CN104958788B - A kind of medical lubricant and preparation method thereof - Google Patents
A kind of medical lubricant and preparation method thereof Download PDFInfo
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- CN104958788B CN104958788B CN201510372138.9A CN201510372138A CN104958788B CN 104958788 B CN104958788 B CN 104958788B CN 201510372138 A CN201510372138 A CN 201510372138A CN 104958788 B CN104958788 B CN 104958788B
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Abstract
A kind of medical lubricant and preparation method thereof, the medical lubricant include following raw material：Glycerine, lemon-grass essential oil, xanthans, peppermint oil, carbomer, vitamin E, vaseline, hyaluronic acid, triethanolamine, preservative.Preparation method：Meter weighs raw material in parts by weight, and the first mixture is stirred to obtain after glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed；After lemon-grass essential oil and peppermint oil are mixed, instilled with 48 drops/min in the first mixture, 320 400rpm add hyaluronic acid and preservative after being stirred and heated to 30 35 DEG C, continue to stir to obtain the second mixture；Xanthans is added dropwise in the second mixture, after the stirring of 300 450rpm speed, distilled water is added and adjusts viscosity and obtain medical lubricant to 100 150mpa.s.Medical lubricant high lubricating effect of the present invention, bacteriostasis is strong, bactericidal effect is good, and prepares simple, suitable industrialization.
Description
Technical field
The invention belongs to field of medical products, and in particular to a kind of medical lubricant and preparation method thereof.
Background technology
Medical lubricant is that one kind provides the aqueous gel for helping lubrication in clinic diagnosis or surgical procedure for all kinds of apparatuses
Agent, mucilage and mineral oil, it is mainly used in intubation or endoscope lubrication, operation suture thread lubrication, the gynaecology of human body natural's cavity
The lubrication of examination apparatus and the lubrication of stapler etc..
Medical lubricant is divided into oily lubricant and water-based lubricant by composition.Oily lubricant is mostly paraffin oil, silicon
The mineral oil components such as oil, its major defect are bad lubricant effect, poor biocompatibility, can reduce the instrumentation life-span.With
The popularization of the Modern Nursing theory of the raising of medical consultations technology and " people-oriented ", use of the doctor and patient to medical lubricant
Performance is proposed higher requirement.Therefore, water-based lubricant is using more and more common.
Current existing water-based lubricant wide variety, some bactericidal abilities, some component non-naturals, hinders to human body
Evil is big, so needing to research and develop the strong medical lubricant of a kind of good water solubility, lubricity.
The content of the invention
In view of the shortcomings of the prior art, should it is an object of the invention to provide a kind of medical lubricant and preparation method thereof
Lubricant sterilizing ability is strong, high lubricating effect, easy cleaning, and preparation method is simple, is adapted to medical.
To solve prior art problem, the technical scheme that the present invention takes is：
A kind of medical lubricant, it is made up of the following raw material counted in parts by weight：Glycerine 30-38 parts, lemon-grass essential oil 3-8
Part, xanthans 12-18 parts, peppermint oil 1-6 parts, carbomer 0.5-1.3 parts, vitamin E 0.5-1.3 parts, vaseline 0.3-1.2
Part, hyaluronic acid 1.4-1.8 parts, triethanolamine 2-8 parts, preservative 0.03-0.08 parts.
It is preferably as medical lubricant, is made up of the following raw material counted in parts by weight：35 parts of glycerine, lemon-grass essence
7 parts of oil, 16 parts of xanthans, 5 parts of peppermint oil, 1.0 parts of carbomer, 1.0 parts of vitamin E, 0.5 part of vaseline, hyaluronic acid 1.6
Part, 6 parts of triethanolamine, 0.03 part of preservative.
It is improved as medical lubricant to be, in addition to sterilizing paraffin oil 0.1-0.5 parts.
The preparation method of above-mentioned medical lubricant, comprises the following steps：
Step 1, meter weighs raw material in parts by weight, and glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed
After stir to obtain the first mixture；
Step 2, after lemon-grass essential oil and peppermint oil being mixed, instilled with 4-8 drops/min in the first mixture, 320-
400rpm adds hyaluronic acid and preservative after being stirred and heated to 30-35 DEG C, continues to stir to obtain the second mixture；
Step 3, xanthans is added dropwise in the second mixture, after 300-450rpm speed stirring, adds distillation
Water adjusts viscosity and obtains medical lubricant to 100-150mpa.s.
It is preferably as preparation method, step 1, mixing speed 150-200rpm.
It is preferably as preparation method, step 3, the speed that xanthans instills the second mixture is 4-8 drops/min.
Beneficial effect
Compared with prior art, the advantage of the invention is that：
（1）Medical lubricant bactericidal effect of the present invention is good, and bacteriostasis is strong, is effectively guaranteed health, avoids feeling
Dye.
（2）The synergy of lemon-grass essential oil and hyaluronic acid improves lubricant effect, convenient use.
（3）Lemon-grass essential oil, peppermint oil and xanthans mix by the way of dropwise in preparation process, improve raw material
Utilization rate, improve the homogeneity of lubricant.
Embodiment
Technical scheme is further described with reference to specific embodiment, it will be appreciated that retouch in this place
The specific embodiment stated only to explain the present invention, is not construed as limiting the invention.
Embodiment 1
A kind of medical lubricant, it is made up of the following raw material counted in parts by weight：30 parts of glycerine, 3 parts of lemon-grass essential oil are yellow
12 parts of virgin rubber, 1 part of peppermint oil, 0.5 part of carbomer, 0.5 part of vitamin E, 0.3 part of vaseline, 1.4 parts of hyaluronic acid, three ethanol
2 parts of amine, 0.03 part of preservative.
The preparation method of above-mentioned medical lubricant, comprises the following steps：
Step 1, meter weighs raw material in parts by weight, and glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed
The first mixture is stirred to obtain with 150rpm speed afterwards；
Step 2, after lemon-grass essential oil and peppermint oil being mixed, instilled in the first mixture with 4 drops/min, stirred with 320rpm
Mix and add hyaluronic acid and preservative after being heated to 30 DEG C, continue to stir to obtain the second mixture；
Step 3, xanthans is added dropwise in the second mixture with 4 drops/min, after 300rpm speed stirring, added
Distilled water adjusts viscosity and obtains medical lubricant to 100mpa.s.
Embodiment 2
A kind of medical lubricant, it is made up of the following raw material counted in parts by weight：35 parts of glycerine, 7 parts of lemon-grass essential oil are yellow
16 parts of virgin rubber, 5 parts of peppermint oil, 1.0 parts of carbomer, 1.0 parts of vitamin E, 0.5 part of vaseline, 1.6 parts of hyaluronic acid, three ethanol
6 parts of amine, 0.03 part of preservative.
The preparation method of above-mentioned medical lubricant, comprises the following steps：
Step 1, meter weighs raw material in parts by weight, and glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed
The first mixture is stirred to obtain with 180rpm afterwards；
Step 2, after lemon-grass essential oil and peppermint oil being mixed, instilled with 7 drops/min in the first mixture, 380rpm stirrings
And hyaluronic acid and preservative are added after being heated to 32 DEG C, continue to stir to obtain the second mixture；
Step 3, xanthans is added dropwise in the second mixture with 6 drops/min, after 400rpm speed stirring, added
Distilled water adjusts viscosity and obtains medical lubricant to 120mpa.s.
Embodiment 3
A kind of medical lubricant, it is made up of the following raw material counted in parts by weight：38 parts of glycerine, 8 parts of lemon-grass essential oil are yellow
18 parts of virgin rubber, 6 parts of peppermint oil, 1.3 parts of carbomer, 1.3 parts of vitamin E, 1.2 parts of vaseline, 1.8 parts of hyaluronic acid, three ethanol
8 parts of amine, 0.08 part of preservative.
The preparation method of above-mentioned medical lubricant, comprises the following steps：
Step 1, meter weighs raw material in parts by weight, and glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed
The first mixture is stirred to obtain with 200rpm speed afterwards；
Step 2, after lemon-grass essential oil and peppermint oil being mixed, instilled with 8 drops/min in the first mixture, 400rpm is stirred
Mix and add hyaluronic acid and preservative after being heated to 35 DEG C, continue to stir to obtain the second mixture；
Step 3, xanthans is added dropwise in the second mixture with 8 drops/min, after 450rpm speed stirring, added
Distilled water adjusts viscosity and obtains medical lubricant to 150mpa.s.
Embodiment 4
A kind of medical lubricant, it is made up of the following raw material counted in parts by weight：35 parts of glycerine, 7 parts of lemon-grass essential oil are yellow
16 parts of virgin rubber, 5 parts of peppermint oil, 1.0 parts of carbomer, 1.0 parts of vitamin E, 0.5 part of vaseline, 1.6 parts of hyaluronic acid, three ethanol
6 parts of amine, 0.03 part of preservative, sterilize paraffin oil 0.1-0.5 parts.
The preparation method of above-mentioned medical lubricant, comprises the following steps：
Step 1, meter weighs raw material in parts by weight, and glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed
The first mixture is stirred to obtain with 180rpm afterwards；
Step 2, after lemon-grass essential oil, peppermint oil and sterilizing paraffin oil being mixed, the first mixture is instilled with 7 drops/min
In, 380rpm adds hyaluronic acid and preservative after being stirred and heated to 32 DEG C, continues to stir to obtain the second mixture；
Step 3, xanthans is added dropwise in the second mixture with 6 drops/min, after 400rpm speed stirring, added
Distilled water adjusts viscosity and obtains medical lubricant to 120mpa.s.
Comparative example 1
A kind of medical lubricant, it is made up of the following raw material counted in parts by weight：35 parts of glycerine, 7 parts of lemon-grass essential oil are yellow
16 parts of virgin rubber, 5 parts of peppermint oil, 1.0 parts of carbomer, 1.0 parts of vitamin E, 0.5 part of vaseline, 1.6 parts of hyaluronic acid, three ethanol
6 parts of amine, 0.03 part of preservative.
The preparation method of above-mentioned medical lubricant, comprises the following steps：
Step 1, meter weighs raw material in parts by weight, and glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed
The first mixture is stirred to obtain with 180rpm afterwards；
Step 2, added after lemon-grass essential oil and peppermint oil being mixed in the first mixture, 380rpm is stirred and heated to 32
Hyaluronic acid and preservative are added after DEG C, continues to stir to obtain the second mixture；
Step 3, xanthans is added in the second mixture, after 400rpm speed stirring, it is viscous adds distilled water regulation
Spend to 120mpa.s and obtain medical lubricant.
Comparative example 2
A kind of medical lubricant, it is made up of the following raw material counted in parts by weight：35 parts of glycerine, 16 parts of xanthans, peppermint
5 parts of oil, 1.0 parts of carbomer, 1.0 parts of vitamin E, 0.5 part of vaseline, 1.6 parts of hyaluronic acid, 6 parts of triethanolamine, preservative
0.03 part.
The preparation method of above-mentioned medical lubricant, comprises the following steps：
Step 1, meter weighs raw material in parts by weight, and glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed
The first mixture is stirred to obtain with 180rpm afterwards；
Step 2, after peppermint oil is mixed, instilled with 7 drops/min in the first mixture, 380rpm is stirred and heated to 32 DEG C
After add hyaluronic acid and preservative, continue to stir to obtain the second mixture；
Step 3, xanthans is added dropwise in the second mixture with 6 drops/min, after 400rpm speed stirring, added
Distilled water adjusts viscosity and obtains medical lubricant to 120mpa.s.
Comparative example 3
A kind of medical lubricant, it is made up of the following raw material counted in parts by weight：35 parts of glycerine, 7 parts of lemon-grass essential oil are yellow
16 parts of virgin rubber, 5 parts of peppermint oil, 1.0 parts of carbomer, 1.0 parts of vitamin E, 0.5 part of vaseline, 6 parts of triethanolamine, preservative
0.03 part.
The preparation method of above-mentioned medical lubricant, comprises the following steps：
Step 1, meter weighs raw material in parts by weight, and glycerine, carbomer, vitamin E, vaseline and triethanolamine are mixed
The first mixture is stirred to obtain with 180rpm afterwards；
Step 2, after lemon-grass essential oil and peppermint oil being mixed, instilled with 7 drops/min in the first mixture, 380rpm stirrings
And preservative is added after being heated to 32 DEG C, continue to stir to obtain the second mixture；
Step 3, xanthans is added dropwise in the second mixture with 6 drops/min, after 400rpm speed stirring, added
Distilled water adjusts viscosity and obtains medical lubricant to 120mpa.s.
Performance test
To 1-4 of the embodiment of the present invention and comparative example 1-3 medical lubricant carry out performance test, the data obtained such as following table
It is shown:
Lubricant high lubricating effect of the present invention is can be seen that from upper table data, bactericidal ability is strong, and quality is homogeneous.
By comparing embodiment 2 and comparative example 1, raw material is added dropwise, is advantageous to improve raw material availability, improves lubricant
Homogeneity, comparing embodiment 2 and comparative example 2-3 understand that lemon-grass essential oil and hyaluronic acid exist simultaneously, improve lubricant
Bactericidal and bacteriostatic effect, infection is efficiently avoid, ensure that health, is worthy to be popularized.
The embodiment of the present invention is the foregoing is only, but protection scope of the present invention is not limited thereto, it is any
Those skilled in the art disclosed herein technical scope in, can without the change that creative work is expected or
Person replaces, and should all be included within the scope of the present invention.Therefore, protection scope of the present invention should be with claims institute
The protection domain of restriction is defined.
Claims (5)
1. a kind of medical lubricant, it is characterised in that be made up of the following raw material counted in parts by weight：Glycerine 30-38 parts, lemongrass
Careless essential oil 3-8 parts, xanthans 12-18 parts, peppermint oil 1-6 parts, carbomer 0.5-1.3 parts, vitamin E 0.5-1.3 parts, all scholars
Woods 0.3-1.2 parts, hyaluronic acid 1.4-1.8 parts, triethanolamine 2-8 parts, preservative 0.03-0.08 parts；Preparation method：Step 1,
Meter weighs raw material in parts by weight, will glycerine, carbomer, vitamin E, vaseline and triethanolamine mix after stir first to mix
Compound；Step 2, after lemon-grass essential oil and peppermint oil being mixed, instilled with 4-8 drops/min in the first mixture, 320-400rpm
Hyaluronic acid and preservative are added after being stirred and heated to 30-35 DEG C, continues to stir to obtain the second mixture；Step 3, by xanthan
Glue is added dropwise in the second mixture, after 300-450rpm speed stirring, is added distilled water and is adjusted viscosity to 100-
150mpa.s obtains medical lubricant.
2. medical lubricant according to claim 1, it is characterised in that be made up of the following raw material counted in parts by weight：
35 parts of glycerine, 7 parts of lemon-grass essential oil, 16 parts of xanthans, 5 parts of peppermint oil, 1.0 parts of carbomer, 1.0 parts of vitamin E, vaseline
0.5 part, 1.6 parts of hyaluronic acid, 6 parts of triethanolamine, 0.03 part of preservative.
3. medical lubricant according to claim 1, it is characterised in that：Also include sterilizing paraffin oil 0.1-0.5 parts.
4. medical lubricant according to claim 1, it is characterised in that：Step 1, mixing speed 150-200rpm.
5. medical lubricant according to claim 1, it is characterised in that：Step 3, xanthans instills the speed of the second mixture
Spend for 4-8 drops/min.
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| CN105343940A (en) * | 2015-10-26 | 2016-02-24 | 佛山市平创医疗器械科技有限公司 | Disposable bactericidal human body lubricant and preparation method thereof |
| CN106178140B (en) * | 2016-07-29 | 2020-03-17 | 上海宇昂水性新材料科技股份有限公司 | Pure natural water-soluble human body lubricant and preparation method and application thereof |
| CN108079385A (en) * | 2017-12-20 | 2018-05-29 | 江苏省健尔康医用敷料有限公司 | High homogeneity sterilizing medical lubricant |
| CN109453439B (en) * | 2019-01-22 | 2021-05-14 | 郑州乐迪生物科技有限公司 | Mucous membrane protective agent for artificial insemination of livestock and preparation method thereof |
| CN111870744A (en) * | 2020-06-24 | 2020-11-03 | 江南大学 | Instrument lubricant suitable for inner cavity of organism pipeline and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101703814A (en) * | 2009-11-24 | 2010-05-12 | 张干元 | Lubricating agent for use in coelom introduction by medicinal appliance |
| CN103007298A (en) * | 2012-12-26 | 2013-04-03 | 江苏省健尔康医用敷料有限公司 | Medical lubricant for sterilizing and balancing potential of hydrogen and preparation process of medical lubricant |
| CN103083733A (en) * | 2013-02-19 | 2013-05-08 | 华熙福瑞达生物医药有限公司 | Medical water-based lubricant for introducing instrument into body cavity |
| CN103203042A (en) * | 2013-04-13 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Water-soluble medical lubricant |
| CN103170016B (en) * | 2013-04-19 | 2014-03-12 | 江苏迪沃生物制品有限公司 | Medical lubricant |
| CN103933621B (en) * | 2014-04-16 | 2015-12-02 | 广西信业生物技术有限公司 | A kind of medical lubricant and preparation method thereof |
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Effective date of registration: 20171211 Address after: Jiaojiang Jia Zhi Village District of Taizhou City, Zhejiang province 318000 Street No. 122 Applicant after: Lin Piaopiao Address before: 208 room 2, building 9, No. 215011, Deng Wei Road, hi tech Zone, Jiangsu, Suzhou Applicant before: SUZHOU JONATHAN NEW MATERIAL TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20200714 Address after: 213200 Jiangsu Province, Changzhou City Industrial Zone jianerkang Town Road No. 1 Patentee after: JIANGSU PROVINCE JIANERKANG MADICAL DRESSING CO.,LTD. Address before: Jiaojiang Jia Zhi Village District of Taizhou City, Zhejiang province 318000 Street No. 122 Patentee before: Lin Piaopiao |
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Address after: No.1, jianerkang Road, Zhixi Town, Changzhou City, Jiangsu Province 213200 Patentee after: Jianerkang Medical Technology Co.,Ltd. Address before: No.1, jianerkang Road, Zhixi Town, Changzhou City, Jiangsu Province 213200 Patentee before: Jiangsu jianerkang Medical Technology Co.,Ltd. Address after: No.1, jianerkang Road, Zhixi Town, Changzhou City, Jiangsu Province 213200 Patentee after: Jiangsu jianerkang Medical Technology Co.,Ltd. Address before: No.1, jianerkang Road, Zhixi Town, Changzhou City, Jiangsu Province 213200 Patentee before: JIANGSU PROVINCE JIANERKANG MADICAL DRESSING CO.,LTD. |