CN103084228A - Micro-fluidic-chip-based photoresponse micropump and manufacture method thereof - Google Patents
Micro-fluidic-chip-based photoresponse micropump and manufacture method thereof Download PDFInfo
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- CN103084228A CN103084228A CN2012105870172A CN201210587017A CN103084228A CN 103084228 A CN103084228 A CN 103084228A CN 2012105870172 A CN2012105870172 A CN 2012105870172A CN 201210587017 A CN201210587017 A CN 201210587017A CN 103084228 A CN103084228 A CN 103084228A
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Abstract
The invention relates to a micro-fluidic-chip-based photoresponse micropump and a manufacture method of the micro-fluidic-chip-based photoresponse micropump. A microstructure and a microchannel are formed on the surface of a micro-fluidic chip, the surface of the microchannel is modified through photoresponse molecules, reversibility change of the surface topography and the chemical configuration of the microchannel enables the surface wetting property to change under the irritation of visible light so that the movement of micro fluid on the surface of the microchannel is controlled, and thus an intelligent micropump for controlling the flowing of the micro fluid is realized and is mainly applied to relevant fields such as electrophoretic separation, chromatographic separation and immunoassay. The micro-fluidic chip is simple in operation, realizes intelligent drive of micro fluid, is greatly reduced in drive cost of the micro fluid, has the characteristics of portability, economy, rapidness and high efficiency, and provides a brand new micropump technology for the drive of the micro fluid.
Description
Technical field
The present invention relates to a kind of photoresponse Micropump based on micro-fluidic chip and preparation method thereof, there are micro-structural and microchannel in this micro-fluidic chip surface, by the optical Response molecule, microchannel surface is carried out modification, under visible light stimulates, the surface topography of microchannel and the invertibity of chemical structure change the variation that causes surface wettability, control microfluid in the motion of microchannel surface, thereby the intelligent Micropump that realization is controlled microfluidic flow is mainly used in the association areas such as electrophoretic separation, chromatographic isolation, immunoassay.
Technical field
The present invention relates to a kind of photoresponse Micropump based on micro-fluidic chip and preparation method thereof, there are micro-structural and microchannel in this micro-fluidic chip surface, by the optical Response molecule, microchannel surface is carried out modification, under visible light stimulates, the surface topography of microchannel and the invertibity of chemical structure change the variation that causes surface wettability, control microfluid in the motion of microchannel surface, thereby the intelligent Micropump that realization is controlled microfluidic flow is mainly used in the association areas such as electrophoretic separation, chromatographic isolation, immunoassay.
Background technology
Microfluidic analysis chip has microminiaturization, automation, the advantage such as integrated, convenient and quick as a kind of novel analysis platform; obtain a wide range of applications for example synthetic screening of cell biology, analytical chemistry, environmental monitoring and protection, judicial expertise and medicine in a lot of fields.In microfluidic analysis chip, the accurate sample introduction of micro liquid is the key of sample treatment and analysis, just need such operation in for example micro-fluid control chip electrophoretic separation, chromatographic isolation, immunoassay, this is that characteristics due to microfluidic analysis chip will operate the microfluid under micro-scale and control, and it is extremely small as the Fluid Volume of operation and control object, cause flow behavior and the macroscopic view of microfluid to be very different, negligible phenomenon becomes the major influence factors of Fluid Flow in A under micro-scale under macro-scale.In recent years, how to realize driving and control to microfluid on microfluidic analysis chip, become a research difficult problem and focus in the microfluidic analysis chip technology.
Driving to microfluid in micro-fluidic chip can realize by Micropump.In recent years, along with development and the maturation of microflow control technique, research and develop a lot of methods and device, realized to a certain extent the driving to microfluid in micro-fluidic chip, also had some limitation simultaneously.Aspect Micropump research, comprise mechanical Micropump and on-mechanical Micropump.For example, compression pump (machinery or syringe pump) simple to operate, easy realization, with low cost, but be difficult for realizing miniaturization on chip.Hot gas power Micropump braking mechanism is simple, conditional request is low, be fit to
A kind of photoresponse Micropump based on micro-fluidic chip and preparation method thereof
Background technology
Microfluidic analysis chip has microminiaturization, automation, the advantage such as integrated, convenient and quick as a kind of novel analysis platform; obtain a wide range of applications for example synthetic screening of cell biology, analytical chemistry, environmental monitoring and protection, judicial expertise and medicine in a lot of fields.In microfluidic analysis chip, the accurate sample introduction of micro liquid is the key of sample treatment and analysis, just need such operation in for example micro-fluid control chip electrophoretic separation, chromatographic isolation, immunoassay, this is that characteristics due to microfluidic analysis chip will operate the microfluid under micro-scale and control, and it is extremely small as the Fluid Volume of operation and control object, cause flow behavior and the macroscopic view of microfluid to be very different, negligible phenomenon becomes the major influence factors of Fluid Flow in A under micro-scale under macro-scale.In recent years, how to realize driving and control to microfluid on microfluidic analysis chip, become a research difficult problem and focus in the microfluidic analysis chip technology.
Driving to microfluid in micro-fluidic chip can realize by Micropump.In recent years, along with development and the maturation of microflow control technique, research and develop a lot of methods and device, realized to a certain extent the driving to microfluid in micro-fluidic chip, also had some limitation simultaneously.Aspect Micropump research, comprise mechanical Micropump and on-mechanical Micropump.For example, compression pump (machinery or syringe pump) simple to operate, easy realization, with low cost, but be difficult for realizing miniaturization on chip.Hot gas power Micropump braking mechanism is simple, conditional request is low, be fit to batch production, but due to heat lag, braking frequency is lower.The characteristics of mems electrostatic pump are that braking frequency is high, simple in structure, but brake force is lower.The electromagnetism Micropump has larger brake force, and operating voltage is low, but there is no advantage on volume.The electrohydrodynamic micro-pump structure is simple, easily processing, cost are low, but requires harsh to the dielectric property of liquid stream.Driven by electroosmosis is to use the widest microfluid to drive and control technology in present microfluidic analysis chip, have flow velocity steadily, no pulse, can realize that the liquid stream of valveless switches, but require material surface energy that electric charge is provided, high voltage source is difficult for microminiaturized, and has heating and air bubble problem.At present, the research drop becomes study hotspot in wellability and the motion of the surface of solids, carry out modification by External field response molecule and self assembly molecule layer effects on surface, under the outfield stimulates, the invertibity of surface topography and chemical structure changes the variation that causes surface wettability, thereby controls drop in wet face state and the motion on surface.Therefore, drive and control microfluid in micro-fluidic chip by the infiltrating variation of control surface, because being one of research direction of little valve/Micropump on micro-fluidic chip.
Yet, routine techniques is difficult to complete the intelligent drives to microfluid in the microchannel, therefore, thereby by utilizing light to come the infiltrating variation of control surface to drive microfluid in micro-fluidic chip, develop a kind of convenient, quick, efficiently, microfluid actuation techniques cheaply, should be one of research direction of Micropump on micro-fluidic chip, substantial breakthrough is not yet arranged at present.
Summary of the invention
The purpose of this invention is to provide a kind of photoresponse Micropump based on micro-fluidic chip and preparation method thereof, there are micro-structural and microchannel in this micro-fluidic chip surface, by the optical Response molecule, microchannel surface is carried out modification, under visible light stimulates, the surface topography of microchannel and the invertibity of chemical structure change the variation that causes surface wettability, control the liquid fluid in the motion of microchannel surface, thereby realize intelligent little valve of microfluid driving is mainly used in the association areas such as electrophoretic separation, chromatographic isolation, immunoassay.
For achieving the above object, the present invention adopts following operating procedure:
(1) design and draw micro-structural and the microchannel figure of each layer chip in micro-fluidic chip with computer aided design software.
(2) by micro-processing technology machining needs on each layer micro-fluidic chip substrate surface and adhesive membrane micro-structural and microchannel, comprise sample holes, separate the main channel and separate subchannel.
(3) utilize double-deck adhesive membrane, with the alignment of each layer micro-fluidic chip, bonding, pressurizing and sealing, form the mobile controlled micro-fluidic chip of droplet.
(4) carry out the optical Response molecule in the microchannel to the surface modification of microchannel.
(5) apply the outfield light source, the wellability of microchannel surface is from hydrophilic to hydrophobic adjustable.
In the present invention, can be PMMA, PC, PVC, COC, copper, aluminium, stainless steel, silicon chip, glass wafer based on the chip substrates of the micro-fluidic chip of the photoresponse Micropump of micro-fluidic chip, also commercially available all kinds of common CD CD.
In the present invention, can be by numerical control mill quarter, laser ablation, LIGA technology, method of molding, pressure sintering, chemical attack preparation, also available soft lithographic technique preparation based on the micro-structural of the micro-fluidic chip of the photoresponse Micropump of micro-fluidic chip and adhesive membrane and microchannel.
In the present invention, be comprised of layers of chips based on the micro-fluidic chip of the photoresponse Micropump of micro-fluidic chip, fit with adhesive membrane between each layer chip, adhesive membrane can be that double-deck power causes adhesive membrane, also common double faced adhesive tape film.
In the present invention, carry out finishing based on the microchannel of the micro-fluidic chip of the photoresponse Micropump of micro-fluidic chip with the optical Response molecule.
In the present invention, produce hydrophilic under the illumination of outfield and variation hydrophobic performance based on the optical Response molecule of the micro-fluidic chip of the photoresponse Micropump of micro-fluidic chip.
The present invention propose based on photoresponse Micropump of micro-fluidic chip and preparation method thereof, intelligent drives simple to operate, as to have realized microfluid, greatly reduced the cost that microfluid drives and controls, have portable, economic, characteristics fast and efficiently, have a good application prospect in the association areas such as electrophoretic separation, chromatographic isolation, immunoassay.
Description of drawings
Fig. 1. the structural representation of the micro-fluidic chip of photoresponse Micropump.
A. solution entrance, the micro-structural of b. optical Response molecular modification, the c. microfluid, d. optical Response molecule is driving microfluid, the e. taphole with/without the variation that surface wettability occurs under illumination.
Specific embodiments
Embodiment 1
Design and draw micro-structural and the microchannel figure of the layers of chips of the controlled micro-fluidic chip of microfluidic flow with computer aided design software.Utilize micro-structural and the microchannel of numerical control CNC system processing preparation two-layer polymethyl methacrylate (PMMA) chip, clean each layer chip with running water, distilled water respectively, and with spots such as the residual fingerprint of ethanol chip surface, oil stains.On the double faced adhesive tape film, with required micro-structural and the microchannel of carving machine processing preparation.With layers of chips carefully align, bonding, pressurizing and sealing, make the intelligent little valve based on micro-fluidic chip.The sample introduction hand-hole that sample solution is added micro-fluidic chip, solution enters the microchannel under the driving of external peristaltic pump in, little valve zone in the microchannel, the photoresponse molecule of microchannel surface responds the outfield light source, obtain the hydrophilic and hydrophobic conversion of surface wettability, realized at last the Based Intelligent Control of Micropump to microfluidic flow.
Embodiment 2
Design and draw micro-structural and the microchannel figure of the layers of chips of centrifugal type microfludic chip with computer aided design software.Utilize micro-structural and the microchannel of numerical control CNC system processing preparation two-layer disc-shaped Merlon (PC) chip, clean each layer chip with running water, distilled water respectively, and with spots such as the residual fingerprint of ethanol chip surface, oil stains.On the double faced adhesive tape film, with required micro-structural and the microchannel of carving machine processing preparation.With layers of chips carefully align, bonding, pressurizing and sealing, make the intelligent little valve based on micro-fluidic chip.The sample introduction hand-hole that sample solution is added micro-fluidic chip, solution enters the microchannel under the driving of external peristaltic pump in, little valve zone in the microchannel, the photoresponse molecule of microchannel surface responds the outfield light source, obtain the hydrophilic and hydrophobic conversion of surface wettability, realized at last the Based Intelligent Control of Micropump to microfluidic flow.
Claims (10)
1. one kind based on photoresponse Micropump of micro-fluidic chip and preparation method thereof, there are micro-structural and microchannel in this micro-fluidic chip surface, by the optical Response molecule, microchannel surface is carried out modification, under visible light stimulates, the surface topography of microchannel and the invertibity of chemical structure change the variation that causes surface wettability, control microfluid in the motion of microchannel surface, thus the intelligent Micropump that realization is controlled microfluidic flow.
2. by photoresponse Micropump based on micro-fluidic chip claimed in claim 1 and preparation method thereof, it is characterized in that, its making step is as follows:
(1) design and draw micro-structural and the microchannel figure of each layer chip in micro-fluidic chip with computer aided design software.
(2) by micro-processing technology machining needs on each layer micro-fluidic chip substrate surface and adhesive membrane micro-structural and microchannel, comprise sample holes, separate the main channel and separate subchannel.
(3) utilize double-deck adhesive membrane, with the alignment of each layer micro-fluidic chip, bonding, pressurizing and sealing, form the mobile controlled micro-fluidic chip of droplet.
(4) carry out the optical Response molecule in the microchannel to the surface modification of microchannel.
(5) apply the outfield light source, the wellability of microchannel surface is from hydrophilic to hydrophobic adjustable.
3. by described photoresponse Micropump based on micro-fluidic chip of claim 1 or 2 and preparation method thereof, it is characterized in that, this base is micro-fluidic chip based on the Core Feature device of the photoresponse Micropump of micro-fluidic chip, and this chip can be produced in batches, repeatedly utilization, flexible design and assembling.
4. by described photoresponse Micropump based on micro-fluidic chip of claim 1 or 2 and preparation method thereof, it is characterized in that, the micro-structural of this photoresponse Micropump based on micro-fluidic chip and microchannel be micro-processing method by numerical control mill quarter, laser ablation, LIGA technology, method of molding, pressure sintering, chemical attack, soft lithographic technique in chip substrates surface preparation, size is in micron level.
5. by described photoresponse Micropump based on micro-fluidic chip of claim 1 or 2 and preparation method thereof, it is characterized in that, this photoresponse Micropump based on micro-fluidic chip is to be formed by stacking by layers of chips, consists of micro-structural and the microchannel network of 3 D stereo.
6. by described photoresponse Micropump based on micro-fluidic chip of claim 1 or 2 and preparation method thereof, it is characterized in that, this photoresponse Micropump based on micro-fluidic chip can be made many group micro-structurals and microchannel on chip piece, consist of many group control modules, the alternative flow direction of controlling microfluid.
7. by described photoresponse Micropump based on micro-fluidic chip of claim 1 or 2 and preparation method thereof, it is characterized in that, this photoresponse Micropump based on micro-fluidic chip has carried out the finishing of optical Response molecule in microchannel surface.
8. by described photoresponse Micropump based on micro-fluidic chip of claim 1 or 2 and preparation method thereof, it is characterized in that, this automatic identification of passing through the optical Response molecule based on the photoresponse Micropump of micro-fluidic chip is carried out hydrophilic and hydrophobic conversion in microchannel surface.
9. by described photoresponse Micropump based on micro-fluidic chip of claim 1 or 2 and preparation method thereof, it is characterized in that, this photoresponse Micropump based on micro-fluidic chip can be realized the driving to solution fast.
10. by described photoresponse Micropump based on micro-fluidic chip of claim 1 or 2 and preparation method thereof, it is characterized in that, it is portable, economical, quick, efficient that this photoresponse Micropump based on micro-fluidic chip has, and is with a wide range of applications in electrophoretic separation, chromatographic isolation, the related numerous association areas of immunoassay.
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| CN108704679A (en) * | 2018-05-24 | 2018-10-26 | 北京大学 | A kind of micro-fluidic composite tube type channel of light |
| WO2020001528A1 (en) * | 2018-06-28 | 2020-01-02 | 京东方科技集团股份有限公司 | Digital micro-fluidic chip and driving method therefor, and digital micro-fluidic apparatus |
| CN113775818A (en) * | 2020-06-10 | 2021-12-10 | 南京工业大学 | Microfluid control valve based on controllable wetting gradient surface |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108704679A (en) * | 2018-05-24 | 2018-10-26 | 北京大学 | A kind of micro-fluidic composite tube type channel of light |
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| CN113775818A (en) * | 2020-06-10 | 2021-12-10 | 南京工业大学 | Microfluid control valve based on controllable wetting gradient surface |
| CN113775818B (en) * | 2020-06-10 | 2022-06-03 | 南京工业大学 | Microfluid control valve based on controllable wetting gradient surface |
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Application publication date: 20130508 |