CN103110756A - 一种治疗肾性血尿的中药组合物 - Google Patents
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Abstract
一种治疗肾性血尿的中药组合物，该中药组合物是由石龙刍，矩圆石韦，笔筒草，含羞草，地骨皮，紫草，荠菜，葎草，黄连，白鲜皮，益母草制成。临床可用于治疗肾性血尿。
Description
技术领域
本发明属于中药技术领域，尤其是涉及一种治疗肾性血尿的中药组合物。
背景技术
肾性血尿是指排除尿路感染、结石、结核、肿瘤及泌尿系统结构畸形等疾病引起的肾外出血因素，血液从肾脏中随小便排出体外的疾病。临床上单纯性肾性血尿亦称无症状血尿，临床表现以镜下血尿或肉眼血尿为主，不伴有明显水肿和高血压，无或伴轻微蛋自尿，肾功能基本正常。目前，对肾性血尿的治疗尚缺乏满意的西药方法。本发明制备得到的中药组合物治疗肾性血尿，取得了良好的效果。
发明内容
本发明的目的在于提供一种治疗效果好、有效率高、对人体无毒副作用的治疗肾性血尿的中药组合物。
本发明的目的是这样实现的，根据中医药理论，利用中药独特的药性，采用石龙刍，矩圆石韦，笔筒草，含羞草，地骨皮，紫草，荠菜，葎草，黄连，白鲜皮，益母草制成，按照一定的配伍要求，经过加工制成。
制备本发明中药组合物由下述原料药制成：石龙刍40-55份，矩圆石韦30-45份，笔筒草30-45份，含羞草30-45份，地骨皮20-30份，紫草20-30份，荠菜20-30份，葎草20-30份，黄连10-15份，白鲜皮10-15份，益母草8-12份。
本发明中药组合物原料药的最佳重量份为：石龙刍50份，矩圆石韦40份，笔筒草40份，含羞草40份，地骨皮25份，紫草25份，荠菜25份，葎草25份，黄连12份，白鲜皮12份，益母草10份。
本发明中药的药理作用如下：
石龙刍：苦、凉。归心、小肠经。利水通淋，安神，凉血止血。临床用于热淋，肾炎水肿，心烦热燥，心悸失眠，口舌生疮，咽痛，齿痛，尿血等症。
矩圆石韦：微苦、凉。归肺、膀胱经。清肺热，利尿，止血。用于慢性支气管炎，尿路感染，尿路结石，血尿，肾炎等症。
笔筒草：甘、苦、平、微寒。归心、肝、膀胱、胃经。清肝明目，止血、利尿通淋。临床用于风热感冒，咳嗽，目赤肿痛，云翳，尿血，淋症，黄疸等症。
含羞草：苦、涩、微寒、小毒。归心、肝、胃、大肠经。凉血解毒，清热利湿，镇静安神。用于感冒、小儿高热，支气管炎，肝炎，肠炎，结膜炎，泌尿结石，水肿，血尿，失眠，带状疱疹，跌打损伤等症。
地骨皮：甘、寒。归肺、肾经。清虚热，泻肺火，凉血。用于阴虚劳热，骨蒸盗汗，小儿疳积发热，肺热喘咳，吐血，尿血，消渴等。
紫草：苦、寒。归心、肝经。凉血、活血、透疹、消毒。主治斑疹，麻疹，吐血，衄血，尿血，紫癜，黄疸，痈疽，烫伤等。
荠菜：甘、淡、凉。归肝、心、肺经。凉肝止血，平肝明目，清热利湿。用于吐血，咳血，尿血，崩漏，目赤疼痛，眼底出血，高血压病，肾炎水肿等症。
葎草：甘、苦、寒。归肺、肾经。清热解毒，利尿通淋。用于肺热咳嗽，肺痈，虚热烦渴，热淋，水肿，小便不利，湿热泻痢，热毒疮疡，皮肤瘙痒等。
黄连：苦、寒。归心、肝、胃、大肠经。清热泻火，燥湿，解毒。主治热病邪入心经之高热，烦躁，湿热胸痞，消谷善饥，肝火目赤肿痛等。
白鲜皮：苦、寒，归脾、胃经。清热燥湿，祛风解毒。外用于湿热疮毒、湿疹疥癣。
益母草：辛、苦。归肝、肾、心经。活血调经，利尿消肿，清热解毒。用于月经不调，经闭，难产，产后血晕，跌打损伤，水肿等症。
本发明石龙刍利水通淋，凉血止血，为君药，矩圆石韦、笔筒草、含羞草利尿、止血，清热利湿，为臣药，地骨皮泻火凉血，紫草凉血、消毒，荠菜凉肝止血，葎草利尿通淋，黄连泻火解毒，白鲜皮清热燥湿，益母草利尿消肿，配伍使用，达到治疗肾性血尿的目的。
本发明中药组合物使用于2007年至2011年临床观察肾性血尿症66例患者，临床报告如下：
1、一般资料
66例患者中，女性32例，男性34例，年龄最小18岁，最大42岁，病程多在1-10个月，平均年龄31.6岁。
2、诊断标准
参照《中药新药临床研究指导原则》：
纳入标准：患者新鲜尿沉渣光镜下每高倍视野红细胞＞3个，尿红细胞位相示红细胞呈多形型改变(＞80％)。
排除标准：妊娠和准备妊娠或哺乳期妇女，过敏体质及对本药过敏者；合并心血管、脑血管、肝脏和造血系统等严重原发性疾病；泌尿系结核、肿瘤、内分泌疾病、精神病患者；不符合纳入标准，未按规定用药，无法判断疗效，或资料不全等影响疗效或安全性判断者。
3、治疗方法
3.1处方：石龙刍50g，矩圆石韦40g，笔筒草40g，含羞草40g，地骨皮25g，紫草25g，荠菜25g，葎草25g，黄连12g，白鲜皮12g，益母草10g。
3.2制备方法：上述药物按常规工艺制成汤剂。
3.3服用方法：每次1剂，每日2次，14天为1疗程。
4、治疗结果：
4.1参照《中药新药临床研究指导原则》：
治愈：血尿症状全部消失，相应西医诊断之主要疾病经检查证实有显著改善；主要理化指标基本正常。
显效：血尿症状明显改善，由重度降至轻度，或个别主症降至中度而其他主症全部消失；相应西医诊断之主要疾病经检查证实有所好转；主要理化指标明显改善。
有效：血尿症状有所好转，程度改善1级以上，或个别症状改善2级以上；相应西医诊断之主要疾病经检查基本稳定；主要理化指标有所改善。
无效：血尿症状、检验指标无改善或反恶化。
4.2结果：66例患者中，治愈28例(42.4％)，显效20例(30.3％)，有效12例(18.2％)，无效6例(9.1％)，总有效率为90.9％。
5、典型病例
5.1王某，男，32岁，血尿病史8个月。诊见：腰背酸胀，尿色深红，时发潮热，舌红、苔薄黄，脉沉细数。尿常规：潜血(+++)；镜检红细胞(30～50)个/HP，尿相差镜检红细胞24.3万/mL，90％肾小球性。诊断为属肾性血尿。服用本发明治疗肾性血尿的中药组合物进行治疗，治疗1个疗程后，腰背酸胀感觉明显缓解，尿色正常，潮热发作次数明显减少，不适症状大幅改善，继续服用2个疗程，无不适症状，二便均正常。尿常规：潜血(-)，镜检红细胞(0～2)个/HP，尿相差镜检红细胞7000/mL，痊愈。
5.2赵某，女，26岁，血尿病史6个月，诊见：小便赤，头晕耳鸣，神疲乏力，颧红，潮热盗汗，腰膝酸软，饮食可，睡眠略差，舌质红，苔薄略黄，脉细。尿常规：潜血(++)；镜检红细胞(25～30)个/HP，尿相差镜检红细胞22.6万/mL。服用了本发明治疗肾性血尿的中药组合物，2个疗程，无不适症状，二便均正常。尿常规：潜血(-)，镜检红细胞(0～1)个/HP，痊愈。
具体实施方式
下面结合实施例对本发明作进一步的说明，下述该实施例仅用于说明本发明而对本发明没有限制。
实施例1，一种治疗肾性血尿的中药组合物，它是由下述原料药制成：石龙刍40g，矩圆石韦30g，笔筒草30g，含羞草30g，地骨皮20g，紫草20g，荠菜20g，葎草20g，黄连10g，白鲜皮10g，益母草8g。
实施例2，一种治疗肾性血尿的中药组合物，它是由下述原料药制成：石龙刍50g，矩圆石韦40g，笔筒草40g，含羞草40g，地骨皮25g，紫草25g，荠菜25g，葎草25g，黄连12g，白鲜皮12g，益母草10g。
实施例3，一种治疗肾性血尿的中药组合物，它是由下述原料药制成：石龙刍55g，矩圆石韦45g，笔筒草45g，含羞草45g，地骨皮30g，紫草30g，荠菜30g，葎草30g，黄连15g，白鲜皮15g，益母草12g。
Claims (2)
1.一种治疗肾性血尿的中药组合物，其特征在于包括以下原料药：
石龙刍40-55份，矩圆石韦30-45份，笔筒草30-45份，含羞草30-45份，地骨皮20-30份，紫草20-30份，荠菜20-30份，葎草20-30份，黄连10-15份，白鲜皮10-15份，益母草8-12份。
2.根据权利要求1所述的中药组合物，其特征在包括以下原料药：
石龙刍50份，矩圆石韦40份，笔筒草40份，含羞草40份，地骨皮25份，紫草25份，荠菜25份，葎草25份，黄连12份，白鲜皮12份，益母草10份。
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