CN107334908A - A kind of extracting method of aloe extract - Google Patents
A kind of extracting method of aloe extract Download PDFInfo
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- CN107334908A CN107334908A CN201710497769.2A CN201710497769A CN107334908A CN 107334908 A CN107334908 A CN 107334908A CN 201710497769 A CN201710497769 A CN 201710497769A CN 107334908 A CN107334908 A CN 107334908A
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- aloe
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- 229940069521 aloe extract Drugs 0.000 title claims abstract description 41
- 238000000034 method Methods 0.000 title claims abstract description 29
- 241001116389 Aloe Species 0.000 claims abstract description 58
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 58
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000284 extract Substances 0.000 claims abstract description 25
- 239000012141 concentrate Substances 0.000 claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000003814 drug Substances 0.000 claims abstract description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000005855 radiation Effects 0.000 claims abstract description 8
- 238000007598 dipping method Methods 0.000 claims abstract description 6
- 201000010099 disease Diseases 0.000 claims abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 6
- 238000007654 immersion Methods 0.000 claims abstract description 6
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 5
- 238000011084 recovery Methods 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 14
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 claims description 11
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 claims description 10
- AFHJQYHRLPMKHU-OSYMLPPYSA-N aloin A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-OSYMLPPYSA-N 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 150000007524 organic acids Chemical class 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 238000007605 air drying Methods 0.000 claims description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 10
- 238000013461 design Methods 0.000 abstract description 9
- 238000004064 recycling Methods 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 27
- 235000008504 concentrate Nutrition 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 8
- 239000006071 cream Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 108010023302 HDL Cholesterol Proteins 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 208000032928 Dyslipidaemia Diseases 0.000 description 4
- 208000017170 Lipid metabolism disease Diseases 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
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- 210000004185 liver Anatomy 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229940006091 aloe polysaccharide Drugs 0.000 description 1
- AFHJQYHRLPMKHU-WEZNYRQKSA-N aloin B Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-WEZNYRQKSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000000246 remedial effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- 210000002784 stomach Anatomy 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000004260 weight control Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of extracting method of aloe extract, belong to food and medicine technical field.The extracting method of the aloe extract, comprises the following steps：1) picking surface is disease-free, immaculate aloe, clean, dry, remove the peel, finish, dry, pulverize and sieve, aloe powder is obtained, after adding alcohol solution dipping into aloe powder, is extracted using microwave radiation, it is filtrated to get the first extract solution, recycling design, obtains the first concentrate, and filter residue is standby；2) filter residue adds water saturated butanol solution immersion, using ultrasonic extraction, is filtrated to get the second extract solution, recycling design, obtains the second concentrate；3) the first concentrate and the second concentrate are mixed, dries, produce aloe extract.The aloe extract that the present invention extracts has curative effect height, steady quality, while recovery rate is high, and technique is simple, easy to operate, and cost is cheap, is adapted to industrialized production.
Description
【Technical field】
The present invention relates to food and medicine technical field, and in particular to a kind of extracting method of aloe extract.
【Background technology】
Aloe is Liliaceae perennial evergreen herbaceous plant, and leafage is raw, big and plump, in seat shape or is born in stem top, Ye Chang
There is sharp tooth thorn at lanceolar or the short width of leaf, edge.Inflorescence is umbrella shape, total shape, spike, cone etc., and color is in red, yellow or tool redness of the skin or complexion
Spot, six, petal, six pieces of gynoecium, the more joints of perianth base portion are into tubular.Open source information shows that the chemical composition of aloe has aloe
Polysaccharide, barbaloin, Barbaloin, isobarbaloin etc., there is enhancing immunologic function, antitumor, lead to diarrhea defaecation, resist
The effect such as bacterium, anti-gastric injury and liver protection, protection skin.
Railway Project be present in existing aloe extracting method, first, effective component extracting is incomplete, cause aloe to waste
Seriously, second, not by the percentage by weight control of main active within the specific limits so that extract health effect is not
It is only single, and curative effect is not notable.
【The content of the invention】
The goal of the invention of the present invention is：For above-mentioned problem, there is provided a kind of extracting method of aloe extract,
The aloe extract of methods described extraction has curative effect height, steady quality, while recovery rate is high, and technique is simple, easy to operate, into
This is cheap, is adapted to industrialized production.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of extracting method of aloe extract, comprises the following steps：
1) picking surface is disease-free, immaculate aloe, cleans, dries, removes the peel, finishes, dries, pulverize and sieve, obtains
Aloe powder, after adding alcohol solution dipping into aloe powder, extracted using microwave radiation, be filtrated to get the first extract solution,
Recycling design, obtains the first concentrate, and filter residue is standby；
2) filter residue adds water saturated butanol solution immersion, using ultrasonic extraction, is filtrated to get the second extract solution, reclaims
Solvent, obtain the second concentrate；
3) the first concentrate and the second concentrate are mixed, dries, produce aloe extract；
The percentage by weight that each component accounts for extract gross weight in the aloe extract is：Barbaloin 55~60% is more
Sugar 20~30%, organic acid 5~12%, amino acid 3~6%, wherein four percentage by weight sums are less than 100%.
Further, described finish is：Aloe after peeling is diced, be put into 90~100 DEG C of hot water fixing 10~
30 seconds.
Further, described dry is：Aloe after fixing filters off moisture, using heated-air drying or vacuum drying, Yu Wen
Under the conditions of 45~65 DEG C of degree, dry to the final water content of aloe and be less than 10%.
Further, it is described pulverize and sieve for：Aloe after drying is subjected to coarse crushing, then by obtained first crushing
Material crosses 60 mesh sieves, obtains the aloe powder that particle diameter is less than 250 μm.
Further, the solid-liquid ratio of the aloe powder and ethanol solution is 1：5~30, the volume fraction of the ethanol solution
For 50~70%.
Further, the power of the microwave radiation is 400W~800W.
Further, the solid-liquid ratio of the aloe powder and water saturated n-butanol is 1：5~30.
Further, it in ultrasonic power is 80~100w that the ultrasonic extraction, which is, extraction 30 under the conditions of 45~50 DEG C~
45 minutes.
" solid-liquid ratio " of the present invention refers to the ratio of the quality and the quality of " liquid " as leaching liquor of " material " of solid-state.
Present invention additionally comprises the pharmaceutical composition prepared with the aloe extract of the present invention, described pharmaceutical composition is by having
Above-mentioned aloe extract and the pharmaceutically acceptable carrier composition of effect amount.Wherein aloe extract as active constituents of medicine,
Its shared percentage by weight in pharmaceutical composition can be 0.1-99.9%, and remaining is pharmaceutically acceptable carrier.
Such as：1st, in field of medicaments：With can be with received disintegrant, excipient, lubricant, bonding in oral formulations
After the conventional auxiliary adding ingredient mixing such as agent, filler, operating method and process routinely, tablet, pill, glue can be made
The medicine of wafer, granule or a variety of solid orally ingestible forms of sustained release agent, controlled release agent etc. accordingly；Matrix, table with routine
After the conventional auxiliary adding ingredient mixing such as face activating agent, penetration enhancers, operating method and process routinely, it can be made outer
With the medicine of the semisolid preparation form such as paste, suppository, jelly.Solubilizer, emulsifying agent, lubricant with routine, bubble or disappear
After the mixing such as the surfactants such as infusion, diluent, preservative, stabilizer, flavouring, thickener, by corresponding conventional method,
The oral drugs of the liquid forms such as aqua, syrup, oral liquid can be prepared into；It is suspending agent, stabilizer with routine, scattered
Agent or the reagent mixing for adjusting solution osmotic pressure, by corresponding conventional method, are configured to the injection systems such as parenteral solution, powder-injection
Agent.
2nd, in functional food field：After conventional auxiliary adding ingredient mixing, operating method and process routinely, it can make
Into the functional food of the forms such as bread, drinks, health protection tea, chewing gum.
Obviously, according to the above of the present invention, according to the ordinary skill and customary means of this area, this hair is not being departed from
Under the premise of bright above-mentioned basic fundamental thought, the modification, replacement or change of other diversified forms can also be made.
Present invention also offers above-mentioned aloe extract or pharmaceutical composition to prepare the application in treating high blood cholesterol drug.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
(1) using present invention extraction aloe, as a result show, can be by the main active weight percent of aloe extract
Than controlling in certain scope, experiment shows, the extract has the effect of reducing blood lipid；
(2) recovery rate of the present invention is high, and technique is simple, easy to operate, and cost is cheap, is adapted to industrialized production.
【Embodiment】
Embodiment 1
A kind of extracting method of aloe extract, comprises the following steps：
1) picking surface is disease-free, immaculate aloe, cleans, dries, removes the peel；
2) finish:Aloe after peeling is diced, is put into 90~100 DEG C of hot water and finishes 10 seconds；
3) dry：Aloe after fixing filters off moisture, using heated-air drying, under the conditions of 45~65 DEG C of temperature, dries extremely
The final water content of aloe is less than 10%；
4) pulverize and sieve：Aloe after drying is subjected to coarse crushing, then the material by obtained first crushing crosses 60 mesh sieves,
Obtain the aloe powder that particle diameter is less than 250 μm；
5) after adding alcohol solution dipping into aloe powder, use power to be extracted for 400W microwave radiation, filter
The first extract solution is obtained, recycling design obtains the first concentrate, and filter residue is standby；The wherein solid-liquid ratio of aloe powder and ethanol solution
For 1：5, the volume fraction of ethanol solution is 50%；
6) filter residue adds water saturated butanol solution immersion, is 80w in ultrasonic power, is extracted under the conditions of 45~50 DEG C
30 minutes, the second extract solution is filtrated to get, recycling design, obtains the second concentrate；Wherein aloe powder and water saturated n-butanol
Solid-liquid ratio be 1：5；
7) the first concentrate and the second concentrate are mixed, vacuum drying, produces aloe extract；
The percentage by weight that each component accounts for extract gross weight in the present embodiment aloe extract is：Barbaloin 55% is more
Sugar 30%, organic acid 5%, amino acid 6%.
The aloe extract dry cream rate that the present embodiment is prepared is the 31.3% (aloe extract after dry cream rate=drying
Weight/medicinal material dosage * 100%).
Embodiment 2
A kind of extracting method of aloe extract, comprises the following steps：
1) picking surface is disease-free, immaculate aloe, cleans, dries, removes the peel；
2) finish:Aloe after peeling is diced, is put into 90~100 DEG C of hot water and finishes 30 seconds；
3) dry：Aloe after fixing filters off moisture, using vacuum drying, under the conditions of 45~65 DEG C of temperature, dries extremely
The final water content of aloe is less than 10%；
4) pulverize and sieve：Aloe after drying is subjected to coarse crushing, then the material by obtained first crushing crosses 60 mesh sieves,
Obtain the aloe powder that particle diameter is less than 250 μm；
5) after adding alcohol solution dipping into aloe powder, use power to be extracted for 800W microwave radiation, filter
The first extract solution is obtained, recycling design obtains the first concentrate, and filter residue is standby；The wherein solid-liquid ratio of aloe powder and ethanol solution
For 1：30, the volume fraction of ethanol solution is 70%；
6) filter residue adds water saturated butanol solution immersion, is 100w in ultrasonic power, is carried under the conditions of 45~50 DEG C
Take 45 minutes, be filtrated to get the second extract solution, recycling design, obtain the second concentrate；Wherein aloe powder and water saturated positive fourth
The solid-liquid ratio of alcohol is 1：30；
7) the first concentrate and the second concentrate are mixed, spray drying, produces aloe extract；
The percentage by weight that each component accounts for extract gross weight in the present embodiment aloe extract is：Barbaloin 60% is more
Sugar 20%, organic acid 12%, amino acid 3%.
The aloe extract dry cream rate that the present embodiment is prepared is the 29.8% (aloe extract after dry cream rate=drying
Weight/medicinal material dosage * 100%).
Embodiment 3
A kind of extracting method of aloe extract, comprises the following steps：
1) picking surface is disease-free, immaculate aloe, cleans, dries, removes the peel；
2) finish:Aloe after peeling is diced, is put into 90~100 DEG C of hot water and finishes 20 seconds；
3) dry：Aloe after fixing filters off moisture, using heated-air drying, under the conditions of 45~65 DEG C of temperature, dries extremely
The final water content of aloe is less than 10%；
4) pulverize and sieve：Aloe after drying is subjected to coarse crushing, then the material by obtained first crushing crosses 60 mesh sieves,
Obtain the aloe powder that particle diameter is less than 250 μm；
5) after adding alcohol solution dipping into aloe powder, use power to be extracted for 600W microwave radiation, filter
The first extract solution is obtained, recycling design obtains the first concentrate, and filter residue is standby；The wherein solid-liquid ratio of aloe powder and ethanol solution
For 1：20, the volume fraction of ethanol solution is 60%；
6) filter residue adds water saturated butanol solution immersion, is 90w in ultrasonic power, is extracted under the conditions of 45~50 DEG C
38 minutes, the second extract solution is filtrated to get, recycling design, obtains the second concentrate；Wherein aloe powder and water saturated n-butanol
Solid-liquid ratio be 1：20；
7) the first concentrate and the second concentrate are mixed, vacuum drying, produces aloe extract；
The percentage by weight that each component accounts for extract gross weight in the present embodiment aloe extract is：Barbaloin 58% is more
Sugar 25%, organic acid 9%, amino acid 4%.
The aloe extract dry cream rate that the present embodiment is prepared is the 30.6% (aloe extract after dry cream rate=drying
Weight/medicinal material dosage * 100%).
Comparative example 1：
The aloe of comparative example 1 is extracted using water, is concentrated and dried and is obtained extract.
As a result：The percentage by weight that active ingredient accounts for extract gross weight in the aloe extract of comparative example 1 is：Barbaloin
32%, polysaccharide 13%, organic acid 6%, amino acid/11 3%.
Comparative example 2：
The aloe of comparative example 2 uses volume fraction to be extracted for 80% ethanol, is concentrated and dried and obtains extract.
As a result：The percentage by weight that active ingredient accounts for extract gross weight in the aloe extract of comparative example 2 is：Barbaloin
46%, polysaccharide 18%, organic acid 13%, amino acid 5%.
The detection method of the present invention is as follows：
(1) content detection of barbaloin：By SN/T 4136-2015 standard tests；
(2) content detection of polysaccharide：By SN/T 4260-2015 standard tests；
(3) content detection of organic acid：By GB/T 5009.157-2003 standard tests；
(4) content detection of amino acid：By GB/T 5009.124-2003 standard tests；
The effect of test example aloe extract reducing blood lipid of the present invention
1st, general information：
500 cases are randomly divided into 5 groups, every group 100, meet hyperlipidemia diagnostic criteria (《It is Chinese cardiovascular miscellaneous
Will》The dyslipidemia diagnostic criteria that editorial board's dyslipidemia Preventing Countermeasures special topic group is formulated)【Chinese Journal of Cardiology editorial member
Meeting.Dyslipidemia Preventing Countermeasures special topic group.Dyslipidemia remedial proposal [J].Chinese Journal of Cardiology, 1997,25 (3)：
169.】, wherein man 55, female 45；It is 31~72 years old age, average 51 years old.
2nd, medicine：Embodiment 1~3, comparative example 1 and 2.
3rd, treatment method：
Using the present embodiment 1~3, aloe extract made from comparative example 1 and 2 is treated, two times a day, every time 5
Gram, soaked drink, it is a course for the treatment of to treat 3 months.
4th, criterion of therapeutical effect：
Reference《New Chinese medicine guideline of clinical investigations》(Zheng Xiao cornel new Chinese medicines guideline of clinical investigations (tentative)
[S] Beijing China Medical Science Press, 2002：85~89.) criterion of therapeutical effect is worked out.Empty stomach 12h after distinguishing before the treatment
After early morning venous blood samples, the indices such as measure TC, TG, LDL-C, HDL-C, heart Liver and kidney function and blood, urine, stool routine.
It is effective：Lipids detection reaches following any one person：TC declines >=20%, TG and declines >=40%.HDL-C risings >=
0.26mmol/L, TC-LDL-C/HDL-C >=20%.
Effectively：Lipids detection reaches following any one person：TC declines >=10% but ＜ 20%, and TG declines >=20% but ＜
40%.HDL-C risings >=0.104mmol/L but ＜ 0.26mmol/L, TC-LDL-C/HDL-C >=10% but ＜ 20%.
It is invalid：Lipids detection is not up to above standard person.
5th, result of the test
The effect of 1 embodiment of table, 1~3 pair for the treatment of high fat of blood
As it can be seen from table 1 the aloe extract treatment high fat of blood effect of embodiment 1~3 is more notable, effective percentage reaches
More than 96.0%, and during medication, find no any toxic side effect, drug safety.
Described above is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair
Bright patent claim, the equal change completed or modification change under the technical spirit suggested by all present invention, all should belong to
Cover the scope of the claims in the present invention.
Claims (10)
1. a kind of extracting method of aloe extract, it is characterised in that comprise the following steps：
1) picking surface is disease-free, immaculate aloe, cleans, dries, removes the peel, finishes, dries, pulverize and sieve, obtains aloe
Powder, after adding alcohol solution dipping into aloe powder, extracted using microwave radiation, be filtrated to get the first extract solution, reclaimed
Solvent, obtains the first concentrate, and filter residue is standby；
2) filter residue adds water saturated butanol solution immersion, using ultrasonic extraction, is filtrated to get the second extract solution, recovery is molten
Agent, obtain the second concentrate；
3) the first concentrate and the second concentrate are mixed, dries, produce aloe extract；
The percentage by weight that each component accounts for extract gross weight in the aloe extract is：Barbaloin 55~60%, polysaccharide 20
~30%, organic acid 5~12%, amino acid 3~6%, wherein four percentage by weight sums are less than 100%.
2. according to the method for claim 1, it is characterised in that the fixing is：Aloe after peeling is diced, is put into 90
Finished 10~30 seconds in~100 DEG C of hot water.
3. according to the method for claim 1, it is characterised in that the drying is：Aloe after fixing filters off moisture, uses
Heated-air drying or vacuum drying, under the conditions of 45~65 DEG C of temperature, dry to the final water content of aloe and be less than 10%.
4. according to the method for claim 1, it is characterised in that it is described pulverize and sieve for：Aloe after drying is carried out thick
Crush, the material of obtained first crushing is then crossed into 60 mesh sieves, obtain the aloe powder that particle diameter is less than 250 μm.
5. according to the method for claim 1, it is characterised in that the solid-liquid ratio of the aloe powder and ethanol solution is 1：5~
30, the volume fraction of the ethanol solution is 50~70%.
6. according to the method for claim 1, it is characterised in that the power of the microwave radiation is 400W~800W.
7. according to the method for claim 1, it is characterised in that the solid-liquid ratio of the aloe powder and water saturated n-butanol is
1：5~30.
8. according to the method for claim 1, it is characterised in that the ultrasonic extraction be ultrasonic power be 80~
100w, extract 30~45 minutes under the conditions of 45~50 DEG C.
9. a kind of pharmaceutical composition, it is characterised in that the aloe prepared by the extracting method of the claim 1~8 of effective dose carries
Thing and pharmaceutically acceptable carrier is taken to form.
10. prepared by aloe extract or the pharmaceutical composition of claim 9 that claim 1~8 extracting method is prepared
Treat the application in high blood cholesterol drug.
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| CN108295174A (en) * | 2018-01-22 | 2018-07-20 | 浙江夏舒生物科技有限公司 | The application and preparation method of a kind of aloe extract on bed |
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| CN108295174A (en) * | 2018-01-22 | 2018-07-20 | 浙江夏舒生物科技有限公司 | The application and preparation method of a kind of aloe extract on bed |
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| CN109622214A (en) * | 2018-12-24 | 2019-04-16 | 贺州市骏鑫矿产品有限责任公司 | A kind of albite method for concentrating |
| CN109674718A (en) * | 2019-01-21 | 2019-04-26 | 秋臣化妆品有限公司 | A kind of vegetation water and preparation method thereof |
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