CN103054911A - Crocodile antineoplastic preparation and production method thereof - Google Patents
Crocodile antineoplastic preparation and production method thereof Download PDFInfo
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- CN103054911A CN103054911A CN2013100030708A CN201310003070A CN103054911A CN 103054911 A CN103054911 A CN 103054911A CN 2013100030708 A CN2013100030708 A CN 2013100030708A CN 201310003070 A CN201310003070 A CN 201310003070A CN 103054911 A CN103054911 A CN 103054911A
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Abstract
The invention relates to a crocodile antineoplastic preparation and a production method thereof. Crocodile meat is cleaned and minced; water is added for enzymolysis; ethanol is added for extraction; after centrifugal separation, an ion exchange column is used for purifying to obtain crocodile extracting solution; the aqueous extraction is implemented for lucid ganoderma, worm grass and poria cocos to obtain accessory extracting solution; and the crocodile extracting solution and the accessory extracting solution are mixed by proportioning, are frozen and dried to obtain the crocodile antineoplastic preparation. Antineoplastic active components in crocodile bodies are fully extracted, and a plurality of accessories are synchronously added, so that the crocodile antineoplastic preparation has comprehensive and balanced nutritive value, has the effects of regulating body immune system functions, resisting tumors, resisting ageing and the like, and a is novel biological preparation capable of being applied in tumor resistance, virus resistance and immunity enhancement.
Description
Technical field
The present invention relates to a kind of novel biological agent, particularly relate to a kind of anti-tumor agent of making take crocodile as primary raw material.
Background technology
Along with the fast development of China's economy, the people's living standard is greatly improved, and meanwhile, the problems such as environmental pollution are also like the shadow following the person and more and more serious, also gets more and more because environment, air, water, food etc. pollute the malignant tumor that causes.Malignant tumor is commonly encountered diseases and the frequently-occurring disease of serious threat human health, and according to World Health Organization's report, in more than 50 hundred million populations of the whole world, the tumor patient of annual new diagnosis is about 9,000,000 people, because the tumor died reached for 7,000,000 people/years, accounts for nearly 20% of total case fatality rate.Update shows, has advanced since nineteen nineties, and cancer has become the second largest cause of the death of Chinese urban and rural residents, and big and medium-sized cities cancer mortality number accounts for 25% of whole death tolls, accounts for 80% in the rural area.
Crocodile is minority one of cancered animal not on the earth, and crocodile also is up to now to one of the strongest animal of adaptive capacity to environment simultaneously, and the life in existing more than 200,003,000 ten thousand years is historical so far.Crocodile all is precious from head to foot, and is just on the books in the Compendium of Material Medica of Ming Dynasty's Li Shizhen (1518-1593 A.D.), claims crocodile " meat is to tonification ", cures mainly " dampness pathogen ", " disease painful abdominal mass malignant boil ".As seen ancients are to the effect existing comparatively comprehensively understanding of crocodile at aspects such as treatment asthma, cough and malignant boil tumors.According to textual criticism, the Xia dynasty of China before more than 4,000 years just begins to utilize crocodile, and to the Shang dynasty, crocodile meat has become the treasure in emperor's banquet.
Crocodile medically is being referred to as again animal gold, and medical value is high.Modern medicine thinks that crocodile finger contains the compositions such as a large amount of osseins, protein, calcium, phosphorus.With itself and Chinese medicine science compatibility extract, have extremely strong " walk to alter that row is loose, activating blood circulation to dissipate blood stasis, tonneau meridians, thoroughly reach close key " effect.It can the collateral dredging expelling wind to alleviate pain, again can direct tumoricidal peripheral protection factor, bring into play it to the killing action of cancerous cell.The crocodile gallbladder contains the materials such as bile acid more than 20 kinds, bilichol.Its contained ursodesoxycholic acid, chenodeoxycholic acid are the special composition that other animal gallbladders do not have except Fel Ursi.Crocodile gallbladder and Chinese medicine reasonable compatibility, the performance synergism can promote macrophage, lymphocyte, mononuclear cell to the splitting action of cancerous cell.Have again simultaneously the ability that promotes bile secretion, improve bile dissolving cholesterol, reduce the effect such as cholelithiasis formation.Crocodile meat contains a large amount of organic substances, is equipped with Chinese medicine and uses, and respiratory tract neoplasms is had clear and definite therapeutical effect.The activity that can inducing interferon produces, enhancing antibody generates, and can strengthen again the phagocytic function of reticuloendothelial system, increases leukocyte, improves immunocompetence, the invasion of blocking-up carcinogenecity virus and copying.Utilizing whole body all is that precious crocodile is developed the biological product with antitumor action, and potentiality are very wide.With the progress of work science, exploitation crocodile series of products, economic benefit and social benefit will be very considerable.
Summary of the invention
The purpose of this invention is to provide a kind of crocodile anti-tumor agent, not only take easily, and the effective antitumor active component in the crocodile can more effectively must be absorbed by the body, thereby give full play to its trophic function.
Another object of the present invention provides a kind of production method of crocodile anti-tumor agent, and the anti-tumor active ingredient in the crocodile can more fully be discharged.
In order to reach the foregoing invention purpose, the present invention has adopted following technical scheme:
A kind of crocodile anti-tumor agent is characterized in that, its prescription comprises the raw material of following weight portion: 80～100 parts of crocodile meat, and 10～15 parts of Ganodermas, 3～9 parts of Cordycepses, 20～30 parts in Poria, its preparation process is as follows:
1. after crocodile meat being cleaned, rub, add the water of 8～10 times of crocodile meat weight, carry out enzymolysis with neutral protease after the heat a little.After enzymolysis finishes, be that 5～10% acetic acid solution extracts with concentration, behind separation, purification, get crocodile extract again;
2. Ganoderma, Cordyceps, Poria are steeped respectively wash, dry, shred after, add the water steaming and decocting 30min of 5～10 times of aforementioned Ganoderma, Cordyceps and Poria gross weights, after steaming and decocting finishes, filter, get the adjuvant extracting solution;
3. with behind the crocodile extract and adjuvant extracting solution mixed preparing that make previously, carry out lyophilization, cryogenic temperature-15 ℃, cooling time 30h after the end, filters with 100 eye mesh screens, gets the crocodile anti-tumor agent.
As preferred version, described preparation prescription comprises following component: 90 parts of crocodile meat, 12 parts of Ganodermas, 6 parts of Cordycepses, 15 parts in Poria.
A kind of production method of crocodile anti-tumor agent is characterized in that comprising following steps:
1. after crocodile meat being cleaned, rub, add the water of 8～10 times of crocodile meat weight, carry out enzymolysis with neutral protease after the heat a little.After enzymolysis finishes, be that 5～10% acetic acid solution extracts with concentration, behind separation, purification, get crocodile extract again;
2. Ganoderma, Cordyceps, Poria are steeped respectively wash, dry, shred after, add the water steaming and decocting 30min of 5～10 times of aforementioned Ganoderma, Cordyceps and Poria gross weights, after steaming and decocting finishes, filter, get the adjuvant extracting solution;
3. with behind the crocodile extract and adjuvant extracting solution mixed preparing that make previously, carry out lyophilization, cryogenic temperature-15 ℃, cooling time 30h after the end, crosses 100 eye mesh screens, gets the crocodile anti-tumor agent.
Further, described step 1. in, the neutral protein enzyme dosage is 0.3～0.5% of crocodile extract weight, temperature is 40～45 ℃, the time is 8～10h.
Further, described neutral protease is selected the neutral protease of 200,000 μ/g.
Further, described step 1. in, adopt 3000～30000rpm tubular-bowl centrifuge to separate, carry out purification with ion exchange column afterwards.
Further, the process of carrying out purification with ion exchange column comprises: select active eluting peak cation exchange column eluting, described cation exchange column is used citric acid-sodium citrate buffer solution balance in advance, and in above-mentioned citric acid-sodium citrate buffer solution eluting in addition.
Further again, described step 2. in, the filter type of employing is micro-pore-film filtration, filtering material is cellulose acetate membrane, the aperture is 0.45 micron.
The present invention is take crocodile as primary raw material, adopt modern enzymolysis and separating and purifying technology, from crocodile, extract and isolate multiple bioactive ingredients with antitumor action, and interpolation multiple auxiliary materials, the crocodile anti-tumor agent for preparing is a kind of novel biological agent that can be used for antitumor, antiviral, raising immunity, not only have comprehensive, balanced nutritive value, and have the immunization machine of adjusting system function, antitumor, the anti-ageing effect of waiting for a long time.
The specific embodiment
Below in conjunction with concrete example the present invention is described further, but the present invention is not limited to this specific examples, following umber all represents weight portion, and content all represents weight content.
Embodiment 1
The production of crocodile anti-tumor agent of the present invention may further comprise the steps:
1. after 80 parts of crocodile meat being cleaned, rub, add the water of 8 times of crocodile meat weight, the neutral protease with 200,000 μ/g carries out enzymolysis after the heat a little, enzyme dosage is 0.3% of crocodile meat weight, temperature is 42 ℃, and the time is 8h, after enzymolysis finishes, be that 5～10% acetic acid solution extracts with concentration, separate with 13000～30000rpm tubular-bowl centrifuge again, use afterwards the ion exchange column purification, get crocodile extract;
2. with 10 portions of Ganodermas, 5 portions of Cordycepses after 20 parts of Poria bubbles are washed, dry, shreds, add the water steaming and decocting 30min of 6 times of aforementioned Ganoderma, Cordyceps and Poria gross weights, and after steaming and decocting finished, the employing micro-pore-film filtration got the adjuvant extracting solution;
3. with after above-mentioned crocodile extract and the adjuvant extracting solution mixed preparing, carry out lyophilization, cryogenic temperature-15 ℃, cooling time 30h after the end, crosses 100 eye mesh screens, gets the crocodile anti-tumor agent.
The crocodile anti-tumor agent of making, its prescription comprises following component: 80 parts of crocodile meat, 10 parts of Ganodermas, 5 parts of Cordycepses, 20 parts in Poria.
Embodiment 2
The production of anti-tumor agent of the present invention may further comprise the steps:
1. after 100 parts of crocodile meat being cleaned, rub, add the water of 10 times of crocodile meat weight, the neutral protease with 200,000 μ/g carries out enzymolysis after the heat a little, enzyme dosage is 0.4% of crocodile meat weight, temperature is 45 ℃, and the time is 10h, after enzymolysis finishes, be that 5～10% acetic acid solution extracts with concentration, separate with 13000～30000rpm tubular-bowl centrifuge again, use afterwards the ion exchange column purification, get crocodile extract;
2. be with 15 portions of Ganodermas, 8 portions of Cordycepses after 25 parts of Poria bubble is washed, dries, shred, add the water steaming and decocting 30min of 8 times of aforementioned Ganoderma, Cordyceps and Poria gross weights, and after steaming and decocting finished, the employing micro-pore-film filtration got the adjuvant extracting solution;
3. with after above-mentioned crocodile extract and the adjuvant extracting solution mixed preparing, carry out lyophilization, cryogenic temperature-15 ℃, cooling time 30h after the end, crosses 100 eye mesh screens, gets the crocodile anti-tumor agent.
The crocodile anti-tumor agent of making, its prescription comprises following component: 100 parts of crocodile meat, 15 parts of Ganodermas, 8 parts of Cordycepses, 25 parts in Poria.
Embodiment 3
The production of anti-tumor agent of the present invention may further comprise the steps:
1. after 90 parts of crocodile meat being cleaned, rub, add the water of 10 times of crocodile meat weight, the neutral protease with 200,000 μ/g carries out enzymolysis after the heat a little, enzyme dosage is 0.4% of crocodile meat weight, temperature is 43 ℃, and the time is 8h, after enzymolysis finishes, be that 5～10% acetic acid solution extracts with concentration, separate with 13000～30000rpm tubular-bowl centrifuge again, use afterwards the ion exchange column purification, get crocodile extract;
2. be with 12 portions of Ganodermas, 6 portions of Cordycepses after 25 parts of Poria bubble is washed, dries, shred, add the water steaming and decocting 30min of 7 times of aforementioned Ganoderma, Cordyceps and Poria gross weights, and after steaming and decocting finished, the employing micro-pore-film filtration got the adjuvant extracting solution;
3. with after above-mentioned crocodile extract and the adjuvant extracting solution mixed preparing, carry out lyophilization, cryogenic temperature-15 ℃, cooling time 30h after the end, crosses 100 eye mesh screens, gets the crocodile anti-tumor agent.
The crocodile anti-tumor agent of making, its prescription comprises following component: 90 parts of crocodile meat, 12 parts of Ganodermas, 6 parts of Cordycepses, 25 parts in Poria.
Embodiment 4
The production of anti-tumor agent of the present invention may further comprise the steps:
1. after 85 parts of crocodile meat being cleaned, rub, add the water of 9 times of crocodile meat weight, the neutral protease with 200,000 μ/g carries out enzymolysis after the heat a little, enzyme dosage is 0.3% of crocodile meat weight, temperature is 40 ℃, and the time is 9h, after enzymolysis finishes, be that 5～10% acetic acid solution extracts with concentration, separate with 13000～30000rpm tubular-bowl centrifuge again, use afterwards the ion exchange column purification, get crocodile extract;
2. be with 12 portions of Ganodermas, 3 portions of Cordycepses after 30 parts of Poria bubble is washed, dries, shred, add the water steaming and decocting 30min of 10 times of aforementioned Ganoderma, Cordyceps and Poria gross weights, and after steaming and decocting finished, the employing micro-pore-film filtration got the adjuvant extracting solution;
3. with after above-mentioned crocodile extract and the adjuvant extracting solution mixed preparing, carry out lyophilization, cryogenic temperature-15 ℃, cooling time 30h after the end, crosses 100 eye mesh screens, gets the crocodile anti-tumor agent.
The crocodile anti-tumor agent of making, its prescription comprises following component: 85 parts of crocodile meat, 12 parts of Ganodermas, 3 parts of Cordycepses, 30 parts in Poria.
In order to keep the active skull cap components of crocodile anti-tumor agent, the embodiment of the invention only shows adds Ganoderma, Cordyceps, Poria as the basic recipe of adjuvant.Wherein, Ganoderma has widely pharmacologically active, can improve immunity of organisms, improve body's hypoxia tolerance, eliminate free radical, suppress tumor, radioprotective, improve liver, bone marrow, blood synthetic DNA, RNA, protein ability, the characteristic that life-saving, Ganoderma also have the non-specific resistance of stimulation of host, immune specific reaction and suppress the transplantation tumor physiologically active; But the Cordyceps activated macrophage stimulates antibody to produce, improve the human body immunity, improve respiratory system, adrenal gland's weight, blood plasma cortisol, aldosterone and adrenal gland's inner cholesterol content are increased, the adrenal effect of promotion is arranged, suppress tumor growth, and have antitumor, radioprotective, blood sugar lowering and lipoprotein, cough-relieving, reduce phlegm, the pharmacological actions such as lung moistening and slow down aging; The effective ingredient that Poria contains can activate local complement, and the complement that the tumor close region is activated passes through to affect macrophage, lymphocyte or other cells and humoral factor, thus the Synergistic killing tumor cell.The present invention prescription is suited the remedy to the case mainly for the characteristic of tumor, and the adjuvant reasonable recipe of adding cooperates ingeniously, and synergism has adjusting body immune system function, antitumor, the anti-ageing multiple efficacies of waiting for a long time.The present invention does not get rid of in order to improve mouthfeel, or in order to satisfy different crowds, prescription is suitably adjusted; Do not get rid of in order to strengthen some miscellaneous function yet, and other adjuvant that adds, such as Radix Ginseng, Fructus Lycii etc.; Therefore, the present invention includes but be not limited to the content of above-described embodiment, other all fall within protection scope of the present invention with method that technical scheme of the present invention has identical essentiality content.
Claims (8)
1. a crocodile anti-tumor agent is characterized in that, its prescription comprises the raw material of following weight portion: 80～100 parts of crocodile meat, and 10～15 parts of Ganodermas, 3～9 parts of Cordycepses, 20～30 parts in Poria, its preparation process is as follows:
1. after crocodile meat being cleaned, rub, add the water of 8～10 times of crocodile meat weight, carry out enzymolysis with neutral protease after the heat a little.After enzymolysis finishes, be that 5～10% acetic acid solution extracts with concentration, behind separation, purification, get crocodile extract again;
2. Ganoderma, Cordyceps, Poria are steeped respectively wash, dry, shred after, add the water steaming and decocting 30min of 5～10 times of aforementioned Ganoderma, Cordyceps and Poria gross weights, after steaming and decocting finishes, filter, get the adjuvant extracting solution;
3. with behind the crocodile extract and adjuvant extracting solution mixed preparing that make previously, carry out lyophilization, cryogenic temperature-15 ℃, cooling time 30h after the end, filters with 100 eye mesh screens, gets the crocodile anti-tumor agent.
2. according to claims 1 described crocodile anti-tumor agent, it is characterized in that: described preparation prescription comprises following component: 90 parts of crocodile meat, 12 parts of Ganodermas, 6 parts of Cordycepses, 15 parts in Poria.
3. the production method of a crocodile anti-tumor agent is characterized in that comprising following steps:
1. after crocodile meat being cleaned, rub, add the water of 8～10 times of crocodile meat weight, carry out enzymolysis with neutral protease after the heat a little.After enzymolysis finishes, be that 5～10% acetic acid solution extracts with concentration, behind separation, purification, get crocodile extract again;
2. Ganoderma, Cordyceps, Poria are steeped respectively wash, dry, shred after, add the water steaming and decocting 30min of 5～10 times of aforementioned Ganoderma, Cordyceps and Poria gross weights, after steaming and decocting finishes, filter, get the adjuvant extracting solution;
3. with behind the crocodile extract and adjuvant extracting solution mixed preparing that make previously, carry out lyophilization, cryogenic temperature-15 ℃, cooling time 30h after the end, crosses 100 eye mesh screens, gets the crocodile anti-tumor agent.
4. according to the production method of claims 3 described crocodile anti-tumor agents, it is characterized in that: described step 1. in, the neutral protein enzyme dosage is 0.3～0.5% of crocodile extract weight, temperature is 40～45 ℃, the time is 8～10h.
5. according to the production method of claims 3 described crocodile anti-tumor agents, it is characterized in that: described neutral protease is selected the neutral protease of 200,000 μ/g.
6. according to the production method of claims 3 described crocodile anti-tumor agents, it is characterized in that: described step 1. in, adopt 3000～30000rpm tubular-bowl centrifuge to separate, carry out purification with ion exchange column afterwards.
7. according to the production method of claims 6 described crocodile anti-tumor agents, it is characterized in that, the process of carrying out purification with ion exchange column comprises: select active eluting peak cation exchange column eluting, described cation exchange column is used citric acid-sodium citrate buffer solution balance in advance, and in above-mentioned citric acid-sodium citrate buffer solution eluting in addition.
8. according to the production method of claims 3 described crocodile anti-tumor agents, it is characterized in that: described step 2. in, the filter type of employing is micro-pore-film filtration, filtering material is cellulose acetate membrane, the aperture is 0.45 micron.
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Cited By (3)
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| CN104644794A (en) * | 2015-01-23 | 2015-05-27 | 广州善康生物科技有限公司 | Drug for treating lumps |
| CN111529552A (en) * | 2020-05-11 | 2020-08-14 | 广东焦点农业科技开发有限公司 | Application of crocodile extract in anticancer |
| CN113229427A (en) * | 2021-03-22 | 2021-08-10 | 武汉名实生物医药科技有限责任公司 | Compound hydrolyzed peptide functional beverage suitable for being drunk by tumor patients and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104644794A (en) * | 2015-01-23 | 2015-05-27 | 广州善康生物科技有限公司 | Drug for treating lumps |
| CN111529552A (en) * | 2020-05-11 | 2020-08-14 | 广东焦点农业科技开发有限公司 | Application of crocodile extract in anticancer |
| CN113229427A (en) * | 2021-03-22 | 2021-08-10 | 武汉名实生物医药科技有限责任公司 | Compound hydrolyzed peptide functional beverage suitable for being drunk by tumor patients and preparation method thereof |
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| CN103054911B (en) | 2014-10-22 |
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