CN103007298A - Medical lubricant for sterilizing and balancing potential of hydrogen and preparation process of medical lubricant - Google Patents
Medical lubricant for sterilizing and balancing potential of hydrogen and preparation process of medical lubricant Download PDFInfo
- Publication number
- CN103007298A CN103007298A CN2012105750062A CN201210575006A CN103007298A CN 103007298 A CN103007298 A CN 103007298A CN 2012105750062 A CN2012105750062 A CN 2012105750062A CN 201210575006 A CN201210575006 A CN 201210575006A CN 103007298 A CN103007298 A CN 103007298A
- Authority
- CN
- China
- Prior art keywords
- buffer
- acid
- lubricant
- buffering
- carbomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention provides a medial lubricant for sterilizing and balancing potential of hydrogen. The lubricant comprises the following components based on the gross weight: 30 to 75wt% of glycerol, 5 to 15wt% of Carbomer, 10 to 20wt% of polyethylene glycol, and 10 to 20wt% of acid-base buffer agent, wherein the acid-base buffer agent is selected from acetic acid buffer pair, boric acid buffer pair, carbonic acid buffer pair, phosphoric acid buffer pair, citric acid buffer pair, acetate buffer pair, borate buffer pair, carbonate buffer pair, phosphate buffer pair and citrate buffer pair.
Description
Technical field
The present invention relates to the health healthcare field, relate in particular to pharmaceutic adjuvant and method for making thereof.
Background technology
People are attempting lubricant applications very early in human body, but use on a large scale or after nineteen fifty.Lubricant (liquid) is applied in the inspection of clinical medicine to human body the earliest: when a lot of medical apparatus and instruments all can be in going deep into human body in various degree cause mechanical injuries, lubricant can at utmost reduce the infringement to bodily tissue, mucosa.Early stage people adopt Vegetable oil lipoprotein such as Fructus Canarii albi wet goods.But owing to becoming branch limit effect unsatisfactory, easily pollute clothes, also be not easy to be absorbed by health; People also attempted using vaseline, baby oil, body lotion, the petroleum-based mineral oily matter of massage wet goods as lubricated afterwards; These materials often viscosity are excessive, and easy cleaning does not easily cause residual after the use.
Summary of the invention
For above-mentioned the deficiencies in the prior art, the purpose of this invention is to provide a kind of Balancing degree, similar to human body fluid, reduced medical lubricant and the preparation technology thereof of the Probability of allergic symptom.
The scheme that is used for dealing with problems is:
To achieve these goals, the invention provides a kind of medical lubricant of the Balancing degree of sterilizing, and in the gross weight of described lubricant, it contains following component:
(a) 30-75wt% glycerol;
(b) 5-15wt% carbomer (Carbomer);
(c) 10-20wt% Polyethylene Glycol;
(d) 10-20wt% acid-base buffer agent; Described acid-base buffer agent is selected from: acetate buffer is right to, citrate buffering to, phosphate-buffered to, carbonate buffering to, borate buffering to, acetate salt buffer to, citric acid buffering to, phosphoric acid buffer to, carbonic acid buffering to, borate buffer.
Preferably, the invention provides a kind of medical lubricant of the Balancing degree of sterilizing, and in the gross weight of described lubricant, it contains following component:
(a) 50-70wt% glycerol;
(b) 5-12wt% carbomer (Carbomer);
(c) 15-20wt% Polyethylene Glycol;
(d) 10-20wt% acid-base buffer agent; Described acid-base buffer agent is selected from: acetate buffer is right to, citrate buffering to, phosphate-buffered to, carbonate buffering to, borate buffering to, acetate salt buffer to, citric acid buffering to, phosphoric acid buffer to, carbonic acid buffering to, borate buffer.
Preferably, described lubricant also contains and is selected from one or more additives of lower group: antiseptic, dispersant, stabilizing agent, ESS.
The preparation method of the medical lubricant of sterilization Balancing degree, described method comprises step: with the medical lubricant of 30-75wt% glycerol, 5-15wt% carbomer (Carbomer), 10-20wt% Polyethylene Glycol, the mixing of 10-20wt% acid-base buffer agent, the swollen described sterilization Balancing of molten formation degree
Beneficial effect of the present invention is:
1, minimizing is to the infringement of bodily tissue, mucosa.When being applicable to the body cavity intubate, lubricated during medical examination, when the dryness utensil such as endoscope enters human body and checks.Exclusive silk is sliding, salubrious, lasting, non-greasy, without properties of product such as wire drawings.
2, its main component is for not having contaminative, and is fully edible, can rinse well with cold water, and it is compatible to have a good mucosa, do not affect the normal pH value of body fluid.
3, do not contain oils and fats, aromatic and ethanol.
4, natural biological macromolecular material protection mucosa assists wound tissue to recover.
5, continue antibiotic, have no drug resistance.
6, nice and cool, pure and fresh, non-stimulated, the sensitization not of sense of touch.
Description of drawings
Fig. 1 is process flow diagram of the present invention.
The specific embodiment
Below in conjunction with the accompanying drawing among the invention embodiment, the technical scheme among the invention embodiment is clearly and completely described, obviously, described embodiment only is the invention part embodiment, rather than whole embodiment.Based on the embodiment in the invention, those of ordinary skills are not making the every other embodiment that obtains under the creative work prerequisite, all belong to the scope of the invention protection.
Embodiment 1
The preparation lubricant solution
With 60 kilograms of glycerol, 10 kilograms of carbomers, 15 kilograms of Polyethylene Glycol, the acetate buffer solution of 2L0.4M and borate buffer solutions of 4L0.3M, stirred 1-2 hour, standing over night, centrifugal 15min removes bubble, adds at last pure water to 100L.Measure pH and viscosity.
Viscosity when result: pH is 6.7,20C is 20-35Pas, and the viscosity in the time of 32 ℃ is 86-110Pas.
Embodiment 2
The preparation lubricant solution
Acetate buffer solution with 50 kilograms of glycerol, 15 kilograms of carbomers, 20 kilograms of Polyethylene Glycol and 2L0.4M stirred 1-2 hour, standing over night, and centrifugal 15min removes bubble, adds at last pure water to 100L.Measure pH and viscosity.
Viscosity when result: pH is 5.7,20C is 23-33Pas, and the viscosity in the time of 32 ℃ is 90-105Pas.
The preparation method of the medical lubricant of sterilization Balancing degree, it is characterized in that, described method comprises step: with the medical lubricant of 30-75wt% glycerol, 5-15wt% carbomer (Carbomer), 10-20wt% Polyethylene Glycol, the mixing of 10-20wt% acid-base buffer agent, the swollen described sterilization Balancing of molten formation degree
Process flow diagram of the present invention as shown in Figure 1.After solution preparation is finished, detect.Carry out the Machinary Packaging operation with detecting qualified lubricant.When carrying out the machine package operation, need to confirm environment, after the affirmation machine parameters (temperature, speed, pressure), packaging material are confirmed, can carry out the machine bag, comprise pipe, pressure pipe, to behind cursor, fluid injection, heating, the package, can form packaging product.
The above; only for the specific embodiment of the invention; but the protection domain of the invention is not limited to this; anyly be familiar with those skilled in the art in the technical scope that the invention discloses; can expect easily changing or replacing, all should be encompassed within the protection domain of the invention.Therefore, the protection domain of the invention should be as the criterion by described protection domain with claim.
Claims (4)
1. the medical lubricant of the Balancing degree of sterilizing is characterized in that, in the gross weight of described lubricant, it contains following component:
(a) 30-75wt% glycerol;
(b) 5-15wt% carbomer (Carbomer);
(c) 10-20wt% Polyethylene Glycol;
(d) 10-20wt% acid-base buffer agent; Described acid-base buffer agent is selected from: acetate buffer is right to, citrate buffering to, phosphate-buffered to, carbonate buffering to, borate buffering to, acetate salt buffer to, citric acid buffering to, phosphoric acid buffer to, carbonic acid buffering to, borate buffer.
2. lubricant according to claim 1 is characterized in that, in the gross weight of described lubricant, it contains following component:
(a) 50-70wt% glycerol;
(b) 5-12wt% carbomer (Carbomer);
(c) 15-20wt% Polyethylene Glycol;
(d) 10-20wt% acid-base buffer agent; Described acid-base buffer agent is selected from: acetate buffer is right to, citrate buffering to, phosphate-buffered to, carbonate buffering to, borate buffering to, acetate salt buffer to, citric acid buffering to, phosphoric acid buffer to, carbonic acid buffering to, borate buffer.
3. lubricant according to claim 2 is characterized in that, described lubricant also contains and is selected from one or more additives of lower group: antiseptic, dispersant, stabilizing agent, ESS.
4. preparation method such as the medical lubricant of the arbitrary described sterilization Balancing degree of claim 1-3, it is characterized in that, described method comprises step: with the medical lubricant of 30-75wt% glycerol, 5-15wt% carbomer (Carbomer), 10-20wt% Polyethylene Glycol, the mixing of 10-20wt% acid-base buffer agent, swollen molten formation sterilization Balancing as claimed in claim 1 degree.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105750062A CN103007298A (en) | 2012-12-26 | 2012-12-26 | Medical lubricant for sterilizing and balancing potential of hydrogen and preparation process of medical lubricant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105750062A CN103007298A (en) | 2012-12-26 | 2012-12-26 | Medical lubricant for sterilizing and balancing potential of hydrogen and preparation process of medical lubricant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103007298A true CN103007298A (en) | 2013-04-03 |
Family
ID=47956759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012105750062A Pending CN103007298A (en) | 2012-12-26 | 2012-12-26 | Medical lubricant for sterilizing and balancing potential of hydrogen and preparation process of medical lubricant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103007298A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958788A (en) * | 2015-06-30 | 2015-10-07 | 苏州乔纳森新材料科技有限公司 | Medical lubricant and preparing method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905041A (en) * | 2009-06-08 | 2010-12-08 | 上海市计划生育科学研究所 | Acid vagina lubricant and preparation method and use thereof |
-
2012
- 2012-12-26 CN CN2012105750062A patent/CN103007298A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905041A (en) * | 2009-06-08 | 2010-12-08 | 上海市计划生育科学研究所 | Acid vagina lubricant and preparation method and use thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958788A (en) * | 2015-06-30 | 2015-10-07 | 苏州乔纳森新材料科技有限公司 | Medical lubricant and preparing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Fumarola et al. | Overlooked and underestimated: medical adhesive-related skin injuries | |
| CN103083733A (en) | Medical water-based lubricant for introducing instrument into body cavity | |
| CN104257639A (en) | Film coating agent for wound surface treatment and preparation method of film coating agent | |
| CN101327346A (en) | Water-soluble human body lubricants | |
| Sakakibara et al. | A simplest method of flap monitoring | |
| CN105194697A (en) | Medical ultrasonic coupling agent and preparation method thereof | |
| CN101332317A (en) | Water soluble human lubricant | |
| CN105342985A (en) | Gel preparation and application thereof | |
| CN101152137A (en) | Body spray cream for baby and technique of preparing the same | |
| CN104958788B (en) | A kind of medical lubricant and preparation method thereof | |
| CN103203042A (en) | Water-soluble medical lubricant | |
| CN106389139A (en) | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof | |
| CN103203014A (en) | Preparation method of blended functional surgical irrigating fluid | |
| CN103007298A (en) | Medical lubricant for sterilizing and balancing potential of hydrogen and preparation process of medical lubricant | |
| CN105031674A (en) | Disinfectant medical ultrasonic coupling agent and production process thereof | |
| CN103405594A (en) | Water-soluble personal lubricant, preparation method thereof, and condom employing lubricant | |
| CN103785068A (en) | Water soluble lubricant and preparation method thereof | |
| CN104721224B (en) | A kind of dry alleviates gargle and preparation method thereof | |
| CN104739738A (en) | Propolis mouthwash and preparation method thereof | |
| CN104888237A (en) | Medical sterilization ultrasound coupling agent and preparation method thereof | |
| CN106178140B (en) | Pure natural water-soluble human body lubricant and preparation method and application thereof | |
| CN104918625A (en) | Enemas | |
| CN103007297A (en) | Preparation method of lubricating agent for gastroscope | |
| CN103990153A (en) | Sterilization and disinfection type medical ultrasonic coupling agent formula and preparation process thereof | |
| CN104337834B (en) | A kind of carboxymethyl chitosan Enema liquid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130403 |