CN103108701B - 分析物的分离 - Google Patents

分析物的分离 Download PDF

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Publication number
CN103108701B
CN103108701B CN201180044834.7A CN201180044834A CN103108701B CN 103108701 B CN103108701 B CN 103108701B CN 201180044834 A CN201180044834 A CN 201180044834A CN 103108701 B CN103108701 B CN 103108701B
Authority
CN
China
Prior art keywords
liquid
laminar flow
bend
capillary channel
equipment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180044834.7A
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English (en)
Chinese (zh)
Other versions
CN103108701A (zh
Inventor
D·奥基弗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Da Yu Enterprises LLC
Original Assignee
Da Yu Enterprises LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Da Yu Enterprises LLC filed Critical Da Yu Enterprises LLC
Publication of CN103108701A publication Critical patent/CN103108701A/zh
Application granted granted Critical
Publication of CN103108701B publication Critical patent/CN103108701B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03B—SEPARATING SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS
    • B03B5/00—Washing granular, powdered or lumpy materials; Wet separating
    • B03B5/48—Washing granular, powdered or lumpy materials; Wet separating by mechanical classifiers
    • B03B5/52—Spiral classifiers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6073—Construction of the column body in open tubular form
    • G01N30/6078—Capillaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6086—Construction of the column body form designed to optimise dispersion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/80—Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J2220/84—Capillaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201180044834.7A 2010-09-26 2011-09-23 分析物的分离 Expired - Fee Related CN103108701B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38651410P 2010-09-26 2010-09-26
US61/386,514 2010-09-26
PCT/US2011/052917 WO2012040555A1 (en) 2010-09-26 2011-09-23 Separation of analytes

Publications (2)

Publication Number Publication Date
CN103108701A CN103108701A (zh) 2013-05-15
CN103108701B true CN103108701B (zh) 2015-03-11

Family

ID=45874179

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180044834.7A Expired - Fee Related CN103108701B (zh) 2010-09-26 2011-09-23 分析物的分离

Country Status (7)

Country Link
US (1) US9821318B2 (https=)
EP (1) EP2618935B1 (https=)
JP (1) JP6049621B2 (https=)
CN (1) CN103108701B (https=)
AU (1) AU2011305254B2 (https=)
CA (1) CA2810805C (https=)
WO (1) WO2012040555A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103575622B (zh) * 2013-10-24 2015-11-25 中国石油大学(北京) 一种蜡分子扩散系数的测试方法
EP3118619A1 (en) * 2015-07-14 2017-01-18 Vrije Universiteit Brussel High-performance liquid chromatography with a vortex flow inducer
JP2018089576A (ja) * 2016-12-02 2018-06-14 東ソー株式会社 粒子分離装置
CN106596692B (zh) * 2017-01-14 2018-12-28 常州大学 一种弯曲毛细管电泳检测抗体多肽相互作用的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010170A1 (en) * 1994-09-29 1996-04-04 The Board Of Trustees Of The Leland Stanford Junior University Capillary-based separation methods for identifying bioactive analytes in a mixture
GB2423266A (en) * 2004-11-25 2006-08-23 Ind Tech Res Inst A structure and method for detecting an analyte in a microfluidic chip
US7111501B2 (en) * 2003-10-03 2006-09-26 Agilent Technologies, Inc. Devices and methods for separating constituents
CN101310025A (zh) * 2005-09-15 2008-11-19 阿尔特弥斯康复公司 分析物富集的系统和方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032283A (en) * 1983-03-03 1991-07-16 The Perkin Elmer Corporation Low dispersion fluid conduit useful in chromatography systems
DE3407065C2 (de) * 1983-03-03 1994-12-22 Perkin Elmer Corp Für Chromatographie-Vorrichtungen verwendbare Gas- oder Flüssigkeitsleitung mit niedriger Dispersion
DE68927019T2 (de) * 1988-04-29 1997-01-23 Beckman Instruments Inc Kassette mit einem kapillaren Detektor für Elektroforese
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5772874A (en) 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6063589A (en) * 1997-05-23 2000-05-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
DE69806499T2 (de) * 1997-11-12 2003-02-27 Pe Corp Ny Foster City Serpentinenförmiger elektroforetischer kanal mit selbstkorrigierenden kurven
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
NZ511560A (en) * 1998-11-05 2002-11-26 Chemometec As A method for the assessment of particles and a system and a device for use in the method
US7011791B2 (en) * 2000-09-18 2006-03-14 University Of Washington Microfluidic devices for rotational manipulation of the fluidic interface between multiple flow streams
US20040224425A1 (en) 2003-05-08 2004-11-11 Gjerde Douglas T. Biomolecule open channel solid phase extraction systems and methods
JP2006090806A (ja) * 2004-09-22 2006-04-06 Yamatake Corp クロマトグラフ装置
CA2505657A1 (en) * 2005-04-28 2006-10-28 York University Method for mixing inside a capillary and device for achieving same
SE529516C2 (sv) * 2005-10-24 2007-09-04 Alfa Laval Corp Ab Universell flödesmodul
US20070122819A1 (en) * 2005-11-25 2007-05-31 Industrial Technology Research Institute Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same
KR100843339B1 (ko) * 2006-12-07 2008-07-03 한국전자통신연구원 혈액 중의 혈장 분리를 위하여 마이크로채널을 이용한혈장분리기 및 이에 의한 혈장분리방법
WO2009002580A2 (en) * 2007-04-02 2008-12-31 Boston Medical Center Corporation Method for bacterial lysis
WO2008130977A2 (en) * 2007-04-16 2008-10-30 The General Hospital Corporation D/B/A Massachusetts General Hospital Systems and methods for particle focusing in microchannels
WO2009038628A2 (en) * 2007-09-19 2009-03-26 Claros Diagnostics, Inc. Liquid containment for integrated assays
JP2009162664A (ja) * 2008-01-08 2009-07-23 Sony Corp 流路を用いた検出方法及び相互作用検出方法、並びに検出装置
US8641267B2 (en) 2008-04-14 2014-02-04 Agilent Technologies, Inc. Fluidic conduit with repeated disturbance of laminar flow

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010170A1 (en) * 1994-09-29 1996-04-04 The Board Of Trustees Of The Leland Stanford Junior University Capillary-based separation methods for identifying bioactive analytes in a mixture
US7111501B2 (en) * 2003-10-03 2006-09-26 Agilent Technologies, Inc. Devices and methods for separating constituents
GB2423266A (en) * 2004-11-25 2006-08-23 Ind Tech Res Inst A structure and method for detecting an analyte in a microfluidic chip
CN101310025A (zh) * 2005-09-15 2008-11-19 阿尔特弥斯康复公司 分析物富集的系统和方法

Also Published As

Publication number Publication date
AU2011305254A1 (en) 2013-03-14
CA2810805C (en) 2014-11-18
CN103108701A (zh) 2013-05-15
EP2618935A4 (en) 2015-10-28
US9821318B2 (en) 2017-11-21
WO2012040555A1 (en) 2012-03-29
US20130180894A1 (en) 2013-07-18
AU2011305254B2 (en) 2014-06-05
EP2618935B1 (en) 2018-11-07
CA2810805A1 (en) 2012-03-29
EP2618935A1 (en) 2013-07-31
JP2013537980A (ja) 2013-10-07
JP6049621B2 (ja) 2016-12-21

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Granted publication date: 20150311