CN103054768B - A kind of desensitization cosmetic composition - Google Patents
A kind of desensitization cosmetic composition Download PDFInfo
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- CN103054768B CN103054768B CN201210476005.2A CN201210476005A CN103054768B CN 103054768 B CN103054768 B CN 103054768B CN 201210476005 A CN201210476005 A CN 201210476005A CN 103054768 B CN103054768 B CN 103054768B
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Abstract
The invention discloses a kind of desensitization cosmetic composition, count by weight percentage formula and comprise: cosmetic base 0.79 ~ 55%, Chinese herbal medicine extract 0.21% ~ 45%, wherein Chinese herbal medicine extract comprises glucosan, flavanone and Aloe extract.Compositions of the present invention have natural have no side effect plant antiallergic, antiinflammatory, do not cause acne, non-stimulated advantage, to responsive skin safety.The present invention may be used in skin-protection product as cleansing milk, cream frost, emulsion, facial film, various aqua product (astringent, toner/smoothing toner, cosmetic water, nutritive water, water of releiving) etc.
Description
Technical field
The present invention relates to household chemicals field, the cosmetic skin care composition of particularly a kind of desensitization.
Background technology
Skin irritation is that all skin quality all can run into, and it is omnipresent, almost has no idea to avoid, and the irritating skin care products of sunlight, environment or tool constantly attacks skin; Sun-proof, antiseptic, pigment, spice, pigment, clean after the skin care products of residue and external environment etc. and necessity also may cause skin irritation; Other zest composition as spice or have irritating plant extract, is do harm rather than good to skin.For this reason consumer need a kind of natural have no side effect plant antiallergic, antiinflammatory, acne, non-stimulated, compositions to responsive skin safety can not be caused.
Summary of the invention
In order to solve the problem, the invention provides a kind of desensitization cosmetic composition, its have reduce stimulation, antiallergic, antiinflammatory preferably, do not cause acne, non-stimulated, compositions to responsive skin safety.
The object of the present invention is achieved like this: a kind of desensitization cosmetic composition, it is characterized in that: count by weight percentage formula and comprise: cosmetic base 0.79 ~ 55%, Chinese herbal medicine extract 0.21% ~ 45%, wherein Chinese herbal medicine extract comprises glucosan, flavanone and Aloe extract.
The content of described glucosan in formula is 0.01-1.0%
Described glucosan is selected from Herba bromi japonici-beta glucan.
The content of described flavanone in formula is 0.1-0.95%.
Described flavanone extracts from mentha leave.
The content of described Aloe extract in formula is 0.1-43.05%.
Described Aloe extract extracts from Folium Aloe.
Compositions of the present invention have natural have no side effect plant antiallergic, antiinflammatory, do not cause acne, non-stimulated advantage, to responsive skin safety.The present invention may be used in skin-protection product as cleansing milk, cream frost, emulsion, facial film, various aqua product (astringent, toner/smoothing toner, cosmetic water, nutritive water, water of releiving) etc.
Accompanying drawing explanation
Fig. 1 be Chinese herbal medicine extract compositions of the present invention to 1L-1 α, 1L-8, PGE2 release impact;
Fig. 2 is that variable concentrations natural Chinese medicine composition of the present invention is on the impact of histamine release;
Fig. 3 is the impact that natural Chinese medicinal herb compositions of the present invention discharged β-Nei calf peptide at 24,48 hours;
Fig. 4 is blank group and uses natural Chinese medicinal herb compositions of the present invention on the impact of the interleukin-1 alpha in skin;
Fig. 5 is the contrast test data to sensitive-skinned analgesic activity;
Fig. 6 is the contrast of the perceptual evaluation of analgesic effect.
Detailed description of the invention
The present invention is a kind of desensitization cosmetic composition, counts by weight percentage and comprises: cosmetic base 0.79 ~ 55%, Chinese herbal medicine extract 0.21% ~ 45%, and wherein Chinese herbal medicine extract comprises glucosan, flavanone and Aloe extract.Chinese herbal medicine extract is gentle to skin, zest is less, and adding of they can better improve the attractive in appearance of skin.The preferred content of Chinese herbal medicine extract is 1.0 ~ 15%.
Preferably, glucosan is selected from Herba bromi japonici-beta glucan, be structure is β-1,3 and β-Isosorbide-5-Nitrae glycosidic bond, extracts from Herba bromi japonici, Herba bromi japonici-beta glucan that the fragrant company of such as moral produces.The content of Herba bromi japonici-beta glucan in formula is 0.01-1.0%, preferred 0.05-0.3%.Herba bromi japonici-beta glucan can promote wound healing, repairs impaired skin, gives skin and moisten smooth sense of touch as silk, have excellent senile-resistant efficacy, can smooth fine wrinkles, improve skin elasticity, improve skin texture degree; There is unique straight-chain molecular structure, impart good transdermal inspiratory dyspnea and enter fibroblast synthesis collagen protein.
Preferably, flavanone extracts from mentha leave, the Folium Menthae extract that such as French SILAB company produces.The content of flavanone in formula is 0.1-0.95%, preferred 0.3-0.7%.Folium Menthae extract, because be rich in the flavanone from mentha leave in its extract, can delay the release of proinflammatory courier, promotes that the generation of happy neuropeptide reduces skin rubefaction and sharp sensation.
Described Aloe extract extracts from Folium Aloe, the Aloe extract that such as U.S. ALOECORP company produces.The content of Aloe extract in formula is 0.1-43.05%, preferred 0.5-15%, the history that Aloe is worldwide applied has had five, 6,000 years, Aloe is with a long history for improving looks, excellent, Aloe has anti-inflammation and sterilization, promotes the effect of wound healing, cell-activating, minimizing skin oil and fat and melanin secretion, and it is mainly containing 99.5% moisture viscose glue and mucopolysaccharide and choline salicylate (its content in formula is 0.1-30.55%)
Above Chinese herbal medicine meets Pharmacopoeia of People's Republic of China 2005 editions standards.
Cosmetic base of the present invention is different according to skin-protection product difference, as cleansing milk, cream frost, emulsion, facial film, each middle aqua product (astringent, toner/smoothing toner, cosmetic water, nutritive water, water of releiving), according to various product formulation ratio routinely.
Cosmetic base generally comprises very easily skin permeation emollient, emulsifying agent, thickening agent and wetting agent.Emollient can be selected from 16/octadecanol, PEG-60 castor oil hydrogenated, soyasterol, plant sterol, dicaprylyl carbonate, sad Propylheptyl, aloe, Jojoba oil, Oleum Helianthi, Semen pruni armeniacae oil, macadimia nut oil, Jojoba ester etc.Wetting agent can be selected from polyhydroxy-alcohol as glycerol, 1.3-butanediol, sorbitol etc.: hyaluronic acid, its precursor and its derivant are as the salt of glucamine and similar hyaluronic sodium and derivant thereof.Emulsifying agent is selected from glucosides class, esters.Glucosides class is selected from coco group glucoside, cetyl glucoside, eicosyl glucoside, C
12-20alkyl androstanediol.Esters is selected from C
20-22alkyl phosphate, tristerin, PEG-100 stearate, sucrose stearate.Thickening agent is selected from HANSHENGJIAO, tapioca, hydroxypropyl phosphorate starch, acrylate copolymer, acrylic acid/sodium acrylate polymer, acrylate copolymer, acrylate/C
10-30alkyl acrylate copolymer, acrylic acid/C
10-30alkyl acrylate copolymer emulsifying agent, acrylic acid/acrylonitrile copolymer, acrylate/behenyl alcohol polyoxyethylene (25) ether metacrylic acid ester, acrylate/Brij-721 (20) methacrylate copolymer, acrylate/aminoacrylate copolymers, acrylic copolymer/white mineral oil/tridecyl polyoxypropylene (1) polyoxyethylene (6) polyethers, sodium acrylate copolymer/soybean oil/tridecyl polyoxypropylene (1)/polyoxyethylene (6) polyethers, sodium polyacrylate/octyl stearate/trideceth (6) ether, the derivant of acrylamide, alkene/alkylene oxide polymer and other base polymers (as acid-thickened dose of Sal care SC 92 ﹑ Sal care SC 95 ﹑ Sal careSC 96 series) one or more combinations wherein.
In desensitization cosmetic skin care compositions of the present invention, in addition to the aforementioned ingredients, also containing other composition used in compositions, as deionized water, Fang Fu Ji ﹑ Ao He Ji ﹑ Xiang Liao ﹑ UV absorbent etc., can not describe in detail at this.Such as antiseptic can select a kind of of Nipagin ester series, imidazolidinyl urea, phenoxyethanol, Methylisothiazolinone, polyhydric alcohol, iodo propinyl butyl carbamate and two kinds and two or more mixture, if but we select not containing preservative system, can with 399870, the fragrant glycol 68T of 177441() 1,2 pentanediols (being all the fragrant raw material of moral above), concrete protective system challenge test result situation does not illustrate one by one at this.
Be described in more detail the present invention further below by way of the following example, but the present invention is not limited to this specific examples.If no special instructions, in example, the ratio of each component is wt%.
The formula of embodiment 1 ~ 5 and comparative example 6 ~ 8 is in table 1, and the formula of embodiment 9 ~ 13 and comparative example 14 ~ 16 is in table 2.
Manufacture table 1, the cosmetic composition of composition shown in table 2, coat cosmetics, look for experienced expert to smear their face with the dermal compositions obtained like this, and according to following standard, evaluate from sensation that it is antipruritic, zest, whole structure.
Evaluation methodology:
(1) antipruritic
◎: effect fine zero: effective
△: effect is general ×: there is no effect
By 4 assistant directors, with each composition product, test tracking verification is carried out to 32 volunteers.
(2) zest
Each compositions is evaluated according to following ageing stability criterion.
◎: non-stimulated zero: have point stimulation, but do not have red, itch
△: have stimulation, have red, itch ×: stimulate, red, swollen
By 4 assistant directors, with each composition product, test tracking verification is carried out to 32 volunteers.
(3) whole structure
Each compositions is carried out whole structure evaluation according to following standard.
◎: effect fine zero: effective
△: effect is general ×: there is no effect
By 4 assistant directors, with each composition product, bulk testing tracking verification is carried out to 32 volunteers.
Table 1
Table 2
The formula of embodiment 17 and preparation method are in table 3
The formula of embodiment 18 and preparation method
Embodiment 19(releives salubrious water)
Embodiment 20(Shu Xing lotion)
The desensitization cosmetic skin care composition obtained by embodiment 17 ~ 20 evaluates that it is antipruritic, zest, whole structure from sensation, and evaluation result is " very well ".
The effect of Chinese herbal medicine extract is described from four aspects below:
One. the impact on Microinflammation: in vitro study
On the impact of proinflammatory medium interleukin-1 alpha, interleukin 8, PGE2 and histamine release, as Fig. 1.
1. measure 1L-1 α, 1L-8, PGE2 (ELISA method)
Model: cell culture
Cell: the horn cell of people
Method: ELISA kit(enzyme-labeled immunosorbent assay (ELISA))
Actual conditions: 1)-inflammation of being caused by UV
UVA 10J/cm2
UVB 0.15J/cm2
2)-inflammation of being caused by PMA
Time: 0-24 hour
Product: Chinese herbal medicine extract (the proportionally 1:1:10 mixing of the flavanone extracted in Herba bromi japonici-beta glucan, mentha leave and Aloe extract) compositions, makes mass percent 0.5%-1%-3% aqueous solution.
Sum up: the horn cell of people stands after UV irradiates, and 3% desensitization Chinese herbal medicine extract compositions can reduce 1L-1 α, and the release of 1L-8, PGE2 reaches 85% respectively, 93%, 75%.Inflammation-inhibiting phenomenon occurs, and antiphlogistic effects depends on dosage.
2. the measuring principle of histamine
Object: measure the ability that Chinese herbal medicine extract compositions suppresses to cause histamine release under neurotransmitter-Substance P (subst.p) existence condition.(as Fig. 2)
Model: cell culture
Cell: Mus mastocyte
Method: ELISA kit(enzyme-labeled immunosorbent assay (ELISA))
Product: Chinese herbal medicine extract (the proportionally 1:1:10 mixing of the flavanone extracted in Herba bromi japonici-beta glucan, mentha leave and Aloe extract) compositions, makes mass percent 1%-3%-5% aqueous solution.
Service time: 0-20 minute
Sum up: the mast cell cultures obtained from rat peritoneum is used for detecting the release of histamine the culture medium that caused by neurotransmitter-Substance P (subst.p).Compare with Substance P, the release that 5% Chinese herbal medicine extract can reduce histamine reaches 60%.
Two, on the impact producing β-Nei calf peptide (happy hormone)
1. the mensuration (as Fig. 3) of β-Nei calf peptide
Skin pain and uncomfortable ability is reduced for measuring the generation of Chinese herbal medicine extract compositions stimulation β-Nei calf peptide in the research of human keratinized cell.Use 1% Chinese herbal medicine extract compositions after 24 hours or 48 hours, the generation that significantly can increase β-Nei calf peptide horn cell reaches 95% or 71%.
Object: assessment Chinese herbal medicine extract compositions promotes---the generation of endorphins
Model: cell culture
Cell: the horn cell of people
Method: ELISAkit(enzyme-labeled immunosorbent assay (ELISA))
Service time: 24 hours or 48 hours
Product: Chinese herbal medicine extract (the proportionally 1:1:10 mixing of the flavanone extracted in Herba bromi japonici-beta glucan, mentha leave and Aloe extract) compositions, makes mass percent 1% aqueous solution.
Three. analgesic activity: human test
The mensuration (as Fig. 4) of skin surface interleukin-1 alpha
Carry out human test by the formula of embodiment 18, measure Chinese herbal medicine extract compositions to sensitive-skinned analgesic activity.
Consumer tests (sensory testing) use the emulsified gel (correspondence twice containing 3% Chinese herbal medicine extract compositions for one day, use after 5 days, contrast with blank product, the quantity that the emulsified gel containing 3% Chinese herbal medicine extract compositions significantly can reduce the interleukin-1 alpha of skin reaches 26%.
Four. twinge test (subjective evaluation)
Object: by twinge testing evaluation Chinese herbal medicine extract compositions to the mitigation of responsive skin.
Tester: 12 testers, age 26-52 year
Method: 1) use 10% lactic acid (LA) solution in nose pleat side, opposite side uses isotonic saline solution (PLACEBO)
2) choose 4 points, measure 30 minutes, use digital representation sensitivity.
Product: containing the emulsion (testing by the formula of embodiment 17) of 5% Chinese herbal medicine extract
Time: 0-5 days
As Fig. 5, after the pretreatment of 5 days, in the middle part of muffle, use lactic acid (LA) solution, sensation of pricking 39% can be reduced by the emulsion containing 5% Chinese herbal medicine extract.The volunteer of 87% confirms this effect.Skin is releived more, more can avoid stimulating cause sensitivity.
The perceptual evaluation (as Fig. 6) of analgesic effect
Object: use self-questionnaire survey, assesses and quantizes and blank, using the responsive case after Chinese herbal medicine extract compositions
Panel:129 people
Method: use containing must the self-questionnaire survey of answer
Product: the cream product (testing by the formula of embodiment 17) containing 5% Chinese herbal medicine extract compositions
Use position: face
Service condition: use twice for 4 weeks interior one day
Test arranges: 129 volunteers are divided into two groups, and group 1 is Chinese herbal medicine extract compositions, and group 2 is blank.
Carry out the consumer tests of month at the panel of 129 male's compositions, half people uses the cream product containing 5% Chinese herbal medicine extract, and second half people uses blank product.To use twice daily composition for desensitizing with after feel to quantize.
Use in the male consumer of composition for desensitizing, people's use of 72%, containing product after the palpus of composition for desensitizing, is recognized its analgesic activity, and 64% people's report has freshness.
Claims (4)
1. a desensitization cosmetic composition, it is characterized in that: count by weight percentage formula and comprise: cosmetic base 0.79 ~ 55%, Chinese herbal medicine extract 0.21% ~ 45%, wherein Chinese herbal medicine extract by the content in formula be the Herba bromi japonici-beta glucan of 0.01-1.0%, the flavanone of 0.1-0.95% and the Aloe extract of 0.1-43.05% form.
2. a kind of desensitization cosmetic composition according to claim 1, is characterized in that: described flavanone extracts from mentha leave.
3. a kind of desensitization cosmetic composition according to claim 1, is characterized in that: described Aloe extract extracts from Folium Aloe.
4. a kind of desensitization cosmetic composition according to claim 1 is cleansing milk, cream frost, emulsion, facial film or aqua product.
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| CN103655439B (en) * | 2013-05-24 | 2015-09-09 | 钱臻 | A kind of biofermentation surfactant and preparation method thereof |
| CN103655437B (en) * | 2013-05-24 | 2015-09-09 | 钱臻 | A kind of biological fermentation day cream and preparation method thereof |
| CN103462818B (en) * | 2013-08-15 | 2016-01-20 | 山东中谷淀粉糖有限公司 | A kind of facial film containing polydextrose and preparation method thereof |
| CN104000758B (en) * | 2014-05-27 | 2016-09-28 | 李秀玲 | A kind of skin care compositions and methods containing Chinese medicine ingredients and preparation method thereof |
| CN105055264A (en) * | 2015-10-02 | 2015-11-18 | 王学建 | Moisturizing and skin-protecting mask liquid and preparation method thereof |
| CN107998037A (en) * | 2015-10-09 | 2018-05-08 | 吴优 | A kind of multiple-effect anti-acne skin care item and preparation method thereof |
| CN109568220A (en) * | 2019-02-14 | 2019-04-05 | 重庆市洲仨科技发展有限公司 | A kind of compound polyphenol antiallergic essence and antiallergic essence lotion |
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