CN103110552B - A kind of preparation method of salix caprea toothpaste - Google Patents
A kind of preparation method of salix caprea toothpaste Download PDFInfo
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- CN103110552B CN103110552B CN201310061320.3A CN201310061320A CN103110552B CN 103110552 B CN103110552 B CN 103110552B CN 201310061320 A CN201310061320 A CN 201310061320A CN 103110552 B CN103110552 B CN 103110552B
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- 244000071131 Salix caprea Species 0.000 title claims abstract description 31
- 235000000516 Salix caprea Nutrition 0.000 title claims abstract description 31
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 28
- 239000000606 toothpaste Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims abstract description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 7
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims abstract description 7
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims abstract description 7
- 229940085605 saccharin sodium Drugs 0.000 claims abstract description 7
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 7
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 7
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 7
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 7
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 7
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims abstract description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 7
- 229940048086 sodium pyrophosphate Drugs 0.000 claims abstract description 7
- 239000000600 sorbitol Substances 0.000 claims abstract description 7
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims abstract description 7
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims abstract description 7
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 7
- 230000001804 emulsifying effect Effects 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 18
- WHWDWIHXSPCOKZ-UHFFFAOYSA-N hexahydrofarnesyl acetone Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)=O WHWDWIHXSPCOKZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- HOWGUJZVBDQJKV-UHFFFAOYSA-N docosane Chemical compound CCCCCCCCCCCCCCCCCCCCCC HOWGUJZVBDQJKV-UHFFFAOYSA-N 0.000 claims description 8
- GOQYKNQRPGWPLP-UHFFFAOYSA-N heptadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 239000011344 liquid material Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000001707 (E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol Substances 0.000 claims description 5
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims description 5
- WHWDWIHXSPCOKZ-SJORKVTESA-N 6,10,14-Trimethyl-2-pentadecanone Natural products CC(C)CCC[C@@H](C)CCC[C@H](C)CCCC(C)=O WHWDWIHXSPCOKZ-SJORKVTESA-N 0.000 claims description 5
- BLUHKGOSFDHHGX-UHFFFAOYSA-N Phytol Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)C=CO BLUHKGOSFDHHGX-UHFFFAOYSA-N 0.000 claims description 5
- HNZBNQYXWOLKBA-UHFFFAOYSA-N Tetrahydrofarnesol Natural products CC(C)CCCC(C)CCCC(C)=CCO HNZBNQYXWOLKBA-UHFFFAOYSA-N 0.000 claims description 5
- BOTWFXYSPFMFNR-OALUTQOASA-N all-rac-phytol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)=CCO BOTWFXYSPFMFNR-OALUTQOASA-N 0.000 claims description 5
- BOTWFXYSPFMFNR-PYDDKJGSSA-N phytol Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CO BOTWFXYSPFMFNR-PYDDKJGSSA-N 0.000 claims description 5
- 241000827798 Hemerocallis citrina Species 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 3
- 238000000638 solvent extraction Methods 0.000 claims description 3
- 230000009897 systematic effect Effects 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 235000010215 titanium dioxide Nutrition 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 7
- 230000000474 nursing effect Effects 0.000 abstract description 6
- 210000000515 tooth Anatomy 0.000 abstract description 6
- 210000004195 gingiva Anatomy 0.000 abstract description 4
- 208000025865 Ulcer Diseases 0.000 abstract description 2
- 231100000397 ulcer Toxicity 0.000 abstract description 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 208000007117 Oral Ulcer Diseases 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 239000003908 antipruritic agent Substances 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000218998 Salicaceae Species 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940095688 toothpaste product Drugs 0.000 description 1
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- Cosmetics (AREA)
Abstract
The preparation method that the invention discloses a kind of salix caprea toothpaste。This toothpaste contains Salix caprea extracting solution, and described toothpaste is mainly made up of the component of following weight portion: deionized water 5-15 part, Salix caprea extracting solution 1-5 part, sorbitol 40-60 part, hydroxymethyl cellulose 0.8-1.5 part, silicon dioxide 20-40 part, sodium lauryl sulfate 1.5-4 part, saccharin sodium 0.1-0.2 part, sodium pyrophosphate 0.1-0.2 part, titanium dioxide 0.2-0.4 part, sodium benzoate 0.1-0.3 part, essence 0.8-1.2 part。The present invention has the advantages that to carry out oral cavity, tooth and gingiva synchronizing nursing and energy efficient solution breach chamber ulcer。
Description
Technical field
The present invention relates to oral cleaning nursing article technical field, be specifically related to a kind of toothpaste containing Salix caprea extracting solution and preparation method thereof。
Background technology
Toothpaste is indispensable oral cavity cleaning hygienic article in people's daily life, and its basic function is in that cleaning tooth, fresh breath, reaches to keep the purpose of oral cavity cleaning。In the past few years, owing to consumer healthcare realizes continuous enhancing, toothpaste is proposed more requirement, also add some auxiliary prevention oral diseases except cleaning one's teeth, oral cavity is had the function of nursing health effect。Therefore, the product having various functional type in domestic and international toothpaste becomes the market mainstream。In recent years, along with the development of modernization of Chinese medicine technology, the method that Chinese medicine study of active components is utilized have also been obtained good development, and this utilizes active ingredient of Chinese herbs to assist prevention oral disease to provide good technical support for toothpaste。
At present, prior art also has the various active ingredient of Chinese herbs of employing as toothpaste ancillary drug。In these medicated toothpaste, some toothpaste has plurality of Chinese composition, and producing process is complicated。Some toothpaste producing process is simple, but effect is had nothing in common with each other, and is difficult to accomplish that gingiva synchronizes effect of nursing health, especially for oral ulcer problem, is difficult to especially play remarkable result to oral cavity, tooth simultaneously。
Salix caprea is Salicaceae, sallow, perennial machaka, bark bitterness。Salix caprea is distributed mainly on Xinjiang of China。
Salix caprea is used as medicine with twig, leaf, root, stem, skin and flower。As the peculiar medical material in Xinjiang, there is very strong antitumor, heart tonifying, antipyretic, antibacterial, analgesia, antiinflammatory, antipruritic, blood pressure lowering, blood fat reducing, defying age, improve the effects such as immunity of organisms。
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that one can to oral cavity, and tooth and gingiva carry out the toothpaste containing Salix caprea extracting solution synchronizing nursing and energy efficient solution breach chamber ulcer。
Another object of the present invention is to for the deficiencies in the prior art, it is provided that a kind of technique simply prepares the method for the above-mentioned toothpaste containing Salix caprea extracting solution。
In order to reach the purpose of foregoing invention, the technical solution used in the present invention is: provide a kind of toothpaste, it is characterised in that: containing Salix caprea extracting solution in the mastic of described toothpaste。
Primary raw material is prepared with weight portion: deionized water 5-15 part, Salix caprea extracting solution 1-5 part, sorbitol 40-60 part, hydroxymethyl cellulose 0.8-1.5 part, silicon dioxide 20-40 part, sodium lauryl sulfate 1.5-4 part, saccharin sodium 0.1-0.2 part, sodium pyrophosphate 0.1-0.2 part, titanium dioxide 0.2-0.4 part, sodium benzoate 0.1-0.3 part, essence 0.8-1.2 part。
Described Salix caprea extracting solution is prepared by the following method: use systematic solvent extraction extract Hemerocallis citrina Baroni Flos Salicis Babylonicae and study on chemical compositions of leaves and separate。
Described Salix caprea extracting solution is mainly made up of following component, 35.84% weight 6,10,14-trimethyl-2-pentadecanone, 20.35% weight 1-heptadecanol, the 14.93% different phytol of weight, 8.38% weight n-docosane, 7.18% weight benzyl alcohol, 4.43% weight phenethanol and 1.76% weight 3,7,11,15-tetramethyl-2-hexadecene-1-alcohol。
Preparation method: 1) by deionized water 13.7 parts, Salix caprea extracting solution 1 part, sorbitol 60 parts, saccharin sodium 0.1 part, sodium pyrophosphate 0.1 part adds liquid material agitated kettle, is evenly stirred until whole dispersing and dissolving；2) by hydroxymethyl cellulose 1.3 parts, silicon dioxide 20 parts, sodium lauryl sulfate 2.4 parts, titanium dioxide 0.2 part, sodium benzoate 0.2 part, 1 part of essence adds powder stirring pot, and stirring is to being completely uniformly dispersed；3) emulsifying pot evacuation is opened stirred tank, by liquid material suction emulsifying pot；4) homogenizer driven by emulsifying pot, and powder slowly suction emulsifying pot is stirred by stirring；5) emulsifying pot evacuation continuation stirring homogenizing turns off homogenizing after 30 minutes, continues stirring evacuation degassed；6) emulsifying pot vacuum adds essence when reaching (0.092hPa), is further continued for stirring 10 minutes；7) coroner samples detection physical and chemical index, qualified rear discharging。
The preparation of described toothpaste: deionized water electrical conductivity used is less than 0.5 μ S/cm, and pH value is 6.5。
The preparation of described toothpaste: Salix caprea extracting solution needs to sterilize with Burdick lamp before addition, uses with after 100 order filter-cloth filterings。
The preparation of described toothpaste: the raw material of product is commercially available prod。
The Salix caprea extracting solution that the present invention selects has very strong antitumor, heart tonifying as the peculiar medical material in Xinjiang, and antipyretic, antibacterial, analgesia, antiinflammatory, antipruritic, blood pressure lowering, blood fat reducing, defying age improves the effects such as immunity of organisms。Therefore the concern of cosmetics circle and medical circle is increasingly received。
The present invention is to the optimum extracting method of total flavones in Xinjiang Hemerocallis citrina Baroni Flos Salicis Babylonicae and leaf, content assaying method has been studied, then systematic solvent extraction is used to extract Hemerocallis citrina Baroni Flos Salicis Babylonicae and study on chemical compositions of leaves and separate, adopt physico-chemical analysis, thin layer detects, infrared spectrum, the modern spectrum means such as nuclear magnetic resonance, NMR are analyzed。
Analysis result shows:
In Salix caprea extracting solution, main chemical compositions is 6,10,14-trimethyl-2-pentadecanones (35.84% weight), 1-heptadecanol (20.35% weight), different phytol (14.93% weight), n-docosane (8.38% weight), benzyl alcohol (7.18%% weight), phenethanol (4.43%% weight), with 3,7,11,15-tetramethyls-2-hexadecene-1-alcohol (1.76% weight) etc.。The overwhelming majority is alcohol and letones, and wherein 6,10,14-trimethyl-2-pentadecanone content are the highest。
According to documents and materials, 6,10,14-trimethyl-2-pentadecanones are widely used in medicine。The existence of 6,10,14-trimethyl-2-pentadecanone may produce certain antifungal activity。6,10, the 14-trimethyl-2-pentadecanones contained in the Salix caprea extracting solution of Xinjiang, benzyl alcohol, phenethanol, the composition such as different phytol has anti-inflammation, reducing swelling and alleviating pain, sterilization, antipruritic effect。
Toothpaste provided by the invention is by adding the Salix caprea extracting solution adopting specific process conditions to make wherein as the effective ingredient playing auxiliary therapeutic action; this extracting solution protects the sp act of Salix caprea to greatest extent; this toothpaste is made not only to have oral cavity; tooth and gingiva synchronize effect of nursing; and in treatment oral ulcer, also there is significant curative effect; therefore, there is huge using value。
Accompanying drawing explanation
Fig. 1 is the process flow diagram of Salix caprea extracting solution tooth paste product。
Detailed description of the invention
The embodiment of invention is described below in conjunction with embodiment。
Embodiment
Primary raw material is with weight portion preparation formula: deionized water 5-15 part, Salix caprea extracting solution 1-5 part, sorbitol 40-60 part, hydroxymethyl cellulose 0.8-1.5 part, silicon dioxide 20-40 part, sodium lauryl sulfate 1.5-4 part, saccharin sodium 0.1-0.2 part, sodium pyrophosphate 0.1-0.2 part, titanium dioxide 0.2-0.4 part, sodium benzoate 0.1-0.3 part, essence 0.8-1.2 part。
Salix caprea extracting solution is mainly made up of following part by weight: 6,10,14-trimethyl-2-pentadecanone 35.84%, 1-heptadecanol 20.35%, different phytol 14.93%, n-docosane 8.38%, benzyl alcohol 7.18%, phenethanol 4.43% and 3,7,11,15-tetramethyl-2-hexadecene-1-alcohol 1.76%。
Adopt above-mentioned Formulation Implementation production technology
The first step: by deionized water 13.7 parts, Salix caprea extracting solution 1 part, sorbitol 60 parts, saccharin sodium 0.1 part, sodium pyrophosphate 0.1 part adds liquid material agitated kettle, is evenly stirred until whole dispersing and dissolving。
Second step: by hydroxymethyl cellulose 1.3 parts, silicon dioxide 20 parts, sodium lauryl sulfate 2.4 parts, titanium dioxide 0.2 part, sodium benzoate 0.2 part, 1 part of essence adds powder stirring pot, and stirring is to being completely uniformly dispersed。
3rd step: emulsifying pot evacuation is opened stirred tank, by liquid material suction emulsifying pot。
4th step: homogenizer driven by emulsifying pot, and powder slowly suction emulsifying pot is stirred by stirring。
5th step: emulsifying pot evacuation continues stirring homogenizing and turns off homogenizing after 30 minutes, continues stirring evacuation degassed。
6th step: emulsifying pot vacuum adds essence when reaching (0.092hPa), is further continued for stirring 10 minutes。
7th step: coroner samples detection physical and chemical index, qualified rear discharging。
Claims (2)
1. a toothpaste, described toothpaste contains Salix caprea extracting solution, and described toothpaste is mainly made up of the component of following weight portion: deionized water 5-15 part, Salix caprea extracting solution 1-5 part, sorbitol 40-60 part, hydroxymethyl cellulose 0.8-1.5 part, silicon dioxide 20-40 part, sodium lauryl sulfate 1.5-4 part, saccharin sodium 0.1-0.2 part, sodium pyrophosphate 0.1-0.2 part, titanium dioxide 0.2-0.4 part, sodium benzoate 0.1-0.3 part, essence 0.8-1.2 part；Described Salix caprea extracting solution is prepared by the following method: use systematic solvent extraction extract Hemerocallis citrina Baroni Flos Salicis Babylonicae and study on chemical compositions of leaves and separate；Described Salix caprea extracting solution is mainly made up of following component, 35.84% weight 6,10,14-trimethyl-2-pentadecanone, 20.35% weight 1-heptadecanol, the 14.93% different phytol of weight, 8.38% weight n-docosane, 7.18% weight benzyl alcohol, 4.43% weight phenethanol and 1.76% weight 3,7,11,15-tetramethyl-2-hexadecene-1-alcohol。
2. toothpaste according to claim 1, it is characterised in that the preparation method of described toothpaste is completed by following steps:
The first step: deionized water, Salix caprea extracting solution, sorbitol, saccharin sodium, sodium pyrophosphate are added liquid material agitated kettle, be evenly stirred until whole dispersing and dissolving；
Second step: hydroxymethyl cellulose, silicon dioxide, sodium lauryl sulfate, titanium dioxide, sodium benzoate are added powder stirring pot, stirring to being completely uniformly dispersed；
3rd step: emulsifying pot evacuation is opened stirred tank, by liquid material suction emulsifying pot；
4th step: homogenizer driven by emulsifying pot, and powder slowly suction emulsifying pot is stirred by stirring；
5th step: emulsifying pot evacuation continues stirring homogenizing and turns off homogenizing after 30 minutes, continues stirring evacuation degassed；
6th step: emulsifying pot vacuum adds essence when reaching 0.092hPa, is further continued for stirring 10 minutes；
7th step: coroner samples detection physical and chemical index, qualified rear discharging。
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| CN103405362B (en) * | 2013-07-27 | 2016-12-28 | 福建爱洁丽日化有限公司 | A kind of extracting solution toothpaste Han Rhizoma Phragmitis |
| CN110742835A (en) * | 2019-12-09 | 2020-02-04 | 新疆亲努尔生物科技有限公司 | Chamomile toothpaste |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091782A (en) * | 2006-06-21 | 2007-12-26 | 买买提巴克阿里木·买尼尕儿汗 | Pearl balls and preparation method thereof |
| CN103347529A (en) * | 2010-12-09 | 2013-10-09 | Y&B妈妈之选有限公司 | Formulations comprising saponins and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091782A (en) * | 2006-06-21 | 2007-12-26 | 买买提巴克阿里木·买尼尕儿汗 | Pearl balls and preparation method thereof |
| CN103347529A (en) * | 2010-12-09 | 2013-10-09 | Y&B妈妈之选有限公司 | Formulations comprising saponins and uses thereof |
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Application publication date: 20130522 Assignee: Urumqi Dilujiuli Trading Co.,Ltd. Assignor: XINJIANG QINNUER BIOTECHNOLOGY Co.,Ltd. Contract record no.: X2024980007928 Denomination of invention: A preparation method of Huanghualiu toothpaste Granted publication date: 20160622 License type: Common License Record date: 20240624 |