Background technology
Herba Dendrobii contains the materials such as polysaccharide, alkaloid, aminoacid, and the trace element such as calcic, potassium, sodium, magnesium, zinc, ferrum, manganese, selenium, copper, chromium, nickel.Through Chinese Medicine institute polyoses content that medicinal plants is identified be 38.974%, total alkaloids is 0.03%, can improve the human body immunity, and the organ diseases such as human body eye, pharynx, lung, stomach, intestinal, kidney are had special efficacy.Be used as medicine with it, blood sugar lowering arranged, suppress cardiovascular disease, enhancing human body immunity power and anticancer usefulness; With for tea, can cleaning throat and moistening larynx, sore throat relieving makes eye bright, expelling summer-heat QI invigorating, nourishing the stomach heat clearing away, because its effect is peculiar, market is rare, have the title of " Chinese Herba mesonae chinensis ", " Herba Hylothelephii Verticillati ".
Fructus Mori contains glucose, tannin, succinic acid, cyanidin, calcareous, inorganic salt, vitamin (A, B, C), malic acid, succinic acid, tartaric acid, pigment etc.The blue or green Fructus Mori of immaturity contains cyanic acid, carotene, adenine, choline, Isoquercitrin, trigonelline, ergosterol, vitamin B1, sugar, tannin.Nature and flavor: sweet; Acid; Cold in nature.Gui Jing: liver; Kidney channel, heart channel.Function cures mainly: nourishing YIN and benefiting blood; Promote the production of body fluid; Intestine moistening.Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; The dryness of the intestine constipation.
Contain polysaccharide, ucleosides, furan derivative, steroid ferment class, alkaloids, protein, polypeptide, amino acids, triterpenes, sesquiterpene, organic germanium, inorganic salt etc. in the sporophore of Ganoderma, mycelium and the spore.Ganoderan is one of main effective ingredient of Ganoderma, has antitumor, immunomodulating, blood sugar lowering, antioxidation, blood fat reducing and anti-aging effects.Not lower over one hundred kind of the contained triterpenes of Ganoderma, wherein take tetracyclic triterpenes as main, the bitterness of Ganoderma is relevant with contained triterpenes.Triterpenes also is one of effective ingredient of Ganoderma, and human liver cancer cell is had cytotoxicity, also can suppress the release of histamine, has hepatoprotective effect and has anti-allergic effects etc.
Herba Cistanches contains the compositions such as abundant alkaloid, crystalline neutral substance, aminoacid, trace element, vitamin.Energy kidney-replenishing, benefiting essence-blood can suppress the appearance of " yang deficiency " symptom, prevent from losing weight.Can effectively prevent, treat the diseases such as male dificiency of kidney sexual impotence, seminal emission premature ejaculation and woman's menoxenia, amenorrhea be infertile.Have nourishing the blood and yin, benefiting QI for activating blood circulation, clear tonifying five ZANG-organs, Yin Yang balancing, QI and blood happy, improve the effect such as body physiological function.
It is mutually auxiliary that Chinese medicine is particular about the monarch and his subjects, reasonable compatibility, drug effect is complementary, so the curative effect of single use a herb is relatively poor, this compatibility have nourishing the blood and yin, benefiting QI for activating blood circulation, clear tonifying five ZANG-organs, Yin Yang balancing, QI and blood happy, improve the effect such as body physiological function; Chinese medicine is particular about whole onset simultaneously, effective ingredient in a herb is wanted combined effect, so guarantee that all effective ingredient can both stripping, because single extracting method and mode are difficult to all effectively strippings of all the components, thus single extracting method and mode to the poor effect of utilizing of Chinese medicine, this extraction process adopts two stage extracting modes, extract respectively water soluble ingredient and Alcohol soluble composition, be condensed into cream after remerging, active ingredient is comprehensive, instant.
For under the condition of not destroying active ingredient, extract to greatest extent effective ingredient whole in the medicine, this extraction process is extracted Alcohol soluble composition and water soluble ingredient in two stages, first in the phase I, utilize 85% edible ethanol and continuous circumfluence extraction device effectively to extract Alcohol soluble composition, ethanol-soluble extractives is separated with residue, and effectively improved the permeability of crude drug cell, increase intercellular substance, be beneficial to the extraction of second stage water soluble ingredient.Second stage adds deionized water, behind the crush and grind pulping, extracts water soluble ingredient under boiled water temperature and normal pressure in grinder, has kept as much as possible its original active ingredient and structure.
Retrieval contrasts as can be known: the compound Chinese medicinal preparation that contains the Herba Dendrobii raw material of present domestic research and development, its medicament composing prescription, dosage form and preparation technology are different, the compound recipe that patent application of the present invention relates to suddenly the prescription of dry measure used in former times Rong sesame extractum and production technology at home there are no bibliographical information, and relate to the compound preparation patent of Herba Dendrobii: application CN 102266491 A, in " a kind of prescription of compound dendrobium huoshanense extract and production technology ", the method adopt High Temperature High Pressure and long-time (temperature: 115 ℃--120 ℃, pressure: 0.15MPa-0. 2Mpa, time: method 15-18h) is extracted the water miscible composition of Herba Dendrobii and other compatibility medical material, this certainly will cause loss and the structural change of effective ingredient, and the inventor does not do any analysis and explanation to this predictable consequence.
Summary of the invention
One of technical problem to be solved by this invention is to provide a kind of fill a hole in the market, realize to valuable ingredient of Chinese medicine rational exploitation and utilization, improve Herba Dendrobii, Fructus Mori, Herba Cistanches and Ganoderma utilization ratio, make compound recipe that the effect of Herba Dendrobii is significantly improved suddenly dry measure used in former times Rong sesame extractum and production technology thereof.
The scheme that the present invention solves the problems of the technologies described above:
A kind of compound recipe is dry measure used in former times Rong sesame extractum suddenly, and the part by weight of each raw material is in its prescription: Herba Dendrobii 20-30%, Fructus Mori 50-60%, Herba Cistanches 10-20%, Ganoderma 10-20%.
Preferably, compound recipe suddenly in the prescription of dry measure used in former times Rong sesame extractum the part by weight of each raw material be: Herba Dendrobii 30%, Fructus Mori 50%, Herba Cistanches 10%, Ganoderma 10%.
Compound recipe suddenly in the prescription of dry measure used in former times Rong sesame extractum the part by weight of each raw material be: Herba Dendrobii 20%, Fructus Mori 60%, Herba Cistanches 10%, Ganoderma 10%.
Compound recipe suddenly in the prescription of dry measure used in former times Rong sesame extractum the part by weight of each raw material be: Herba Dendrobii 20%, Fructus Mori 50%, Herba Cistanches 10%, Ganoderma 20%.
Compound recipe suddenly in the prescription of dry measure used in former times Rong sesame extractum the part by weight of each raw material be: Herba Dendrobii 20%, Fructus Mori 50%, Herba Cistanches 20%, Ganoderma 10%.
Compound recipe is the production technology of dry measure used in former times Rong sesame extractum suddenly, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, clean, spreading for cooling is pulverized, and crosses the 40-50 mesh sieve, and Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, the Ganoderma rear adding 10-15 that stirs doubly measures 85% edible ethanol, extract 5-6h in the continuous circumfluence extraction device, bath temperature is 98-100 ℃, and the negative pressure concentrated extracting solution is to the thick paste shape, Recycled ethanol keeps filtering residue;
(3) filtering residue in the step (2) adds the deionized water of 10-15 times of weight, in grinder behind the crush and grind pulping, carry 2 times boiling to carry boiling respectively in the device, duration is respectively 3-4h, 2-3h, boil the temperature and pressure of carrying and be respectively boiled water temperature and normal pressure, leach cooking liquid filters and merges, and negative pressure is concentrated into paste;
(4) extractum that step (2) and step (3) is obtained merges, more further negative pressure to be concentrated into density be 1.1x10
3-1.2x10
3Kg/m
3
(5) sterile packaged is in vial.
The condition that described negative pressure satisfies is :-0.07MPa--0.08Mpa.
Advantage of the present invention is:
1,, effectively development and use reasonable to this valuable ingredient of Chinese medicine of Herba Dendrobii have been realized;
2, efficiently solve the low problem of effective ingredient dissolution rate with techniques such as continuous backflow alcohol extraction and crush and grind water extractions, and guaranteed structure and the curative effect of crude drug effective ingredient;
3, the concentrated paste that forms of negative pressure by the sterile packaged technology, is contained in the vial, can take a morsel at any time, washes wet suit open and uses;
4, this invention has effectively been brought into play the efficacy effect of Herba Dendrobii, Fructus Mori, Herba Cistanches and Ganoderma by the compound recipe combination, and test shows that compound preparation is than the high several times of effect of unitary agent.
The specific embodiment
The invention will be further described below in conjunction with embodiment, can be implemented so that those skilled in the art can better understand the present invention also, but illustrated embodiment is not as a limitation of the invention.
Embodiment 1
A kind of compound recipe is dry measure used in former times Rong sesame extractum suddenly, and the part by weight of each raw material is in its prescription: Herba Dendrobii 30%, Fructus Mori 50%, Herba Cistanches 10%, Ganoderma 10%.
Compound recipe is the production technology of dry measure used in former times Rong sesame extractum suddenly, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, clean, spreading for cooling is pulverized, and crosses 40 mesh sieves, and Fructus Mori need not be pulverized;
(2) add 10 times after Herba Dendrobii, Fructus Mori, Herba Cistanches, the Ganoderma mixing and stirring and measure 85% edible ethanol, extract 6h in the continuous circumfluence extraction device, bath temperature is 100 ℃, and the negative pressure concentrated extracting solution is to the thick paste shape, and negative pressure is-0.07MPa; Recycled ethanol keeps filtering residue;
(3) filtering residue in the step (2) adds the deionized water of 10 times of weight, in grinder behind the crush and grind pulping, carry 2 times boiling to carry boiling respectively in the device, duration is respectively 4h, 3h boils the temperature and pressure of carrying and is respectively boiled water temperature and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.07MPa;
(4) extractum that step (2) and step (3) is obtained merges, more further negative pressure to be concentrated into density be 1.1x10
3Kg/m
3, negative pressure is-0.07MPa;
(5) sterile packaged is in vial.
Embodiment 2
A kind of compound recipe is dry measure used in former times Rong sesame extractum suddenly, and the part by weight of each raw material is in its prescription: Herba Dendrobii 20%, Fructus Mori 60%, Herba Cistanches 10%, Ganoderma 10%.
Compound recipe is the production technology of dry measure used in former times Rong sesame extractum suddenly, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, clean, spreading for cooling is pulverized, and crosses 45 mesh sieves, and Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, the Ganoderma edible ethanol of 12 times of rear addings amount 85% that stirs extracts 6h in the continuous circumfluence extraction device, and bath temperature is 100 ℃, the negative pressure concentrated extracting solution is to the thick paste shape, negative pressure is-0.075MPa that Recycled ethanol keeps filtering residue;
(3) filtering residue in the step (2) adds the deionized water of 12 times of weight, in grinder behind the crush and grind pulping, carry 2 times boiling to carry boiling respectively in the device, duration is respectively 4h, 3h boils the temperature and pressure of carrying and is respectively boiled water temperature and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.075MPa;
(4) extractum that step (2) and step (3) is obtained merges, more further negative pressure to be concentrated into density be 1.15x10
3Kg/m
3, negative pressure is-0.075MPa;
(5) sterile packaged is in vial.
Embodiment 3
A kind of compound recipe is dry measure used in former times Rong sesame extractum suddenly, and the part by weight of each raw material is in its prescription: Herba Dendrobii 20%, Fructus Mori 50%, Herba Cistanches 10%, Ganoderma 20%.
Compound recipe is the production technology of dry measure used in former times Rong sesame extractum suddenly, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, clean, spreading for cooling is pulverized, and crosses 50 mesh sieves, and Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, the Ganoderma edible ethanol of 15 times of rear addings amount 85% that stirs extracts 5h in the continuous circumfluence extraction device, and bath temperature is 98 ℃, the negative pressure concentrated extracting solution is to the thick paste shape, negative pressure is-0.08MPa that Recycled ethanol keeps filtering residue;
(3) filtering residue in the step (2) adds the deionized water of 15 times of weight, in grinder behind the crush and grind pulping, carry 2 times boiling to carry boiling respectively in the device, duration is respectively 4h, 3h boils the temperature and pressure of carrying and is respectively boiled water temperature and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.08MPa;
(4) extractum that step (2) and step (3) is obtained merges, more further negative pressure to be concentrated into density be 1.2x10
3Kg/m
3, negative pressure is-0.08MPa;
(5) sterile packaged is in vial.
Embodiment 4
A kind of compound recipe is dry measure used in former times Rong sesame extractum suddenly, and the part by weight of each raw material is in its prescription: Herba Dendrobii 20%, Fructus Mori 50%, Herba Cistanches 20%, Ganoderma 10%.
Compound recipe is the production technology of dry measure used in former times Rong sesame extractum suddenly, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, clean, spreading for cooling is pulverized, and crosses 45 mesh sieves, and Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, the Ganoderma edible ethanol of 12 times of rear addings amount 85% that stirs extracts 6h in the continuous circumfluence extraction device, and bath temperature is 98 ℃, the negative pressure concentrated extracting solution is to the thick paste shape, negative pressure is-0.07MPa that Recycled ethanol keeps filtering residue;
(3) filtering residue in the step (2) adds the deionized water of 15 times of weight, in grinder behind the crush and grind pulping, carry 2 times boiling to carry boiling respectively in the device, duration is respectively 3h, 2h boils the temperature and pressure of carrying and is respectively boiled water temperature and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.07MPa;
(4) extractum that step (2) and step (3) is obtained merges, more further negative pressure to be concentrated into density be 1.1x10
3Kg/m
3, negative pressure is-0.07MPa;
(5) sterile packaged is in vial.
Embodiment 5
A kind of compound recipe is dry measure used in former times Rong sesame extractum suddenly, and the part by weight of each raw material is in its prescription: Herba Dendrobii 20%, Fols Rehmanniae 20%, Fructus Trichosanthis leaf 15%, leaf of Caulis Sacchari sinensis 15%, Herba Cistanches 20%, Ganoderma 10%.
Compound recipe is the production technology of dry measure used in former times Rong sesame extractum suddenly, comprises the steps:
(1) get Herba Dendrobii, Fols Rehmanniae, Fructus Trichosanthis leaf, leaf of Caulis Sacchari sinensis, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, clean, spreading for cooling is pulverized, and crosses 45 mesh sieves;
(2) Herba Dendrobii, Fols Rehmanniae, Fructus Trichosanthis leaf, leaf of Caulis Sacchari sinensis, Herba Cistanches, the Ganoderma edible ethanol of 12 times of rear addings amount 85% that stirs, in the continuous circumfluence extraction device, extract 6h, bath temperature is 98 ℃, the negative pressure concentrated extracting solution is to the thick paste shape, negative pressure is-0.07MPa, Recycled ethanol keeps filtering residue;
(3) filtering residue in the step (2) adds the deionized water of 15 times of weight, in grinder behind the crush and grind pulping, carry 2 times boiling to carry boiling respectively in the device, duration is respectively 3h, 2h boils the temperature and pressure of carrying and is respectively boiled water temperature and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.07MPa;
(4) extractum that step (2) and step (3) is obtained merges, more further negative pressure to be concentrated into density be 1.1x10
3Kg/m
3, negative pressure is-0.07MPa;
(5) sterile packaged is in vial.
More than fill a prescription, collaborative playing a role strengthened the effect of Herba Dendrobii, can be used for diabetic to take.Every day 20-30 mL.Divide secondary to take.
Case 1:
Lin, man, 53 years old.
Health is tired, loses weight companion's poor appetite, agitation, insomnia, sometimes dry stool.Blood fat when medical: total sterin 7.5 mmol/l triglyceride 3.3 mmol/l, fasting glucose: 13.1mmol/l, blood glucose 16.6 mmol/l are diagnosed as type Ⅱdiabetes mellitus after meal.Cooperate do appropriate exercise every day, give present embodiment after three months again, blood glucose descends to some extent, surveys its fasting glucose 6.4 mmol/l, and 2 hours blood glucoses are 7.9 mmol/l after meal, and follow-up is healed after half a year.
Case 2:
Zhang, woman, 69 years old.
The headache dreaminess, companion's poor appetite, agitation, appetite increases, and loses weight.Fasting glucose: 10.3mmol/l, after meal blood glucose 15.5mmol/l when medical.Give again present embodiment after two months, blood glucose descends to some extent, and the myasthenia of limbs sense disappears, and surveys its fasting glucose 6.4 mmol/l, 2 hours blood glucoses are 7.9 mmol/l after meal, the suggestion diet should be light, transfers smooth emotion, eats vegetable and fruit more, suitably take exercise, follow-up is healed after half a year, and health is fine so far, glucostasis.
Case 3:
Wu so-and-so, man, 53 years old.
Numb limbs and tense tendons, uncomfortable in chest, headache dreaminess, agitation, insomnia, red and uncoated tongue, deep and stringy pulse.Give present embodiment after three months, blood glucose descends to some extent, surveys its fasting glucose 6.8 mmol/l, and 2 hours blood glucoses are 8.9 mmol/l after meal, and follow-up is healed after half a year, and glucostasis, blood fat are normal.
Although more than described the specific embodiment of the present invention; but being familiar with those skilled in the art is to be understood that; our described specific embodiment is illustrative; rather than for the restriction to scope of the present invention; those of ordinary skill in the art are in modification and the variation of the equivalence of doing according to spirit of the present invention, all should be encompassed in the scope that claim of the present invention protects.