CN103041188A - Composition for improving symptoms of cerebrovascular disease - Google Patents
Composition for improving symptoms of cerebrovascular disease Download PDFInfo
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- CN103041188A CN103041188A CN2011103059338A CN201110305933A CN103041188A CN 103041188 A CN103041188 A CN 103041188A CN 2011103059338 A CN2011103059338 A CN 2011103059338A CN 201110305933 A CN201110305933 A CN 201110305933A CN 103041188 A CN103041188 A CN 103041188A
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Abstract
The invention relates to a composition for improving symptoms of a cerebrovascular disease. The composition is composed of Ligusticum wallichii, rhizoma Gastrodiae and nervonic acid, and has advantages of synergistic and complementary pharmacological effects, high content of active ingredients, quick taking-effect, controllable quality, small taking dose and definite therapeutic effect. The composition can be prepared into various healthcare product dosage forms suitable for clinical application.
Description
Technical field
The present invention relates to a kind of compositions, especially relate to a kind of compositions that can be used for health product of improving the cerebrovascular symptom.
Background technology
In recent years, China's Stroke Death rate has the trend of obvious rising, and annual new apoplexy 2,000,000 people in the whole nation die from the patient Yue Da 1,500,000 of apoplexy every year, and a routine new patient is just arranged average per 15 seconds, per 21 seconds a dead people.And in elderly population, become to disable, live and rely on and the main cause of forfeiture social competence.At present, still to approach the speed rising in every year 9%, every increase of age is 10 years after 55 years old for Cerebral Haemorrhage Invasion Rate, and the danger of apoplexy just increases by 1 times.So further strengthen and prevent and treat dynamics, reduce as early as possible the M ﹠ M of apoplexy, become current instant vital task.Although China has detailed Chinese cerebrovascular guideline of prevention and treatment at present, and the medicine that the determined curative effects such as picture rt-PA (rt-PA) are arranged is tackled the cerebrovascular of super early stage (falling ill 3 hours in), but still have expensive, the drawbacks such as hemorrhagic hidden danger are arranged, more can not contain all Treatment of Cerebrovascular Diseases.Turn to gradually medicine and the health product of from natural animal-plant, seeking the control cerebral infarction from synthetic drug in the world at present.Chinese medicine China clinical for the prevention and the treatment apoplexy occupy prior status than other countries, the research effort of input is also more.Now therefrom find many Chinese medicine compound, effective ingredient in Chinese and Chinese medicine monomer that have exploitation to be worth.Especially effective ingredient in Chinese and monomer have very strong pharmacologically active, are the field of Chinese medicines of apoplexy new drug development.
DCXW derives from " should bright opinion side " volume two, for gold begins to be used for the treatment of " head-wind syndrome revolves dizzy urgency, and outer Heyang gas, wind and cold are rich mutually, and the stomach phlegm in the diaphragm is drunk, migraine and general headache, body is inflexible tired " towards cold medical school Liu Wansu (1110-1209).Its Rhizoma Chuanxiong itself just has clear and definite pharmacological action (Yin Dawei, Chen Zhengai etc.: cnidium officinale makino is to the protective effect of cerebral ischemia/reperfusion injury of rats, Yanbian University's medical journal, 2008,31 (3) p381-384) to ischemic brain injury.DCXW is one of traditional prescription of the simplest and determined curative effect, only is comprised of Rhizoma Chuanxiong and Rhizoma Gastrodiae two flavor Chinese medicines.In modernization of Chinese medicine process, country drops into huge fund by projects such as " 95 " Program for Tackling Key Problems, " 973 " state key base growth planning DCXW is carried out scientific research.The result proves that DCXW is effective to Treatment of Cerebral Ischemic Diseases.The Study on Modernization that material base and the mechanism of action of its prescription are carried out shows, the party has protective effect (He Li to rat cerebral ischemia, Zhang Zhijian: " DCXW is to the protective effect of rat cerebral ischemia ", Sichuan University's journal (medicine), 06 phase in 2004); Ferulic acid wherein is owing to there is obvious anti-platelet aggregation, discharge the effect of serotonin (5-HT), one of pharmacological basis for the treatment cerebrovascular, the party's main effective ingredient (Wang Xing etc., healthy rabbits is taken behind the DCXW pharmacokinetic of ferulic acid in the body, country's 973 fund projects: the research of prescription modern scientific research-prescription mechanism of action and material base, bullets G1999054402).The experiment that also has shows that Chuanxiong Tianma liquid can improve the nervous function damage that cerebral ischemic reperfusion in rats causes; alleviate cerebral edema; and has the removing free radical; the functions such as anti peroxidation of lipid; cerebral ischemia/reperfusion injury of rats had a neuroprotective (night peak; the king admires first-class: Chuanxiong Tianma liquid is to the experimentation of cerebral ischemia/reperfusion injury of rats protective effect, Chinese Chinese and western medicine magazine the 5th phase of the 4th volume March in 2003).
The present existing sodium ferulate (or ferulic acid) that contains respectively clinically, the medicine of gastrodine is used for the treatment of the report of apoplexy (Chen Li: the clinical analysis of sodium ferulate treatment cerebral infarction, the practical medicine of China, 05 phase in 2008; Yu Zhaorui, Wang Lingxiao: the observation of curative effect of Clinical observation of gastrodine injection on treatment acute ischemic cerebral apoplexy, Chinese combination of Chinese and Western medicine magazine, 04 phase in 2007), but use Rhizoma Chuanxiong and Rhizoma Gastrodiae prescription to prevent and treat medicine or the health product of cerebrovascular disease.For the multifactor Complex Diseases of this class of cerebrovascular disease, the Drug therapy effect that composition is single is comprehensive not enough, and the Comprehensive Clinical curative effect is not ideal enough.
DCXW belongs to classical hospital, and it is rigorous to have a compatibility, and the flavour of a drug refine is evident in efficacy, the unfailing characteristic and advantage of centuries.The compatibility of Chinese medicine compound is neither drug effect simple addition quantitatively, the counteracting of toxic and side effects that neither machinery, but by the mutual compatibility between the medicine, make the change of compound recipe effect generation matter.So the drug effect of Chinese medicine compound is not to be the stack of every flavor herbal function, but has the not available comprehensive effectiveness of any single medicinal material (galloping, " the Chinese medicine compound drug effect engineering " that the sea is write, Chinese Medicine science and technology publishing house, 2008).
On the other hand, recently achievement in research proves, large Rhizoma Chuanxiong prescription Active parts to enter blood component clear and definite, prototype composition (Wei Yuanfeng in the Rhizoma Gastrodiae Active parts such as prototype composition in the Rhizoma Chuanxiong Active parts such as ferulic acid, senkyunolide I and gastrodine is arranged, Lin Xiao etc., effective constituents UPLC-MS analyzes CHINA JOURNAL OF CHINESE MATERIA MEDICA 09 phase in 2011 in the large Rhizoma Chuanxiong side Active parts blood).As everyone knows, only enter blood component and just might be absorbed by the body, and then the screening by blood brain barrier enters and brings into play therapeutical effect in the brain.
Summary of the invention
Technical problem solved by the invention provides a kind of compositions of improving the cerebrovascular symptom, formed by Rhizoma Chuanxiong, Rhizoma Gastrodiae and nervonic acid, and the pharmacological action cooperative compensating, active constituent content is high, rapid-action, quality controllable, taking dose is little, determined curative effect.
The technical solution used in the present invention is:
A kind of compositions of improving the cerebrovascular symptom, each components by weight is:
Rhizoma Chuanxiong: Rhizoma Gastrodiae: nervonic acid is (1-5): (1-2): (1-4).
Compositions of the present invention, each components by weight is preferably: Rhizoma Chuanxiong: Rhizoma Gastrodiae: nervonic acid is 4: 1: 1.
Compositions of the present invention, each components by weight is preferably: Rhizoma Chuanxiong: Rhizoma Gastrodiae: nervonic acid is 5: 2: 4.
Compositions of the present invention, each components by weight is preferably: Rhizoma Chuanxiong: Rhizoma Gastrodiae: nervonic acid is 1: 1: 1.
The health product dosage form that is suitable for clinical practice includes but not limited to tablet, capsule, pill, powder.
The preparation method of the health product of Tabules is: the component that takes by weighing described compositions, be mixed to get mixed material, adding and mixed material weight ratio are 1: 1～1: 4 medical starch again, 1: 0.1～1: 0.8 sodium carboxymethyl cellulose, 1: 0.01～1: 0.1 magnesium stearate, mix homogeneously, tabletting, sterilization.
The preparation method of the health product of capsule dosage form is: the component that takes by weighing described compositions, be mixed to get mixed material, adding and mixed material weight ratio are 1: 1～1: 2 medical starch again, 1: 0.2～1: 1 lactose, 1: 0.1～1: 0.8 sodium carboxymethyl cellulose, 1: 0.01～1: 0.1 magnesium stearate, mix homogeneously, record capsule, sterilization.
The effect of the component of compositions of the present invention is as follows:
Rhizoma Chuanxiong is principal agent of the present invention.Rhizoma Chuanxiong derives from the rhizome (English Rhizoma chuanxiong by name) of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.Have another name called the mountain and bring up (" left biography ", B.C. 722 years-front 454 years), rhizome of chuanxiong (the B.C. approximately century of Shennong's Herbal), Ligusticum slnense (" danxi's experiential therapy ", 1347 Christian eras), western rhizome of chuanxiong (Compendium of Material Medica, 1578 Christian eras) etc.Rhizoma Chuanxiong sees left biography the earliest, as medicine, begins to be stated from Shennong's Herbal, to Ming Dynasty's Compendium of Material Medica say " Sichuan is cold less, and plant of people transplanted more, clear and bright after perennial root give birth to Seedling, minute its horizontally bury it, then successively take root, the knot rhizome of chuanxiong begins under the root August ".Ming Dynasty's Li Shizhen (1518-1593 A.D.) has been put down in writing the rhizome of chuanxiong of Sichuan plantation in detail in Compendium of Material Medica, point out its adapt circumstance and cultural method, and is identical with modern Rhizoma Chuanxiong basistipe on the ground breeding (nourishing and generating).So far physician's the rhizome of chuanxiong that produced from Sichuan is particularly paid attention to after, becomes the main representative product of rhizome of chuanxiong, classify as top grade, name day " Rhizoma Chuanxiong ".Rhizoma Chuanxiong (rhizome of chuanxiong) acrid in the mouth temperature, main apoplexy enters brain, brains arthralgia due to cold, clonic spasm of the muscle emergency " etc." Mingyi Bielu " meaning " except cold moving in the brain, urticaria goes on the face, the order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated ... ".These records are the earliest evidences that Rhizoma Chuanxiong is applied to treat apoplexy (common saying " apoplexy ").Rhizoma Chuanxiong worldwide has been widely used in medicine, the foods and cosmetics commercial production a few days ago.
Modern Pharmaceutical Chemistry research point out Rhizoma Chuanxiong mainly contain volatile oil, alkaloid, phenolic substance, organic acid, etc. 4 constituents.
1) volatile oil: main component is 96 chemical compounds such as vinegar (1igustilide) in the Rhizoma Ligustici, cnidiumm lactone (cnidilide), neocindilide (neocnidil-ide), senkyunolide (senkyunolide), the 4-hydroxyl-thick lactone of 3-butyl (4-hydroxy-3-butylphthalide), senkyunolide (senkyunolide), 3-butylphthalide, 3-butylidenephthalide, sabinene, a-pinene, myrcene, 21 compositions.With terpinene-4 alcohol of Guanxian county Rhizoma Chuanxiong, butylphthalide and 3-butylidenephthalide content are the highest.
2) alkaloid: loline (pelolyrine), ILE-Valine acid anhydride, 1-β-ethyl acrylate-7-aldehyde radical-B-carboline, 1-acetyl group-B-carboline, L-valyl-Valine acid anhydride, trimethylamine, choline, uracil, adenine and adenosine etc.
3) phenols and organic acid: ferulic acid ((ferulic acid, chemical name are ferulic acid), sedanoic acid, chrysophanol, 4-hydroxy-3-methoxy-styrene, 1-hydroxyl-1-(3-methoxyl group-4-hydroxyphenyl)-ethanol 14-hydroxy benzoic acid, vanillic acid, caffeic acid, protocatechuic acid, linoleic acid.Cao Fengyin etc. get Palmic acid, 5 from Rhizoma Chuanxiong, 5-dioxygen methyl furan is fed aldehyde, vanillin, Palmiticacid etc.
It must be noted that the ligustrazine (chemical name tetramethylpyazine) that only contains a ten million/order of magnitude in the Rhizoma Chuanxiong crude drug.Therefore why be appreciated that inspection does not measure ligustrazine in the Rhizoma Chuanxiong preparation.Also show simultaneously the composition that in taking the Chinese medicine (comprising patent medicine and decoction) that contains Rhizoma Chuanxiong, does not in fact have ligustrazine.In other words, the drug action of chuanxiong and ligustrazine have nothing to do, and (Bian Mutang, Wang Xiaohuan is about the objection of ligustrazine name, Chinese Medical Journal, 1997.77 (7): p.554-555).Yet do not cause yet at present enough attention, ligustrazine is thought the main pharmacodynamics composition of Rhizoma Chuanxiong by mistake, come across repeatedly in pertinent literature and the patent.
Modern pharmacology research thinks that Rhizoma Chuanxiong has many therapeutical effect to cardiovascular and cerebrovascular disease: the main Physiological Function of the contained ferulic acid of Rhizoma Chuanxiong has: antioxidation is with removing free radical, antithrombotic, blood fat reducing and prevent and treat coronary heart disease, and has anti-inflammation and mutation and protective effect on cancer risk.Trans-ferulaic acid has allowed as food additive in the U.S., Japan.The main pharmacological basis that Rhizoma Chuanxiong can be treated the central nervous system disease such as apoplexy is: (1) Rhizoma Chuanxiong can make adenosine-3 ' in the platelet, 5 '-cyclisation-phosphoric acid (cAMP) content raises nearly 1 times, thereby anticoagulant, and suppress the thrombocyte release reaction.Particularly contained ferulic acid has obvious antiplatelet aggregative activity, can suppress thrombosis.(2) Rhizoma Chuanxiong has obvious sedation.Rhizoma Chuanxiong water extraction liquid 10g/kg gavage Dichlorodiphenyl Acetate induced mice writhing response has obvious inhibitory action.(3) Rhizoma Chuanxiong has preferably analgesic activity, and the ancient doctor of Chinese medicine nationality is put down in writing for a long time, " close the angle pain, use Rhizoma Chuanxiong ".Report with Rhizoma Chuanxiong treatment headache is general especially.(4) Rhizoma Chuanxiong can make Ischemic Myocardium In Rabbits avoid pouring into the damage of penetrating again, and its effect may be with blood circulation promoting and blood stasis dispelling, increase coronary flow, reduce myocardial oxygen consumption, and it is relevant to improve the myocardial metabolism effect.(4) Rhizoma Chuanxiong has obvious and lasting hypotensive effect.
Rhizoma Gastrodiae is accessory drugs of the present invention.Being derived from medicinal Rhizoma Gastrodiae (Gastrodia elata Blume, English Rhizoma Gastrodiae by name), is that perennial the orchid family height waits fungivorous plant.Its underground tuber is classified as top grade by the successive dynasties book on Chinese herbal medicine.Rhizoma Gastrodiae has the effect of suppressing the hyperactive liver and subsiding YANG and relieving spasm by subduing liver-wind, can according to different diseases with nourish blood, dispel the wind, reduce phlegm, the same usefulness of class medicine such as collateral dredging, treat various types of apoplexy.In ancient times, Rhizoma Gastrodiae is widely used in health care.Shennong's Herbal record, Rhizoma Gastrodiae have the special effect of " mainly kill terrible smart thing, diseases due to noxious agents produced by various parasites bad odor, take for a long time physical strength profiting, long cloudy fertilizer are good for, making light of one's life by commiting suicide increases year "; Relevant with cerebrovascular records, " aid yang qi is mended five kinds of strain and seven kinds of impairment, and promoting blood circulation is had one's ideas straightened out " (Japan hanako materia medica); " main all rheumatism numbness, spasm of the limbs, children's's acute infantile convulsion, frightened gas, sharp waist knee joint, bone and muscle strengthening " (Kaibao Bencao); Compendium of Material Medica is then to having done sum up to conclude about the discussion of Rhizoma Gastrodiae effect in the successive dynasties books: take for a long time QI invigorating, fertilizer and be good for, increase year, disappear too fat to move; Cure mainly: migraine, apoplexy hands and feet caused by paralysis, bones and muscles pain, walking hardship etc..Rhizoma Gastrodiae is the compatibility related drugs respectively, can treat spasm tic, migraine and general headache, dizzy, numb limbs and tense tendons, facial hemiparalysis, hands and feet caused by paralysis, apoplectic hemiplegia, etc. disease (Shengji Zonglu, Prescriptions for Universal Relief, Chinese Pharmacopoeia etc.).Existing preparation is QUANTIANMA JIAONANG, day dizzy clear (gastrodine injection Gastrodin Injection), powerful gastrodia elata-cortex capsule, Rhizoma Gastrodiae Pilulae, the Rhizoma Gastrodiae ball etc. that dispels the wind.
The clinical indication of Rhizoma Gastrodiae and gastrodine mainly contains: (1) is used for that god declines, god declines syndrome and the brain traumatic syndrome; (2) be used for vertigo: Meniere, medicinal vertigo, traumatic vertigo, sudden deafness, vestibular neuronitis, vertebro-basilar artery insufficiency etc.; (3) be used for neuralgia: trigeminal neuralgia, sciatica, occipital bone neuralgia etc.: (4) are used for headache: decline syndrome etc. of vascular headache, migraine, neurasthenia and god all has preferably curative effect.
Modern pharmacological research proves: Rhizoma Gastrodiae contains gastrodin, vanillyl alcohol, vanillin, glycoside and alkaloid etc.Existing artificial synthetic gastrodin (gastrodin).Gastrodine injection has pain relieving spasmolytic, blood vessel dilating, enhancing blood vessel elasticity, improves cerebral blood perfusion and improves brain microcirculation, strengthens the resolution capability of optic nerve, to treating dizzy nervous symptoms and the cerebrovascular system disease that causes with the brain basilar artery insufficiency significant curative effect is arranged.Even as seen use separately Rhizoma Gastrodiae, Rhizoma Gastrodiae or Rhizoma Gastrodiae effective ingredient-gastrodine that the effect for the treatment of cerebrovascular disease is also arranged.As the auxiliary compatibility composition of DCXW, Rhizoma Gastrodiae in the present invention Rhizoma Chuanxiong is regulated hemorheological property and hemodynamic ability plays the collaborative effect that promotes.
Nervonic acid (Nervonic Acid) has another name called Nervonic Acid (Selacholeic Acid), chemical name NA (cis-15-Tetracosenic Acid), molecular formula C
24H
46O
2, molecular weight: 366.6, white plates crystal, fusing point 42-43 ℃, structural formula: CH
3-(CH
2)
7-CH=CH-(CH
2)
11-COOH.Nervonic acid is found in mammiferous nervous tissue the earliest, is biomembranous important composition composition in the nervous tissue, is the significant composition of medullary substance in the brain glycoside.
Nervonic acid is as the essential nutrient of cerebrum metabolism, and is active to the normal activity of keeping brain cell, prevents that aging from having great role.Human thinking, memory, issue an order etc. all be unable to do without information transmission and information processing.Cranial nerve cell is finished information transmission and information processing by the ion channel on its film and receptor.Nervonic acid is the important component part of cranial nerve cell film, and ion channel and receptor are played important regulating action.By the adjusting of nervonic acid to the brain cell membrane function, can strengthen the transmission of neurotransmitter between brain cell.Thereby accelerate and the increase memory function.Reduce the accumulation of brain cell lipofuscin by nervonic acid, thereby play the effect of delaying cell aging.
Nervonic acid can be used as a kind of blood fat reducing content, resisting fatigue, and slow down aging promotes brain development, improves the Medicines and Health Product of memory, also can be used as the active component of health food or cosmetics, as adds the baby to, in child or the old people's milk powder.Nervonic acid improves memory promoting brain development, slow down aging, and resisting fatigue, the efficacy test of blood fat reducing aspect be the evaluation by health ministry.Nervonic acid is the nucleus of cerebral nerve fiber and neurocyte.The shortage of nervonic acid can cause nervous system disease.Nervonic acid human body self is difficult to generate, and lean on external picked-up to replenish.Nervonic acid can completely directly act on nerve fiber and repair dredging by blood brain barrier, recovers patient in the function of the aspects such as language, memory, sensation, limbs.Nervonic acid is effective to following cerebrovascular:
1) apoplexy: reparation dredging nerve fiber, and then activate neurocyte, and the multiple brain of Yan is to the domination function of extremity, language, memory, face, and the sequela such as the hemiplegia that the elimination apoplexy causes, numb limbs and tense tendons, slurred speech realize independently standing and walking.2) senile dementia: strengthen the brain cell energy, promote cell proliferation and differentiation, prevent the old and feeble and damage of cranial nerve cell, promote the tissue growth of brain to grow and perfect in shape and function, improve intelligence and the response speed of brain.3) parkinson: stablize nervous system, eliminate that limbs are involuntary to tremble, recover pliability, motility and the equilibrium function of health.4) brain atrophy: suppress the distortion of cerebral nerve neurocyte, impel brain injury to recover, prevent the subsiding of cerebral tissue, atrophy and sclerosis.5) delay brain aging: improve the cerebrum blood circulation, ensure the Enough supply of brain cell blood oxygen, the prevention brain aging.
Compositions of the present invention is mainly used in improving the cerebrovascular symptom:
Cerebrovascular refers to the neck arteries generation pathological changes of brain tremulous pulse or domination brain, thereby causes the intracranial disturbance of blood circulation, one group of disease that cerebral tissue is impaired.The symptom main manifestations of cerebrovascular is:
1) is unexpected onset, often starts from a side upper limb, other parts that then its carrying out property of delayed ischemic neurological deficits symptom is involved these side limbs within a few hours or, two day.2) the headache headache is the outstanding symptom of subarachnoid hemorrhage.Chang Weiquan head splitting sample pain.And patients with cerebral hemorrhage because blood directly stimulates the pain structure of meninges and brain, has 80%～90% patient that severe headache is arranged approximately.Characteristics be when beginning pain be positioned at the disease side, when intracranial hypertension or blood flow into subarachnoid space, full headache can appear.The headache of transient ischemic attack and cerebral infarction is much slighter, but Big Area Cerebral Infarction also severe headache can occur when merging intracranial hypertension.
3) the vomiting vomiting is the common sympton of cerebrovascular, particularly hemorrhagic apoplexy, often is projectile vomiting such as subarachnoid hemorrhage, and incidence rate is more than 80%; Intracranial hypertension during cerebral hemorrhage, all aggravations of vomiting and headache.If patient vomits coffee-like gastric content, expression has upper gastrointestinal hemorrhage, is the critical omen of the state of an illness.It is more rare that the vomiter occurs ischemic cerebrovascular, but Big Area Cerebral Infarction also can cause vomiting when merging intracranial hypertension.
4) disturbance of consciousness is especially common with Patients with Cerebral Hemorrhage, is that brain is subject to serious and result that extensively damage.It is reported that disturbance of consciousness can appear in 60%～80% Patients with Cerebral Hemorrhage.Clinical characters is except the light-duty Patients with Cerebral Hemorrhage of small part, and outside consciousness can keep regaining consciousness, hemorrhage of brain stem and cerebellar hemorrhage disturbance of consciousness were all more serious; Stupor can appear rapidly in the ventricular hemorrhage patient; Subarachnoid hemorrhage disturbance of consciousness degree is lighter.The less disturbance of consciousness that occurs of cerebral infarction, and Big Area Cerebral Infarction is many with disturbance of consciousness.
5) the hemiplegia hemiplegia refers to the dyskinesia of a side upper and lower extremities and homonymy tongue and facial muscle, also be cerebrovascular than common sympton, no matter pathological changes appears in any side of cerebral hemisphere, all can cause the pathological changes contralateral hemiplegia, its degree can have gently to be had heavily, can be incomplete paralysis and fully paralysed.Not exclusively paralysis is again paresis, can cane walking.Paralysis also is panplegia fully, and bedridden patient does not rise, and can't take care of oneself.Some patients may face, tongue paralysis degree is heavier, and degree of paralysis is lighter; Also possibility upside limbs paralysis is heavier, and downside limbs paralysis is lighter; Or the lower extremity paralysis degree is heavier, and upside limbs paralysis is lighter.Paralysis becomes incomplete hemiplegia fully, illustrates that sb.'s illness took a favorable turn; Otherwise not exclusively paralysis develops into complete paralysis, represents that then the state of an illness increases the weight of gradually.
6) aphasia is due to dominant hemisphere cerebral cortex auditory word center damages.Different with clinical manifestation according to damaging part, componental movement aphasia, sensory aphasia, mixed aphasia and nominal aphasia etc.The motor aphasia patient has lost the language competence, and is not sociable, but can understand the meaning of others' speech, and gestures available or put is first-classly answered question; Sensory aphasia patient does not understand the meaning of others' speech, but this patient is intact owing to motor speech center, so, can speak, and speak, fast and fluent, but then do not give a direct answer to a question with people's dialogue.The existing motor aphasia of mixed aphasia patient, again feeling property aphasia.Not sociable, can not understand the content of others' speech etc.Nominal aphasia performance patient can talk, and also can understand others, cans say character and the purposes of article, but can not be the title of article.
The present invention can promote the recovery of above-mentioned symptom, and particularly to headache, hemiplegia and aphasia effect are especially remarkable.
The present invention is on the basis of DCXW, add the nervonic acid effective ingredient, make the health product of the various dosage forms that are suitable for clinical practice, be fit to patients with cerebrovascular disease or group of people at high risk's prognosis treatment or daily maintenence and use, instructions of taking is simple, can day take a slice or a capsule; Or the morning and evening respectively takes a slice or a capsule, one day twice.Compositions of the present invention adopts Rhizoma Chuanxiong, Rhizoma Gastrodiae Chinese medicine as the main pharmacodynamics composition, be aided with the nervonic acid material that directly to repair the injured nerve cell, prognosis treatment to patients with cerebrovascular disease has good caring effect, adhere to for a long time taking, can effectively improve the cerebrovascular symptom, have rehabilitative action at a specified future date; If use as prevention and health care, also can effectively reduce the probability of cerebrovascular outbreak.Compositions pharmacological action cooperative compensating of the present invention, active constituent content is high, rapid-action, quality controllable, taking dose is little, determined curative effect.
The specific embodiment
Oral formulations contain commonly used can received auxiliary adding ingredient, such as binding agent, filler, diluent, disintegrating agent, lubricant, flavoring agent etc., can carry out coating to tablet in case of necessity.The specific embodiment of form is described further foregoing of the present invention by the following examples, but is not limited to the scope of following examples.
Embodiment 1:
Rhizoma Chuanxiong 5kg, Rhizoma Gastrodiae 2kg, nervonic acid 4kg, medical starch 3kg, sodium carboxymethyl cellulose 2kg, magnesium stearate 0.2kg, mix homogeneously is granulated, tabletting, the Co 60 sterilization namely gets oral tablet.
Embodiment 2:
Rhizoma Chuanxiong 3kg, Rhizoma Gastrodiae 1kg, nervonic acid 2kg, medical starch 2kg, sodium carboxymethyl cellulose 1kg, magnesium stearate 0.5kg, mix homogeneously is granulated, tabletting, the Co 60 sterilization namely gets oral tablet.
Embodiment 3:
Rhizoma Chuanxiong 2kg, Rhizoma Gastrodiae 2kg, nervonic acid 2kg, lactose 1kg, sodium carboxymethyl cellulose 1kg, magnesium stearate 0.5kg, mix homogeneously is recorded capsule, and the Co 60 sterilization namely gets oral capsule.
Embodiment 4:
Rhizoma Chuanxiong 2kg, gastrodine 0.5kg, nervonic acid 0.5kg, lactose 0.5kg, sodium carboxymethyl cellulose 0.8kg, magnesium stearate 0.3kg, mix homogeneously is recorded capsule, and the Co 60 sterilization namely gets oral capsule.
The oral formulations clinical trial that the embodiment of the invention makes is taken as health product for 100 routine volunteers, and morning and evening every day is each a slice or a capsule after meal, and one day twice, every day, dose was no more than 6 grams.Without other taboos.Adhere to taking more than three months.Wherein 85 examples are apoplexy prognosis patient, have headache in various degree, hemiplegia and aphasia symptom.15 examples are the cerebrovascular group of people at high risk, have in various degree hypertension, hyperlipidemia symptom.Tracking results shows, 85 routine apoplexy prognosis patients took oral formulations after 3 months, there is 76.2% patient's headache symptom to alleviate to some extent, 11.5% patient's hemiplegia symptom takes a turn for the better to some extent, reflex appears in one side limbs of hemiplegia once in a while, and 12.3% patient's aphasia symptom has certain improvement in addition.And that 15 routine group of people at high risks' hypertension symptom is tending towards blood pressure is normally stable.
Above-described embodiment is described preferred implementation of the present invention; be not that scope of the present invention is limited; design under the prerequisite of spirit not breaking away from the present invention; various distortion and improvement that the common engineers and technicians in this area make technical scheme of the present invention all should fall in the definite protection domain of claims of the present invention.
Claims (8)
1. compositions of improving the cerebrovascular symptom, it is characterized in that: each components by weight is: Rhizoma Chuanxiong: Rhizoma Gastrodiae: nervonic acid is (1-5): (1-2): (1-4).
2. compositions according to claim 1, it is characterized in that: each components by weight is: Rhizoma Chuanxiong: Rhizoma Gastrodiae: nervonic acid is 4: 1: 1.
3. compositions according to claim 1, it is characterized in that: each components by weight is: Rhizoma Chuanxiong: Rhizoma Gastrodiae: nervonic acid is 5: 2: 4.
4. compositions according to claim 1, it is characterized in that: each components by weight is: Rhizoma Chuanxiong: Rhizoma Gastrodiae: nervonic acid is 1: 1: 1.
5. the health-care preparation that contains each described compositions of claim 1-4.
6. health-care preparation according to claim 5, it is characterized in that: described preparation is tablet, capsule, pill and/or powder.
7. tablet health product that improve the cerebrovascular symptom, it is characterized in that: the component that takes by weighing each described compositions of claim 1-4, be mixed to get mixed material, adding and mixed material weight ratio are 1: 1～1: 4 medical starch again, 1: 0.1～1: 0.8 sodium carboxymethyl cellulose, 1: 0.01～1: 0.1 magnesium stearate, mix homogeneously, tabletting, sterilization.
8. capsule health product that improve the cerebrovascular symptom, it is characterized in that: the component that takes by weighing each described compositions of claim 1-4, be mixed to get mixed material, adding and mixed material weight ratio are 1: 1～1: 2 medical starch again, 1: 0.2～1: 1 lactose, 1: 0.1～1: 0.8 sodium carboxymethyl cellulose, 1: 0.01～1: 0.1 magnesium stearate, mix homogeneously is recorded capsule, sterilization.
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| CN2011103059338A CN103041188A (en) | 2011-10-11 | 2011-10-11 | Composition for improving symptoms of cerebrovascular disease |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587266A (en) * | 2015-02-05 | 2015-05-06 | 福州乾正药业有限公司 | Composition of nervonic acid and bamboo leaf flavonoid as well as preparation method and application thereof |
-
2011
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Non-Patent Citations (2)
| Title |
|---|
| 张霄峰等: "川芎天麻液对大鼠脑缺血再灌注损伤保护作用的实验研究", 《中华中西医杂志》 * |
| 王性炎等: "神经酸研究现状及应用前景", 《中国油脂》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587266A (en) * | 2015-02-05 | 2015-05-06 | 福州乾正药业有限公司 | Composition of nervonic acid and bamboo leaf flavonoid as well as preparation method and application thereof |
| CN104587266B (en) * | 2015-02-05 | 2018-01-26 | 福州乾正药业有限公司 | The composition of nervonic acid and bamboo-leaves flavones, its preparation method and application |
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