CN103041011A - Oral drug for treating gosling candidiasis - Google Patents
Oral drug for treating gosling candidiasis Download PDFInfo
- Publication number
- CN103041011A CN103041011A CN2013100291515A CN201310029151A CN103041011A CN 103041011 A CN103041011 A CN 103041011A CN 2013100291515 A CN2013100291515 A CN 2013100291515A CN 201310029151 A CN201310029151 A CN 201310029151A CN 103041011 A CN103041011 A CN 103041011A
- Authority
- CN
- China
- Prior art keywords
- parts
- candidiasis
- treatment
- oral cavity
- young goose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an oral drug for treating gosling candidiasis and a preparation method thereof. The oral drug for treating gosling candidiasis, provided by the invention, is prepared from the following components in parts by weight: 15-25 parts of cortex dictamni, 12-18 parts of patrinia, 12-18 parts of golden cypress, 12-18 parts of sophora flavescens, 8-12 parts of indigo naturalis, 6-8 parts of nystatin, 2-4 parts of borneol and 50-70 parts of mature vinegar. The medicines are organically combined, dialectically matched and mutually assisted, and then the effects of the oral drug of clearing heat, drying dampness, detoxifying and removing stasis are enhanced, so that the aim of healing oral lesions of gosling candidiasis is achieved. Especially, the drug is directly thrown to the oral lesions of a goose suffering from gosling candidiasis, so that the pharmaceutical effect is directly played. The oral drug for treating gosling candidiasis, prepared by adopting a preparation method of the oral drug for treating gosling candidiasis, is low in cost and easy to prepare, produces no toxic or side effect, and is obvious in curative effect. Clinical practices prove that the cure rate of the oral drug is 96.68% and the effective rate is 100%.
Description
Technical field
The present invention relates to a kind of oral cavity medicine thing for the treatment of young goose candidiasis and preparation method thereof.
Background technology
Young goose candidiasis claims again thrush, it is a kind of birds upper digestive tract fungal infectious disease that is caused by Candida albicans, feature is to form milky patch (pseudomembrane) and cause the mucosa inflammation at upper alimentary tract mucosas such as oral cavity, throats, causes ulcer or squama shape pathological changes.This bacterium extensively is present in the digestive tract, respiratory tract of nature and healthy fowl.When a variety of causes descends Abwehrkraft des Koepers, such as bad environmental condition, vitamin deficiency and life-time service antibiotics etc., make the archenteric flora dysequilibrium and bring out primary disease.Primary disease birds susceptible, goose is high with interior young goose susceptibility with 6 ages in week.Primary disease is mainly through transmission, and the feedstuff of pollution, drinking-water, bedding and padding etc. all are communication medias; Also can propagate through eggshell simultaneously.Primary disease is propagated rapidly, and incidence and mortality is all high, brings very large economy loss to the raiser.
Clinical symptoms and pathological change
Multiplely be born in for 6 ages in week with interior young goose, suffer from the goose lethargy, the feather pine disorderly, poor growth, slow-witted vertical, poor appetite or absolutely useless, the crop expansion, sagging, soft of shouting is oppressed pain is arranged (pipe and struggle).Sick goose is held the liquid that often has in a large number with rancid flavor flows out from the mouth and nose chamber.Milky or yellow spotting appear at oral mucosa and lingual surface, after be fused into tunica albuginea.Caseous typical thrush is arranged, firmly peel off the hemorrhagic ulcer face of rear red color visible, ill young goose becomes thin and death at last.Pathology cuts open inspection, and outside the pathological change of oral cavity, the caseous necrosis pseudomembrane is more common in crop and is shouted, and mucosa forms the large lesser tubercle of white beans and ulcer, covers one deck white pseudomembrane on it.Locate also can see above-mentioned pathological changes at esophagus and glandular stomach etc.Scrape crop mucosa sphacelus smear processed, microscopy after the dyeing can be found yeast-like fungi.
2 present prophylactico-therapeutic measuress
For the treatment of this disease, there is not clinically preferably medicine, the Western medicine curative effect is relatively poor, and has dependency strong, and side effect is larger, easily repeatedly waits not enough.And oral local administration thing commonly used is not remarkable such as effect after the medicinal applications such as iodine glycerol, often to suffering from goose the pain increased the impact feed.
For overcoming above-mentioned deficiency, the objective of the invention is to provide a kind of oral cavity medicine thing for the treatment of young goose candidiasis and preparation method thereof, this medicine can effectively ease the pain take topical therapeutic as the master symptom, do not promote healing, not repeatedly, and without any side effects.
Summary of the invention:
The object of the invention is to overcome the at present weak point on the young goose candidiasis for the treatment of, provide a kind of draw materials easy, easy to prepare, reduce drug residue and toxic and side effects, and the oral cavity medicine thing of the higher young goose candidiasis for the treatment of of cheap curative effect.
A kind of oral cavity medicine thing for the treatment of young goose candidiasis, its composition by weight is: Cortex Dictamni 15-25 part, Herba Patriniae 12-18 part, Cortex Phellodendri 12-18 part, Radix Sophorae Flavescentis 12-18 part, Indigo Naturalis 8-12 part, 1,000,000 units/gram nystatin 6-8 parts, Borneolum Syntheticum 2-4 part, mature vinegar 50-70 part.
Preferred composition by weight is:
25 parts of Cortex Dictamni, 12 parts of Herba Patriniae, 18 parts of Cortex Phellodendris, 12 parts of Radix Sophorae Flavescentiss, 12 parts of Indigo Naturaliss, 6 parts of nystatins, 2 parts of Borneolum Syntheticums, 70 parts in mature vinegar.
Or be:
15 parts of Cortex Dictamni, 18 parts of Herba Patriniae, 12 parts of Cortex Phellodendris, 18 parts of Radix Sophorae Flavescentiss, 8 parts of Indigo Naturaliss, 8 parts of nystatins, 4 parts of Borneolum Syntheticums, 50 parts in mature vinegar.
Or be:
20 parts of Cortex Dictamni, 15 parts of Herba Patriniae, 15 parts of Cortex Phellodendris, 15 parts of Radix Sophorae Flavescentiss, 10 parts of Indigo Naturaliss, 7 parts of nystatins, 3 parts of Borneolum Syntheticums, 60 parts in mature vinegar.
Another purpose of the present invention provides a kind of oral cavity medicine thing for the treatment of young goose candidiasis, is by following method preparation:
Take by weighing each component by a kind of proportioning raw materials for the treatment of the oral cavity medicine thing of young goose candidiasis, after Chinese medicine pulverizing wherein, after crossing 120 mesh sieves, with the nystatin sheet adding normal saline that is crushed into powder, be prepared into the aqueous suspension of 50,000～100,000 U/ml, mix with other drug, and the adding mature vinegar, constantly stir in the process that adds, make its medicament mixed even, fully dissolving becomes unguentum, both must treat the oral cavity Chinese medicine composition unguentum of young goose candidiasis.
A kind of oral cavity medicine thing for the treatment of young goose candidiasis, in the side:
Cortex Dictamni:Bitter; Salty; Cold.Return spleen, lung, small intestinal, stomach, urinary bladder channel.Has heat clearing and damp drying; Dispelling wind for relieving itching; The merit of detoxifcation.Cure mainly: the rubella due to the wind heat noxious dampness; Eczema; Scabies; Jaundice; Damp-heat arthralgia.In vitro tests shows, fungus is had in various degree inhibitory action, particularly candidiasis had preferably therapeutical effect, and the effects such as heart tonifying and heat clearing away are arranged.
Herba Patriniae:Hot, bitter, be slightly cold.Return stomach, large intestine, Liver Channel.Has heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, the merit of stasis-dispelling and pain-killing.The hot loose hardship of this product is let out cold and cool, but both heat-clearing and toxic substances removing, but again eliminating carbuncle evacuation of pus, and can promoting blood circulation and stopping pain, so be the choice drug for the treatment of abdominalgia with intestinal abscess.Multiple pathogen and virus there is inhibitory action.Be usually used in the various acute infectious disease, but also decocting fumigation and wash method, or mash external application with fresh goods, can obtain satisfactory effect for illness such as treatment thrush especially.Also can treat the suppurative dermatosis such as folliculitis, furuncle.
Cortex Phellodendri:Bitter, cold.Return kidney, bladder, large intestine channel.Have heat clearing and damp drying, eliminating fire and detoxication, the merit of reducing the asthenic fever, in vitro tests all has stronger inhibitory action to multiple pathogen, and stronger antifungic action is particularly arranged, and especially the inhibitory action to Candida albicans is stronger.For controlling carbuncle sore, eczema, eczema has preferably therapeutic effect, especially to aphtha of the mouth and tongue; Conjunctival congestion and swelling pain; Skin sore waits curative effect of disease remarkable.And the effects such as antiulcer, diuresis, stomach invigorating, external are arranged.
Radix Sophorae Flavescentis:Bitter, cold.Enter the heart, liver, stomach, large intestine, urinary bladder channel.Have heat clearing and damp drying, the merit of wind dispelling insecticide and diuresis has good curative effect for jaundice, dysentery due to damp and hot, for short-tempered skin pruritus, some dermatomycosiss, noxious dampness skin infection, the aphtha etc. of waiting of lung-wind syndrome preferably therapeutical effect is arranged.Indigo Naturalis: salty, cold.Return Liver Channel.Has heat-clearing and toxic substances removing, the merit of removing heat from blood.Can be used for the diseases such as maculae caused by violent heat pathogen, aphtha, mumps, for goose candidiasis aphtha preferably therapeutic effect is arranged.
Borneolum Syntheticum:Hot, bitter, be slightly cold.Enter the heart, liver, spleen, lung meridian.Have logical all keys, loose stagnated fire, removing nebula makes eye bright, and the merit of reducing swelling and alleviating pain is main with controlling the diseases such as calentura coma, sore throat, aphtha, carbuncle.This product bitter cold has the merit of clearing away heat to alleviate pain, detumescence, is the department of eye common medicine, and external has stronger bacteriostasis, and mucosa, subcutaneous tissue all easily absorb, and are usually used in the diseases such as laryngopharynx swelling and pain, aphtha of the mouth and tongue.
Mature vinegar:Acid, temperature.Enter liver, stomach warp.Effect with dissipating blood stasis, hemostasis, detoxifcation, parasite killing; good antibacterial and bactericidal action is arranged; can effectively prevent some infectious disease; but vessel softening; cholesterol reducing; external also has good protective effect to skin, and is multiplex in the swollen treatment of some carbuncle skin ulcers, for fungal infection good therapeutical effect arranged also.
Nystatin:Polyenoid class antifungal agent, the effect of tool broad-spectrum antifungal, high to candidal antibacterial activity.This product can combine with the sterol on the fungal cell membrane, causes the change of permeability of cell membrane, so that the important cells content is missed and the performance antifungic action.
Said medicine is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country has strengthened the party's heat clearing and damp drying, the effect of detoxifcation dissipating blood stasis, thus reach the purpose of curing young goose candidiasis pathological change of oral cavity.Particularly medicine is directly invested and suffered from thrush chamber focus, thereby directly bring into play drug effect.Adopt that the oral cavity medicine thing of the young goose candidiasis that a kind of preparation method for the treatment of the oral cavity medicine thing of young goose candidiasis of the present invention makes has that cost is low, preparation easily, have no side effect and evident in efficacy.Clinical practice proves, the cure rate 96.68% of this medicine, effective percentage 100%.
The specific embodiment
Embodiment 1
25 parts of Cortex Dictamni, 12 parts of Herba Patriniae, 18 parts of Cortex Phellodendris, 12 parts of Radix Sophorae Flavescentiss, 12 parts of Indigo Naturaliss, 6 parts of nystatins, 2 parts of Borneolum Syntheticums, 70 parts in mature vinegar.
Or be:
Embodiment 2
15 parts of Cortex Dictamni, 18 parts of Herba Patriniae, 12 parts of Cortex Phellodendris, 18 parts of Radix Sophorae Flavescentiss, 8 parts of Indigo Naturaliss, 8 parts of nystatins, 4 parts of Borneolum Syntheticums, 50 parts in mature vinegar.
Embodiment 3
Composition by weight: 20 parts of Cortex Dictamni, 15 parts of Herba Patriniae, 15 parts of Cortex Phellodendris, 15 parts of Radix Sophorae Flavescentiss, 10 parts of Indigo Naturaliss, 7 parts of nystatins, 3 parts of Borneolum Syntheticums, 60 parts in mature vinegar.
Embodiment 4
Weigh by embodiment 1,2 or 3 proportionings, after wherein Chinese medicine powder is broken into fine powder, cross behind 120 mesh sieves for subsequent usely, with the nystatin sheet adding normal saline that is crushed into powder, be prepared into the aqueous suspension of 50,000～100,000 U/ml, mix with Chinese medicine for subsequent use after the pulverizing, and the adding mature vinegar, constantly stir in the process that adds, make its medicament mixed even, fully dissolving becomes unguentum, both must treat the oral cavity Chinese medicine composition unguentum of young goose candidiasis.
Clinical effect trial
1. method: publish two of the plants of giving birth to young goose candidiasis, select altogether 1287 young geese of young goose of pathological change of oral cavity, the age is 3-4 age in week.The young goose that will fall ill is divided into three groups, is respectively of the present invention group, nystatin group and iodine glycerol group.
Weigh by embodiment 3 proportionings for of the present invention group, after wherein Chinese medicine powder is broken into fine powder, cross behind 120 mesh sieves for subsequent usely, with the nystatin sheet adding normal saline that is crushed into powder, be prepared into the aqueous suspension of 50,000～100,000 U/ml, mix with Chinese medicine for subsequent use after the pulverizing, and the adding mature vinegar, constantly stir in the process that adds, make its medicament mixed even, fully dissolving becomes unguentum, both must treat the oral cavity Chinese medicine composition unguentum of young goose candidiasis.Directly dip liquid medicine painting with cotton balls and suffer from thrush chamber ulcer surface.
The nystatin group is with the nystatin sheet adding normal saline that is crushed into powder, and is prepared into the aqueous suspension of 50,000～100,000 U/ml, directly dips liquid medicine painting with cotton balls and suffers from thrush chamber ulcer surface.
Iodine glycerol is produced by the good Huangpu of upper sea-freight pharmaceutical Co. Ltd available from large pharmacy, Jilin, Changchun, and every milliliter contains 10 milligrams of main component iodine, directly dips liquid medicine painting with cotton balls and suffers from thrush chamber ulcer surface.
Treatment time is 5 days, and each coating of every day at upper and lower noon once.
The young goose grouping of table 1 and primary treatment method
----------------------
Each organizes case in oral local administration, adopts same wholistic therapy method, adds nystatin in the feedstuff, and medicine is produced by Jinan Jia Dexin veterinary drug raw material company limited, and the dosage that adds 1,000,000 units by the per kilogram feedstuff is admixed, and is used in conjunction five days.
2. efficacy determination:
Cure: ulcer surface complete obiteration on young goose Candida albicans disease symptoms and oral mucosa and the lingual surface.
Take a turn for the better: ulcer surface partly disappears on young goose Candida albicans disease symptoms and oral mucosa and the lingual surface.
Invalid: ulcer surface does not change on young goose Candida albicans disease symptoms and oral mucosa and the lingual surface.
3. result: 1287 young geese are by different dosage regimens, and after three days treatment, therapeutic effect of each group sees Table 2.
The various therapeutic schemes of table 2 are treated young goose effect
By table 2 as seen, three kinds of medicines have different therapeutic effect to young goose candidiasis, and wherein best with of the present invention group of therapeutic effect, cure rate reaches 96.68%, and total effective rate 100%, the utmost point are significantly higher than other two groups (P＜0. 01); The nystatin group is taken second place, the iodine glycerol group again, statistical result shows, each group difference is (P＜0. 05) significantly.
For many years, adopt embodiment 1,2,3 proportioning, press the medicine of embodiment 4 methods preparation, treat through the young geese of many oidiomycotic plants of the young goose of generation, all about 96, total effective rate all reaches 100% to cure rate.Medicine of the present invention has putrefaction-removing granulation-promoting, pain relieving, removing dampness, anti-inflammation and sterilization, the effect of repairing ulcer face, and the symptom that eases the pain, promotion healing, and without any side effects.Pathological change of oral cavity for young goose candidiasis has preferably curative effect.For this disease of clinical treatment provides a kind of practicable new drug.
Claims (5)
1. oral cavity medicine thing for the treatment of young goose candidiasis, its composition by weight is: Cortex Dictamni 15-25 part, Herba Patriniae 12-18 part, Cortex Phellodendri 12-18 part, Radix Sophorae Flavescentis 12-18 part, Indigo Naturalis 8-12 part, nystatin 6-8 part, Borneolum Syntheticum 2-4 part, mature vinegar 50-70 part.
2. a kind of oral cavity medicine thing for the treatment of young goose candidiasis according to claim 1 is characterized in that, 25 parts of Cortex Dictamni, 12 parts of Herba Patriniae, 18 parts of Cortex Phellodendris, 12 parts of Radix Sophorae Flavescentiss, 12 parts of Indigo Naturaliss, 6 parts of nystatins, 2 parts of Borneolum Syntheticums, 70 parts in mature vinegar.
3. a kind of oral cavity medicine thing for the treatment of young goose candidiasis according to claim 1 is characterized in that, 15 parts of Cortex Dictamni, 18 parts of Herba Patriniae, 12 parts of Cortex Phellodendris, 18 parts of Radix Sophorae Flavescentiss, 8 parts of Indigo Naturaliss, 8 parts of nystatins, 4 parts of Borneolum Syntheticums, 50 parts in mature vinegar.
4. a kind of oral cavity medicine thing for the treatment of young goose candidiasis according to claim 1, it is characterized in that its composition by weight is: 20 parts of Cortex Dictamni, 15 parts of Herba Patriniae, 15 parts of Cortex Phellodendris, 15 parts of Radix Sophorae Flavescentiss, 10 parts of Indigo Naturaliss, 7 parts of nystatins, 3 parts of Borneolum Syntheticums, 60 parts in mature vinegar.
5. oral cavity medicine thing for the treatment of young goose candidiasis is by following method preparation:
Take by weighing each component by a kind of proportioning raw materials for the treatment of the oral cavity medicine thing of young goose candidiasis claimed in claim 1, after Chinese medicine pulverizing wherein, after crossing 120 mesh sieves, with the nystatin sheet adding normal saline that is crushed into powder, be prepared into the aqueous suspension of 50,000～100,000 U/ml, and the other drug mixing, and add mature vinegar, stir, fully dissolving becomes unguentum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310029151.5A CN103041011B (en) | 2013-01-25 | 2013-01-25 | Oral drug for treating gosling candidiasis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310029151.5A CN103041011B (en) | 2013-01-25 | 2013-01-25 | Oral drug for treating gosling candidiasis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103041011A true CN103041011A (en) | 2013-04-17 |
| CN103041011B CN103041011B (en) | 2014-06-04 |
Family
ID=48054022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310029151.5A Expired - Fee Related CN103041011B (en) | 2013-01-25 | 2013-01-25 | Oral drug for treating gosling candidiasis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103041011B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334781A (en) * | 2016-05-02 | 2017-11-10 | 南昌市第九医院 | A kind of medicine for being used to prevent and treat buccal cavity fungal infection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732403A (en) * | 2010-01-26 | 2010-06-16 | 王斐芬 | Chinese medicament for treating muguet |
-
2013
- 2013-01-25 CN CN201310029151.5A patent/CN103041011B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732403A (en) * | 2010-01-26 | 2010-06-16 | 王斐芬 | Chinese medicament for treating muguet |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103041011B (en) | 2014-06-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101869626A (en) | Chinese medicinal compound preparation private care liquid, and preparation and application thereof | |
| CN105727236A (en) | Powder for treating red skin disease of osphronemus goramy and preparation method thereof | |
| CN101439114B (en) | Chinese medicine for treating burn and scald, and preparation method thereof | |
| CN101972391A (en) | Medicinal composition used for treating swine mastitis and preparation method thereof | |
| CN101856481A (en) | Externally used ointment for dispersing swelling and dissipating binds | |
| CN102240353A (en) | Traditional Chinese drug anesthetic and preparation method thereof | |
| CN101194995B (en) | Proprietary Chinese medicine for treating animal virus, bacterium and mix infection | |
| CN103041011B (en) | Oral drug for treating gosling candidiasis | |
| CN107397886A (en) | Chinese medicine composition for preventing and treating piglet red dysentery and its preparation method and application | |
| CN106418530A (en) | Health care product capable of clearing heat from throat | |
| CN108653402A (en) | giant knotweed skin antibacterial liquid | |
| CN103142751B (en) | Traditional Chinese medicine composition for treating piglet iron-deficiency anemia | |
| CN1544003A (en) | Medicine for treating trauma and sores and its preparing process | |
| CN104547137A (en) | Composite fermented traditional Chinese medicine composition for preventing and treating chicken infectious bursal disease | |
| CN104971210A (en) | External lotion for treating tinea pedis and preparation method thereof | |
| CN104707008B (en) | A kind of composite drug and preparation method for preventing chickens respiratory disease | |
| CN109248244A (en) | A kind of Chinese medicine and preparation method thereof for treating gynaecological imflammation | |
| CN102961732B (en) | The composition and method of making the same for the treatment of rabbit enteritis | |
| CN108785383A (en) | A kind of antibacterial gynecology externally used pharmaceutical combination and the preparation method and application thereof | |
| CN114470144B (en) | Prostate eliminating soup for inhibiting prostate fibrosis and preparation method thereof | |
| CN102727669B (en) | Compound propolis composition used for treating swine erysipelas, and preparation method thereof | |
| CN106361902A (en) | Traditional Chinese medicine composition for preventing and treating livestock diarrhea and preparation method thereof | |
| CN105998542A (en) | Traditional Chinese medicine spray for treating acute laryngopharyngitis and preparation method of traditional Chinese medicine spray | |
| CN106727926B (en) | Medicine for resisting hepatic fibrosis and treating liver cirrhosis and preparation method thereof | |
| CN105168638A (en) | Traditional Chinese medicinal liquid band aid for preventing and treating bedsore complicated with bacterial infection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wen Wei Inventor after: Wang Dan Inventor after: Gao Guang Inventor after: Feng Yuanchun Inventor after: Sui Yujian Inventor after: Zhou Pin Inventor after: Hu Dan Inventor after: Sun Yongfeng Inventor after: Zhao Lifeng Inventor after: Yang Xiaojie Inventor before: Wen Wei |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: WEN WEI TO: WEN WEI GAO GUANG FENG YUANCHUN SUI YUJIAN ZHOU PIN HU DAN SUNYONGFENG ZHAO LIFENG YANG XIAOJIE WANG DAN |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140604 Termination date: 20150125 |
|
| EXPY | Termination of patent right or utility model |