CN103071010A - Traditional Chinese medicine preparation for treating disorders of gastrointestinal motility - Google Patents
Traditional Chinese medicine preparation for treating disorders of gastrointestinal motility Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating disorders of gastrointestinal motility, in particular to a traditional Chinese medicine preparation prepared from mangnolia officinalis, radix ophiopogonis, dried tangerine or orange peel, raw radix aucklandiae, the root of three-nerved spicebush, pericarpium arecae, codonopsis pilosula, raw bighead atractylodes rhizome and endothelium corneum gigeriae galli as raw materials. The invention further relates to a preparation method of the traditional Chinese medicine.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation for the treatment of gastrointestinal motility disorders, be particularly related to take Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, give birth to the Radix Aucklandiae, the Radix Linderae, Pericarpium Arecae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Raphani, Radix Glycyrrhizae Preparata as the Chinese medicine preparation that raw material prepares, the invention still further relates to the preparation method of this medicine.
Background technology:
Gastrointestinal motility disorders is the modal disease of digestive system, and recent statistics shows, the prevalence of Chinese gastrointestinal motility disorders is 10% ~ 30%, and accounts for 50% of Gastroenterology dept.'s outpatient service by the outpatients due to it.Mainly refer to the gastroenteropathy take various symptoms of digestive tract as clinical manifestation that causes because of gastrointestinal motility disorders.Such disease is the general name of one group of gastrointestinal syndrome, is the main cause that causes functional dyspepsia.Clinical main manifestations is the glutted discomfort of epigastrium, is main manifestations with symptoms such as belch, inappetence, heartburn, pantothenic acid and retrosternal pains often, can be with other functional symptom.
" gastric motility " is the power of the digesting and emptying motor function of stomach, with the electrical activity of pipe smooth muscle, and the regulatory mechanism of neural and hormone, the secretion of Digestive system is at the bottom of the stomach, the result of the common coordination exercise of gastric antrum, pylorus, duodenum and small intestinal; Be to be participated in by many internal organs, multisystem, and keeping whole harmony.At present clinical treatment to functional dyspepsia mainly gives gastro-kinetic agent, acid inhibitor and the Hp symptomatic treatment that goes out.Full digestive tract power reinforcing medicine can obviously improve clinical symptoms, but life-time service has and causes than severe arrhythmia and diarrhoea, borborygmus, and cross the side effect such as property stomachache.
Become one of study hotspot so seek a kind of curative effect short digestive tract power Chinese medicine high, that have no side effect from tcm field.
The Chinese medicine that comprises some improvement gastric motilitys in the prior art, but some uses expensive raw material of Chinese medicine, and some interrupts because uncertain therapeutic efficacy is cut using.
The present invention finds a kind of brand-new Chinese medicine formula through years of researches, develops the short digestive tract power Chinese medicine preparation that a kind of curative effect is high, have no side effect.
Summary of the invention:
The invention discloses a kind of Chinese medicine preparation for the treatment of gastrointestinal motility disorders.
The present invention also provides the preparation method of this Chinese medicine preparation.
Chinese medicine of the present invention, take Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, give birth to the Radix Aucklandiae, the Radix Linderae, Pericarpium Arecae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Raphani, Radix Glycyrrhizae Preparata as the raw material preparation,
Chinese medicine preparation of the present invention is prepared from by the raw material of Chinese medicine medicine of following weight proportion:
Cortex Magnoliae Officinalis 9-20 grams, Fructus Aurantii Immaturus 9-20 grams, Pericarpium Citri Reticulatae 9-25 restrain, the living Radix Aucklandiae 3-10 restrains,
The Radix Linderae 5-15 grams, Pericarpium Arecae 9-25 grams, Radix Codonopsis 9-30 restrain, Rhizoma Atractylodis Macrocephalae 9-20 restrains,
Endothelium Corneum Gigeriae Galli 9-30 grams.
Preferably, Chinese medicine preparation of the present invention is prepared from by the raw material of Chinese medicine medicine of following weight proportion:
Cortex Magnoliae Officinalis 15 restrains, Fructus Aurantii Immaturus 15 restrains, Pericarpium Citri Reticulatae 15 restrains, gives birth to the Radix Aucklandiae 5 grams, the Radix Linderae 10 restrains,
Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams.
In the above composition, weight is calculated with crude drug, and above composition can be made into pharmaceutical preparation 1-3 days dose.
Above composition is by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, can be take kilogram as unit such as large-scale production, or take ton as unit, small-scale production also can be take milligram as unit, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, and is fat or modest such as serious symptom or light disease for special circumstances, and the proportioning of the amount that can corresponding adjustment forms increases or reduce being no more than 100%, and drug effect is constant.
Single medicinal material in the above composition, especially ministerial drug and adjuvant drug also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine preparation of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, take this material as raw material, add the medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting respectively raw material of Chinese medicine, also can obtain by common extraction raw material of Chinese medicine, also can obtain by other means, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water extraction, alcohol extraction, ester are carried, the methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be fluid extract, make different concentration according to the different needs decisions of preparation.
Pharmaceutically active substance in the Chinese medicine preparation of the present invention, its shared percentage by weight in preparation can be 0.1-99.9%, all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form refers to the unit of preparation, such as every of tablet, and every capsules of capsule, every bottle of oral liquid, every bag of granule etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, granule, pill, powder, unguentum, sublimed preparation, powder, solution, injection, suppository, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.
Chinese medicine preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent.
Applicable filler comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The suitable acceptable wetting agent of medicine comprises sodium lauryl sulphate.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Repeatedly mix active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of before use available water or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if necessary, can contain conventional flavouring agent or coloring agent.
Injection contains active substance of the present invention and sterile carrier.According to carrier and concentration, this chemical compound can be suspended or dissolving.The preparation of solution is normally by being dissolved in active substance in a kind of carrier filter-sterilized before it is packed into a kind of suitable bottle or ampoule, then sealing.Adjuvant for example a kind of local anesthetic, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
Chinese medicine preparation of the present invention, when being prepared into medicament, optionally add suitable medicine acceptable carrier, such as adjunct ingredient commonly used: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention is determined usage and dosage according to condition in use, but takes every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.
The preparation method of Chinese medicine preparation of the present invention is as follows:
All medical material decocts with water, and obtains decoction liquor, is condensed into extractum, obtains pharmaceutically active substance, adds adjuvant and makes pharmaceutical preparation according to the galenic pharmacy routine techniques, namely gets Chinese medicine preparation of the present invention.
Preferably, preparation method of the present invention is as follows:
All medical materials add the decocting that 2-10 doubly measures and boil 1-3 time, and each 1-3h merges decoction liquor, is concentrated into relative density 1-1.5(60 ℃) extractum, the adding adjuvant is made pharmaceutical preparation according to the galenic pharmacy routine techniques, namely gets Chinese medicine preparation of the present invention.
Below further specify beneficial effect of the present invention by test data:
The present invention uses the method among the embodiment 1 to extract to obtain extractum and is called " stomach function regulating drink extract " or " Hwy ", carries out following animal and human's body with extractum as Experimental agents and tests
The impact that material one: embodiment 1 extract is emptying on Mouse Stomach
Summary: the purpose research stomach function regulating drink extract impact emptying on Mouse Stomach.Method adopts different instrument recurrence due to taking drug Mouse Stomach air emptying function processed Disorder Model, observes the administration of various dose stomach function regulating drink extract oral to the impact of gastric emptying.Stomach function regulating drink extract can obviously resist the Mouse Stomach gastric emptying disability in gastric that atropine and dopamine cause as a result.
Experimental result
Hwy causes the impact of Mouse Stomach gastric emptying disability in gastric on atropine sulfate
Compare with the blank group, model group gastric pigment residual rate obviously raises (p＜0.05), shows that mouse peritoneal injecting atropine gastric emptying is suppressed; Compare with model group, Hwy respectively organizes gastric pigment residual rate and obviously reduces (p＜0.05).
Hwy causes the impact of gastric emptying disorder on dopamine
Compare with the blank group, model group gastric pigment residual rate obviously raises (p＜0.05), shows that mouse peritoneal Injection of Dopamine gastric emptying is suppressed; Compare with model group, dosage and high dose gastric pigment residual rate obviously reduce (p＜0.05) among the Hwy.
Hwy causes the emptying hyperfunction impact of Mouse Stomach to neostigmine
Compare with the blank group, model group gastric pigment residual rate obviously reduces (p＜0.05), shows that mouse peritoneal injection neostigmine gastric emptying is hyperfunction; Each dosage group of Hwy and model group be (p〉0.05) relatively, Hwy is described and neostigmine is caused emptying hyperfunction without antagonism of Mouse Stomach.
Material two: embodiment 1 extract is on the impact of rat isolated stomach smooth muscle contraction
Summary: purpose research stomach function regulating drink extract is on the impact of rat isolated stomach smooth muscle contraction.Method is utilized the cholinergic pathway smooth muscle, observes stomach function regulating drink extract to the impact of the pipe smooth muscle activity of exsomatizing under normal and dopamine, the Action of Isoproterenol.It is movable that stomach function regulating drink extract can obviously strengthen the rat pipe smooth muscle that normally exsomatizes as a result, and antagonism dopamine and isoproterenol are to the inhibitory action of isolated rat pipe smooth muscle activity.
Experimental result
The impact that Hwy shrinks the pipe smooth muscle that exsomatizes under normal and the different inhibitor effects
Blank group compares, and Hwy can significantly improve the amplitude (p＜0.05) of pipe smooth muscle, (2.60 * 10
-4, 3.85 * 10
-4, 5.06 * 10
-4); And can significantly increase the tension force (p＜0.05) of pipe smooth muscle, (3.85 * 10
-4, 5.06 * 10
-4).
The impact that Hwy suppresses rat isolated stomach smooth muscle contraction due to the dopamine
Compare with the blank group, model group can obviously reduce pipe smooth muscle amplitude and tension force (p＜0.05); Compare with model group, each concentration group of Hwy all can obviously improve pipe smooth muscle amplitude and tension force (p＜0.05); Concentration is 3.85 * 10
-4Amplitude and 1.32 * 10
-4Comparing difference is (p＜0.05) significantly; Concentration is 5.06 * 10
-4Tension force and 1.32 * 10
-4, 2.60 * 10
-4Relatively (p＜0.05), the show dose dependence; The model group frequency compares (p＜0.05) with blank group; Each concentration class frequency of Hwy and model group frequency ratio be (p＜0.05).
The impact that Hwy suppresses rat isolated stomach smooth muscle contraction due to the isoproterenol
Compare with the blank group, model group can obviously reduce pipe smooth muscle amplitude and tension force (p＜0.05); With the model group ratio, each concentration group of Hwy all can obviously improve pipe smooth muscle amplitude and tension force (p＜0.05); Concentration 3.85 * 10
-4, 5.06 * 10
-4Amplitude and 1.32 * 10
-4Amplitude Comparison (p＜0.05), the show dose dependence; The model group frequency compares (p＜0.05) with blank group; Each concentration class frequency of Hwy and model group be (p＜0.05) relatively.
Material three: embodiment 1 extract is on the impact of functional dyspepsia rat stomach motion frequency
Summary: purpose research stomach function regulating drink extract is on the impact of functional dyspepsia rat at body stomach motion frequency and general state.Method adopts and to enrage method copy function dyspepsia rat model, observes stomach function regulating drink extract on the animal general status and in the impact of body stomach motion frequency.Stomach function regulating drink extract can obviously improve functional dyspepsia rat functional status as a result, increases functional dyspepsia rat stomach motion frequency.
Experimental result
Hwy is to functional dyspepsia rat stomach contraction frequency fixed point record
With the blank group relatively, model group contraction frequency obviously slow down (p＜0.05); Compare with model group, Hwy high dose contraction frequency is obviously accelerated (p＜0.05); And high dose and low dosage be (p＜0.05) relatively, the show dose dependency.
Material four: model case
Case one: Wang male 56 years old
2010.2.1 first visit
The main suit: the gastral cavilty distension, belch, heartburn pantothenic acid showed effect more than 10 years repeatedly, increased the weight of more than the moon.
Before 10 years, this trouble vague epigastralgia that repeatedly shows effect, taking " omeprazole " can alleviate, therefore not systems inspection and treatment.Nearly January aggravation, epigastric upset is uncomfortable when hungry, the then gastral cavilty distension of taking food is early full, belch, heartburn pantothenic acid, the companion feels sick, clothes " omeprazole " are not imitated and the traditional Chinese medical science of seeing a doctor certainly.Gastral cavity abdomen fear of cold, still can be slept the dark red white and thin fur of tongue, stringy pulse by just rare 1 times/day usually.
2010.1.23 Attached Hospital No.1, dalian Medical Univ.:
Gastroscope: HP+ chronic superficial gastritis (moderate)
Pathology: gastric antrum chronic gastritis, moderate inflammation
2010.1.28 the hospital of traditional Chinese hospital, Daliang City:
Barium bar gastric emptying rate detects: gastric emptying weakens, and the prompting gastric motility descends.
Clectrogastrogram detects: stomach electricity rhythm disturbance, the prompting gastric motility descends.
Diagnosis: doctor trained in Western medicine: the functional dyspepsia traditional Chinese medical science: feeling of fullness
Take " granule of the present invention " 2 weeks
2010.2.15 two examine
Heartburn pantothenic acid is alleviated behind the medicine, and flatulence alleviates after the meal, just has been shaped 1 times/day, receive can, chronic pharyngitis more than 10 years, morning, time-out was nauseating, the dark red white and thin fur of tongue, stringy pulse.
Continue to take " granule of the present invention " 2 weeks
2010.2.28 three examine
Throat is without discomfort, feels sick at disappearing, and the flatulence idol is done after the meal, and even pantothenic acid, improper diet are still heartburn, receive can, just transfer the peace of sleeping, the dark red white and thin fur of tongue, stringy pulse.
Continue to take " granule of the present invention " 2 weeks
2010.3.14 the four diagnostic methods
Heartburn pantothenic acid disappears, and gastral cavilty is without discomfort, receives to increase, and just transfers the dark red white and thin fur of tongue, stringy pulse.
Continue to take " granule of the present invention " 2 weeks
2010.3.28 five examine
Recently eat peppery idol have heartburn, without pantothenic acid, the dark red white and thin fur of tongue, stringy pulse.
Continue to take " granule of the present invention ", after treatment 1 month.
2010.4.11 six examine
Withdraw medicine, advise it to keep on a diet, fasting is pungent, fry.
Visit: the check of 2010.9.19 Attached Hospital No.1, dalian Medical Univ.:
Gastroscope: HP-, chronic superficial gastritis (slightly)
Barium bar gastric emptying rate detects and clectrogastrogram detects all normal.
Case two: poplar women 51 years old
2011.4.15 first visit
The main suit: gastral cavilty distension, anorexia are early full, belch pantothenic acid 3 months.
Unsuccessful because of feelings will before 3 months, the gastral cavilty distension appears, and the decreased food intake of receiving is few, increase the weight of gradually, and occur early satisfying belch pantothenic acid, be hard and dry such as sheep stool shape 1 time/3 days abdominal distention, anus tenesmus, just unclean, vexed bitter taste, dormancy is felt unwell, menstruation tide 13 the beginning of the year was passed through 3 days in per 25 days, and the few color of amount is dark red, the dark red white and thin fur of tongue, stringy and thready pulse.
History of past illness: gallbladder Polypus operation in 96 years gallbladder is extractd iron deficiency anemia more than 10 years, calculus of intrahepatic duct 6 years.Once suffered from before 4 years in " barratt esophagus ", and took Chinese medicine and cure.
2011.3.30 Attached Hospital No.1, dalian Medical Univ.: gastroscope: HP: the positive, chronic superficial gastritis.
2011.4.7 the hospital of traditional Chinese hospital, Dalian:
Barium bar gastric emptying rate detects: gastric emptying weakens, and the prompting gastric motility descends.
Clectrogastrogram detects: the stomach electricity rhythm and pace of moving things is slightly disorderly, and the prompting gastric motility descends.
Diagnosis: doctor trained in Western medicine: the functional dyspepsia traditional Chinese medical science: feeling of fullness
After 4 weeks, symptom is obviously improved to take " granule of the present invention ", adheres to again taking 1 month, and the food of receiving is normal, and the gastral cavilty symptom all disappears, and just still not smooth 1 time/2 days, the dark red white and thin fur of tongue, stringy and thready pulse.
Visit after 6 months, gastral cavilty is without unusual uncomfortable.Check in the hospital of traditional Chinese hospital, 2011.6.24 Dalian: gastrin detects, clectrogastrogram detects all normal.
Case three: woman Lee 50 years old
2012.4.10 first visit
The main suit: stifled the expanding of gastral cavilty shown effect constipation more than 10 years repeatedly 3 years.
Gastral cavilty is stifled swollen, and anorexia is early full, and feed increases the weight of, and belch is done frequently, without heartburn pantothenic acid, is hard and dry 1 time/4-5 day, the insomnia difficulty is slept, dreaming often and waking easily, and rise weak morning, dizzy profound, backache, Hypomenorrhea, per 30 days delegation passed through 3-4 days, and color is red in clot, painless warp, and the large white and thin fur of enlarged tongue has indentation, thready pulse.
Gastroscope: chronic superficial gastritis
B ultrasonic: gallbladder Polypus
Clectrogastrogram: stomach electricity rhythm disturbance, the prompting gastric motility descends.
Barium bar gastric emptying rate detects: gastric emptying weakens, and the prompting gastric motility descends.
Diagnosis: doctor trained in Western medicine: the functional dyspepsia traditional Chinese medical science: feeling of fullness
Take " granule of the present invention " after 4 weeks, the food of receiving increases, early full disappearance, and the gastral cavilty distension obviously reduces, and belch alleviates, and defecation improves, and 1 time/2 days, remaining disease was steady.After taking for 4 weeks, the flatulence belch disappears, and feed is normal, defecates 1 time/2 days.Check clectrogastrogram, barium bar gastric emptying rate detect all normal.
Visit after half a year, the gastral cavilty distension is not repeatedly.
Case four: woman Lee 29 years old
2012.7.21 first visit
The main suit: the gastral cavilty distension, uncomfortable behind companion's breastbone, do not swallow and freely feel more than the January of repeatedly showing effect.
Flatulence, anorexia, uncomfortable behind the breastbone, swallow not smooth, belch after the feed, throat are arrested tight uncomfortable, and idol has burning sensation behind gastral cavilty and the breastbone, but without pantothenic acid, just be shaped 1 times/day, dormancy can, vexed, psychentonia plays the xerostomia hardship morning, body is thin, and per 37 days delegation of menstruation were through row 7 days, but the amount color is red clot, the dark red fat large yellow and greasy fur of tongue, stringy and thready pulse arranged.
History of past illness: once because esophagitis, chronic superficial gastritis companion bile reflux come to go to a doctor, check gastroscope after the treatment by Chinese herbs: esophagitis is cured before 1 year, and bile reflux disappears.Gastroptosis medical history 5 years.
2012.7.14 Attached Hospital No.1, dalian Medical Univ.:
The esophagus pressure measurement: hypomere power descends in the esophagus.
Clectrogastrogram: the stomach electricity rhythm and pace of moving things is slightly disorderly, and the prompting gastric motility descends.
Diagnosis: doctor trained in Western medicine: the functional dyspepsia traditional Chinese medical science: feeling of fullness
Take " granule of the present invention " 4 weeks, the food of receiving increases, and discomfort alleviates behind the breastbone, and the flatulence belch reduces, heartburn disappearance, and after taking for 2 weeks, transference cure, 2 weeks of after treatment, check esophagus pressure measurement: no abnormality seen.Clectrogastrogram: normal.
Cortex Magnoliae Officinalis pungent drugs can disperse and bitter drugs can descend among the present invention enters taste lung large intestine channel, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, and relieving distension and oppression is the key medicine for the treatment of stagnation of QI in spleen and stomach, is to be monarch drug.Get it and pleasantly stagnate except full row, logical effect of falling the three warmers mechanism of qi, and kindly demonstrate,prove with Fructus Aurantii Immaturus compatibility treatment stagnation of QI in spleen and stomach.Pericarpium Citri Reticulatae invigorating the spleen and regulating the stomach, regulating QI and lowering the adverseness.Compendium of Material Medica opinion Pericarpium Citri Reticulatae: " then mend with tonic, then rush down with cathartic, then rise with Hydrargyri Oxydum Rubrum, then fall with falling medicine." Fructus Aurantii Immaturus and Pericarpium Citri Reticulatae 5 strengthened the Cortex Magnoliae Officinalis relieving distension and oppression mutually, held along the descending merit of gastric qi, and be ministerial drug.Radix Aucklandiae pungent drugs can disperse and bitter drugs can purge temperature is logical, the benefaction taste large intestine gas that stagnates, and as Compendium of Material Medica institute cloud: " Radix Aucklandiae is the medicine of three warmers edema caused by disorder of QI, can open and fall all gas." reach the spleen lung on the Radix Linderae, descending Liver and kidney, promoting the circulation of QI to alleviate the stagnation in middle-JIAO is evacuated not smoothly, and Li Shizhen (1518-1593 A.D.) claims the Radix Linderae " all gas can fall apart ", " holding concurrently in falling rises, and rushes down middle band and mends ".Modern aerofluxus soup (Radix Linderae, the Radix Aucklandiae are main component) has the promotion creeping effect to intestinal tube in place.The Pericarpium Arecae promoting the circulation of QI to alleviate the stagnation in middle-JIAO is applicable to the diseases such as gastral cavity abdomen feeling of fullness, belch acid regurgitation, the stool of stagnation of QI in spleen and stomach be not well, helps altogether monarch drug with the Radix Aucklandiae, the Radix Linderae.Radix Codonopsis is gentle, gas in spleen reinforcing nourishing the stomach, the strong fortune, and spleen invigorating fortune is not and dry, and the taste spleen is cloudy and wet.Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI is given birth to especially strengthening its moist merit.The Shi Shoutang meaning: " medication is cured the disease, and opens and must help less to close, and closes and must help out less; Rise and to help less to fall, fall and to help less to rise.Or just helping into auxiliary merit, or using corrigent to be to be used as guide, and there is person like this in the road of negative and positive mutual reinforcement between." Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae just helping all qi-activating drugs to become auxiliary merit, residence is mended in letting out simultaneously, and tonification gas is cloudy in case dryization; Residence rises in falling, and rises spleen and transport in falling among the gastric qi, be that the negative and positive mutual reinforcement between is usefulness.Endothelium Corneum Gigeriae Galli is sweet puts down into the stomach warp, and invigorating the stomach and promoting digestion helps fortune, and grain millingization stagnates, and draws in the through stomach of all medicines to be guiding drug.All medicine compatibilities have method in the method, Fang Zhongyou side, and unimpeded taste mechanism of qi, the circulation of qi promoting relieving distension and oppression is given and altogether along the power of gastric qi.
The modern pharmacological research Cortex Magnoliae Officinalis can stimulate the sense of taste, reflexively causes the quickening of saliva, gastric secretion, gastrointestinal peristalsis.Fructus Aurantii Immaturus can make gastrointestinal shrink the rhythm and pace of moving things to be increased.Pericarpium Citri Reticulatae promotes the discharge of gastric secretion and gastrointestinal pneumatosis.The Radix Aucklandiae can make enterokinesia increase, and myenteron contraction frequency and amplitude all increase.The Radix Linderae has dual regulation to gastrointestinal smooth muscle, the secretion of energy facilitating digestion liquid.Radix Linderae water decoction obviously increases In The Rabbit Stomach electricity amplitude, and contraction of stomach strengthens.The excited gastrointestinal smooth muscle of Pericarpium Arecae energy, short digestive tract power, and the promotion fibrinolysis is arranged.Radix Codonopsis has regulating action to gastrointestinal motility, and the merit of anti-gastric mucosa injury is arranged.Activity has dual regulation to the Rhizoma Atractylodis Macrocephalae to gastrointestinal.Endothelium Corneum Gigeriae Galli can make the gastric motility function obviously strengthen, and gastric emptying rate is accelerated greatly.
It is a course for the treatment of that the present invention takes one month.In the Long-term clinical use procedure, cure rate is more than 85%, and total effective rate reaches 95%.The present invention obtains satisfied curative effect on clinical and the course of disease, and the effect of the gastrointestinal motility of adjustment is arranged again; Be pure Chinese medicinal preparation, without toxicity, for vast gastrointestinal motility disorder disease patient has brought Gospel.
The specific embodiment:
Embodiment 1:
Take off the Chinese crude drug of stating weight portion: Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the living Radix Aucklandiae 5 grams, the Radix Linderae 10 grams, Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 restrain, Endothelium Corneum Gigeriae Galli 15 grams.
All the medical materials decocting that adds 8 times of amounts boils 3 times, and each 3h merges decoction liquor, is concentrated into relative density 1-1.5(60 ℃) extractum, add starch, dextrin, the adjuvants such as magnesium stearate are made tablet according to the galenic pharmacy routine techniques.
Embodiment 2:
Take off the Chinese crude drug of stating weight portion: Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the living Radix Aucklandiae 5 grams, the Radix Linderae 10 grams, Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 restrain, Endothelium Corneum Gigeriae Galli 15 grams.
All medical materials decoct with water, and decocting boils 2 times, and each 2h merges decoction liquor, is concentrated into relative density 1-1.5(60 ℃) extractum, add starch, dextrin, the adjuvants such as magnesium stearate are made capsule according to the galenic pharmacy routine techniques.
Embodiment 3:
Take off the Chinese crude drug of stating weight portion: Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the living Radix Aucklandiae 5 grams, the Radix Linderae 10 grams, Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 restrain, Endothelium Corneum Gigeriae Galli 15 grams.
All medical materials decoct with water, and decocting boils 1 time, and each 1h merges decoction liquor, is concentrated into relative density 1-1.5(60 ℃) extractum, add sucrose, dextrin, the adjuvants such as magnesium stearate are according to the agent of galenic pharmacy routine techniques granulation.
Embodiment 4:
Take off the Chinese crude drug of stating weight portion: Cortex Magnoliae Officinalis 15 grams, Fructus Aurantii Immaturus 15 grams, Pericarpium Citri Reticulatae 15 grams, the living Radix Aucklandiae 5 grams, the Radix Linderae 10 grams, Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 restrain, Endothelium Corneum Gigeriae Galli 15 grams.
All medical materials decoct with water, and decocting boils 3 times, and each 2h merges decoction liquor, is concentrated into relative density 1-1.5(60 ℃) extractum, add the adjuvant such as sucrose and make oral solutions according to the galenic pharmacy routine techniques.
Embodiment 5:
Cortex Magnoliae Officinalis 9 grams, Fructus Aurantii Immaturus 9 grams, Pericarpium Citri Reticulatae 9 grams, the living Radix Aucklandiae 3 grams, the Radix Linderae 5 grams, Pericarpium Arecae 9 grams, Radix Codonopsis 9 grams, Rhizoma Atractylodis Macrocephalae 9 restrain, Endothelium Corneum Gigeriae Galli 9 grams.
Preparation method:
The first step with the Chinese crude drug of above-mentioned weight portion, different is divided into the first and second 2 groups according to the ester dissolubility of its composition with water miscible;
Second step is ground into respectively coarse powder with first and second liang of group Chinese medicines;
The 3rd step placed percolation vat to get the ethanol percolate of first medicated powder by the contained percolation diafiltration of Chinese Pharmacopoeia appendix with ethanol first medicine coarse powder, and recovered alcohol becomes thick paste;
The 4th step, the pure water that second medicine coarse powder is by volume added ten times of amounts, boiling keeps seething with excitement filtered in 30 minutes, added the pure water of 5 times of amounts in medicinal residues again, boiling keeps seething with excitement filtered in 15 minutes, merged under reduced pressure to control the thick paste that temperature is condensed into twice filtrate adding;
The 5th step added the thick paste that first medicine group recovered alcohol becomes with second medicine thick paste, made into 1 gram Chinese medicine/milliliter and get final product.Be used for making oral liquid, granulated quickly dissolving.
Embodiment 6:
Cortex Magnoliae Officinalis 20 grams, Fructus Aurantii Immaturus 20 grams, Pericarpium Citri Reticulatae 25 grams, the living Radix Aucklandiae 10 grams, the Radix Linderae 15 grams, Pericarpium Arecae 25 grams, Radix Codonopsis 30 grams, Rhizoma Atractylodis Macrocephalae 20 restrain, Endothelium Corneum Gigeriae Galli 30 grams.
Preparation method:
The first step with the Chinese crude drug of above-mentioned weight portion, different is divided into the first and second 2 groups according to the ester dissolubility of its composition with water miscible;
Second step is ground into respectively coarse powder with first and second liang of group Chinese medicines;
The 3rd step placed percolation vat to get the ethanol percolate of first medicated powder by the contained percolation diafiltration of Chinese Pharmacopoeia appendix with ethanol first medicine coarse powder, and recovered alcohol becomes thick paste;
The 4th step, the pure water that second medicine coarse powder is by volume added ten times of amounts, boiling keeps seething with excitement filtered in 30 minutes, added the pure water of 5 times of amounts in medicinal residues again, boiling keeps seething with excitement filtered in 15 minutes, merged under reduced pressure to control the thick paste that temperature is condensed into twice filtrate adding;
The 5th step added the thick paste that first medicine group recovered alcohol becomes with second medicine thick paste, made into 1 gram Chinese medicine/milliliter and get final product.Be used for making oral liquid, granulated quickly dissolving.
Claims (9)
1. Chinese medicine preparation for the treatment of gastrointestinal motility disorders is prepared from by the raw material of Chinese medicine medicine of following weight proportion:
Cortex Magnoliae Officinalis 9-20 grams, Fructus Aurantii Immaturus 9-20 grams, Pericarpium Citri Reticulatae 9-25 restrain, the living Radix Aucklandiae 3-10 restrains,
The Radix Linderae 5-15 grams, Pericarpium Arecae 9-25 grams, Radix Codonopsis 9-30 restrain, Rhizoma Atractylodis Macrocephalae 9-20 restrains,
Endothelium Corneum Gigeriae Galli 9-30 grams.
2. according to claim 1 Chinese medicine preparation is prepared from by the raw material of Chinese medicine medicine of following weight proportion:
Cortex Magnoliae Officinalis 15 restrains, Fructus Aurantii Immaturus 15 restrains, Pericarpium Citri Reticulatae 15 restrains, gives birth to the Radix Aucklandiae 5 grams, the Radix Linderae 10 restrains,
Pericarpium Arecae 15 grams, Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams.
3. according to claim 1 Chinese medicine preparation is any pharmaceutically useful dosage form.
4. according to claim 1 Chinese medicine preparation, dosage form comprises: tablet, capsule, granule, pill, powder, unguentum, sublimed preparation, powder, solution, injection, suppository, spray, drop, patch.
5. the preparation method of the Chinese medicine preparation of claim 1 is by raw material of Chinese medicine being processed through extraction or other modes, being made pharmaceutically active substance, subsequently, take this material as raw material, add the medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.
6. according to claim 5 preparation method, described active substance can obtain by extracting respectively raw material of Chinese medicine, also can obtain by common extraction raw material of Chinese medicine, also can obtain by other means, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water extraction, alcohol extraction, ester are carried, the methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be fluid extract, make different concentration according to the different needs decisions of preparation.
7. according to claim 5 preparation method, step is as follows: all medical materials decoct with water, and obtain decoction liquor, are condensed into extractum, obtain pharmaceutically active substance, add adjuvant and make pharmaceutical preparation according to the galenic pharmacy routine techniques.
8. according to claim 5 preparation method, step is as follows: all medical materials add the decocting that 2-10 doubly measures and boil each 1-3h, merging decoction liquor 1-3 time, be concentrated into relative density 1-1.5(60 ℃) extractum, add adjuvant and make pharmaceutical preparation according to the galenic pharmacy routine techniques.
9. according to claim 5 preparation method, step is as follows:
The first step with the Chinese crude drug of above-mentioned weight portion, different is divided into the first and second 2 groups according to the ester dissolubility of its composition with water miscible;
Second step is ground into respectively coarse powder with first and second liang of group Chinese medicines;
The 3rd step placed percolation vat to get the ethanol percolate of first medicated powder by the contained percolation diafiltration of Chinese Pharmacopoeia appendix with ethanol first medicine coarse powder, and recovered alcohol becomes thick paste;
The 4th goes on foot, and second medicine coarse powder is by volume added the pure water of 10 times of amounts, boiling to keep boiling to filter in 30 minutes, filtrate for later use, the pure water that in medicinal residues, adds again 5 times of amounts, boiling keeps seething with excitement filtered in 15 minutes, merged under reduced pressure to control the thick paste that temperature is condensed into twice filtrate adding;
The 5th step added the thick paste that first medicine group recovered alcohol becomes with second medicine thick paste, made into 1 gram Chinese medicine/milliliter and get final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105521190A (en) * | 2014-11-10 | 2016-04-27 | 李锦梁 | Traditional Chinese medicine for treating torpid stomach intake |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030194451A1 (en) * | 2002-04-12 | 2003-10-16 | Pangenomics Co., Ltd. | Crude drug composition for preventing and treating gastrointestinal dyskinetic diseases |
| CN1473590A (en) * | 2003-04-01 | 2004-02-11 | 贵州太和制药有限公司 | Chinese medicinal preparation for treating stomach swelling pain caused by splenic-gastric Qi stagnation and its preparing method |
| CN102018845A (en) * | 2010-11-24 | 2011-04-20 | 荣成市新技术应用研究所 | Chinese medicinal composition for treating abdominal pain |
| WO2012091440A2 (en) * | 2010-12-30 | 2012-07-05 | Lg Life Sciences Ltd. | Composition for improvement, treatment and prevention of gastrointestinal motility disorders |
| CN102600281A (en) * | 2012-03-31 | 2012-07-25 | 江西省中医药研究院 | Traditional Chinese medicine composition for promoting digestion as well as preparation method and use |
-
2013
- 2013-01-17 CN CN201310017627.3A patent/CN103071010B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030194451A1 (en) * | 2002-04-12 | 2003-10-16 | Pangenomics Co., Ltd. | Crude drug composition for preventing and treating gastrointestinal dyskinetic diseases |
| CN1473590A (en) * | 2003-04-01 | 2004-02-11 | 贵州太和制药有限公司 | Chinese medicinal preparation for treating stomach swelling pain caused by splenic-gastric Qi stagnation and its preparing method |
| CN102018845A (en) * | 2010-11-24 | 2011-04-20 | 荣成市新技术应用研究所 | Chinese medicinal composition for treating abdominal pain |
| WO2012091440A2 (en) * | 2010-12-30 | 2012-07-05 | Lg Life Sciences Ltd. | Composition for improvement, treatment and prevention of gastrointestinal motility disorders |
| CN102600281A (en) * | 2012-03-31 | 2012-07-25 | 江西省中医药研究院 | Traditional Chinese medicine composition for promoting digestion as well as preparation method and use |
Non-Patent Citations (2)
| Title |
|---|
| 刘书芝等: "宽肠行气汤治疗肝脾曲综合征175例", 《辽宁中医杂志》 * |
| 欧阳钦等: "《消化病诊疗手册》", 31 October 2000, 人民卫生出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105521190A (en) * | 2014-11-10 | 2016-04-27 | 李锦梁 | Traditional Chinese medicine for treating torpid stomach intake |
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