CN108079385A - High homogeneity sterilizing medical lubricant - Google Patents
High homogeneity sterilizing medical lubricant Download PDFInfo
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- CN108079385A CN108079385A CN201711380947.XA CN201711380947A CN108079385A CN 108079385 A CN108079385 A CN 108079385A CN 201711380947 A CN201711380947 A CN 201711380947A CN 108079385 A CN108079385 A CN 108079385A
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- medical lubricant
- high homogeneity
- silver
- antimicrobial agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to medical lubricant technical field, especially a kind of high homogeneity sterilizing medical lubricant；Its mass parts composition is as follows：0.01 0.8 parts of organic silicon defoamer, 10 20 parts of glycerine, 0.2 0.8 parts of xanthans, 0.01 0.08 parts of silver-based antimicrobial agent, 0.01 0.03 parts of preservative, 0.02 0.08 parts of vitamin E, 0.1 0.9 parts of hyaluronic acid, 13 parts of peppermint extracting solution, 0.2 0.8 parts of aloe extract；High homogeneity sterilizing medical lubricant in the present invention can largely reduce the frictional force of instrument and cavity, mechanical injuries effectively are avoided, and mucous membrane foam can be eliminated, expansion is opened and checks local mucous membrane pain stove degree of getting a clear view, be conducive to Accurate Diagnosis lesion, work efficiency greatly improves.
Description
Technical field
The present invention relates to medical lubricant technical field, especially a kind of high homogeneity sterilizing medical lubricant.
Background technology
Clinically to make a definite diagnosis various intracavitary diseases, various cavity endoscopes are widely used, (are inside peeped in these medical instruments
The diagnostors such as mirror, gynecatoptron, cervical clamps, medical catheter) into during body cavities, it generally requires in medical instrument table
Face coats suitable lubricant, to reduce damage of the instrument to tissue.Requirement to this lubricant is that should be able to rise first
To certain anesthetic effect, and corrosion-free to mirror body, self stability is good, small to patient's irritation and without any toxicity and side effects,
There is the effects that anesthesia, disinfection, defoaming to cavity mucomembranous surface.
But clinically the lubricant properties of cavity endoscope-use are single in practical application at present, mostly using silicone oil, glycerine, liquid
Body paraffin etc., and these drugs can only play lubricating action, not possess local anaesthesia and good lubricity, patient is difficult to receive.
It has also been found that the scattered unevenness of silicone oil in Clinical practice, preparation is sticky, poorly water-soluble, uneven, and transparency is inadequate, after use easily
The cement of block solid fraction is formed, is attached on the tube walls such as alimentary canal, blocks lesions position instead, influences the accuracy checked or missing inspection.
The content of the invention
The technical problem to be solved by the present invention is to：Overcome deficiency of the prior art, a kind of transparency height, homogeneity are provided
Good, prevented from caking high homogeneity sterilizing medical lubricant.
In order to solve the above technical problems, the technical solution adopted by the present invention is as follows：
A kind of high homogeneity sterilizing medical lubricant, mass parts composition are as follows：0.01-0.8 parts of organic silicon defoamer,
10-20 parts of glycerine, 0.2-0.8 parts of xanthans, 0.01-0.08 parts of silver-based antimicrobial agent, 0.01-0.03 parts of preservative, vitamin
E0.02-0.08 parts, 0.1-0.9 parts of hyaluronic acid, 1-3 parts of peppermint extracting solution, 0.2-0.8 parts of aloe extract.
Preferably, the viscosity of the medical lubricant is 80-120mpa.
Preferably, the preservative selects methyl hydroxybenzoate.
Preferably, the silver-based antimicrobial agent is by entering AgNO3、Co(NO3)2, butyl titanate and montmorillonite particle be made.
Preferably, the silver-based antimicrobial agent is made using one kettle way, specifically by AgNO3、Co(NO3)2, butyl titanate
It is placed in montmorillonite particle in ethanol solution, silver-based antimicrobial agent is obtained by filtration in reflux 10-24h postcoolings, and then drying and crushing is extremely
100-200 mesh is spare.
Preferably, barbaloin 55-60%, polysaccharide 20-28%, organic acid 8-10%, amino acid in the aloe extract
4-5%, the weight percent content of four kinds of ingredients are less than 100%.
Preferably, menthones content 46-50% in the mint extract, isomenthone content 5-8%, Determination of menthol
2-4%.
The method for preparing high homogeneity sterilizing medical lubricant, the preparation method comprise the following steps：
(1) organic silicon defoamer of formula ratio, glycerine, xanthans, silver-based antimicrobial agent, preservative, vitamin E, thoroughly are weighed
Bright matter acid, peppermint extracting solution, aloe extract；
(2) xanthans of the formula ratio is uniformly trickled down into purified water, is allowed to fully be swollen, obtain xanthans swelling
Body, it is spare；
(3) the peppermint extracting solution, preservative, hyaluronic acid of the formula ratio are dissolved respectively, is then defoamed with organosilicon
Agent, glycerine, silver-based antimicrobial agent, vitamin E, aloe extract mixing, stir evenly, obtain mixed liquor；
(4) xanthans swelling body is added in into mixed liquor, purified water is added to be settled to 1L, is stirred evenly, is sterilized to get Gao Jun
One property sterilizing medical lubricant.
The advantageous effect of technical solution using the present invention is：
High homogeneity sterilizing medical lubricant in the present invention can largely reduce the frictional force of instrument and cavity, effectively
Mechanical injuries are avoided, and mucous membrane foam can be eliminated, expansion is opened and checks local mucous membrane pain stove degree of getting a clear view, it is accurate to be conducive to
Lesion is diagnosed, work efficiency greatly improves.
Specific embodiment
The preferred embodiment of the present invention is illustrated below, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
A kind of high homogeneity sterilizing medical lubricant, mass parts composition are as follows：0.01 part of organic silicon defoamer, glycerine 10
It is part, 0.2 part of xanthans, 0.01 part of silver-based antimicrobial agent, 0.01 part of preservative, 0.02 part of vitamin E, 0.1 part of hyaluronic acid, thin
1 part of lotus extracting solution, 0.2 part of aloe extract, the viscosity of medical lubricant is 80mpa, and preservative selects methyl hydroxybenzoate, silver-based
Antiseptic is by entering AgNO3、Co(NO3)2, butyl titanate and montmorillonite particle be made.
Silver-based antimicrobial agent is made using one kettle way in the present embodiment, specifically by AgNO3、Co(NO3)2, butyl titanate and
Montmorillonite particle is placed in ethanol solution, and silver-based antimicrobial agent is obtained by filtration in reflux 10-24h postcoolings, then drying and crushing to 100
Mesh is spare.
Barbaloin 55%, polysaccharide 20%, organic acid 8%, amino acid 4% in aloe extract in the present embodiment.
Menthones content 46% in mint extract, isomenthone content 5%, Determination of menthol 2% in the present embodiment.
The preparation method of high homogeneity sterilizing medical lubricant in the present embodiment comprises the following steps：
(1) organic silicon defoamer of formula ratio, glycerine, xanthans, silver-based antimicrobial agent, preservative, vitamin E, thoroughly are weighed
Bright matter acid, peppermint extracting solution, aloe extract；
(2) xanthans of the formula ratio is uniformly trickled down into purified water, is allowed to fully be swollen, obtain xanthans swelling
Body, it is spare；
(3) the peppermint extracting solution, preservative, hyaluronic acid of the formula ratio are dissolved respectively, is then defoamed with organosilicon
Agent, glycerine, silver-based antimicrobial agent, vitamin E, aloe extract mixing, stir evenly, obtain mixed liquor；
(4) xanthans swelling body is added in into mixed liquor, purified water is added to be settled to 1L, is stirred evenly, is sterilized to get Gao Jun
One property sterilizing medical lubricant.
Embodiment 2
A kind of high homogeneity sterilizing medical lubricant, mass parts composition are as follows：0.4 part of organic silicon defoamer, glycerine 15
It is part, 0.5 part of xanthans, 0.05 part of silver-based antimicrobial agent, 0.02 part of preservative, 0.05 part of vitamin E, 0.5 part of hyaluronic acid, thin
2 parts of lotus extracting solution, 0.4 part of aloe extract, the viscosity of medical lubricant is 100mpa, and preservative selects methyl hydroxybenzoate, silver
Based antimicrobials are by entering AgNO3、Co(NO3)2, butyl titanate and montmorillonite particle be made.
Silver-based antimicrobial agent is made using one kettle way in the present embodiment, specifically by AgNO3、Co(NO3)2, butyl titanate and
Montmorillonite particle is placed in ethanol solution, and silver-based antimicrobial agent is obtained by filtration in reflux 10-24h postcoolings, then drying and crushing to 200
Mesh is spare.
Barbaloin 58%, polysaccharide 24%, organic acid 9%, amino acid 4.5% in aloe extract in the present embodiment, four kinds
The weight percent content of ingredient is less than 100%.
Menthones content 48% in mint extract, isomenthone content 6.5%, Determination of menthol 3% in the present embodiment.
The preparation method of high homogeneity sterilizing medical lubricant in the present embodiment comprises the following steps：
(1) organic silicon defoamer of formula ratio, glycerine, xanthans, silver-based antimicrobial agent, preservative, vitamin E, thoroughly are weighed
Bright matter acid, peppermint extracting solution, aloe extract；
(2) xanthans of the formula ratio is uniformly trickled down into purified water, is allowed to fully be swollen, obtain xanthans swelling
Body, it is spare；
(3) the peppermint extracting solution, preservative, hyaluronic acid of the formula ratio are dissolved respectively, is then defoamed with organosilicon
Agent, glycerine, silver-based antimicrobial agent, vitamin E, aloe extract mixing, stir evenly, obtain mixed liquor；
(4) xanthans swelling body is added in into mixed liquor, purified water is added to be settled to 1L, is stirred evenly, is sterilized to get Gao Jun
One property sterilizing medical lubricant.
Embodiment 3
A kind of high homogeneity sterilizing medical lubricant, mass parts composition are as follows：0.8 part of organic silicon defoamer, glycerine 20
It is part, 0.8 part of xanthans, 0.08 part of silver-based antimicrobial agent, 0.03 part of preservative, 0.08 part of vitamin E, 0.9 part of hyaluronic acid, thin
3 parts of lotus extracting solution, 0.8 part of aloe extract, the viscosity of medical lubricant is 120mpa, and preservative selects methyl hydroxybenzoate, silver
Based antimicrobials are by entering AgNO3、Co(NO3)2, butyl titanate and montmorillonite particle be made.
Silver-based antimicrobial agent is made using one kettle way in the present embodiment, specifically by AgNO3、Co(NO3)2, butyl titanate and
Montmorillonite particle is placed in ethanol solution, and silver-based antimicrobial agent is obtained by filtration in reflux 10-24h postcoolings, then drying and crushing to 100
Mesh is spare.
Barbaloin 60%, polysaccharide 28%, organic acid 10%, amino acid 5% in aloe extract in the present embodiment, four kinds into
The weight percent content divided is less than 100%.
Menthones content 50% in mint extract, isomenthone content 8%, Determination of menthol 4% in the present embodiment.
The preparation method of high homogeneity sterilizing medical lubricant in the present embodiment comprises the following steps：
(1) organic silicon defoamer of formula ratio, glycerine, xanthans, silver-based antimicrobial agent, preservative, vitamin E, thoroughly are weighed
Bright matter acid, peppermint extracting solution, aloe extract；
(2) xanthans of the formula ratio is uniformly trickled down into purified water, is allowed to fully be swollen, obtain xanthans swelling
Body, it is spare；
(3) the peppermint extracting solution, preservative, hyaluronic acid of the formula ratio are dissolved respectively, is then defoamed with organosilicon
Agent, glycerine, silver-based antimicrobial agent, vitamin E, aloe extract mixing, stir evenly, obtain mixed liquor；
(4) xanthans swelling body is added in into mixed liquor, purified water is added to be settled to 1L, is stirred evenly, is sterilized to get Gao Jun
One property sterilizing medical lubricant.
The medical lubricant biocompatibility of the present invention meets GB/T16886.11-2011 requirements.
Sample is placed each 10 days under the conditions of illumination (4500Lux), high temperature (60 DEG C), accelerate (40 DEG C, RH75%) and
The inspection for carrying out medicament contg, Shape Indexes in 6 months is placed under room temperature condition (25 DEG C, RH60%).
The study on the stability result of medical lubricant in embodiment 1-3.
The above results show that medical lubricant stability of the present invention is good, and 6 are placed under the conditions of long-term and accelerated test
Month, significant changes do not occur for content, shape and the ph of sample.
Using above-mentioned desirable embodiment according to the invention as enlightenment, by above-mentioned description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property scope is not limited to the content on specification, it is necessary to determine its technical scope according to right.
Claims (8)
- The medical lubricant 1. a kind of high homogeneity sterilizes, which is characterized in that its mass parts composition is as follows：Organic silicon defoamer 0.01-0.8 parts, 10-20 parts of glycerine, 0.2-0.8 parts of xanthans, 0.01-0.08 parts of silver-based antimicrobial agent, preservative 0.01-0.03 Part, 0.02-0.08 parts of vitamin E, 0.1-0.9 parts of hyaluronic acid, 1-3 parts of peppermint extracting solution, 0.2-0.8 parts of aloe extract.
- The medical lubricant 2. high homogeneity according to claim 1 sterilizes, it is characterised in that：The medical lubricant glues It spends for 80-120mpa.
- The medical lubricant 3. high homogeneity according to claim 1 sterilizes, it is characterised in that：The preservative selects Ni Bo Tortoise beetle ester.
- The medical lubricant 4. high homogeneity according to claim 1 sterilizes, it is characterised in that：The silver-based antimicrobial agent is by entering AgNO3、Co(NO3)2, butyl titanate and montmorillonite particle be made.
- The medical lubricant 5. high homogeneity according to claim 1 sterilizes, it is characterised in that：The silver-based antimicrobial agent uses One kettle way is made, specifically by AgNO3、Co(NO3)2, butyl titanate and montmorillonite particle be placed in ethanol solution, flow back 10- Silver-based antimicrobial agent is obtained by filtration in postcooling for 24 hours, and then drying and crushing is spare to 100-200 mesh.
- The medical lubricant 6. high homogeneity according to claim 1 sterilizes, it is characterised in that：Reed in the aloe extract Luxuriant growth glycosides 55-60%, polysaccharide 20-28%, organic acid 8-10%, amino acid 4-5%, the weight percent content of four kinds of ingredients are less than 100%.
- The medical lubricant 7. high homogeneity according to claim 1 sterilizes, it is characterised in that：It is thin in the mint extract Lotus ketone content 46-50%, isomenthone content 5-8%, Determination of menthol 2-4%.
- 8. prepare the method for the high homogeneity sterilizing medical lubricant as any one of claim 1-7, it is characterised in that： The preparation method comprises the following steps：(1) organic silicon defoamer of formula ratio, glycerine, xanthans, silver-based antimicrobial agent, preservative, vitamin E, hyalomitome are weighed Acid, peppermint extracting solution, aloe extract；(2) xanthans of the formula ratio is uniformly trickled down into purified water, is allowed to fully be swollen, obtains xanthans swelling body, It is spare；(3) the peppermint extracting solution, preservative, hyaluronic acid of the formula ratio are dissolved respectively, then with organic silicon defoamer, sweet Oil, silver-based antimicrobial agent, vitamin E, aloe extract mixing, stir evenly, obtain mixed liquor；(4) xanthans swelling body is added in into mixed liquor, purified water is added to be settled to 1L, is stirred evenly, is sterilized to get high homogeneity Sterilize medical lubricant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711380947.XA CN108079385A (en) | 2017-12-20 | 2017-12-20 | High homogeneity sterilizing medical lubricant |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711380947.XA CN108079385A (en) | 2017-12-20 | 2017-12-20 | High homogeneity sterilizing medical lubricant |
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| CN108079385A true CN108079385A (en) | 2018-05-29 |
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| CN201711380947.XA Pending CN108079385A (en) | 2017-12-20 | 2017-12-20 | High homogeneity sterilizing medical lubricant |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111944595A (en) * | 2020-08-21 | 2020-11-17 | 江苏省健尔康医用敷料有限公司 | Lubricant for medical surgical instruments and preparation and use methods thereof |
| CN116474176A (en) * | 2023-03-21 | 2023-07-25 | 宁波汉科医疗器械有限公司 | Lubricating fluid suitable for natural cavity and tract of human body and application thereof |
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2017
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| US20090018188A1 (en) * | 2007-07-09 | 2009-01-15 | John Texter | Bactericidal silver surfactant delivery into coating and polymer compositions |
| CN102973986A (en) * | 2012-07-19 | 2013-03-20 | 黄斌 | Medical super-lubricity antibacterial catheter coating liquid |
| CN104686577A (en) * | 2013-12-05 | 2015-06-10 | 大连奥林匹克电子城咨信商行 | Inorganic compound silver-based antibacterial agent |
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| CN105942430A (en) * | 2016-05-03 | 2016-09-21 | 王胜 | Plant salt containing sea salt and peppermint extract and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111944595A (en) * | 2020-08-21 | 2020-11-17 | 江苏省健尔康医用敷料有限公司 | Lubricant for medical surgical instruments and preparation and use methods thereof |
| CN116474176A (en) * | 2023-03-21 | 2023-07-25 | 宁波汉科医疗器械有限公司 | Lubricating fluid suitable for natural cavity and tract of human body and application thereof |
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Address after: No.1 jianerkang Road, Zhixi Town, Jintan District, Changzhou City, Jiangsu Province Applicant after: Jianerkang Medical Technology Co.,Ltd. Address before: No.1 jianerkang Road, Zhixi Town, Jintan District, Changzhou City, Jiangsu Province Applicant before: Jiangsu jianerkang Medical Technology Co.,Ltd. Address after: No.1 jianerkang Road, Zhixi Town, Jintan District, Changzhou City, Jiangsu Province Applicant after: Jiangsu jianerkang Medical Technology Co.,Ltd. Address before: No.1 jianerkang Road, Zhixi Town, Jintan District, Changzhou City, Jiangsu Province Applicant before: JIANGSU PROVINCE JIANERKANG MADICAL DRESSING CO.,LTD. |
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| CB02 | Change of applicant information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180529 |
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| RJ01 | Rejection of invention patent application after publication |