CN103040929A - Traditional Chinese medicine composition for treating chronic eczema, dermatitis and keratoderma, and use of same - Google Patents
Traditional Chinese medicine composition for treating chronic eczema, dermatitis and keratoderma, and use of same Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating chronic eczema, dermatitis and keratoderma. The traditional Chinese medicine composition mainly comprises the following drug substances in part by weight: 28 to 38 parts of chaulmoogra, 13 to 20 parts of Chinense golden larch bark, 22 to 32 parts of sulfur, 13 to 20 parts of radix sophorae flavescentis, 0.5 to 1.5 parts of radix euphorbiae lantu and 1 to 2 parts of calomel; and the traditional Chinese medicine composition further comprises 50 to 500 parts of sesame oil. The invention further provides an ointment of the traditional Chinese medicine composition and the use of the traditional Chinese medicine composition in preparation of drugs for treating chronic eczema, dermatitis and keratoderma. The traditional Chinese medicine composition provided by the invention has the advantages that the curative effect of treating chronic eczema, dermatitis and keratoderma is exact, the number of ingredients is less at the same time, the preparation technology is simple, the cost is low, the traditional Chinese medicine composition can be manufactured into ointments, plaster, gelata, patches and other external-use medicament forms, and the traditional Chinese medicine composition is more convenient to use and is easy to be accepted by patients.
Description
Technical field
The present invention relates to the Chinese patent medicine of the preparation take Chinese herbal medicine as raw material, specifically, is a kind of Chinese medicine composition for the treatment of chronic eczema, dermatitis or keratinization dermatoses and uses thereof.
Background technology
Atopic dermatitis claims again atoipc dermatitis, atopic dermatitis, disseminated neurodermatitis, endogenous eczema and diathetic prurigo etc., is that a kind of common chronic, recurrent, inflammatory skin are sick, and the cause of disease is not yet fully clear and definite.Eczema (eczema) is that a kind of that the inside and outside factor by Various Complex causes has the pleomorphism skin lesion and the scytitis reaction of oozing out tendency is easily arranged, and cause of disease complexity is difficult to determine more, the subjective symptoms acute pruritus, and the state of an illness easily repeatedly can be delayed for many years and not heal.Chronic eczema shows as that local skin thickens, infiltrates, lichenification in various degree and pigmentation or go down, and pruritus is obvious.The keratinization dermatoses be take keratinization of epidermis excessively as one group of dermatosis of Main change, can show local skin hyperkeratosis, xerosis cutis, squama is arranged, chaps, general can have pruritus or pain sometimes without subjective uncomfortable, increase the weight of the winter of being everlasting.Above-mentioned three kinds of skin disorders all have the clinical symptoms such as pruritus, inflammation, Gu medication mechanism is basic identical.But above-mentioned three kinds of skin disorders show as obstinate refractory clinically, there is no so far the method for thorough radical cure.
Chinese periodical " Journal of Traditional Chinese Medicine ", the 8th phase of the 53rd volume April in 2012, the paper of publishing " the 30 routine clinical observations of No. 1 side's treatment of Semen Hydnocarpi cream associating antiallergic atopic dermatitis ", a kind of prescription Semen Hydnocarpi cream for the treatment of atopic dermatitis is disclosed, paper discloses this Semen Hydnocarpi cream and has comprised the main components such as Semen Hydnocarpi 2.4g, Cortex Pseudolaricis 1.2g, Radix Sophorae Flavescentis 1.2g, Oleum Sesami 7.2g, function is removing damp to relieve itching, is used for the treatment of anaphylaxis dermatosis.Wherein, Semen Hydnocarpi is hot, the effect of its counteracting toxic substances that dispels the wind, killing parasites for relieving itching is strong, and " Bencao Jingshu " carries Semen Hydnocarpi " the hot wind that can fall apart, bitter energy parasite killing dampness; the warm energy meridians that pass through; common people are all skin ulcers of tinea corporis mange in order to control large maple pestilence disease, know this ear of anticipating ", its can establishment multiple Pseudomonas, so we reuse and are monarch.The Radix Sophorae Flavescentis bitter cold has the effect of heat clearing and damp drying, killing parasites for relieving itching, and the various skin fungus is had inhibitory action.Cortex Pseudolaricis is hot, warm, and the energy Anti-Puritic and insecticidal all has certain antibacterial action to dermatophytes and Candida albicans.Two medicines are ministerial drug altogether, to help the Semen Hydnocarpi killing parasites for relieving itching.The Oleum Sesami nature and flavor are sweet, cool, granulation promoting meat, the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin, and the while can also be alleviated the zest of other drug.All medicines share, and play altogether the effect of the antipruritic skin moistening of removing dampness and killing parasites.In addition, Cortex Pseudolaricis, Semen Hydnocarpi have certain toxicity in the side, and that interior dose too much often causes is nauseating, vomiting, breast abdomen pain, and the pathological changes such as haemolysis, nephritis, fatty degeneration of liver can appear in severe patient.
But those skilled in the art all know, the composing principle of Chinese medicinal formulae compatibility is monarch, wherein adjuvant drug has three kinds of meanings, and the one, supplementary drug namely assists monarch, ministerial drug to strengthen therapeutical effect, or directly treat less important accompanied symptoms, the 2nd, supplementary inhibitory medicine is namely in order to eliminate or to slow down the toxicity of monarch, ministerial drug or strong, the 3rd, corrigent, namely according to state of an illness needs, use the medicine that can in treatment, work on the contrary mutually the effect of coordinating with the monarch drug nature and flavor; Making medicine meaning one is guiding drug, in the side of drawing all medicines through sick medicine, the 2nd, harmonizing drug, i.e. the effect of coordinating the actions of various ingredients in a prescription makes it eliminating evil with joint efforts.As seen adjuvant drug and make medicine bring into play indispensable effect in Chinese medicinal formulae only has monarch, all medicines to share and just can reach best therapeutic effect.And this paper only discloses monarch drug and the ministerial drug of Semen Hydnocarpi cream.For reaching better therapeutic effect, need a kind of monarch combination principle that meets badly, treatment chronic eczema, dermatitis or keratinization dermatoses definite Chinese medicine composition evident in efficacy, but yet there are no report about this class Chinese medicine composition at present.
[summary of the invention]
The objective of the invention is for deficiency of the prior art, a kind of Chinese medicine composition for the treatment of chronic eczema, dermatitis or keratinization dermatoses is provided.
Again one purpose of the present invention is that the purposes of above-mentioned Chinese medicine composition is provided.
Another purpose of the present invention is that a kind of ointment for the treatment of the Chinese medicine composition of chronic eczema, dermatitis or keratinization dermatoses is provided.
The 4th purpose of the present invention is that the purposes of the ointment of above-mentioned Chinese medicine composition is provided.
The 5th purpose of the present invention is that the ointment of the Chinese medicine composition of another kind for the treatment of chronic eczema, dermatitis or keratinization dermatoses is provided.
The 6th purpose of the present invention is that the purposes of the ointment of above-mentioned Chinese medicine composition is provided.
For achieving the above object, the technical scheme taked of the present invention is:
A kind of Chinese medicine composition for the treatment of chronic eczema, dermatitis or keratinization dermatoses, it mainly is to be made by the crude drug of following weight portion: Semen Hydnocarpi 28-38 part, Cortex Pseudolaricis 13-20 part, sulfur 22-32 part, Radix Sophorae Flavescentis 13-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 0.5-1.5 part, Calomelas 1-2 part.
Preferably, described Chinese medicine composition mainly is to be made by the crude drug of following weight portion: 33 parts of Semen Hydnocarpi, 17 parts of Cortex Pseudolariciss, 27 parts of sulfurs, 17 parts of Radix Sophorae Flavescentiss, 1 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 1.6 parts of Calomelass.
Described Chinese medicine composition can also comprise the crude drug of following weight portion: Oleum Sesami 50-500 part.
Preferably, described Chinese medicine composition also comprises the crude drug of following weight portion: 100 parts in Oleum Sesami.
The dosage form of described Chinese medicine composition is ointment, plaster, gel or patch.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is:
As above arbitrary described Chinese medicine composition is preparing the purposes for the treatment of in chronic eczema, dermatitis or the keratinization dermatoses medicine.
For realizing above-mentioned the 3rd purpose, the technical scheme that the present invention takes is:
A kind of ointment for the treatment of the Chinese medicine composition of chronic eczema, dermatitis or keratinization dermatoses, it is prepared by following methods: get by weight Semen Hydnocarpi 28-38 part, Cortex Pseudolaricis 13-20 part, Radix Sophorae Flavescentis 13-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 0.5-1.5 part, conventional method decocts, get filtrate and add Cera Flava and Yellow Vaselin, decoct and be cooled to paste, add again sulfur 22-32 part, the Calomelas 1-2 part of pulverizing in advance, mix well and get final product.
For realizing above-mentioned the 4th purpose, the technical scheme that the present invention takes is:
The purposes of the ointment of aforesaid Chinese medicine composition in preparation treatment chronic eczema, dermatitis or keratinization dermatoses medicine.
For realizing above-mentioned the 5th purpose, the technical scheme that the present invention takes is:
A kind of ointment for the treatment of the Chinese medicine composition of chronic eczema, dermatitis or keratinization dermatoses, it is prepared by following methods: get by weight Semen Hydnocarpi 28-38 part, Cortex Pseudolaricis 13-20 part, Radix Sophorae Flavescentis 13-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 0.5-1.5 part, add Oleum Sesami 50-500 part, soak, decoct, get filtrate and add Cera Flava and Yellow Vaselin, decoct and be cooled to paste, add again sulfur 22-32 part, the Calomelas 1-2 part of pulverizing in advance, mix well and get final product.
For realizing above-mentioned the 6th purpose, the technical scheme that the present invention takes is:
The purposes of the ointment of aforesaid Chinese medicine composition in preparation treatment chronic eczema, dermatitis or keratinization dermatoses medicine.
The invention has the advantages that:
1, traditional Chinese medicine composition for treating chronic eczema of the present invention, dermatitis or keratinization dermatoses determined curative effect are better than monarch drug and the ministerial drug prescription of disclosed Semen Hydnocarpi cream in the prior art;
2, Chinese medicine composition flavour of a drug number of the present invention is less, and preparation technology is simple, and is with low cost;
3, the present invention can be made into the exterior-applied formulations such as ointment, plaster, gel and patch, and more convenient use is easy to be accepted by the patient.
The specific embodiment
The below elaborates to the specific embodiment provided by the invention.
Need to prove that the preparation method of Chinese medicine composition of the present invention comprises the employed substrate of various dosage forms of described Chinese medicine composition all being not limited only to following embodiment.
The preparation (one) of embodiment 1 Chinese medicine composition one ointment of the present invention
Get by weight 28 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 20 parts of Radix Sophorae Flavescentiss, 0.5 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.Add 22 parts in sulfur, 2 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (two) of embodiment 2 Chinese medicine composition one ointments of the present invention
Get by weight 38 parts of Semen Hydnocarpi, 13 parts of Cortex Pseudolariciss, 13 parts of Radix Sophorae Flavescentiss, 1.5 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.Add 32 parts in sulfur, 1 part of the Calomelas pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (three) of embodiment 3 Chinese medicine composition one ointments of the present invention
Get by weight 28 parts of Semen Hydnocarpi, 13 parts of Cortex Pseudolariciss, 20 parts of Radix Sophorae Flavescentiss, 0.5 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.Add 32 parts in sulfur, 1 part of the Calomelas pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (four) of embodiment 4 Chinese medicine composition one ointments of the present invention
Get by weight 38 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 13 parts of Radix Sophorae Flavescentiss, 1.5 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.Add 22 parts in sulfur, 2 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (five) of embodiment 5 Chinese medicine composition one ointments of the present invention
Get by weight 28 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 13 parts of Radix Sophorae Flavescentiss, 0.5 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.Add 32 parts in sulfur, 2 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (six) of embodiment 6 Chinese medicine composition one ointments of the present invention
Get by weight 38 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 13 parts of Radix Sophorae Flavescentiss, 0.5 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.Add 31 parts in sulfur, 1 part of the Calomelas pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (seven) of embodiment 7 Chinese medicine composition one ointments of the present invention
Get by weight 28 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 20 parts of Radix Sophorae Flavescentiss, 1.5 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.Add 22 parts in sulfur, 2 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (eight) of embodiment 8 Chinese medicine composition one ointments of the present invention
Get by weight 33 parts of Semen Hydnocarpi, 17 parts of Cortex Pseudolariciss, 17 parts of Radix Sophorae Flavescentiss, 1 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.Add 27 parts in sulfur, 1.6 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (one) of embodiment 9 Chinese medicine composition two ointments of the present invention
Get by weight 28 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 20 parts of Radix Sophorae Flavescentiss, 0.5 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), put in the iron pan, add 50 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Add 22 parts in sulfur, 2 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (two) of embodiment 10 Chinese medicine composition two ointments of the present invention
Get by weight 38 parts of Semen Hydnocarpi, 13 parts of Cortex Pseudolariciss, 13 parts of Radix Sophorae Flavescentiss, 1.5 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), put in the iron pan, add 500 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Add 32 parts in sulfur, 1 part of the Calomelas pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (three) of embodiment 11 Chinese medicine composition two ointments of the present invention
Get by weight 28 parts of Semen Hydnocarpi, 13 parts of Cortex Pseudolariciss, 20 parts of Radix Sophorae Flavescentiss, 0.5 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), put in the iron pan, add 50 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Add 32 parts in sulfur, 1 part of the Calomelas pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (four) of embodiment 12 Chinese medicine composition two ointments of the present invention
Get by weight 38 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 13 parts of Radix Sophorae Flavescentiss, 1.5 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), put in the iron pan, add 100 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Add 22 parts in sulfur, 2 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (five) of embodiment 13 Chinese medicine composition two ointments of the present invention
Get by weight 28 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 13 parts of Radix Sophorae Flavescentiss, 0.5 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), put in the iron pan, add 500 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Add 32 parts in sulfur, 2 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (six) of embodiment 14 Chinese medicine composition two ointments of the present invention
Get by weight 38 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 13 parts of Radix Sophorae Flavescentiss, 0.5 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), put in the iron pan, add 50 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Add 32 parts in sulfur, 1 part of the Calomelas pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (seven) of embodiment 15 Chinese medicine composition two ointments of the present invention
Get by weight 28 parts of Semen Hydnocarpi, 20 parts of Cortex Pseudolariciss, 20 parts of Radix Sophorae Flavescentiss, 1.5 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), put in the iron pan, add 300 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Add 22 parts in sulfur, 2 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation (eight) of embodiment 16 Chinese medicine composition two ointments of the present invention
Get by weight 33 parts of Semen Hydnocarpi, 17 parts of Cortex Pseudolariciss, 17 parts of Radix Sophorae Flavescentiss, 1 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), put in the iron pan, add 100 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Add 27 parts in sulfur, 1.6 parts of the Calomelass pulverizing in advance and cross No. five sieves, mix well and get final product.
The preparation of embodiment 17 Chinese medicine composition one plaster of the present invention
Vegetable oil (such as Oleum Brassicae campestris, Semen arachidis hypogaeae wet goods) is put in the pot, after the slight fever spice Semen Hydnocarpi, Cortex Pseudolaricis, Radix Sophorae Flavescentis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) are dropped into, heating and constantly stirring are until spice is fried inner sallow for spending to surperficial dark brown.Drag for medicinal residues with iron wire after exploding well, the oil after removing slag is medicine oil.The oil of getting it filled continues to temper to dripping into pearl.After being smelt, from Huo Xiadan, general 500g oil adds the 250g pellet, and Plumbum preparatium adds pellet on a small quantity at lower front first dry 100 mesh sieves of also crossing, and the limit edged stirs until stir into the mastic of thickness.After spraying removes " fire-toxin ", be blended into sulfur, Calomelas, stir evenly, get a certain amount of plaster with bamboo let and get final product at kraft paper or plaster cloth, Moschus and volatile Borneolum Syntheticum, Camphora, Herba Menthae etc. can sprinkle at last.Wherein the weight proportion of above each crude drug is any among the embodiment 1-8.
The preparation of embodiment 18 Chinese medicine composition two plaster of the present invention
Oleum Sesami is put in the pot, after the slight fever crude drug Semen Hydnocarpi, Cortex Pseudolaricis, Radix Sophorae Flavescentis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) are dropped into, heating and constantly stirring are until spice is fried inner sallow for spending to surperficial dark brown.Drag for medicinal residues with iron wire after exploding well, the oil after removing slag is medicine oil.The oil of getting it filled continues to temper to dripping into pearl.After being smelt, from Huo Xiadan, general 500g oil adds the 250g pellet, and Plumbum preparatium adds pellet on a small quantity at lower front first dry 100 mesh sieves of also crossing, and the limit edged stirs until stir into the mastic of thickness.After spraying removes " fire-toxin ", be blended into sulfur, Calomelas, stir evenly, get a certain amount of plaster with bamboo let and get final product at kraft paper or plaster cloth, Moschus and volatile Borneolum Syntheticum, Camphora, Herba Menthae etc. can sprinkle at last.Wherein the weight proportion of above each crude drug is any among the embodiment 9-16.
The preparation of embodiment 19 Chinese medicine composition one gels of the present invention
A small amount of vegetable oil (such as Oleum Brassicae campestris, Semen arachidis hypogaeae wet goods) is put in the pot, after the slight fever spice Semen Hydnocarpi, Cortex Pseudolaricis, Radix Sophorae Flavescentis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) are dropped into, heating decocts and constantly stirs, and gets filtrate.Carbomer added in the glycerol to grind make moisteningly, add again after a small amount of distilled water grinds, move on in the measuring cup, other gets triethanolamine, oxybenzene second fat, distilled water and makes in right amount dissolving, stirs into gel, adds an amount of distilled water again and stirs evenly, add above-mentioned medical material filtrate and sulfur, Calomelas, grind well and get final product.Wherein the weight proportion of above each crude drug is any among the embodiment 1-8.
The preparation of embodiment 20 Chinese medicine composition two gels of the present invention
Oleum Sesami is put in the pot, after the slight fever spice Semen Hydnocarpi, Cortex Pseudolaricis, Radix Sophorae Flavescentis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) are dropped into, heating decocts and constantly stirs, and gets filtrate.Carbomer added in the glycerol to grind make moisteningly, add again after a small amount of distilled water grinds, move on in the measuring cup, other gets triethanolamine, oxybenzene second fat, distilled water and makes in right amount dissolving, stirs into gel, adds an amount of distilled water again and stirs evenly, add above-mentioned medical material filtrate and sulfur, Calomelas, grind well and get final product.Wherein the weight proportion of above each crude drug is any among the embodiment 9-16.
The preparation of embodiment 21 Chinese medicine composition one patches of the present invention
A small amount of vegetable oil (such as Oleum Brassicae campestris, Semen arachidis hypogaeae wet goods) is put in the pot, after the slight fever spice Semen Hydnocarpi, Cortex Pseudolaricis, Radix Sophorae Flavescentis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) are dropped into, heating decocts and constantly stirs appropriate time, gets filtrate.In filtrate, add the conventional patch substrates such as Kaolin, glycerol, add simultaneously sulfur, Calomelas, stir evenly, coat backing layer, add protective layer and get final product.Wherein the weight proportion of above each crude drug is any among the embodiment 1-8.
The preparation of embodiment 22 Chinese medicine composition two patches of the present invention
Oleum Sesami is put in the pot, after the slight fever spice Semen Hydnocarpi, Cortex Pseudolaricis, Radix Sophorae Flavescentis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) are dropped into, heating decocts and constantly stirs appropriate time, gets filtrate.In filtrate, add the conventional patch substrates such as Kaolin, glycerol, add simultaneously sulfur, Calomelas, stir evenly, coat backing layer, add protective layer and get final product.Wherein the weight proportion of above each crude drug is any among the embodiment 9-16.
Atopic dermatitis in embodiment 23 traditional Chinese medicine composition for treating chronic eczemas of the present invention, dermatitis or the keratinization dermatoses clinical trial
1 clinical data
1.1 diagnostic criteria
1.1.1 Western medicine diagnose standard
" atopic dermatitis " standard of writing with reference to Hao Fei, Song Zhiqiang (Hao Fei, Song Zhiqiang. atopic dermatitis [M]. Beijing: People's Medical Officer Press, 2008:14,186-226.).All cases all meet by Britain's atopic dermatitis cooperative groups formulated Williams diagnostic criteria (the Williams HC that delivers in 1994, Burney PG, Hay Rj, et al. The UK working Party ' s Diagnostic Criteria for Atopic Dermatitis. I. Derivation aminimum set of discriminators for atopic dermatitis[J]. Br J Dermatol, 1994,131 (3): 383-396.).1. essential condition: have skin pruritus symptom (or the head of a family narrates the infant skin medical history of scratching, rub).2. subsidiary conditions: a, age of onset＜2 years old (child is inapplicable below 4 years old).B, side skin involvement history (child below 10 years old comprises face) in the wrong.C, the dry history of whole skin.D, individual have other atopic disease histories (or the first degree relative of child below 4 years old has the atopic disease history).E, identifiable side dermatitis in the wrong (or the volume of child below 4 years old/face and distal limb dermatitis).3. diagnosis requires: require to possess essential condition, satisfy at least simultaneously 3 subsidiary conditions.
1.1.2 tcm diagnosis standard
Reference " People's Republic of China's Chinese medicine industry standard disease of tcm Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine. People's Republic of China's Chinese medicine industry standard disease of tcm Standardization of diagnosis and curative effect (ZY) [M]. Nanjing: publishing house of Nanjing University, 1994:147.).The diagnostic criteria of traditional Chinese medical science atopic eczema disease: 1. skin lesion is dry, coarse, plump lichenization, can have acute or the subacute dermatitis outbreak.Conscious play is itched.2. skin lesion is apt to occur in the patella ulnaris joint and bends side, also be found in shank stretch side and face neck, mouthful around etc. the position.3. the infantile eczema medical history can be arranged, outbreak continues not heal repeatedly.4. have the irritated tendency of heredity, family or I often have the medical histories such as asthma, urticaria.
1.2 include in and exclusion standard
Inclusive criteria: 1. meet the AD diagnostic criteria of Williams.2. meet the AD diagnostic criteria of the traditional Chinese medical science.3. 2～60 years old age, male or female.
Exclusion standard: 1. gestation or women breast-feeding their children.2. irritated to this medicine, or to the ingredient allergy sufferers.3. anabolic agent is crossed in external in nearly 1 week.4. be associated with the serious primary disease such as diabetes, cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic.
1.3 physical data
120 routine patients derive from year June in July, 2009 to 2011, and case 120 examples are collected by Shanghai Chinese Medicine Hospital out-patient department, adopt the table of random number method to be divided into treatment group one, treatment group two, matched group one, matched group two.In treatment group one 30 examples, male 16 examples, women 14 examples; 5～41 years old age, average (19.8 ± 5.2) year, the course of disease 1～40 year, average (10.5 ± 5.0) year, quantizing integration before the treatment is 58.60 ± 13.96.In treatment group 2 30 examples, male 15 examples, women 15 examples; 6～40 years old age, average (20.6 ± 5.1) year, the course of disease 1～38 year, average (10.9 ± 4.8) year, quantizing integration before the treatment is 57.73 ± 14.46.In matched group one 30 examples, male's 14 examples, women's 16 examples, 7～40 years old age, average (20.8 ± 5.6) year, the course of disease 1～39 year, average (10.7 ± 5.4) year, quantizing integration before the treatment is 58.02 ± 13.65.In matched group 2 30 examples, male's 15 examples, women's 15 examples, 6～42 years old age, average (19.7 ± 5.3) year, the course of disease 1～38 year, average (10.8 ± 4.9) year, quantizing integration before the treatment is 58.37 ± 14.23.Four groups of no difference of science of statistics aspect the quantification integration before sex, age, the course of disease and treatment (P〉0.05), have comparability.
2 methods
2.1 Therapeutic Method
Treatment group one: the Chinese medicine composition ointment of getting 4g embodiment 8 preparations is applied to the skin affected part, each 1 time sooner or later.
Treatment group two: the Chinese medicine composition ointment of getting 4g embodiment 16 preparations is applied to the skin affected part, each 1 time sooner or later.
Matched group one: get 34 parts of Semen Hydnocarpi, 17 parts of Cortex Pseudolariciss, 17 parts of Radix Sophorae Flavescentiss according to following weight portion, put in the iron pan, add 102 parts in Oleum Sesami, soak after 24 hours, temperature fire (approximately 100 ℃) decocts 40-50 minute.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30 minute again, is cooled to paste.Get this paste 4g and be applied to the skin affected part, each 1 time sooner or later.
Matched group two: get by weight 33 parts of Semen Hydnocarpi, 17 parts of Cortex Pseudolariciss, 17 parts of Radix Sophorae Flavescentiss, 0.8 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), soak, conventional method temperature fire (approximately 100 ℃) decocts 40-50min.Get filtrate, add Cera Flava and Yellow Vaselin is an amount of, temperature fire (approximately 100 ℃) decocts 15-30min again, is cooled to paste.1.6 parts of the Calomelass that adding is pulverized are in advance mixed well and be get final product.Get this paste 4g and be applied to the skin affected part, each 1 time sooner or later.
Four groups cooperate Chinese medicine for oral administration simultaneously.(form: Herba Ephedrae 6g, Fructus Forsythiae 9g, Semen Phaseoli 15g, Radix Scutellariae 9g, Radix Rehmanniae 15g etc.) for adding and subtracting diagnosis and prescription in the basis through side of proved recipe antiallergic with commonly used.Decoct by boiling machine is unified, the 200ml/ bag, each 1 bag, every day 2 times, sooner or later oral.
Four groups of patients are 1 course for the treatment of in equal 4 weeks, observe after treating two courses for the treatment of.
2.2 observation index and method
By European atopic dermatitis standards of grading (Hao Fei, Song Zhiqiang. atopic dermatitis [M]. Beijing: People's Medical Officer Press, 2008:14,186-226.) each clinical symptoms of (SCORAD) comprising, comprising: skin lesion scope (A), the skin being grievously injured degree (B), pruritus and sleep influence degree (C).
Main individual event symptom erythema, pimple or edema, ooze out or incrustation, exfoliation, lichenization, xerosis cutis by without, light, in, 0,1,2,3 minute heavily respectively.Fall more than 1 minute after the treatment of individual event symptom integral and be improvement.
Method: require to include in the weekly further consultation of patient of research, adjust Chinese medicine for oral administration according to the state of an illness, and, treatment rear 1 course for the treatment of front to treating and treat and estimate the state of an illness, record scoring rear 2 courses for the treatment of respectively.
2.3 criterion of therapeutical effect
The SCORAD integration is brought formula " Evaluation of Synthetic Effect of Holistic=[the front integration of (integration after integration before the treatment-treatment)/treatment] * 100% " into according to the nimodipine method and is calculated before and after will treating, and formulate according to level Four criterion of therapeutical effect (with reference to the guideline of clinical investigations of eczema " new Chinese medicine treatment "): recovery from illness: pruritus disappears or obviously alleviates therapeutic index 〉=90%; Produce effects: pruritus obviously alleviates, therapeutic index 60%～89%; Effectively: pruritus alleviates, therapeutic index 20%～59%; Invalid: pruritus increases the weight of therapeutic index＜20% before treating.Total effective rate=cure rate+obvious effective rate+effective percentage.
2.3 statistical method
Adopt SPSS 18.0 statistics softwares to carry out statistical procedures, (mean ± sd) expression adopts the t check to measurement data, and enumeration data adopts χ with mean ± standard deviation
2Check.
3 results
3.1 four groups of patient's curative effects relatively
Treatment group one 30 example recoveries from illness 1 example, produce effects 16 examples, effective 10 examples, invalid 3 examples, total effective rate 90%; Treatment group 2 30 example recoveries from illness 1 example, produce effects 18 examples, effective 9 examples, invalid 2 examples, total effective rate 93.33%; Matched group one 30 example recoveries from illness 0 example, produce effects 14 examples, effective 7 examples, no effect 9, total effective rate 70%; Matched group 2 30 example recoveries from illness 0 example, produce effects 12 examples, effective 6 examples, invalid 12 examples, total effective rate 60%.Four groups of patient clinical curative effects compare, treatment group one and treatment group two difference not statistically significants (P〉0.05); Treatment group one and matched group one significant difference (P＜0.05); Treatment group one and matched group two significant differences (P＜0.05); Treatment group two and matched group one significant difference (P＜0.05); Treatment group two and matched group two significant differences (P＜0.05); Matched group one and matched group two difference not statistically significants (P〉0.05).
3.2 the comparison of four groups of patient treatment front and back scorings
The comparative result of four groups of patient treatment front and back scorings is as shown in table 1.As shown in Table 1, each all has statistical significance (P＜0.05) with the rear every diversity of values of this group treatment before organizing treatment; Treatment group one all has statistical significance (P＜0.05) with together time SCORAD scoring of matched group, skin lesion scope, the skin being grievously injured degree, pruritus and sleep influence degree aspect difference after the treatment; Treatment group one all has statistical significance (P＜0.05) with matched group two with time SCORAD scoring, skin lesion scope, the skin being grievously injured degree, pruritus and sleep influence degree aspect difference after the treatment; Treatment group two all has statistical significance (P＜0.05) with together time SCORAD scoring of matched group, skin lesion scope, the skin being grievously injured degree, pruritus and sleep influence degree aspect difference after the treatment; Treatment group two all has statistical significance (P＜0.05) with matched group two with time SCORAD scoring, skin lesion scope, the skin being grievously injured degree, pruritus and sleep influence degree aspect difference after the treatment; Treatment group one and treatment group two are with time SCORAD scoring, skin lesion scope, the skin being grievously injured degree, pruritus and sleep influence degree aspect after the treatment, and treatment group two all is better than treatment group one, but difference not remarkable (P〉0.05).
Mark relatively before and after four groups of patient treatments of table 1 (minute,
± S)
Annotate: relatively front with the treatment of this group, * P＜0.05; Together the time is compared △ P＜0.05 with matched group; Compare ▲ P＜0.05 with the time with matched group two.
3.3 four groups of each individual event doing well,improving situations of patient relatively
Four groups of patient treatments after 2 courses for the treatment of each individual event doing well,improving rate comparative result as shown in table 2.As shown in Table 2, treat 2 courses for the treatment of after, treatment group one is oozed out or incrustation, exfoliation, xerosis cutis improve and be better than matched group one (P＜0.05) and matched group two (P＜0.05), and aspect other individual event symptoms not statistically significant (P〉0.05); Treatment group two is oozed out or incrustation, exfoliation, xerosis cutis improve and be better than matched group one (P＜0.05) and matched group two (P＜0.05), and aspect other individual event symptoms not statistically significant (P〉0.05); Treatment group one and the more equal not statistically significant for the treatment of group two each individual event symptoms (P〉0.05).
Four groups of patient treatments of table 2 each individual event doing well,improving situation (%) after 2 courses for the treatment of
Annotate: with together symptom comparison of matched group, * P＜0.05; Compare △ P＜0.05 with symptom with matched group two.
In sum, as seen the effect of traditional Chinese medicine composition for treating atopic dermatitis of the present invention is better than monarch drug and the ministerial drug composition formula of the disclosed Semen Hydnocarpi cream of prior art, also namely in this prescription, add sulfur, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Calomelas etc., can assist Semen Hydnocarpi, Cortex Pseudolaricis, Radix Sophorae Flavescentis, strengthened therapeutic effect.
Because chronic eczema, keratinization dermatoses are close with the dermatitis pathogeny, symptom is similar, and therefore, Chinese medicine composition of the present invention can be used for the treatment of the dermatosis that chronic eczema, keratinization dermatoses etc. possess pruritus, inflammatory reaction equally.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and replenish, these improvement and replenish and also should be considered as protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition for the treatment of chronic eczema, dermatitis or keratinization dermatoses is characterized in that, it mainly is to be made by the crude drug of following weight portion: Semen Hydnocarpi 28-38 part, Cortex Pseudolaricis 13-20 part, sulfur 22-32 part, Radix Sophorae Flavescentis 13-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 0.5-1.5 part, Calomelas 1-2 part.
2. Chinese medicine composition according to claim 1 is characterized in that, it mainly is to be made by the crude drug of following weight portion: 33 parts of Semen Hydnocarpi, 17 parts of Cortex Pseudolariciss, 27 parts of sulfurs, 17 parts of Radix Sophorae Flavescentiss, 1 part of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 1.6 parts of Calomelass.
3. Chinese medicine composition according to claim 1 is characterized in that, it also comprises the crude drug of following weight portion: Oleum Sesami 50-500 part.
4. Chinese medicine composition according to claim 3 is characterized in that, it also comprises the crude drug of following weight portion: 100 parts in Oleum Sesami.
5. arbitrary described Chinese medicine composition is characterized in that according to claim 1-4, and the dosage form of described Chinese medicine composition is ointment, plaster, gel or patch.
6. the arbitrary described Chinese medicine composition of claim 1-4 is preparing the purposes for the treatment of in chronic eczema, dermatitis or the keratinization dermatoses medicine.
7. the ointment of Chinese medicine composition claimed in claim 1, it is characterized in that, it is prepared by following methods: get by weight Semen Hydnocarpi 28-38 part, Cortex Pseudolaricis 13-20 part, Radix Sophorae Flavescentis 13-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 0.5-1.5 part, conventional method decocts, get filtrate and add Cera Flava and Yellow Vaselin, decoct and be cooled to paste, add again sulfur 22-32 part, the Calomelas 1-2 part of pulverizing in advance, mix well and get final product.
8. the ointment of Chinese medicine composition claimed in claim 7 is preparing the purposes for the treatment of in chronic eczema, dermatitis or the keratinization dermatoses medicine.
9. the ointment of Chinese medicine composition claimed in claim 3, it is characterized in that, it is prepared by following methods: get by weight Semen Hydnocarpi 28-38 part, Cortex Pseudolaricis 13-20 part, Radix Sophorae Flavescentis 13-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 0.5-1.5 part, add Oleum Sesami 50-500 part, soak, decoct, get filtrate and add Cera Flava and Yellow Vaselin, decoct and be cooled to paste, add again sulfur 22-32 part, the Calomelas 1-2 part of pulverizing in advance, mix well and get final product.
10. the ointment of Chinese medicine composition claimed in claim 9 is preparing the purposes for the treatment of in chronic eczema, dermatitis or the keratinization dermatoses medicine.
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