CN103076449A - Colloidal gold label detector - Google Patents
Colloidal gold label detector Download PDFInfo
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- CN103076449A CN103076449A CN2013100256719A CN201310025671A CN103076449A CN 103076449 A CN103076449 A CN 103076449A CN 2013100256719 A CN2013100256719 A CN 2013100256719A CN 201310025671 A CN201310025671 A CN 201310025671A CN 103076449 A CN103076449 A CN 103076449A
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Abstract
The invention discloses a colloidal gold label detector. The colloidal gold label detector comprises an image acquisition system for acquiring an image of a test strip, a central control system for analyzing and processing the acquired image and a printing device for printing an analyzed and processed result, wherein the image acquisition system and the printing device are connected with the central control system for information communication. The colloidal gold label detector can qualitatively and quantitatively detect information of the test strip, record and analyze a data result and print and output the result.
Description
Technical field
The present invention relates to a kind of automatic detection device of Biosample, especially a kind of collaurum gold mark detector, the qualitative and quantitative analysis that can be correlated with to the test strips (melamine, Clenbuterol etc.) of being made by collaurum.
Background technology
The colloidal gold strip baffled photometer is called for short collaurum gold mark detector, quick and precisely quantitative test colloidal gold immuno-chromatography test paper strip.According to the characteristic of colloid gold particle between the 10-100nm to the peak absorbance of light, by visible light or laser scanning, measure the reflection case on the colloidal gold strip, by the integral contrast of micro computer to detection band and quality control band, calculate the quantity of colloid gold particle on the relative quality control band of colloid gold particle of immune combination, calculated by the concentration of check reagent by formula again.And then realize that the detection of dynamic of colloidal gold immunochromatographimethod reaction is had good response characteristic in large concentration range.
Colloidal gold immunochromatographimethod technology (colloidal gold immunochromatography assay, GICA) is a kind of solid phase labelling immunoassay technology that the multiple technologies such as colloidal gold-labeled method, immunoassay technology and chromatographic analysis technology are organically combined.Easy and simple to handle, quick because of it, and has very high specificity and susceptibility, in the clinical medicine check, obtain quickly development, be widely used in the clinical detection such as diseases such as human chorionic gonadotrophin, the plague, hepatitis B, parasite, myocardial damage, acquired immune deficiency syndrome (AIDS) at present.
Collaurum can show numerous characteristics, particularly absorption Spectrum characteristic at size reduction during to nanometer scale, has important using value in fields such as materialogy, clinical medicine, life sciences.To studies show that of colloid gold particle absorption Spectrum characteristic, when the nanogold particle particle diameter was between 10-100nm, its absorption peak was between 510-550nm; Along with the increase of nanogold particle particle diameter, its absorption peak moves east to ruddiness, and basically is the linear changing relation between absorption peak wavelength and the particle diameter, so be shown as kermesinus when a large amount of nanogold particle is assembled.
Collaurum is the aqueous solution of gold chloride, and it aggregates into the colloid gold particle of specific size (3nm-80nm) under the effect of reductive agent, and owing to electrostatic interaction forms a kind of stable colloidal state.Colloid gold label is in fact the coated process that the macromolecules such as protein molecule are adsorbed to the colloid gold particle surface, adsorption mechanism is colloid gold particle electronegative character under alkali condition, lean on electrostatic interaction and strong bonded with the positive charge group of protein molecule, thereby have good stability.Immunochromatographiassays assays method take collaurum as label has been widely used in the fields such as histopathology and immunology diagnosis.
Although the colloidal gold immunochromatographimethod technology has a wide range of applications in clinical medicine check field, at present only with ocular estimate to dripping having or not of on gold-marking immunity test strips checking matter and do qualitative or sxemiquantitative being judged.Have following shortcoming: 1) measurement result is subject to the interference of human factor, and objectivity is poor; 2) can not monitoring bio the dynamic process of reaction.3) inaccurate.
Summary of the invention
For existing ocular estimate to be subject in the prior art to think factor to disturb the not high problem of accuracy, the invention provides a kind of collaurum gold mark detector, test strip information that can be qualitative, quantitative, and record analysis data result, printable output.
To achieve these goals, a kind of collaurum gold of the present invention mark detector, described collaurum gold mark detector comprises for the image capturing system that test strips is carried out image acquisition, the image that gathers is carried out the central control system of analyzing and processing and the printing equipment that the result of analyzing and processing is printed, described image capturing system and printing equipment all are connected on the described central control system, interactive information.
Further, described central control system connects the multiplex image acquisition system simultaneously, and the described image capturing system of multichannel can send to central control system simultaneously with image information.
Further, described image capturing system comprises camera and lamp plate, and described camera is connected with described central control system, and described lamp plate provides light source when the camera collection image.
Further, described central control system is carried out analyzing and processing by OpenCV to image information, draws T/C line ratio, and then draws corresponding reagent concentration.
Further, also be connected with the display screen for man-machine interaction on the described collaurum gold mark detector, described display screen is connected with described central control system.
Further, be provided with the USB expansion board that can be connected with external input device on the described central control system, described multiplex image acquisition system is connected with central control system by the USB expansion board.
The invention provides a kind of collaurum gold mark detector, the setting of multiplex image acquisition system can detect a plurality of test paper information simultaneously, is conducive to the big data quantity analysis, has improved detection efficiency; The USB expansion board can be connected with external input device, can realize the communications such as Data Enter, utilizes central control system that test paper information is carried out analyzing and processing; Utilize printing device that result is recorded on the paper, be convenient to read and preserve; Display screen is convenient to man-machine interaction.
Description of drawings
Fig. 1 is the structural representation of collaurum gold mark detector of the present invention.
Embodiment
Below in conjunction with accompanying drawing, the specific embodiment of the present invention is elaborated.
Be illustrated in figure 1 as the specific embodiment of collaurum gold mark detector of the present invention, central control system comprises the center-control mainboard, central processing unit on the mainboard adopts the EPIA-P820 series control processor of VIA Technologies, this mainboard adopts the x86 framework, can perfect integration windows operating system, so just greatly simplified the design cycle of software program, while this processor adopting Pico-ITX standard, size only has 10cm
7.2cm, can perfectly realize handheld operation.2G DDR3 internal storage and 4G Flash have been installed as program storage on the mainboard, central control system is carried out analyzing and processing by OpenCV to image information, draws T/C line ratio, and then draws corresponding reagent concentration.。6.4 cun technical grade liquid crystal display are adopted in the output of processor, are connected with processor by the LVDS interface, realize that resolution is 640
The screen display output of 480 pixels.And the input of processor adopts one to realize with the touch-screen that covers on the display screen, this touch-screen by a drive circuit board after, be connected with master controller employing USB interface.Adopt simultaneously in addition camera and the lamp plate for the camera power supply of USB interface, camera and lamp plate consist of the image capturing system of test paper information, and lamp plate adopts the 5V of USB output to power.Also expanded in addition the image capturing system of 8 passages by the USB expansion board, also can be connected with other USB input equipments, this module can realize that 8 passages of collaurum detect simultaneously, also can realize some common input/output functions by this USB interface, for example be equipped with wireless wifi module, radio keyboard mouse or insertion USB flash disk etc.By the RS232 interface of mainboard, connected a mini-printer, adopt the ZY-TP12 series printer of Zhou Ligong company, can realize that collaurum detects the output of information, so that keep and reading.Whole control system adopts a block power supply adapter and DC-DC module to realize power supply, and output has 12V direct current and two standards of 5V direct current, and the 12V power supply is control panel, monitor power supply, and the 5V power supply is display, printer power supply.Adopt this Control System Design, can realize easily Software for Design, simultaneity factor can have one and the similar function of PC.
Above-mentioned example just is used for explanation the present invention, and embodiments of the present invention are not limited to these examples, and the various embodiments that meet inventive concept that those skilled in the art make are all within protection scope of the present invention.
Claims (6)
1. a collaurum gold is marked detector, it is characterized in that, described collaurum gold mark detector comprises for the image capturing system that test strips is carried out image acquisition, the image that gathers is carried out the central control system of analyzing and processing and the printing equipment that the result of analyzing and processing is printed, described image capturing system and printing equipment all are connected on the described central control system, interactive information.
2. a kind of collaurum gold mark detector as claimed in claim 1 is characterized in that described central control system connects the multiplex image acquisition system simultaneously, and the described image capturing system of multichannel can send to central control system simultaneously with image information.
3. a kind of collaurum gold mark detector as claimed in claim 2 is characterized in that described image capturing system comprises camera and lamp plate, and described camera is connected with described central control system, and described lamp plate provides light source when the camera collection image.
4. a kind of collaurum gold mark detector as claimed in claim 3 is characterized in that described central control system is carried out analyzing and processing by OpenCV to image information, draws T/C line ratio, and then draws corresponding reagent concentration.
5. a kind of collaurum gold mark detector as claimed in claim 4 is characterized in that, also is connected with the display screen for man-machine interaction on the described collaurum gold mark detector, and described display screen is connected with described central control system.
6. a kind of collaurum gold as claimed in claim 5 is marked detector, it is characterized in that, be provided with the USB expansion board that can be connected with external input device on the described central control system, described multiplex image acquisition system is connected with central control system by the USB expansion board.
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| CN2013100256719A CN103076449A (en) | 2013-01-21 | 2013-01-21 | Colloidal gold label detector |
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| CN2013100256719A CN103076449A (en) | 2013-01-21 | 2013-01-21 | Colloidal gold label detector |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103439486A (en) * | 2013-09-05 | 2013-12-11 | 凌中鑫 | PCT (Paper of Colloidal Test) chromatographic detector |
| CN103472218A (en) * | 2013-09-27 | 2013-12-25 | 张沈平 | Colloidal gold chart reader and corresponding control method |
| CN105466921A (en) * | 2015-11-23 | 2016-04-06 | 北京普析通用仪器有限责任公司 | Simultaneous detection method of many samples |
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| CN101726587A (en) * | 2008-10-13 | 2010-06-09 | 周中人 | Instrument for indentifying and quantitatively analyzing image of immune test paper in moving process |
| CN102279263A (en) * | 2011-05-06 | 2011-12-14 | 杭州顿力医疗器械股份有限公司 | CCD-type quantitative analysis system of colloidal gold immunity chromatography diagnosis test papers |
| CN203164187U (en) * | 2013-01-21 | 2013-08-28 | 中国检验检疫科学研究院 | Gold label detector for colloidal gold |
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| CN1257204A (en) * | 1998-11-23 | 2000-06-21 | 普莱克斯生物系统股份有限公司 | Method and apparatus for side flow analysis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103439486A (en) * | 2013-09-05 | 2013-12-11 | 凌中鑫 | PCT (Paper of Colloidal Test) chromatographic detector |
| CN103472218A (en) * | 2013-09-27 | 2013-12-25 | 张沈平 | Colloidal gold chart reader and corresponding control method |
| CN103472218B (en) * | 2013-09-27 | 2015-05-27 | 智锐达仪器科技南通有限公司 | Colloidal gold chart reader and corresponding control method |
| CN105466921A (en) * | 2015-11-23 | 2016-04-06 | 北京普析通用仪器有限责任公司 | Simultaneous detection method of many samples |
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Application publication date: 20130501 |