CN103055148A - Traditional Chinese medicine composition for preventing and treating acne and sequelae stain and cicatrisation, and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating acne and sequelae stain and cicatrisation, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating acne and sequelae stain and cicatrisation, and a preparation method thereof. The composition consists of 20-40 parts of sea-buckthorn, 10-30 parts of forged nacre mother of pearl, 10-30 parts of calamine, 6-15 parts of exocarpium, 6-15 parts of bletilla striata, 3-12 parts of golden cypress, 3-12 parts of angelica sinensis, 3-9 parts of commelina communis L., 3-9 parts of rhizoma cyperi, 3-9 parts of elecampane, 3-9 parts of eclipta, 3-6 parts of lithospermum and 0.5-1.0 part of borneol; and the materials are made into powder, hot-dipped by using plant oil and subjected to oil extraction so as to prepare the composition. The clinical treating and observation of 90 acne patients for two weeks show that the cure rate is 90%, the total effective rate is 95.5%, and the recurrence rate is 6%. All healed patients or healed skin parts are free of skin itch, banding feeling increase, cicatrisation, hardness increase, poor elasticity and difference from normal skin in color, so that the composition has remarkable functions of preventing and treating acne, sequelae stain and cicatrisation, is high in security and low in recurrence rate.
Description
Technical field
The present invention relates to a kind of acne and rear something lost mottle, synulotic external medicine composition prevented and treated, and preparation method thereof.
Background technology
Acne is clinical common multiple pilosebaceous chronic inflammatory disease dermatoses, and sickness rate is high, easily repeatedly.Suffered from various degree seat skin ulcer youth 95 boy % and 83 girls %.Acne is mainly in Head And Face, and the position that the sebaceous gland such as cervical region, shirtfront, back are abundant can show as the skin lesion such as acne, pimple, pustule, tuberosity, cyst and cicatrix, and serious acne easily forms cicatrix and pigmentation.Therefore, after the trouble acne, can have a strong impact on people's beauty, sometimes also can certain impact be arranged to patient's emotion and way of act.Therefore, acne is a kind of somatopsychic illness that can not be ignored, thereby the research pathogeny of acne and treatment are still clinical and one of focus that the beauty treatment circle pays close attention to.
Modern medicine thinks that acne is a kind of multifactorial disease, and its morbidity is main and sex hormone level, sebaceous gland are secreted in a large number, propionibacterium acnes propagation, the factor analysis such as the dyskeratosis of pilosebaceous duct and inflammation.Acne is called as " rosacea caused by lung-wind ", " heir's face ", " whelk " or " face scar " in the traditional Chinese medical science.The traditional Chinese medical science thinks that a skin ulcer mainly is that mutually fiery menses is excessively prosperous owing to congenital plain body deficiency of kidney yin, in addition the dietetic life imbalance day after tomorrow, cause lung stomach-fire heat, accumulate and amass into poison, upper steaming women's head-ornaments, the heat in blood stasis of blood stagnates and to form, and the pungent greasy product of diet, cosmetics for external use stimulation etc. all can cause primary disease.
At present, to the treatment of acne, there is no desirable method.The various factors that doctor trained in Western medicine mainly is aimed at the acne generation carries out symptomatic treatment.Mainly can be divided into following four classes: 1. anti-androgens medicine; 2. the medicine that suppresses abnormal cornification of pilosebaceous duct; 3. seborrhea goes out the class medicine; 4. antimicrobial class medicine etc.And the traditional Chinese medical science adopts the methods such as Chinese medicine for oral administration or acupuncture mostly according to patient's pattern of syndrome.
In the acne treatment process and after curing, ubiquity a common issue with, i.e. pigmentation and cicatrix rhabdion.Although acne has been cured, and acne more after pigmentation often to retain long time and just can disappear and take off, short then some months, long then several years.Some acne harder subcutaneous rhabdion or indenture occur after existing and curing.The phenomenon of this " old complaint is just new sick again ", long-term, as to have a strong impact on patient psychology.
Summary of the invention
The objective of the invention is based on the traditional Chinese medical science to acne and acne after pigmentation and synulotic understanding and the rule for the treatment of, employing has the Chinese medicine of the effects such as blood circulation promoting and blood stasis dispelling, dredging the meridian, heat-clearing and toxic substances removing, poison holding putrefaction removing, convergence granulation promoting, blood-cooling itch-relieving pain relieving, according to the theory of Chinese medical science prescription, a kind of evident in efficacy, with low cost, preparation is provided and uses the external medicine composition simple, that side effect is little, relapse rate is low for preventing and treating acne and rear something lost mottle, cicatrization.
Another object of the present invention provides the preparation method of this external medicine composition.
Concrete prescription of the present invention is:
20~40 parts of Fructus Hippophaes, 10~30 parts of calcined Concha Margaritifera, 10~30 parts of Calaminas, 6~15 parts of Exocarpium Citri Grandises, 6~15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 3~12 parts of Cortex Phellodendris, 3~12 parts of Radix Angelicae Sinensis, 3~9 parts of Herba Commelinaes, 3~9 parts of Rhizoma Cyperis, 3~9 parts of the Radix Aucklandiae, 3~9 parts of Herba Ecliptaes, 3~6 parts of Radix Arnebiae (Radix Lithospermi)s, 0.5~1.0 part of Borneolum Syntheticum.
Optimum ratio is: 30 parts of Fructus Hippophaes, 20 parts of calcined Concha Margaritifera, 20 parts of Calaminas, 9 parts of Exocarpium Citri Grandises, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 12 parts of Cortex Phellodendris, 12 parts of Radix Angelicae Sinensis, 6 parts of Herba Commelinaes, 6 parts of Rhizoma Cyperis, 6 parts of the Radix Aucklandiae, 6 parts of Herba Ecliptaes, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 1.0 parts of Borneolum Syntheticums.
The dosage form of described compositions is the external preparation such as oil preparation, unguentum, liniment, tincture or gel.
Preparation method can be by dosage form need to be by making according to a conventional method the dosage form that needs behind the lixiviating effective components.
Wherein the concrete preparation method of oil preparation is as follows:
Above-mentioned raw materials is ground into fine powder by proportioning crosses 200 mesh sieves, place 50 ℃ of vegetable oil of 4 times of volumes to soak 8 hours the fine powder after sieving, cross leaching oil, cooling gets target product.
Advise preferred Oleum Sesami, Oleum Arachidis hypogaeae semen, Oleum Glycines, safflower oil about vegetable oil.
The conventional Chinese medicine that the used raw material of Chinese medicine medicine of the present invention is all put down in writing in state-promulgated pharmacopoeia is bought from the Chinese medicine shop easily.
The present invention is according to the principle-method-recipe-medicines principle of whole prescription of the traditional Chinese medical science, various crude drug coordinate at utmost to bring into play drug effect mutually, can blood circulation promoting and blood stasis dispelling, dredging the meridian, heat-clearing and toxic substances removing, poison holding putrefaction removing, convergence granulation promoting, blood-cooling itch-relieving pain relieving, effectively prevent and treat acne and rear something lost mottle, cicatrization, in addition, this invention also has rapid-action, the advantages such as cure rate is high, relapse rate is low, have no adverse reaction, short treating period, medication is convenient, expense is cheap.Through 90 routine patients with acne clinical observations, cure rate is 90%, total effective rate 95.5%, and relapse rate is 6%.The not equal phenomenon of pruritus, banding sense, cicatrization, hardness increase, poor flexibility, color and normal skin does not all appear in 81 examples of all recoveries from illness; In the case of produce effects and improvement, the skin part of having fully recovered also has no the not equal phenomenon of skin pruritus, banding sense growth, cicatrization, hardness increase, poor flexibility, color and normal skin.Illustrating that this invention has prevents and treats acne and rear something lost mottle, synulotic effect significantly, and safe, and relapse rate is low.
The specific embodiment
The present invention is described further below in conjunction with embodiment.
Embodiment 1: the preparation of external medicine composition
Take by weighing each raw medicinal material by following weight portion: 30 parts of Fructus Hippophaes, 20 parts of calcined Concha Margaritifera, 20 parts of Calaminas, 9 parts of Exocarpium Citri Grandises, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 12 parts of Cortex Phellodendris, 12 parts of Radix Angelicae Sinensis, 6 parts of Herba Commelinaes, 6 parts of Rhizoma Cyperis, 6 parts of the Radix Aucklandiae, 6 parts of Herba Ecliptaes, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 1.0 parts of Borneolum Syntheticums.Above-mentioned raw materials is ground into fine powder in the constant weight ratio crosses 200 mesh sieves, place 50 ℃ of Oleum Sesami of 4 times of volumes to soak 8 hours the fine powder after sieving, cross leaching oil, the outer affected part that is applied to after the cooling.
External medicine composition is summed up for the clinical treatment of preventing and treating acne and rear something lost mottle, cicatrization 90 examples
1, physical data: treatment group 90 examples, male 53 examples, women 37 examples.Minimum 12 years old of age, maximum 34 years old, average 16.6 years old; The course of disease is the shortest 15 days, and is the longest 12 months.
2, case is selected
2.1 inclusion criteria: clinical manifestation meets the acne vulgaris diagnostic criteria, does not take antibiotic or hormone medicine in nearly 1 month, in nearly 2 weeks not external cross the medicine of other Acne treatment, can partner treatment, hand-in-glove, regularly further consultation person.
2.2 exclusion standard: face merges allergic dermatitis or internal organs systemic disease or the tumors such as severe cardiac, liver, kidney is arranged, and the patient of anemia of pregnant woman or women breast-feeding their children's acne does not include the treatment object of observation in.
3, Therapeutic Method: in the acne parti affectase applicetur, every day 3 times, 7 days is 1 course for the treatment of, treats continuously and carries out the curative effect statistics after 2 courses for the treatment of.
4, curative effect determinate standard:
By the doctor trained in Western medicine diagnosis and treatment standard of acne, before the treatment and after the treatment patient's symptom (acne, pimple, pustule, inflammatory tubercle) is carried out objective scoring with Estimating curative effect.Therapeutic index=(total skin lesion scoring after total skin lesion scoring-treatment before the treatment)/(total skin lesion scoring before the treatment) * 100%.Evaluation of clinical curative effect is divided into recovery from illness, produce effects, improvement, invalid 4 grades according to the doing well,improving rate.Recovery from illness: skin lesion all disappears; Produce effects: skin lesion disappears therapeutic index more than 70%; Take a turn for the better: skin lesion disappears therapeutic index more than 30%; Invalid: skin lesion disappears therapeutic index below 30%.Total effective rate=(recovery from illness number+produce effects number+good revolution)/total case load * 100%.The symptoms such as the pruritus of patient's skin of face, banding sense, cicatrix scope, hardness, elasticity, color after the simultaneously observation treatment.With estimate this invention to acne after pigmentation and synulotic prevention effect.
5, untoward reaction and prognosis: the clinical adverse that the patient occurs in the record therapeutic process.And treating further consultation later six months and Effect of follow-up visit by telephone to observe patient's prognosis.
6, therapeutic outcome: when 90 routine patients finished through 2 courses for the treatment of, 81 examples of fully recovering; Produce effects 3; 2 examples take a turn for the better; Invalid 4 examples.Cure rate is 90%, total effective rate 95.5%.The not equal phenomenon of pruritus, banding sense, cicatrization, hardness increase, poor flexibility, color and normal skin does not all appear in 81 examples of all recoveries from illness; In the case of produce effects and improvement, the skin part of having fully recovered also has no the not equal phenomenon of skin pruritus, banding sense growth, cicatrization, hardness increase, poor flexibility, color and normal skin.In therapeutic process, there are 2 examples untoward reaction to occur, main manifestations is the slight erythema of medication local skin, burning sensation, occurs in treatment the 2nd day, reduces the coating number of times and does not do special handling, disappears voluntarily continual cure after 4 days.After 2 course of therapy 1 year, 5 example recurrences are arranged, relapse rate is 6%, continuing the medication symptom can very fast alleviation or healing.Illustrating that this invention has prevents and treats acne and rear something lost mottle, synulotic effect significantly, and safe, and relapse rate is low.
Claims (5)
1. prevent and treat acne and rear something lost mottle, synulotic Chinese medicine composition for one kind, it is characterized in that it is to be made by following raw materials in part by weight: 20~40 parts of Fructus Hippophaes, 10~30 parts of calcined Concha Margaritifera, 10~30 parts of Calaminas, 6~15 parts of Exocarpium Citri Grandises, 6~15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 3~12 parts of Cortex Phellodendris, 3~12 parts of Radix Angelicae Sinensis, 3~9 parts of Herba Commelinaes, 3~9 parts of Rhizoma Cyperis, 3~9 parts of the Radix Aucklandiae, 3~9 parts of Herba Ecliptaes, 3~6 parts of Radix Arnebiae (Radix Lithospermi)s, 0.5~1.0 part of Borneolum Syntheticum.
2. Chinese medicine composition according to claim 1 is characterized in that its weight portion proportioning is: 30 parts of Fructus Hippophaes, 20 parts of calcined Concha Margaritifera, 20 parts of Calaminas, 9 parts of Exocarpium Citri Grandises, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 12 parts of Cortex Phellodendris, 12 parts of Radix Angelicae Sinensis, 6 parts of Herba Commelinaes, 6 parts of Rhizoma Cyperis, 6 parts of the Radix Aucklandiae, 6 parts of Herba Ecliptaes, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 1.0 parts of Borneolum Syntheticums.
3. the dosage form of compositions according to claim 1 and 2 is external-use oil preparation, unguentum, liniment, tincture or gel.
4. the preparation method of Chinese medicine composition according to claim 1 and 2, comprise the steps: that above-mentioned raw materials is ground into fine powder by proportioning crosses 200 mesh sieves, place 50 ℃ of vegetable oil of 4 times of volumes to soak 8 hours the fine powder after sieving, cross leaching oil, cooling gets target product.
5. preparation method according to claim 4 is characterized in that, described vegetable oil is selected from Oleum Sesami, Oleum Arachidis hypogaeae semen, Oleum Glycines or safflower oil.
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CN101352513A (en) * | 2008-09-08 | 2009-01-28 | 邵厚仁 | Spot-eliminating beauty treatment composition and preparation thereof |
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CN101020031A (en) * | 2007-03-08 | 2007-08-22 | 王俊川 | Acne treating Chinese herbal medicine prepn |
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