of Fructus Hordei Germinatus (parched to brown)s, 12 parts of the Radixs Astragali, 12 parts of Pericarpium Citri Reticulataes, 12 parts of Fructus Aurantii Immaturuss, 12 parts of Semen Raphanis, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Angelicae Sinensis, 12 parts of Fructus Cannabiss, 6 parts, Radix Glycyrrhizae.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount can corresponding adjustment forming, increases or reduces being no more than 100%, and drug effect is substantially constant.
The Chinese medicine composition that above-mentioned treatment abdominal post-operation gastrointestinal function goes down, its dosage form is granule.
The preparation method of the Chinese medicinal composition granules that above-mentioned treatment abdominal post-operation gastrointestinal function goes down, comprises following steps:
(a) decocting that Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae 10 taste medical materials is added to 8～12 times of weight of above-mentioned medical material boils 2 times, each decoction 0.5～1.5 hour, merge the fried liquid of twice, at 60 ℃, be evaporated to half that former fried liquid amasss, incline and to cool, cold preservation 12 hours, filters, and it is 1.25～1.28 clear paste that 60 ℃ of filtrates are evaporated to relative density;
(b) by 75% soak with ethanol of 3～5 times of amounts of medical material volume reflux, extract, 2 times after 10～14 hours for Fructus Aurantii Immaturus, Semen Raphani, Fructus Cannabis, Radix Angelicae Sinensis, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.05～0.07MPa for filtrate, and 60 ℃ are evaporated to relative density is 1.20～1.25 clear paste;
(c) merge two parts clear paste, mix, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, is prepared into extract powder, adds pharmaceutically acceptable adjuvant, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
The preparation method of the Chinese medicinal composition granules that above-mentioned treatment abdominal post-operation gastrointestinal function goes down, comprises following steps:
(a) decocting that Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae 10 taste medical materials is added to 10 times of weight of above-mentioned medical material boils 2 times, each decoction 1 hour, merge the fried liquid of twice, at 60 ℃, be evaporated to half that former fried liquid amasss, incline and to cool, cold preservation 12 hours, filters, and it is 1.25～1.28 clear paste that 60 ℃ of filtrates are evaporated to relative density;
(b) by 75% soak with ethanol of 4 times of amounts of medical material volume reflux, extract, 2 times after 12 hours for Fructus Aurantii Immaturus, Semen Raphani, Fructus Cannabis, Radix Angelicae Sinensis, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.06MPa for filtrate, and 60 ℃ are evaporated to relative density is 1.20～1.25 clear paste;
(c) merge two parts clear paste, mix, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, is prepared into extract powder, adds pharmaceutically acceptable adjuvant, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
Product carries out quality inspection, after the assay was approved package sterilization.Every bag heavy 5g, every gram contains crude drug in whole 3.1～3.5g, takes each 1 bag every day three times.
Described pharmaceutically acceptable adjuvant is selected from: sucrose, starch, magnesium stearate, mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, tie up main plain E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, polysorbate60～80, department class～80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, fine jade, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, β～cyclodextrin, phospholipid material, Kaolin, Pulvis Talci, calcium stearate etc.
Chinese medicine composition of the present invention has invigorating the spleen and benefiting QI, and the effect of removing stagnancy of indigested food and relieving flatulence clinically goes down for abdominal postoperative gastrointestinal function, and disease is seen poor appetite, abdominal distention, dyschesia, vomiting, diarrhoea etc.
Generally believe at present, abdominal operation operation, anesthesia and patient's primary disease, the medicine for the treatment of, postoperative water electrolysis acid base imbalance, postoperative pain, malnutrition, positive position etc. all can cause the nerve of intestinal wall endogenous locomotor activity to suppress, thereby cause the generation of the slow and enteroparalysis of restoration of gastrointestinal function.Traditional Chinese medical science viewpoint thinks, abdominal postoperative is because mistake department falls in gastrointestinal smoother, and stomachache appears in patient, swollen, the card marquis such as close, vomit, and operation causes patient consumption and hinders vigour, there is the deficiency of vital energy, anemia syndrome of blood stasis marquis in loss Tianjin blood, thereby has increased the weight of enteroparalysis degree, theory of Chinese medical science is also thought, after abdominal surgery because of wound, lose blood, anaesthetize, QI-blood circulation is unable, gastrointestinal function dereliction of duty, clear QI failing to ascend, turbid QI failing to descend, hinders in middle Jiao, and internal organs gas is difficult logical.
The present invention treats in the Chinese medicine composition that abdominal post-operation gastrointestinal function goes down, Radix Codonopsis, Radix Astragali invigorating the spleen and replenishing QI; Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown) are collectively referred to as JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) invigorating the spleen and regulating the stomach, and removing food stagnancyization is stagnant; The Rhizoma Atractylodis Macrocephalae, Poria invigorating the spleen and benefiting QI, dampness diuretic; Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Semen Raphani circulation of qi promoting de-swelling; Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation; Fructus Cannabis loosening bowel to relieve constipation, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and play altogether invigorating the spleen and benefiting QI, the merit of removing stagnancy of indigested food and relieving flatulence.Chinese medicine composition of the present invention can promote gastrointestinal motility, antiinflammatory, prevention of postoperative intestinal adhesion.
The invention has the advantages that:
(1) the invention provides the Chinese medicine composition that a kind of new treatment abdominal post-operation gastrointestinal function goes down, met clinical needs.
(2) Chinese medicine composition that treatment abdominal post-operation gastrointestinal function is gone down in the present invention is prepared into granule, both kept decoction to absorb fast, effective feature rapidly, overcome again decoction and taken front interim decoction, be long placed in and easily mouldly lose rotten shortcoming, and can cover the bitterness of Chinese medicine.Chinese medicine granules Chinese crude drug of the present invention all extracts through refining, and volume-diminished is transported, carried, taking convenience.
(3) clinical test results shows, the present invention treats traditional Chinese medicine composition for treating group and the matched group comparison that abdominal post-operation gastrointestinal function goes down: the 19.5h that heard borborygmus time advance after treatment; Micturition time has shifted to an earlier date 22.5h.Defecation time has shifted to an earlier date 33h, and diet has shifted to an earlier date 29.8h recovery time, illustrates that Chinese medicine composition of the present invention is conducive to the recovery of gastrointestinal function recovery after operation, and gastrointestinal function recovery after operation is gone down and has good curative effect.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1: the preparation of Chinese medicinal composition granules of the present invention
Prescription: Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 12g, Poria 12g, Massa Medicata Fermentata (parched to brown) 9g, Fructus Crataegi (parched to brown) 9g, Fructus Hordei Germinatus (parched to brown) 9g, Radix Astragali 12g, Pericarpium Citri Reticulatae 12g, Fructus Aurantii Immaturus 12g, Semen Raphani 12g, Radix Salviae Miltiorrhizae 12g, Radix Angelicae Sinensis 12g, Fructus Cannabis 12g, Radix Glycyrrhizae 6g
Preparation method:
(a) decocting that Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae 10 taste medical materials is added to 10 times of weight of above-mentioned medical material boils 2 times, each decoction 1 hour, merge the fried liquid of twice, at 60 ℃, be evaporated to half that former fried liquid amasss, incline and to cool, cold preservation 12 hours, filters, and it is 1.25～1.28 clear paste that 60 ℃ of filtrates are evaporated to relative density;
(b) by 75% soak with ethanol of 4 times of amounts of medical material volume reflux, extract, 2 times after 12 hours for Fructus Aurantii Immaturus, Semen Raphani, Fructus Cannabis, Radix Angelicae Sinensis, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.06MPa for filtrate, and 60 ℃ are evaporated to relative density is 1.20～1.25 clear paste;
(c) merge two parts clear paste, mix, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, is prepared into extract powder, adds sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent 50g, obtains.
Product carries out quality inspection, after the assay was approved package sterilization.Every bag heavy 5g, every g is equivalent to crude drug 3.12g, takes each 1 bag every day three times.
Embodiment 2: the preparation of Chinese medicinal composition granules of the present invention
Prescription: Radix Codonopsis 12g, Rhizoma Atractylodis Macrocephalae 15g, Poria 9g, Massa Medicata Fermentata (parched to brown) 12g, Fructus Crataegi (parched to brown) 6g, Fructus Hordei Germinatus (parched to brown) 12g, Radix Astragali 9g, Pericarpium Citri Reticulatae 15g, Fructus Aurantii Immaturus 9g, Semen Raphani 15g, Radix Salviae Miltiorrhizae 9g, Radix Angelicae Sinensis 15g, Fructus Cannabis 9g, Radix Glycyrrhizae 9g
Preparation method:
(a) decocting that Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae 10 taste medical materials is added to 12 times of weight of above-mentioned medical material boils 2 times, each decoction 0.5 hour, merge the fried liquid of twice, at 60 ℃, be evaporated to half that former fried liquid amasss, incline and to cool, cold preservation 12 hours, filters, and it is 1.25～1.28 clear paste that 60 ℃ of filtrates are evaporated to relative density;
(b) by 75% soak with ethanol of 3 times of amounts of medical material volume reflux, extract, 2 times after 14 hours for Fructus Aurantii Immaturus, Semen Raphani, Fructus Cannabis, Radix Angelicae Sinensis, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.05MPa for filtrate, and 60 ℃ are evaporated to relative density is 1.20～1.25 clear paste;
(c) merge two parts clear paste, mix, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, is prepared into extract powder, adds sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent 50g, obtains.
Product carries out quality inspection, after the assay was approved package sterilization.Every bag heavy 5g, every g is equivalent to crude drug 3.32g and takes three times every day, each 1 bag.
Embodiment 3: the preparation of Chinese medicinal composition granules of the present invention
Prescription: Radix Codonopsis 18g, Rhizoma Atractylodis Macrocephalae 9g, Poria 15g, Massa Medicata Fermentata (parched to brown) 6g, Fructus Crataegi (parched to brown) 12g, Fructus Hordei Germinatus (parched to brown) 6g, Radix Astragali 15g, Pericarpium Citri Reticulatae 9g, Fructus Aurantii Immaturus 15g, Semen Raphani 9g, Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 9g, Fructus Cannabis 15g, Radix Glycyrrhizae 3g
Preparation method:
(a) decocting that Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae 10 taste medical materials is added to 8 times of weight of above-mentioned medical material boils 2 times, each decoction 1.5 hours, merge the fried liquid of twice, at 60 ℃, be evaporated to half that former fried liquid amasss, incline and to cool, cold preservation 12 hours, filters, and it is 1.25～1.28 clear paste that 60 ℃ of filtrates are evaporated to relative density;
(b) by 75% soak with ethanol of 5 times of amounts of medical material volume reflux, extract, 2 times after 10 hours for Fructus Aurantii Immaturus, Semen Raphani, Fructus Cannabis, Radix Angelicae Sinensis, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.05MPa for filtrate, and 60 ℃ are evaporated to relative density is 1.20～1.25 clear paste;
(c) merge two parts clear paste, mix, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, is prepared into extract powder, adds sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent 50g, obtains.
Product carries out quality inspection, after the assay was approved package sterilization.Every bag heavy 5g, every g is equivalent to crude drug 3.32g and takes three times every day, each 1 bag.
Embodiment 4: the preparation of Chinese medicinal composition granules of the present invention
Prescription: Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 17g, Poria 7g, Massa Medicata Fermentata (parched to brown) 14g, Fructus Crataegi (parched to brown) 4g, Fructus Hordei Germinatus (parched to brown) 14g, Radix Astragali 7g, Pericarpium Citri Reticulatae 17g, Fructus Aurantii Immaturus 7g, Semen Raphani 17g, Radix Salviae Miltiorrhizae 7g, Radix Angelicae Sinensis 17g, Fructus Cannabis 7g, Radix Glycyrrhizae 10g
Preparation method is with embodiment 1.
Embodiment 5: the preparation of Chinese medicinal composition granules of the present invention
Prescription: Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 7g, Poria 17g, Massa Medicata Fermentata (parched to brown) 4g, Fructus Crataegi (parched to brown) 14g, Fructus Hordei Germinatus (parched to brown) 4g, Radix Astragali 17g, Pericarpium Citri Reticulatae 7g, Fructus Aurantii Immaturus 17g, Semen Raphani 7g, Radix Salviae Miltiorrhizae 17g, Radix Angelicae Sinensis 7g, Fructus Cannabis 17g, Radix Glycyrrhizae 2g
Preparation method is with embodiment 2.
The preparation of embodiments of the invention l has been carried out to clinical pharmacodynamics test, and result is as follows:
There is the obvious heart, lung, liver, renal insufficiency and complications thereof in 150 routine patients with abdominal operations eliminatings. and cloth hypersensitivity and operation are done around umbilicus abdominal part median incision patient.Be divided at random each 75 examples for the treatment of group and matched group.Treatment group man 50 examples, female's 25 examples; 13～65 years old age, 55.2 years old mean age; Gastroduodenal surgery 21 examples, appendectomy 34 examples, adhesion of small intestine loosen operation 8 examples, hepatobiliary surgery 12 examples; General anesthesia 3O example, epidural anesthesia 45 examples.Matched group man 45 examples, women's 30 examples; 15～65 years old age, 56.8 years old mean age; Gastroduodenal surgery 2O example, appendectomy 32 examples, adhesion of small intestine operation 10 examples of loosening, hepatobiliary surgery 13 examples; General anesthesia 36 examples, epidural anesthesia 39 examples.The physical data such as 2 groups of case sexes, age are learned by statistics and are processed there was no significant difference (P > 0.05), have comparability.
Therapeutic Method
The postoperative fasting of matched group 6 hours, conventional gastrointestinal decompression, infection, pain relieving, hemostasis, supports and maintains the symptomatic treatments such as water-electrolyte balance, and assisting patients early ambulation, treats the aerofluxus of anus nature simultaneously.
Treatment group adopts the Chinese medicine composition of the present invention of embodiment 1 preparation on the basis for the treatment of of control group, every day 3 times, and each 1 bag, postoperative anesthetic action starts to take for the first time after disappearing.The excision person of the large portion of stomach, the mid-nasal feeding tube of art is in jejunum loop far away, and from then on postoperative anesthetic action manages injection by medicinal liquid after disappearing.
Observation of curative effect
Observation index borborygmus recovery time, micturition time, anus defecation time and diet recovery time.Gastrointestinal functions resumed is relatively in Table 1.
Table 1 treatment group and matched group gastrointestinal functions resumed comparison (h)
| Group | Number of cases | Borborygmus recovers | Passage of gas by anus | Defecation | Diet recovers |
| Treatment group | 75 | 21.6±10.7 * | 33.3±17.0 * | 41.9±17.7 * | 41.5±20.5 * |
| Matched group | 75 | 41.1±15.9 | 55.8±23.2 | 77.9±24.8 | 71.3±35.5 |
Note:<sup TranNum="168">*</sup>with matched group comparison, P<O.05.
Treatment group and matched group comparison: the 19.5h that heard borborygmus time advance after treatment; Micturition time has shifted to an earlier date 22.5h.Defecation time has shifted to an earlier date 33h, and diet has shifted to an earlier date 29.8h recovery time, illustrates that Chinese medicine composition of the present invention is conducive to the recovery of gastrointestinal function recovery after operation, and gastrointestinal function recovery after operation is gone down and has good curative effect.
Model case
King so-and-so, man, 79 years old, because acute appendicitis merges perforation, diffuse peritonitis row appendectomy, intraperitoneal drainage art.Postoperative abdominal distention unbearably, can not be put down sleeping.Through conventional western medical treatment 48 hours, patient's abdominal distention continued not subtract, and abdominal part be can't hear borborygmus.Then give Chinese medicinal composition granules of the present invention, each 1 bag, every 8 hours 1 time, take medicine latter 8 hours be bowel sounds active, passage of gas by anus, abdominal distention is eliminated, and pulls out stomach tube thereupon, influent stream food.
Zhang, 45 years old.Menorrhagia 5 years, through western medicines in treatment effect, after every inspection, is diagnosed as and gives palace muscular tumor, secondary anemia.In the descending total hysterectomy of epidural anesthesia, postoperative conscious stomachache, abdominal distention, a little less than auscultation borborygmus.Within postoperative 6 hours, start to take Chinese medicinal composition granules of the present invention, each 1 bag, every day 3 times, takes latter 2 hours, patient's aerofluxus, and stomachache, abdominal distention alleviate thereupon.Take medicine after 1 day, above-mentioned symptom disappears, auscultation bowel sounds active, and stomach is received improvement.
Above example is only representative case, has above curative effect person many in addition, at this, no longer enumerates.
Claims (4)
1. treat the Chinese medicine composition that abdominal post-operation gastrointestinal function goes down, by the raw material of Chinese medicine medicine of following weight portion, made: 10～20 parts of Radix Codonopsis, 7～17 parts of the Rhizoma Atractylodis Macrocephalaes, 7～17 parts, Poria, 4～14 parts of Massa Medicata Fermentata (parched to brown), 4～14 parts of Fructus Crataegi (parched to brown)s, 4～14 parts of Fructus Hordei Germinatus (parched to brown)s, 7～17 parts of the Radixs Astragali, 7～17 parts of Pericarpium Citri Reticulataes, 7～17 parts of Fructus Aurantii Immaturuss, 7～17 parts of Semen Raphanis, 7～17 parts of Radix Salviae Miltiorrhizaes, 7～17 parts of Radix Angelicae Sinensis, 7～17 parts of Fructus Cannabiss, 2～10 parts, Radix Glycyrrhizae;
The dosage form of the Chinese medicine composition that described treatment abdominal post-operation gastrointestinal function goes down is granule;
The preparation method of the Chinese medicinal composition granules that described treatment abdominal post-operation gastrointestinal function goes down, comprises following steps:
(a) decocting that Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae 10 taste medical materials is added to above-mentioned medical material 8～l2 times weight boils 2 times, each decoction 0.5～1.5 hour, merge the fried liquid of twice, at 60 ℃, be evaporated to half that former fried liquid amasss, incline and to cool, cold preservation 12 hours, filters, and it is 1. 25～1.28 clear paste that 60 ℃ of filtrates are evaporated to relative density;
(b) by 75% soak with ethanol of 3～5 times of amounts of medical material volume reflux, extract, 2 times after 10～14 hours for Fructus Aurantii Immaturus, Semen Raphani, Fructus Cannabis, Radix Angelicae Sinensis, each l hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0. 05～0.07MPa for filtrate, and 60 ℃ are evaporated to relative density is 1. 20～1.25 clear paste;
(C) merge two parts clear paste, mix, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, is prepared into extract powder, adds pharmaceutically acceptable adjuvant, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
2. the Chinese medicine composition going down according to the treatment abdominal post-operation gastrointestinal function described in claim l, is characterized in that, by the raw material of Chinese medicine medicine of following weight portion, is made:
12～18 parts of Radix Codonopsis, 9～15 parts of the Rhizoma Atractylodis Macrocephalaes, 9～15 parts, Poria, 6～12 parts of Massa Medicata Fermentata (parched to brown), 6～12 parts of Fructus Crataegi (parched to brown)s, 6～12 parts of Fructus Hordei Germinatus (parched to brown)s, 9～15 parts of the Radixs Astragali, 9～15 parts of Pericarpium Citri Reticulataes, 9～15 parts of Fructus Aurantii Immaturuss, 9～15 parts of Semen Raphanis, 9～15 parts of Radix Salviae Miltiorrhizaes, 9～15 parts of Radix Angelicae Sinensis, 9～15 parts of Fructus Cannabiss, 3～9 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition that treatment abdominal post-operation gastrointestinal function according to claim 2 goes down, is characterized in that, by the raw material of Chinese medicine medicine of following weight portion, is made:
15 parts of Radix Codonopsis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria, 9 parts of Massa Medicata Fermentata (parched to brown), 9 parts of Fructus Crataegi (parched to brown)s, 9 parts of Fructus Hordei Germinatus (parched to brown)s, 12 parts of the Radixs Astragali, 12 parts of Pericarpium Citri Reticulataes, 12 parts of Fructus Aurantii Immaturuss, 12 parts of Semen Raphanis, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Angelicae Sinensis, 12 parts of Fructus Cannabiss, 6 parts, Radix Glycyrrhizae.
4. the preparation method of the Chinese medicinal composition granules that treatment abdominal post-operation gastrointestinal function according to claim 1 goes down, comprises following steps:
(a) decocting that Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), the Radix Astragali, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, twenty careless 10 taste medical materials is added to 10 times of weight of above-mentioned medical material boils 2 times, each l hour that decocts, merge the fried liquid of twice, at 60 ℃, be evaporated to half that former fried liquid amasss, incline and to cool, cold preservation 12 hours, filters, and it is 1. 25～1.28 clear paste that 60 ℃ of filtrates are evaporated to relative density;
(b) by 75% soak with ethanol of 4 times of amounts of medical material volume reflux, extract, 2 times after 12 hours for Fructus Aurantii Immaturus, Semen Raphani, Fructus Cannabis, Radix Angelicae Sinensis, each l hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0. 06MPa for filtrate, and 60 ℃ are evaporated to relative density is 1. 20～1.25 clear paste;
(C) merge two parts clear paste, mix, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, is prepared into extract powder, adds pharmaceutically acceptable adjuvant, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310041692.XA CN103110859B (en) | 2013-02-04 | 2013-02-04 | Traditional Chinese medicine composition for treating gastrointestinal function decline after abdominal operation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310041692.XA CN103110859B (en) | 2013-02-04 | 2013-02-04 | Traditional Chinese medicine composition for treating gastrointestinal function decline after abdominal operation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103110859A CN103110859A (en) | 2013-05-22 |
| CN103110859B true CN103110859B (en) | 2014-01-15 |
Family
ID=48409267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310041692.XA Expired - Fee Related CN103110859B (en) | 2013-02-04 | 2013-02-04 | Traditional Chinese medicine composition for treating gastrointestinal function decline after abdominal operation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103110859B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656013B (en) * | 2013-12-19 | 2015-10-21 | 滨州医学院附属医院 | A kind of Chinese medicine for the treatment of gastrointestinal function decline after abdominal operation and preparation method thereof |
| CN104147427A (en) * | 2014-08-28 | 2014-11-19 | 山东川成医药股份有限公司 | Children fever-abating medicine containing bupleurum and preparation method thereof |
| CN104306894B (en) * | 2014-11-05 | 2017-06-16 | 滨州医学院附属医院 | A kind of Chinese medicine for treating cancer of the esophagus radical excision chylothorax and preparation method thereof |
| CN104906408A (en) * | 2015-05-15 | 2015-09-16 | 朱丽萍 | Foot-bath care solution for promoting abdomen postoperation intestinal function recovery |
| CN105749050A (en) * | 2016-05-10 | 2016-07-13 | 李勇 | Traditional Chinese medicine composition used for abdominal distension after cesarean anaesthesia |
| CN105832847B (en) * | 2016-05-12 | 2019-11-08 | 陕西开元制药有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating hypertension |
| CN106110149A (en) * | 2016-07-30 | 2016-11-16 | 王道繁 | A kind of warm umbilicus patch and preparation method thereof |
| CN106822720A (en) * | 2017-04-06 | 2017-06-13 | 孙晓风 | A kind of instant particles as Chinese medicine and preparation method for treating postoperative intestinal adhesion |
| CN112057589A (en) * | 2020-10-21 | 2020-12-11 | 江阴市人民医院 | Traditional Chinese medicine for preventing and treating intestinal adhesion after abdominal operation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
-
2013
- 2013-02-04 CN CN201310041692.XA patent/CN103110859B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103110859A (en) | 2013-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103110859B (en) | Traditional Chinese medicine composition for treating gastrointestinal function decline after abdominal operation and preparation method thereof | |
| CN101224282B (en) | Medicine compounds for treating infantile anorexia and preparing method thereof | |
| CN101129660A (en) | Medicament for treating chronic obstructive emphysema and chronic pulmonary heart disease | |
| CN103405707A (en) | Chinese medicine preparation for regulating ti-flowing for strengthening spleen and eliminating dampness and phlegm | |
| CN103536881B (en) | A kind of medicine for the treatment of chronic gastritis | |
| CN103386074B (en) | Traditional Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
| CN101647979B (en) | Traditional Chinese medicine for treating bronchial asthma | |
| CN103656013B (en) | A kind of Chinese medicine for the treatment of gastrointestinal function decline after abdominal operation and preparation method thereof | |
| CN106377720A (en) | Stomach medicine and preparation method thereof | |
| CN108939026A (en) | It is a kind of can blood-enrich medlar red date particle and preparation method thereof | |
| CN103028093A (en) | Traditional Chinese medicine composition for treating chronic obstructive pulmonary emphysema and preparation method of traditional Chinese medicine composition | |
| CN106421053A (en) | Traditional Chinese medicine capable of tonifying spleen and warming stomach | |
| CN103041233A (en) | Pharmaceutical composition for treating infantile diarrhea and preparation method thereof | |
| CN105288413A (en) | Medicine for treating infantile enuresis and preparation method thereof | |
| CN104857454A (en) | Traditional Chinese medicine decoction for treating severe acute pancreatitis | |
| CN104623152A (en) | Traditional Chinese medicine composition for treating thyroid adenoma due to phlegm-damp stagnation and preparation method thereof | |
| CN103656014B (en) | A kind ofly treat Chinese medicine of diabetes patient's gastrointestinal function decline after abdominal operation and preparation method thereof | |
| CN104474445A (en) | Traditional Chinese medicine preparation for treating pernicious vomiting disease | |
| CN105287736A (en) | Pulmonary emphysema treating traditional Chinese medicine composition and preparation method thereof | |
| CN104771734B (en) | A kind of Chinese medicine composition for treating chronic cardiopulmonary disease | |
| CN106266968A (en) | Herba Artemisiae Scopariae liver heat removing choleretic granules and its preparation method and application | |
| CN105853872A (en) | Novel traditional Chinese medicine composition for treating lassitude and asthenia and preparation method thereof | |
| CN106362074A (en) | Novel traditional Chinese medicine composition for treating anorexia and preparation method thereof | |
| CN105232879A (en) | Traditional Chinese medicine preparation treating chronic pharyngitis and preparation technology thereof | |
| CN104587251A (en) | Traditional Chinese medicine capsules for treating gout and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140115 Termination date: 20150204 |
|
| EXPY | Termination of patent right or utility model |