CN103055169B

CN103055169B - External use plaster for treating hypertensive disease

Info

Publication number: CN103055169B
Application number: CN201310006421.0A
Authority: CN
Inventors: 汪世龙
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-02-27
Filing date: 2013-01-08
Publication date: 2014-09-17
Anticipated expiration: 2033-01-08
Also published as: CN103055169A; CN102552712A

Abstract

The invention provides an external use plaster for treating the hypertensive disease. The main components of the plaster comprise Fructus Evodiae, Salvia miltiorrhiza, Gambir Plant, Stephania terandra, wild chrysanthemum flower, Ligusticum wallichii, Rhizoma Cibotii, Radix Polygalae, borneol and the like, so the plaster has the efficacies of liver and kidney benefiting, liver calming, yang tranquilizing, dizziness calming and tranquillizing. The plaster is different from previous schemes for simply treating the hypertensive disease, is adopted through an acupoint plastering method, and has the advantages of multilevel and multi-targeting, prevention and treatment combination, simultaneous treatment of principal and subordinate symptoms, unique treatment method, and curative effect reliability.

Description

A kind of external plaster of Hypertension

Technical field

The present invention relates to a kind of external plaster of Hypertension.

Background technology

Hypertension be a kind of by factor reciprocal actions such as polygenic inheritance and environment, emotions, produced take the systemic disease that arteriotony rising is feature, be a kind of take body fluid circulation, arteriotony raises is main syndrome.

Hyperpietic is generally overweight people, middle-aged and elderly people and suffers from the people of diabetes hyperlipidemia, nephropathy, excessive drinking, the many people of smoking also easily suffer from hypertension, as suffer from hypertension and ignore, will fall sick from overwork and go from bad to worse, apoplexy to be occurred, arteriosclerosis, coronary heart disease, renal failure, hemiplegia, waist cervical spondylosis are treated again, the one, treatment time, long cost was many, and the 2nd, missed the good opportunity of early recovery.

Antihypertensive drug therapy has (1) diuretic hypotensive agent: hydrochlorothiazide, cyclopenthiazide, furosemide etc.; (2) nervus centralis and sympathetic inhibitor: reserpine, verticil, clonidine hydrochloride; (3) adrenergic receptor blocker: beta-blocker is as propranolol and metoprolol etc.; Alpha blocker is felt at ease as willow ammonia benzyl as Phenoxybenzamine, alpha+beta blocker; (4) enzyme inhibitor is if angiotensin converting enzyme inhibitor is as captopril, enalapril etc.; (5) calcium ion antagonist is if nifedipine, amlodipine etc. (6) vasodilation is as hydralazine, Minoxidil, prazosin, the pyridine of croak cyanogen etc.But western medicine exists, and side effect is large, expense is high, treat the shortcomings such as thorough, easy recurrence.

Summary of the invention

The object of the invention is for the deficiencies in the prior art, a kind of external plaster of Hypertension is provided, this unguentum curative effect is high, and expense is low, easy to use simple and direct, has no side effect, and does not recur after more.

The external plaster of Hypertension of the present invention consists of by weight following bulk drugs:

90～120 parts of Fructus Evodiaes, 80～100 parts of Radix Salviae Miltiorrhizaes, 30～50 parts of Rhizoma Chuanxiongs, 40～60 parts of Ramulus Uncariae Cum Uncis, 30～50 parts of Radix Stephaniae Tetrandrae, 40～60 parts of the Radixs Angelicae Dahuricae, 30～50 parts of Cortex Cinnamomis, 40～60 parts of Flos Chrysanthemi Indicis, 100～130 parts of the Cortexs Eucommiae, 30～50 parts, Rhizoma Gastrodiae, 80～100 parts of Rhizoma Cibotii, 30～50 parts of Radix Polygalaes, 40～60 parts of Semen Ziziphi Spinosaes, 20～40 parts of Borneolum Syntheticums, 10～20 parts of laurocaprams, 150～250 parts of refined honeys, 100～250 parts of lanolines, 70～150 parts of propylene glycol.

The preparation method of this plaster is: Fructus Evodiae, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis, Radix Stephaniae Tetrandrae, the Radix Angelicae Dahuricae, Cortex Cinnamomi, Flos Chrysanthemi Indici, Rhizoma Gastrodiae, Radix Polygalae, Semen Ziziphi Spinosae, Borneolum Syntheticum powder is broken into fine powder (crossing 100 mesh sieves), mixes, and standby; Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Rhizoma Cibotii add the decocting of 8 times of amounts to boil 2 hours, filter, and medicinal residues add 6 times of water gagings to decoct 1.5 hours, filter, and merging filtrate, is concentrated into relative density 1.20～1.25(60 ℃) clear paste; After refined honey, lanoline, propylene glycol heating and melting, constantly stir, add laurocapram to continue stirring and evenly mixing, when temperature is down to 45～55 ℃, add above-mentioned clear paste to stir, mix; Add above-mentioned fine powder, stir, mix, cream core processed, and be placed in sticker, obtain.

To the treatment of hypertension, not to fall that The faster the better, but a long-term arteriovenous adjustment for the treatment of process to whole body, its starting point does not lie in merely and reduces blood pressure, and focuses on reconditioner yin-yang and remove the immanent cause that development occurs hypertension.Treatment in recent years facts have proved, Chinese hypotensor plaster Hypertension, truly have blood pressure lowering, improve the effect of heart and brain blood flow imbalance between supply and demand, that hypertension and meridians internal organs are regulated comprehensively, by blood circulation promoting and blood stasis dispelling, make the blood vessel of whole body recover elasticity, thereby can obviously improve symptom, promote the rehabilitation that cardiovascular and cerebrovascular vessel pathology changes.Chinese hypotensor plaster is to adjust the desirable medicine of human body, person in middle and old age's defying age, arteriosclerosis, control cerebrovascular, diabetes, a kind of good selection of cervical and lumbar diseases, hyperpietic uses Chinese hypotensor plaster after 2-3 the course for the treatment of (be 20 days 1 course for the treatment of), effective active molecule in medicine enters blood, through diseased region, in steady blood pressure lowering process, take nourishing liver and kidney as main, repair each impaired histoorgan of human body, progressively control hypertensive pathogenesis, mediator's somatic nervous system, blood circulation promoting, steadily in blood pressure lowering, playing coordination and Comprehensive Treatment function, fundamentally thoroughly reverse hypertension incidence mechanism, to start with from hypertensive morbidity root, play blood pressure lowering and recover the multi-efficiencies such as the impaired function normalization of human body and whole medical treatment complication.

The present invention is according to theory of Chinese medical science and theory of channels and collaterals, use method dialectical and that differential diagnosis of diseases combines, through years of researches and practice, choose the Chinese medicine of the effect of blood pressure lowering, " Shenque " cave (being Qizhong) and the Yongquan acupoint of applying ointment or plaster and leading to through hundred pulse-phases all, reach " YIN and YANG in a relative equilibrium " with YIN and YANG balance regulating.Meanwhile, by the effect of passages through which vital energy circulates, make medicine until ill position reaches the object of preventing and treating HCD.The present invention not only can thoroughly effect a radical cure hypertension, and can across-the-board regulation each organ of human body, particularly better to the heart, brain, kidney curative effect.

The present invention adopts root, stem, leaf flower, fruit, the seed of Chinese herbal medicine, through cleaning, and the techniques such as oven dry, under defined terms, by Chinese medicine preparation technology, Chinese herbal medicine be ground into respectively to fine powder and be extracted into extractum, by proportioning blending, mixing and form, this emplastrum, easy to use, blood pressure lowering in proper order, stable curative effect, thorough treatment, without any side effects, be mainly used in treating the concomitant diseases such as hypertension and hyperlipidemia, coronary heart disease.

Feature of the present invention

1, tcm characteristic, Yin Yang balancing, treating both the principal and secondary aspects of a disease.It breaks through traditional treatment limitation, and this medicine, in the hypertensive while for the treatment of, can suppress the pathological changes of the important internal organs such as the heart, brain, kidney to greatest extent, whole adjustment; Nourishing liver and kidney YANG hyperactivity suppressing, what break traditions is blood pressure lowering blood pressure lowering, it can adjust the imbalance of each internal organs, excess in the upper and deficiency in the lower and the wind-fire expectorant stasis of blood due to yin and yang imbalance; All medicines and closing, the therapy of breaking the normal procedure, it is with multi-medicament, improves for blood circulation, the blood pressure of regulation and control imbalance, corrects equilibrium between yin and yang, removes smooth muscle spasm, makes the reverse conversion of blood pressure; Clear stasis of blood blowdown, can reduce blood fat and blood viscosity, removes rapidly the noxious substance in blood, reduces vascular resistance, recovers blood vessel elasticity, alleviates cardiac pressure (as the headache causing thus, dizziness, insomnia, cardio palmus).

2, technical breakthrough, the present invention adopts unique infiltration technology, directly imposes on affected part, Transdermal absorption, multi-level, many target position dispenser, medicine directly infiltrates focus deep skin tissue; Avoid loss and the poisoning to human viscera organ of medication amount.

3, product is through a large amount of clinical verifications, and it is to epiderm skin tissue, subcutaneous tissue not damaged, and nonirritant, has no side effect.Sum up the hypertension plaster therapy that clinical experience for many years and gains in depth of comprehension are created out simple and direct practicability and effectiveness, steadily blood pressure lowering.When medicine takes to a certain extent, the slow slow release of drug effect, human body self Adjust System blood pressure mechanism starts progressively normalization, until basic rehabilitation permanent stable; Thoroughly radical cure, does not need Long-term taking medicine, and Gene regulation and the bioactive molecule in plant in medicine enter after human body, activate and regulate disorderly hormonal system, make it be tending towards normal secretion.Use 3～4 courses for the treatment of, body function rehabilitation, blood pressure all can reach normally, and is consolidated, and does not rebound, in health status.

Be below to adopt strapping treatment hypertension 36 examples, therapeutic outcome report is as follows:

1. clinical data

1.1 physical data: accept altogether hyperpietic's 36 examples for medical treatment, male 20 examples, female's 16 examples.The oldest 65 years old, minimum 35 years old.The course of disease is the longest 10 years, the shortest 2 months.

Under the non-rest state on the same day of 1.2 diagnostic criterias, systolic pressure >=140mmHg, diastolic pressure >=90mmHg, can be diagnosed as hypertension.According to hypertension level, divide 1,2,3 grade in Table 1.

Table 1

2. Therapeutic Method

External sticks, and is directly affixed on SHENQUE acupoint, Yongquan acupoint, and within 2 days, change one and paste, within 20 days, be a course for the treatment of.Use the 2-3 course for the treatment of.

3. observation of curative effect

3.1 criterions of therapeutical effect are effective: diastolic pressure decline >=10mmHg, and be down to normal or more than decline >=20mmHg.Effective: though diastolic pressure declines, not reach 10mmHg, be down to normal or decline 10-19mmHg, systole hypertension systolic pressure decline >=30mmHg.Invalid: blood pressure drops does not reach above-mentioned standard.

3.2 therapeutic outcomes: compare curative effect after treating two courses for the treatment of, the results are shown in Table 2

Table 2 treatment hypertension Comparison of therapeutic (example/%)

This law is treated two courses for the treatment of of 36 routine patients with hypertension, result obvious effective rate 61.1%, and effective percentage is 30.6%, total effective rate is 91.7%.

4. discuss

This plaster treatment hypertension effective percentage 91.7%, curative effect is sure, easy to use, and clinic is promoted the use of.

Effect of the present invention

Compare with conventional depressor, the unique distinction of Chinese hypotensor plaster shows: the one, in line with starting with from hypertensive morbidity root, for the conversion of complication, develop, with numerous medicines, human body is regulated comprehensively, from brain-benefiting blood pressure-reducing, to blood circulation promoting and blood stasis dispelling, nourishing liver and kidney.The 2nd, in line with the vigor that strengthens cell, thrombus, removes endovascular alluvial rapidly, makes the blood vessel of sclerosis recover elasticity.The 3rd, in line with many medicines and closing, when reducing blood fat and blood viscosity, can effectively remove harmful substance unnecessary in blood vessel, fundamentally reverse hypertensive pathogenesis, finally reach the object of rehabilitation.The hypertensive cause of disease is comparatively complicated, should take deficiency and excess as guiding principle, different cause of disease diseases, establishes corresponding treatment rule in the hypertensive process of whole treatment, necessary regulating YIN and YANG, nourishing liver and kidney, purging liver-fire, suppressing the hyperactive liver to relieve the wind syndrome, blood circulation promoting and blood stasis dispelling, this is the hypertensive effective way for the treatment of, and in numerous medicines, various medicines play effect separately in vivo, depend merely on certain Drug therapy or the treatment of a few herbal medicine, effect is so not desirable.Medication, as used military forces, must be regarded an organic whole as human body, reverses its pathomechanism, prevents the generation of complication, thereby steps into basic treatment, integral rehabilitation, the optimal treatment boundary for the treatment of both the principal and secondary aspects of a disease.

Accompanying drawing explanation

Fig. 1 is the production technological process of plaster.

The specific embodiment

Embodiment 1 presses column weight amount weighting raw materials (unit: g)

Fructus Evodiae 95g, Radix Salviae Miltiorrhizae 85g, Rhizoma Chuanxiong 40g, Ramulus Uncariae Cum Uncis 50g, Radix Stephaniae Tetrandrae 45g, Radix Angelicae Dahuricae 50g, Cortex Cinnamomi 40g, Flos Chrysanthemi Indici 55g, Cortex Eucommiae 110g, Rhizoma Gastrodiae 45g, Rhizoma Cibotii 90g, Radix Polygalae 40g, Semen Ziziphi Spinosae 40g, Borneolum Syntheticum 25g, laurocapram 15g, refined honey 220g, lanoline 120g, propylene glycol 80g.

Embodiment 2 presses column weight amount weighting raw materials (unit: g)

Fructus Evodiae 100g, Radix Salviae Miltiorrhizae 90g, Rhizoma Chuanxiong 35g, Ramulus Uncariae Cum Uncis 45g, Radix Stephaniae Tetrandrae 50g, Radix Angelicae Dahuricae 45g, Cortex Cinnamomi 35g, Flos Chrysanthemi Indici 50g, Cortex Eucommiae 100g, Rhizoma Gastrodiae 35g, Rhizoma Cibotii 85g, Radix Polygalae 35g, Semen Ziziphi Spinosae 55g, Borneolum Syntheticum 30g, laurocapram 15g, refined honey 220g, lanoline 120g, propylene glycol 80g.

Embodiment 3 presses column weight amount weighting raw materials (unit: g)

Fructus Evodiae 105g, Radix Salviae Miltiorrhizae 95g, Rhizoma Chuanxiong 55g, Ramulus Uncariae Cum Uncis 40g, Radix Stephaniae Tetrandrae 35g, Radix Angelicae Dahuricae 45g, Cortex Cinnamomi 35g, Flos Chrysanthemi Indici 45g, Cortex Eucommiae 105g, Rhizoma Gastrodiae 35g, Rhizoma Cibotii 95g, Radix Polygalae 45g, Semen Ziziphi Spinosae 50g, Borneolum Syntheticum 35g, laurocapram 15g, refined honey 220g, lanoline 120g, propylene glycol 80g.

The preparation method of above embodiment is:

In writing out a prescription, each taste Chinese crude drug is according to the clean system of regulation under Chinese Pharmacopoeia and this kind item of drug standard, the preparation method of plaster is: Fructus Evodiae, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis, Radix Stephaniae Tetrandrae, the Radix Angelicae Dahuricae, Cortex Cinnamomi, Flos Chrysanthemi Indici, Rhizoma Gastrodiae, Radix Polygalae, Semen Ziziphi Spinosae, Borneolum Syntheticum powder are broken into fine powder (crossing 100 mesh sieves), mix, standby; Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Rhizoma Cibotii add the decocting of 8 times of amounts to boil 2 hours, filter, and medicinal residues add 6 times of water gagings to decoct 1.5 hours, filter, and merging filtrate, is concentrated into relative density 1.20～1.25(60 ℃) clear paste; After refined honey, lanoline, propylene glycol heating and melting, constantly stir, add laurocapram to continue stirring and evenly mixing, when temperature is down to 45～55 ℃, add above-mentioned clear paste to stir, mix; Add above-mentioned fine powder, stir, mix, cream core processed, and be placed in sticker, obtain.

Using method: external sticks, is directly affixed on SHENQUE acupoint, Yongquan acupoint, and within 2 days, change one and paste, within 20 days, be a life cycle.

Points for attention: 1, anemia of pregnant woman, skin injury place forbidding.2, skin allergy person is cautious use of.

Claims

1. an external plaster for Hypertension, is characterized in that being made by weight by following bulk drugs: 90～120 parts of Fructus Evodiaes, 80～100 parts of Radix Salviae Miltiorrhizaes, 30～50 parts of Rhizoma Chuanxiongs, 40～60 parts of Ramulus Uncariae Cum Uncis, 30～50 parts of Radix Stephaniae Tetrandrae, 40～60 parts of the Radixs Angelicae Dahuricae, 30～50 parts of Cortex Cinnamomis, 40～60 parts of Flos Chrysanthemi Indicis, 100～130 parts of the Cortexs Eucommiae, 30～50 parts, Rhizoma Gastrodiae, 80～100 parts of Rhizoma Cibotii, 30～50 parts of Radix Polygalaes, 40～60 parts of Semen Ziziphi Spinosaes, 20～40 parts of Borneolum Syntheticums, 10～20 parts of laurocaprams, 150～250 parts of refined honeys, 100～250 parts of lanolines, 70～150 parts of propylene glycol;

The preparation method of above-mentioned plaster is: Fructus Evodiae, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis, Radix Stephaniae Tetrandrae, the Radix Angelicae Dahuricae, Cortex Cinnamomi, Flos Chrysanthemi Indici, Rhizoma Gastrodiae, Radix Polygalae, Semen Ziziphi Spinosae, Borneolum Syntheticum powder is broken into fine powder, crosses 100 mesh sieves, mix, and standby; Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Rhizoma Cibotii add the decocting of 8 times of amounts to boil 2 hours, filter, and medicinal residues add 6 times of water gagings to decoct 1.5 hours, filter, and merging filtrate, is concentrated into the clear paste that 60 ℃ of relative densities are 1.20～1.25; After refined honey, lanoline, propylene glycol heating and melting, constantly stir, add laurocapram to continue stirring and evenly mixing, when temperature is down to 45～55 ℃, add above-mentioned clear paste to stir, mix; Add above-mentioned fine powder, stir, mix, cream core processed, and be placed in sticker, obtain.