CN103055026A - Pharmaceutical composition for treating obesity - Google Patents
Pharmaceutical composition for treating obesity Download PDFInfo
- Publication number
- CN103055026A CN103055026A CN2013100157925A CN201310015792A CN103055026A CN 103055026 A CN103055026 A CN 103055026A CN 2013100157925 A CN2013100157925 A CN 2013100157925A CN 201310015792 A CN201310015792 A CN 201310015792A CN 103055026 A CN103055026 A CN 103055026A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- radix rehmanniae
- lyophilizing
- treatment
- obesity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a pharmaceutical composition for treating obesity, which is characterized by consisting of freeze-dried rehmannia and purslane. The pharmaceutical composition disclosed by the invention is prepared by adding other traditional Chinese medicine raw materials according to practical requirements and has an obvious obesity treatment effect.
Description
Technical field
The present invention relates to medicine, particularly a kind of medicine for the treatment of obesity belongs to medical technical field.
Background technology
According to the data that World Health Organization (WHO) announces, the whole world has had the adult above 1,000,000,000 overweight, and it is the obesity patient that 300,000,000 people are wherein arranged, and these overweight peoples become the main force of some fat metabolic syndromes.Obesity is accompanied by a series of metabolic syndrome such as insulin resistance, П-diabetes, and hypertension, atherosclerosiss etc. become the disease that threatens the whole mankind.Therefore, how to prevent and treat obesity and correlated metabolism diseases thereof, become problem demanding prompt solution.
Radix Rehmanniae is the tuber of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa L-ibosch., begins to be stated from Shennong's Herbal, classifies as top gradely, is one of conventional Chinese medicine.At present Radix Rehmanniae comparatively common clinical being used as medicine, be divided into Radix Rehmanniae, Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Rehmanniae charcoal, Radix Rehmanniae Preparata charcoal etc.After Radix Rehmanniae was processed through different concocting methods, corresponding change also can occur in its nature and flavor, effect.Cold in nature, the sweet-bitter flavor of Radix Rehmanniae is take clearing away heat and promoting production of body fluid, cooling blood for hemostasis as main.Radix Rehmanniae is name Radix Rehmanniae or Radix Rehmanniae after place of production processing is dried, and its cold in nature, sweet in the mouth is take clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting as main.Radix Rehmanniae is the name Radix Rehmanniae Preparata after steaming, and its property is by the cold temperature that turns, and its flavor turns sweet by hardship, and its effect is filled out marrow as main by turning clearly benefit take nourishing YIN and supplementing blood, beneficial essence.
The pharmacological research of Radix Rehmanniae has been subject to paying close attention to widely in recent years, and is widely used in clinical.Be used for hemostasis, be used for diabetes, be used for cardiovascular and cerebrovascular disease, be used for hypertension, be used for nephritis, be used for dull-witted, be used for urinary system, be used for oral ulcer etc.
Herba Portulacae (Portulaca oleracea L.) is the annual meat herbaceous plant of Portulacaceae (Portulacease) Portulaca (Portulaca).Another name is horse Herba Amaranthi tricoloris, five elements' grass, rope made of hemp dish, HERBA PORTULACAE, horse three-coloured amaranth, locust dish, Dens Equi dish, melon rice dish, horse Serpentis dish, Formica fusca dish, the female dish of pig, Pericarpium Lagenariae hispidae dish, lion high mountain dish, sauerkraut, five elements' dish, the fertile dish of pig etc.Herba Portulacae is conventional Chinese medicine, is used as medicine mainly with its dry aerial parts, and nature and flavor acid, cold has the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving, is used for that toxic-heat and blood stasis, carbuncle are treated skin ulcer, eczema, erysipelas, snake bite and insect sting, had blood in stool, hemorrhoidal bleeding and metrostaxis.Dens Equi is looked for and is contained the number of chemical composition, is mainly organic acid, flavonoid, mushrooms, Coumarins, alkaloids, volatile oil and polysaccharide etc.; Modern pharmacological research shows that Dens Equi grassland and active component thereof have the effects such as antibiotic, antiviral, antitumor, accent blood fat, blood sugar lowering, defying age, atherosclerosis.Modern nutriology research finds that Herba Portulacae has stronger bactericidal antiphlogistic effect, can be used for the auxiliary treatment of inflammation, together lists the row of " natural antibiotic " in Bulbus Allii.2009, after Ministry of Public Health and the State Administration of Traditional Chinese Medicines recommend the overgrown with weeds 30-60g of bright Dens Equi to mourn with boiled water in " influenza A H1N1 Chinese medicine prevention scheme ", with the cold and dressed with sauce food of Bulbus Allii juice vinegar with the prevention swine flu.
It is remarkable that we find that lyophilizing Radix Rehmanniae and Herba Portulacae combination are used for the treatment of the obesity effect, has no side effect.
Summary of the invention
The purpose of this invention is to provide a kind of fat pharmaceutical composition for the treatment of.
A kind of pharmaceutical composition for the treatment of obesity is comprised of lyophilizing Radix Rehmanniae, Herba Portulacae.
A kind of each amounts of components of pharmaceutical composition for the treatment of obesity of the present invention has preferably curative effect in following ranges, and pharmaceutical composition of the present invention contains:
Lyophilizing Radix Rehmanniae 5-20 part, Herba Portulacae 5-20 part.
A kind of each amounts of components of pharmaceutical composition for the treatment of obesity of the present invention is optimized for:
9 parts of lyophilizing Radix Rehmanniae, 9 parts of Herba Portulacaes.
Of the present inventionly a kind ofly treat that fat each amounts of components of pharmaceutical composition is excellent further to be turned to:
9 parts of lyophilizing Radix Rehmanniae, 9 parts of lyophilizing Herba Portulacaes.
A kind of fat pharmaceutical composition for the treatment of of the present invention can further add other raw material of Chinese medicine according to actual needs, makes oral formulations.
A kind of fat pharmaceutical composition for the treatment of of the present invention, in the above each component, weight is calculated with crude drug, and in the present invention, if weight is in grams, this consists of one day taking dose of adult.
More than each form to be by weight as proportioning, when producing, can increase or reduce according to corresponding ratio, can be with kilogram or take ton as unit such as large-scale production, weight can increase or reduce, but the crude drug weight proportion constant rate between the each component, the taking dose of being grown up a day is constant.
Medicine of the present invention can adopt prior art to be prepared into any pharmaceutically useful conventional formulation.For example these crude drug pulverizing mixings can be made powder takes after mixing it with water; Also can be with these crude drug extract at low temperature, cryoconcentration, cold drying adds adjuvant and makes tablet, capsule, granule; But this does not limit protection scope of the present invention.
So far finished the present invention, the present invention is prescription under instruction of Chinese Medicine theory, and the early stage transformation and transportation of the spleen and stomach of obesity is hyperfunction, has a liking for food delicious food savoury, and bulimia, food ration that this moment, stomach excessive heat caused are greatly that fat key occurs.Li Dongyuan " Treatise on the spleen and stomach " cloud: " unit is arrogant in the stomach, and polyphagia is not hindered, and is out-of-date not hungry; Stomach-fire is contained, and then polyphagia and famine can be eaten and large loose stool, and this gastric heat is apt to disappear, and the splenopathy is not changed yet.So " treat and work as to rush down clearly gastric heat as method, the sweet Han Zhirun of Radix Rehmanniae in the side, clearing up internal heat by using drugs of bitter in taste and cold in nature, YIN nourishing and the production of body fluid promoting, the bulimia that stomach excessive heat is caused must press down, and is principal agent.Herba Portulacae matter cold in nature is sliding, and acid can restrain, and enters large intestine channel, can help the merit of Radix Rehmanniae clearing away stomach-heat, and can overcoming again Radix Rehmanniae, to increase the weight of the thin side effect in large loose stool be accessory drugs.Two medicines share plays clearing away stomach-heat, the merit of YIN nourishing and the production of body fluid promoting altogether.Gastric heat gets clearly, and body fluid must be living, and what transformation and transportation of the spleen and stomach was hyperfunction presses down, and food ration must subtract, and obesity can disappear.
For a better understanding of the present invention, further set forth the present invention by clinical research below and treat fat beneficial effect.The below's test is intended to further specify effect of the present invention, but not restriction of the present invention.
1, physical data simple obesity patient 20 examples meet the diagnostic criteria of the special Asia adult physical fitness volume index (BMI) 〉=25 that proposes of international obesity standard in 2000, and are divided into two groups by the table of random number method.Treatment group, each 10 example of matched group.
2, Therapeutic Method
Matched group: the patient is carried out health education, keep on a diet, suitable exercise.
Treatment group: in that the patient is carried out health education, keep on a diet, take the powder that lyophilizing Radix Rehmanniae, Montmorillonitum are made on the basis of suitable exercise, 9g/ time, 2 times/days.
Require inactive other all relevant Chinese and western drugses in the patient treatment process, 2 months is 1 course for the treatment of.
3, the observational technique all cases is all filled in the observation registration form in detail, follow up a case by regular visits to weekly and survey weight 1 time, and before and after treatment is measured respectively in medical history, health check-up following index: 1. height, weight, BMI, waistline (WC), waist-to-hipratio (WHR), fat percentage; 2. fasting glucose (FBG), T-CHOL (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), HDL-C (HDL-C), insulin (INS).
4, two groups of indices all were improved in varying degrees after two groups of patient body quality of result, BMI, WC, WHR, fat percentage changed treatment, weight, BMI, WC, WHR, fat percentage, matched group is all meaningful with the front comparing difference for the treatment of, treatment group has significant with the front comparing difference for the treatment of, and namely the treatment group curative effect is better than matched group.Two groups of indices all were improved in varying degrees after two groups of FBG, TC, TG, HDL-C, LDL-C, INS changed treatment, and comparing difference has significant before treatment group and the treatment, and namely the treatment group curative effect obviously is better than matched group.
The specific embodiment
Embodiment 1
Lyophilizing Radix Rehmanniae 5kg, Herba Portulacae 3kg pulverize, and mixing gets powder.
Embodiment 2
Get lyophilizing Radix Rehmanniae 20kg, Herba Portulacae 20kg uses ethanol percolate extraction, the extracting solution Recycled ethanol, and natural outer circulation two phase flow concentrates, and the adding carboxymethyl starch sodium is an amount of, gelatinized corn starch is granulated, drying, arrangement, the adding Pulvis Talci is an amount of, mixing, tabletting gets tablet.
Embodiment 3
Get lyophilizing Radix Rehmanniae 20kg, lyophilizing Herba Portulacae 20kg with 15 times of amount 50% ethanol, by " cold infusion process " operation, collects impregnation liquid, leaves standstill 24 hours, filter, and Recycled ethanol, with DGS type low-temperature drier, temperature control 40 degree are dry.It is an amount of to add dextrin, granulate, and drying, granulate gets granule.
Embodiment 4
Get lyophilizing Radix Rehmanniae 5kg, Herba Portulacae 20kg with 15 times of amount 50% ethanol, by " cold infusion process " operation, collects impregnation liquid, leaves standstill 24 hours, filter, and Recycled ethanol, with DGS type low-temperature drier, temperature control 40 degree are dry.It is an amount of to add dextrin, granulates drying, granulate, tabletting.
Embodiment 5
Get Radix Astragali 10kg, Radix Et Rhizoma Rhei 15kg, Folium Nelumbinis 3kg, Semen Cassiae 20kg, Herba Portulacae 5kg; With water extraction 2 times, add 8 times of water gagings for the first time, extracted 1.5 hours, add 6 times of water gagings for the second time and extracted 1 hour, merge extractive liquid, filters, and concentrates, and drying gets medicinal substances extract.
Get lyophilizing Radix Rehmanniae 20kg, use ethanol percolate extraction, extracting solution Recycled ethanol, the freeze dryer of packing into, lyophilizing.Vacuum is-35.0Pa, and pre-freeze temperature-40 ℃ is incubated 2 hours; 40 ℃/h of first phase programming rate heated up 0.5 hour, was incubated 0.5 hour; 20 ℃/h of second phase programming rate heated up 1 hour, was incubated 5 hours; 40 ℃/h of three phase programming rates heated up 0.5 hour, was incubated 8 hours; 40 ℃/h of fourth phase programming rate heated up 0.5 hour, was incubated 6 hours.Terminal point determining is: vacuum gets the lyophilizing Radix Rehmanniae extract less than-5.0Pa.
Get lyophilizing Radix Rehmanniae extract, medicinal substances extract, add Montmorillonitum 3kg, mixing adds dextrin, granulate, and drying, granulate gets granule.
Embodiment 6
Get lyophilizing Radix Rehmanniae 5kg, lyophilizing Herba Leonuri 5kg, lyophilizing Herba Portulacae 15kg; Add 20 times of water gagings, stir at 0～10 ℃ and extracted 4 hours, extracting liquid filtering, natural outer circulation two phase flow is concentrated, and cold drying adds Montmorillonitum, mixing, the Capsules of packing into is made capsule.
Embodiment 7
Get Fructus Trichosanthis 10kg, Semen Raphani 15kg, Radix Salviae Miltiorrhizae 3kg, Radix Glycyrrhizae 2kg, semen juglandis 3kg, Radix Notoginseng 1kg, Fructus Crataegi 2kg, Oletum Trogopterori 2kg, Rhizoma Cyperi 1kg, Herba Portulacae 5kg; With water extraction 2 times, add 8 times of water gagings for the first time, extracted 1.5 hours, add 6 times of water gagings for the second time and extracted 1 hour, merge extractive liquid, filters, and concentrates, and drying gets medicinal substances extract.
Get lyophilizing Radix Rehmanniae 15kg, add 20 times of water gagings, stir at 0～10 ℃ and extracted 4 hours, extracting liquid filtering, natural outer circulation two phase flow is concentrated, adds dextrin, cold drying, granulate gets extract.
Get extract, medicinal substances extract adds Montmorillonitum 4kg, and mixing adds dextrin, granulate, and drying, granulate gets granule.
Claims (6)
1. treat fat pharmaceutical composition for one kind, it is characterized in that being formed by lyophilizing Radix Rehmanniae, Herba Portulacae.
2. according to claim 1 a kind of treats fat pharmaceutical composition, it is characterized in that containing lyophilizing Radix Rehmanniae 5-20 part, Herba Portulacae 5-20 part.
According to claim 1 or claim 2 a kind of treat fat pharmaceutical composition, it is characterized in that containing 9 parts of lyophilizing Radix Rehmanniae, 9 parts of Herba Portulacaes.
According to claim 1 or claim 2 a kind of treat fat pharmaceutical composition, it is characterized in that containing 9 parts of lyophilizing Radix Rehmanniae, 9 parts of lyophilizing Herba Portulacaes.
5. according to claim 1 a kind of treats fat pharmaceutical composition, it is characterized in that adding other raw material of Chinese medicine, makes oral formulations.
According to claim 1 or claim 2 or claim 3 or claim 4 or claim 5 a kind of treat fat pharmaceutical composition, it is characterized in that adopting prior art to be prepared into tablet, capsule, granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100157925A CN103055026A (en) | 2013-01-16 | 2013-01-16 | Pharmaceutical composition for treating obesity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100157925A CN103055026A (en) | 2013-01-16 | 2013-01-16 | Pharmaceutical composition for treating obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103055026A true CN103055026A (en) | 2013-04-24 |
Family
ID=48098121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013100157925A Pending CN103055026A (en) | 2013-01-16 | 2013-01-16 | Pharmaceutical composition for treating obesity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103055026A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317337A (en) * | 2001-04-04 | 2001-10-17 | 复旦大学 | Rehmannia root extract and its preparing process and application |
-
2013
- 2013-01-16 CN CN2013100157925A patent/CN103055026A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317337A (en) * | 2001-04-04 | 2001-10-17 | 复旦大学 | Rehmannia root extract and its preparing process and application |
Non-Patent Citations (1)
| Title |
|---|
| 杨林华等: "马齿苋的营养保健功能与开发研究", 《内蒙古农业科技》, 31 December 2009 (2009-12-31), pages 88 - 90 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104856968B (en) | A kind of Chinese medicinal tablet with eliminating thrombus and removing obstruction in channels effect and preparation method thereof | |
| CN104126746A (en) | Blood sugar-reducing and blood lipid-reducing dendrobium officinale kimura et migo composition and preparation method thereof | |
| WO2010135858A1 (en) | Pharmaceutical composition and use for preparing medicament thereof | |
| CN106492084A (en) | A kind of pure draft traditional Chinese medicine capable of reducing weight product and preparation method thereof | |
| CN105192025A (en) | Nutritious biscuit capable of strengthening spleen and stomach as well as preparation method of biscuit | |
| CN107890528B (en) | Traditional Chinese medicine composition for treating hyperuricemia and preparation method thereof | |
| CN105617023A (en) | Caulis dendronii healthcare product having efficacy of improving immunity and preparation method and application thereof | |
| CN104435567A (en) | Traditional Chinese medicinal composition containing gynostemma pentaphyllum for treating gout | |
| CN103239551A (en) | Freeze-dried radix rehmanniae for preventing and curing obesity | |
| CN103055099A (en) | Freeze-dried pharmaceutical composition for preventing and treating obesity | |
| CN103055026A (en) | Pharmaceutical composition for treating obesity | |
| CN103877513A (en) | Chinese herbal compound composition with blood fat reduction effect, and applications thereof | |
| CN104352672A (en) | Tortoise plastron-containing traditional Chinese medicine composition for treating diabetes | |
| CN105641621B (en) | Phlegm and blood stasis treating granule and taking method thereof | |
| CN103054895A (en) | Medicine composition for preventing and treating obesity | |
| CN105749199A (en) | Traditional Chinese medicinal composition for warming middle warmer and invigorating spleen, and preparation method thereof | |
| CN104127826A (en) | Traditional Chinese medicine composition for treating chronic alcoholic liver disease | |
| CN103054920A (en) | Purslane for preventing and treating obesity | |
| CN104337909B (en) | A kind of Chinese medicine composition of the treatment gout containing Aspongopus | |
| CN107661392A (en) | A kind of Chinese medicine compound prescription for treating cancer of the esophagus and preparation method thereof | |
| CN103055025A (en) | Medicine composition for preventing and treating obesity | |
| CN108553584B (en) | Composition for assisting in reducing blood sugar and application thereof | |
| CN108404068B (en) | Pharmaceutical composition for treating and/or preventing diarrhea and preparation method thereof | |
| CN104352862A (en) | Emblic leafflower fruit-containing traditional Chinese medicine composition for treating diabetes | |
| CN104984261A (en) | Traditional Chinese medicine composition for treating liver-qi attacking stomach type gastral cavity pain |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130424 |