CN103054044A - Sleep-improving health food composition - Google Patents
Sleep-improving health food composition Download PDFInfo
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- CN103054044A CN103054044A CN2012105760863A CN201210576086A CN103054044A CN 103054044 A CN103054044 A CN 103054044A CN 2012105760863 A CN2012105760863 A CN 2012105760863A CN 201210576086 A CN201210576086 A CN 201210576086A CN 103054044 A CN103054044 A CN 103054044A
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Abstract
The invention relates to a sleep-improving health food composition which comprises the following raw materials by weight: 8 to 40 parts of gamma-aminobutyric acid powder, 0.8 to 8 parts of a Chinese magnoliavine extract, 5 to 20 parts of a calcium-containing compound, 5 to 20 parts of a magnesium-containing compound and 0.01 to 1 part of vitamin B6. The invention further provides a sleep-improving preparation and a preparation method thereof. The sleep-improving health food composition and the sleep-improving preparation use gamma-aminobutyric acid powder, the Chinese magnoliavine extract, the calcium-containing compound, the magnesium-containing compound and the vitamin B6 as main components, do not contain the component of hypnotics, can effectively soothe emotion of a stressed population and people with bad sleep and improve sleep quality.
Description
Technical field
The present invention relates to food or field of health care products, particularly a kind of health-care food composition that improves sleep.
Background technology
Sleep in the whole world that international mental hygiene tissue is sponsored and health plan has initiated in calendar year 2001 that a global activity-with the March 21 in every year, namely the first day in spring is decided to be " World Sleep Day ".The people has time of 1/3rd to spend in sleep in life, and sitting up in five days to affect the survival of human beings, and visible sleep is one of important physiological requirements of people.Sleep is the necessary process of life, is the important step of body recovery, integration and consolidating memory, is healthy indispensable part.
Because modern society's dog-eat-dog, people's thought pressure is large, causes the long-term insomnia of many people or sleep quality not high.Show that according to interrelated data the whole nation at present existing people 50% or more has and is difficult to sleeping and the insomnia phenomenon, owing to have a sleepless night for a long time, many people have suffered from many relevant diseases.Sleep-disorder has become a human large killer.Now become a disease that is difficult to cure, brought huge hidden danger for people's life, work, study.Up to the present, the Cure for insomnia aspect there is no effective ways and specific medicament, many people take hypnotic and come relieving insomnia, if things go on like this make people produce drug dependence, have also caused thus the generation of other diseases, many toxic and side effects have also been caused, serious harm people's health, people's thought pressure is increased, insomnia has been produced powerful fear, Psychological phobia causes vicious circle.
The hypnotic of commonly using clinically at present has Benzodiazepines, barbiturates and other non-barbiturateses, the effect of its Cure for insomnia is apparent in view, but affect larger on its liver, kidney, the user produces the dependence to medicine easily, usually continue to increase pharmaceutical dosage and could keep effect, but also can produce very large toxic and side effect, therefore be not the medicine that is fit to long-term taking.The people that some is taken medicine for a long time in a large number, if reduce suddenly dosage or cut out, also can be with n or V, the coarse tremor of hand, tongue and eyelid causes conduct disorder, illusion occurs, even epileptic attack.
At present, existing a lot of materials that adopt integration of drinking and medicinal herbs, the health food that can improve sleep composite according to the Chinese medical discrimination principle.
CN102600299A discloses a kind of compound improvement sleep electuary and preparation method thereof, processes take the 30-35% fruit of Chinese magnoliavine, 20-25% wilsonii, 5-10% polygala root, 10-15% spina date seed, 20-25% matrimony vine and 5-10% red date as primary raw material.
CN102133331A discloses a kind of capsule and preparation technology thereof who improves sleep function that have, and is by spina date seed 600g, the capsule that fruit of Chinese magnoliavine 500g, ginseng 200g, the tuber of dwarf lilyturf, 150g, polygala root 150g, Poria cocos 30g, starch 20g made.
Therefore develop the composite health-care food composition that forms of a kind of material by integration of drinking and medicinal herbs, have widely prospect.
Summary of the invention
The purpose of this invention is to provide a kind of health-care food composition that improves sleep, can effectively releive high pressure crowd and dyssomnia person's mood of described health-care food composition is improved sleep.
Health-care food composition provided by the invention comprises the raw material of following weight portion: GABA powder 8-40 part, Schisandra chinens P.E 0.8-8 part, calcium containing compound 5-20 part, magnesium-containing compound 5-20 part, Cobastab
60.01-1 part.
Preferably, described health-care food composition comprises the raw material of following weight portion: GABA powder 12-25 part, Schisandra chinens P.E 1-5 part, calcium containing compound 10-15 part, magnesium-containing compound 10-15 part, Cobastab
60.1-0.5 part.
Most preferably, described health-care food composition comprises the raw material of following weight portion: 25 parts in GABA powder, 5 parts of Schisandra chinens P.Es, 12 parts of calcium containing compounds, 12 parts of magnesium-containing compounds, Cobastab
60.5 part.
Wherein, described GABA powder is extractive from fermentative, and commercially available acquisition is preferably 20 type GABA powder, and the mass content of its GABA is 20%.
Wherein, described Schisandra chinens P.E is water extract, and its withdrawal ratio is 5:1, commercially available acquisition.
Described calcium containing compound is the salt of calcic, the oxide of calcic etc.; Described magnesium-containing compound is the salt that contains magnesium, the oxide that contains magnesium etc.
Preferably, described calcium containing compound is selected from one or more in calcium carbonate, calcium gluconae, calcium citrate, calcium lactate, the calcium glycine.
Preferably, described magnesium-containing compound is selected from one or more in magnesium sulfate, magnesium gluconate, magnesia, magnesium chloride, magnesium lactate, the magnesium glycinate.
GABA has another name called 4-Aminobutanoicacid (4-Aminobutanoic acid, 4-AB, be called for short GABA) and GABA, it is a kind of naturally occurring nonprotein amino acid, be the important inhibitory neurotransmitter of mammalian central nervous system, about 50% nervous centralis cynapse position is take GABA as mediator.In human brain cortex, hippocampus, thalamus, basal ganglion and cerebellum, play an important role, and the several functions of body is had regulating action.Have important physiological function, the physiologically active of having reported has to be regulated blood pressure, impel ataraxy, promotes the brain blood flow, promotes the brain vigor, the trophic nerve cell, increase growth hormone secretion, strong liver sharp kidney, prevention of obesity, promotion alcohol metabolism (sobering up), improve the multiple efficacies such as climacteric metancholia.It can promote the reactivity of brain, brain tonic and intelligence development, and anti-epileptic promotes sleep, the beauty treatment moisturizing delays the brain aging function, can replenish the human body inhibitory neurotransmitter, has good blood pressure reduction effect; Promote the kidney function to improve and protective effect; Suppress fatty liver and obesity, the activation liver function.GABA belongs to strong neural inhibitory aminoacid, has calmness, hypnosis, anticonvulsion, hypotensive physiological action.Can suppress the activity of animal, reduce the consumption of energy.Aminobutyric acid acts on the GABA acceptor in the zooblast, the GABA acceptor is a chloride channel, the inhibition of GABA or excitability are to depend on the inside and outside chlorine ion concentration of cell membrane, after the GABA acceptor is activated, cause chloride channel open, can increase cell membrane to the chlorion permeability, chlorion is flowed in the nerve cell, cause the cell membrane hyperpolarization, it is exciting to suppress nerve cell unit, thereby reduces the amount of exercise of animal.It is by reducing the unintentional motion of animal, coming energy saving, thereby reach somatotrophic purpose.Gabanergic promotes the secretion of animal gastric juice and growth hormone, thereby improves the speed of growth and feed intake; The maincenter of searching for food of the excited animal of energy, thus feed intake increased.In recent years finding that GABA has trophism in neural growth course, is a kind of neurotrophic factor.Early stage at nervous system development, GABA can be used as a kind of chemical signal, the motion of the unit that affects the nerves, the migration of stimulating neuronal.GABA is especially larger on relating to synthetic organelle impact with the transhipment AQP-CHIP on some organelles, so GABA can promote the synthetic of AQP-CHIP, comprises GABA acceptor and some neural GAP-associated protein GAP and Enzyme Production.GABA also has certain regulating action to the expression of some neural GAP-associated protein GAPs and enzyme.
Fruit of Chinese magnoliavine flavor acid, sweet, warm in nature has that convergence is astringent or styptic treatment for spontaneous sweating, a function of nourishing generate fluid, kidney calming.Fruit of Chinese magnoliavine ethanol extract, fructus schisandrae water extract all can make the mouse autonomic activities obviously reduce, and can strengthen maincenter tranquilizer chlorpromazine and reserpine to the inhibitory action of autonomic activities, and antagonism central stimulant amphetamine is to the excitation of autonomic activities.Schizandrin is one of main active ingredient in the magnolia vine fruit kernel ethanol extract.Schizandrin suppresses mouse and enrages behavior by what electro photoluminescence or long-term Dan Ju caused, to rat avoidance conditioned reflex and the selective inhibition syngignoscism of the conditioned reflex of second order.Chinese magnoliavine fruit super fine powder decocting liquid, schisandra fruit decoction, fructus schisandrae water extract and active ingredient schizandrin A thereof, the third element, pure the second grade all can increase under the threshold sleep dosage pentobarbital sodium in mice sleep number of elements, prolong the dosage pentobarbital sodium in mice length of one's sleep of above threshold sleeping.Wherein second element and ester second prolong first the two-phase impact of shortening afterwards to having length of one's sleep of mouse.Fructus Schisandrae Chinensis volatile oil can obviously shorten the mouse sleep time that yellow Jackets cause, but with central stimulant pentylenetetrazole and strychnine without synergy.When Fructus Schisandrae Chinensis volatile oil dosage is 1.24g/kg and 0.71g/kg, can causes the movable minimizing of mouse, and can significantly increase liver cell cytochrome P-450 content.Therefore, Fructus Schisandrae Chinensis volatile oil there is no the central excitation effect, and its mechanism that shortens the length of one's sleep that yellow Jackets cause is relevant to the liver drug enzyme inducing action with it, but not to the direct effect of central nervous system.
Calcium is the maximum a kind of inorganic salts of people's in-vivo content, and to safeguarding the health of body, what guarantee that normal growth grows has important function smoothly.Calcium can promote the activity of some enzyme in the body, the active function of regulatory enzyme; Participate in nerve, the activity of muscle and the release of neurotransmitter; Regulate the secretion of hormone.The contraction movement of the solidifying of blood, cell adherence, muscle also all needs calcium.Calcium also tool is regulated the rhythm of the heart, reduces cardiovascular permeability, controls inflammation and oedema, is kept the effect such as acid-base balance.Calcium can reduce the excitability of nerve cell, is a kind of natural sedative.Calcium deficiency can cause nervous migraine (accounting for women's 10%-20%), dysphoria, insomnia.
Magnesium is the interior cation of cell that is only second to potassium in the human body, and its participates in a series of metabolic processes in body, comprises the formation of bone and cell, with neuromuscular and cardiac function substantial connection is arranged.Under the synergy of magnesium, calcium can make N﹠M reduce excitability, in the blood magnesium cross low or calcium excessively low, excitability all increases; Otherwise sedation is arranged then.
Cobastab
6To keep the necessary material of nervous system normal function, can more effective mood placating.
Another object of the present invention provides a kind of preparation that improves sleep, and described preparation comprises described health-care food composition and pharmaceutically acceptable auxiliary material.
Wherein, described preparation is solid pharmaceutical preparation or liquid preparation, and described solid pharmaceutical preparation is tablet, capsule, pulvis or soft capsule; Described liquid preparation is oral liquid.
Wherein, described auxiliary material is pharmaceutically acceptable carrier or diluent.
Wherein, described pharmaceutically acceptable auxiliary material is one or more in xylitol, D-sorbite, isomalt, isomaltoketose, mannitol, starch, dextrin, water, microcrystalline cellulose, lactose, HPMC, soybean oil, phosphatide, the dolomol.
Wherein, described water is preferably purified water.
Wherein, described auxiliary material is conventional amount used.That is, described preparation is on the prescription basis of described health-care food composition, and the auxiliary material that contains is 10-50 part.Preferably, described auxiliary material is 30-40 part.Most preferably, described auxiliary material is 40 parts.
Wherein, if described preparation is oral liquid, then the consumption of water is 1600-3200 part in the described auxiliary material.Preferably, the consumption of water is 2000-3000 part in the described auxiliary material, and most preferably, the consumption of water is 2000 parts in the described auxiliary material.
Another object of the present invention provides the preparation method of the preparation of described improvement sleep, and described method is for taking by weighing in proportion GABA powder, Schisandra chinens P.E, calcium containing compound, magnesium-containing compound, Cobastab
6, sieve, add pharmaceutically acceptable auxiliary material, mix, be prepared into conventional formulation.
Health-care food composition and the preparation of improvement sleep of the present invention have the following advantages:
The health-care food composition of improvement sleep of the present invention and preparation are with GABA powder, Schisandra chinens P.E, calcium containing compound, magnesium-containing compound and Cobastab
6Be main component, do not contain the hypnotic composition, can effectively releive high pressure crowd and dyssomnia person's mood is improved sleep.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Raw material GABA powder of the present invention is 20 type GABA powder (the GABA mass content is 20%), available from system garden, Shanghai food technology Co., Ltd;
Schisandra chinens P.E is water extract, and brown fine powder, withdrawal ratio are 5:1, available from Jiahe, Shaanxi bio tech ltd;
Used other each raw materials of the present invention are the commercially available prod;
If do not specialize, the conventional means that used technological means is well known to those skilled in the art among the embodiment.
Embodiment 1 capsule
1, prescription (weight): GABA powder 800g, Schisandra chinens P.E 80g, magnesia (containing magnesium 60%) 500g, calcium carbonate (calcic 40%) 500g, Cobastab
61g, hydroxypropyl methylcellulose 600g, dolomol 400g, specification 600mg/ grain.
2, preparation method:
1) takes by weighing GABA powder, Schisandra chinens P.E, magnesia, calcium carbonate, Cobastab according to prescription
6, hydroxypropyl methylcellulose and dolomol, cross respectively 40 mesh sieves, for subsequent use;
2) above-mentioned supplementary material is mixed by the equivalent method of progressively increasing, pour in the capsule-filling mould, can capsule, polishing, packing.
3, specification: contain GABA 0.033g, Schisandra chinens P.E 0.017g, magnesium 0.0625g, calcium 0.042g, Cobastab in every capsules
60.21mg.
4, taking dose: take 2 every day.
Embodiment 2 tablets
1, prescription (weight): GABA powder 1200g, Schisandra chinens P.E 300g, magnesium gluconate (containing magnesium 5.39%) 2000g, calcium lactate (calcic 13%) 1000g, Cobastab
68g, lactose 2000g, xylitol 1500g, dextrin 500g, microcrystalline cellulose 800g, specification 1.0g/ sheet.
2, preparation method:
1) takes by weighing GABA powder, Schisandra chinens P.E, magnesium gluconate, calcium lactate, Cobastab according to prescription
6, lactose, xylitol, microcrystalline cellulose, dextrin cross respectively 80 mesh sieves, and be for subsequent use;
2) above-mentioned supplementary material (except microcrystalline cellulose, dextrin) is mixed by the equivalent method of progressively increasing, make water as adhesive, softwood processed is with the oscillating granulator granulation of above-mentioned softwood through 14 eye mesh screens, particle is inserted in the multi-functional boiling drier, about 40 minutes of 50 ℃ of fluidized dryings, the control pellet moisture was 5%, whole grain, then in particle, add microcrystalline cellulose, dextrin, total mixed, compressing tablet, packing;
3, specification: every contains GABA 0.026g, contains Schisandra chinens P.E 0.032g, contains magnesium 0.012g, calcic 0.014g, Cobastab
60.86mg.
4, taking dose: take 2 every day.
Embodiment 3 pulvis
1, prescription (weight): GABA powder 900g, Schisandra chinens P.E 100g, magnesium lactate (containing magnesium 8%) 800g, calcium citrate (calcic 21%) 600g, Cobastab
65g, isomalt 1200g, isomaltoketose 1000g, mannitol 2800g, specification 2g/ bag.
2, preparation method:
1) claims GABA powder, Schisandra chinens P.E, magnesium lactate, calcium citrate, Cobastab according to prescription
6, isomalt, mannitol, isomaltoketose cross respectively 40 mesh sieves, and be for subsequent use;
2) above-mentioned supplementary material is mixed packing by the equivalent method of progressively increasing.
3, specification: every bag contains GABA 0.049g, Schisandra chinens P.E 0.027g, magnesium 0.017g, calcium 0.034g, Cobastab
61.35mg.
4, taking dose: take 1 bag every day.
Embodiment 4 soft capsules
1, prescription (weight): GABA powder 2000g, Schisandra chinens P.E 800g, magnesium glycinate (containing magnesium 12.6%) 1000g, calcium glycine (calcic 21%) 1500g, Cobastab
610g, soybean oil 1200g, phosphatidase 13 00g, specification 0.5g/ grain.
2, preparation method:
1) takes by weighing GABA powder, Schisandra chinens P.E, magnesium glycinate, calcium glycine, Cobastab according to prescription
6, cross respectively 100 mesh sieves, for subsequent use;
2) above-mentioned supplementary material is mixed by the equivalent method of progressively increasing, then with soybean oil, phosphatide homogeneous, with automatic rotation Zhanang machine, pressing moulding.
3, specification: contain GABA 0.029g, Schisandra chinens P.E 0.059g, magnesium 0.009g, calcium 0.023g, Cobastab in per 1 soft capsule
60.73mg.
4, taking dose: take 1 every day.
Embodiment 5 oral liquids
1, prescription (weight): GABA powder 4000g, Schisandra chinens P.E 200g, magnesium chloride (containing magnesium 12%) 1500g, calcium carbonate (calcic 40%) 2000g, Cobastab
6100g, D-sorbite 3000g, purified water 200000ml, specification 10ml/ props up.
2, preparation method:
1) takes by weighing GABA powder, Schisandra chinens P.E, magnesium chloride, calcium carbonate, Cobastab according to prescription
6, D-sorbite, cross respectively 80 mesh sieves, for subsequent use;
2) above-mentioned supplementary material all is dissolved in the 200000ml purified water, then stirs, can, and get final product.
3, specification: contain GABA 0.04g, Schisandra chinens P.E 0.01g, magnesium 0.009g, calcium 0.04g, Cobastab in per 1 oral liquid
60.005g.
4, taking dose: take 1 every day.
Embodiment 6 capsules
1, prescription (weight): GABA powder 2500g, Schisandra chinens P.E 500g, magnesium sulfate (containing magnesium 9.9%) 1200g, calcium gluconae (calcic 9%) 1200g, Cobastab
650g, hydroxypropyl methylcellulose 2700g, dolomol 1000g, starch 300g, specification 600mg/ grain.
2, preparation method:
1) takes by weighing GABA powder, Schisandra chinens P.E, magnesium sulfate, calcium gluconae, Cobastab according to prescription
6, hydroxypropyl methylcellulose, starch, dolomol, cross respectively 40 mesh sieves, for subsequent use;
2) above-mentioned supplementary material is mixed by the equivalent method of progressively increasing, pour in the capsule-filling mould, can capsule, polishing, packing.
3, specification: contain GABA 0.032g, Schisandra chinens P.E 0.032g, magnesium 0.008g, calcium 0.007g, Cobastab in every capsules
63.2mg.
4, taking dose: take 2 every day.
Experimental example
1 materials and methods
1.1 test specimen and grouping
Experiment is divided into 6 groups, be designated as respectively control group, experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, the product that experimental group 1-5 makes take the embodiment of the invention 1,2,3,5,6 respectively is as the test specimen administration, the product administration that control group makes with patent CN102133331A.
1.2 animal used as test
Kunming mouse, 18-22g, male and female half and half are provided by Chinese Academy of Sciences animal.
1.3 test dose design
Experiment is divided into 6 groups, every morning 8:00-9:00 gastric infusion, and animal ad lib and drinking-water, suitable temperature is 24 ± 5 ℃, relative humidity 40-70% to guarantee feeding environment, noiselessness.
1.4 experimental technique
1.4.1 the mouse hypnosis that threshold dose and sub-threshold dose yellow Jackets are induced test
Adopt male mice 2 weeks of successive administration, 15min after the last administration, the threshold dose animal is by 35mg/kg dosage lumbar injection yellow Jackets (capacity is 0.1ml/10g), the sub-threshold dose animal is by 22mg/kg dosage lumbar injection yellow Jackets (injection volume is 0.1ml/10g), reach 1min as the sleep index take the mouse righting reflex loss, observe mouse to the prolongation effect of the length of one's sleep of threshold dose yellow Jackets, and on inducing the impact that the sleep number of animals occurs in the 30min after the administration of sub-threshold dose yellow Jackets.
1.4.2 barbital sodium hypnosis test
Select female mice, continuous 2 weeks of gavage, 15min after the last administration, each organizes mouse by 300mg/kg dosage lumbar injection barbital sodium (injection volume is 0.1ml/10g), reach more than the 1min as sleeping criterion with the mouse righting reflex loss, observe to respectively organizing the incubation period that mouse begins to sleep behind the barbital sodium.
1.5 statistical method
Measurement data adopts variance analysis, and enumeration data adopts X
2Check.
2 results
2.1 learning, observes general behavior
After giving given the test agent, each is organized mouse and shows the behaviors such as peace and quiet, autonomic activities minimizing, but does not observe tested material to the direct syngignoscism of mouse.
2.2 the mouse hypnosis that threshold dose and sub-threshold dose yellow Jackets are induced test
Different given the test agent is as shown in table 1 on the impact of yellow Jackets inducing mouse hypnosis time and sleep incidence.
Table 1 is on the impact of the yellow Jackets inducing mouse length of one's sleep and sleep incidence
# represents each experimental group and control group relatively, significant difference is arranged, P＜0.05; * represent that each experimental group and control group relatively, have utmost point significant difference, P＜0.01.
From table 1 as seen, each experimental group all can obviously prolong the mouse sleep time that the threshold dose yellow Jackets are induced, and tests 1 group, tests 2 groups, tests 4 groups and control group comparison, significant difference (P＜0.05), test 5 groups of 3 groups and experiments and control group relatively, difference is (P＜0.01) extremely significantly; Simultaneously, each experimental group is increased significantly sub-threshold dose yellow Jackets inducing mouse sleep incidence, tests 1 group and control group comparison, significant difference (P＜0.05); Other experimental group and control group compare, and difference is (P＜0.01) extremely significantly.
2.3 barbital sodium hypnosis test
Different given the test agent on barbital sodium inducing mouse Sleep latency to affect the result as shown in table 2.
Table 2 is on the impact of barbital sodium inducing mouse Sleep latency
As seen, experimental group 1, experimental group 4 compare with control group, can obviously shorten barbital sodium inducing mouse Sleep latency, significant difference (P＜0.05) from table 2; Other experimental group and control group relatively can extremely obviously shorten barbital sodium inducing mouse Sleep latency, and difference is (P＜0.01) extremely significantly.
3 conclusions
From whole experimentation, improvement of the present invention sleep composition and preparation thereof are to the mouse sleep effect that improves significantly.
In sum, the health-care food composition of improvement sleep of the present invention and preparation are with GABA powder, Schisandra chinens P.E, calcium containing compound, magnesium-containing compound and Cobastab
6Be main component, do not contain the hypnotic composition, can effectively releive high pressure crowd and dyssomnia person's mood is improved sleep.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. health-care food composition that improves sleep, it is characterized in that described health-care food composition comprises the raw material of following weight portion: GABA powder 8-40 part, Schisandra chinens P.E 0.8-8 part, calcium containing compound 5-20 part, magnesium-containing compound 5-20 part, Cobastab
60.01-1 part.
2. health-care food composition according to claim 1, it is characterized in that described health-care food composition comprises the raw material of following weight portion: GABA powder 12-25 part, Schisandra chinens P.E 1-5 part, calcium containing compound 10-15 part, magnesium-containing compound 10-15 part, Cobastab
60.1-0.5 part.
3. want 2 described health-care food compositions according to right, it is characterized in that described health-care food composition comprises the raw material of following weight portion: 25 parts in GABA powder, 5 parts of Schisandra chinens P.Es, 12 parts of calcium containing compounds, 12 parts of magnesium-containing compounds, Cobastab
60.5 part.
4. each described health-care food composition is characterized in that according to claim 1-3, and described GABA powder is 20 type GABA powder, and the mass content of its GABA is 20%.
5. each described health-care food composition is characterized in that according to claim 1-3, and described Schisandra chinens P.E is water extract, and its withdrawal ratio is 5:1.
6. each described health-care food composition is characterized in that according to claim 1-3, and described calcium containing compound is selected from one or more in calcium carbonate, calcium gluconae, calcium citrate, calcium lactate, the calcium glycine; The described magnesium compound that contains is selected from magnesium sulfate, magnesium gluconate, magnesia, magnesium chloride, magnesium lactate, the magnesium glycinate one or more.
7. a preparation that improves sleep is characterized in that, described preparation comprises each described health-care food composition of claim 1-6 and pharmaceutically acceptable auxiliary material.
8. preparation according to claim 7 is characterized in that, described preparation is solid pharmaceutical preparation or liquid preparation, and described solid pharmaceutical preparation is tablet, capsule, pulvis or soft capsule; Described liquid preparation is oral liquid.
9. preparation according to claim 7, it is characterized in that described pharmaceutically acceptable auxiliary material is one or more in xylitol, D-sorbite, isomalt, isomaltoketose, mannitol, starch, dextrin, water, microcrystalline cellulose, lactose, HPMC, soybean oil, phosphatide, the dolomol.
10. prepare the method for each described improvement sleep preparation of claim 7-9, it is characterized in that described method is for taking by weighing in proportion GABA powder, Schisandra chinens P.E, calcium containing compound, magnesium-containing compound, Cobastab
6, sieve, add pharmaceutically acceptable auxiliary material, mix, be prepared into conventional formulation.
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| CN110269897B (en) * | 2019-07-12 | 2021-04-13 | 成都中医药大学 | Composition for resisting fatigue and improving sleep and application thereof |
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| CN114732132A (en) * | 2020-12-21 | 2022-07-12 | 北京朗迪制药有限公司 | Calcium-magnesium niacin liquid nutrient supplement for improving sleep and preparation method thereof |
| CN114617256A (en) * | 2022-03-14 | 2022-06-14 | 深圳中科欣扬生物科技有限公司 | A health promotion formula containing SOD and 5-HTP for resisting oxidation, relieving fatigue and improving sleep |
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