CN101327346A - Water-soluble human body lubricants - Google Patents
Water-soluble human body lubricants Download PDFInfo
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- CN101327346A CN101327346A CNA2008101322986A CN200810132298A CN101327346A CN 101327346 A CN101327346 A CN 101327346A CN A2008101322986 A CNA2008101322986 A CN A2008101322986A CN 200810132298 A CN200810132298 A CN 200810132298A CN 101327346 A CN101327346 A CN 101327346A
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Abstract
The invention relates to a water-soluble lubricant for human body, which is characterized in that the water-soluble lubricant comprises 25 portions to 35 portions of glycerol, 20 portions to 45 portions of polyethylene glycol, 0.1 portion to 1.5 portions of tackifier, 0.11 portion to 0.13 portion of preservative, 1 portion to 6 portions of 1,2-propylene glycol, and 15 portions to 30 portions of deionized water. The polyethylene glycol ranges from 200 to 800 in average molecular weight. The water-soluble lubricant not only can be used as a lubricant in sexual life, in massage and on a condom, but also can be used as a lubricant for an instrument to diagnose and examine human cavities. The water-soluble lubricant is nonviscous with moderate characteristics and is mutually soluble with feminine secretion, which is convenient for cleaning, thus ensuring that users have a slight sense of hotness on the coating parts and enhancing the excitement and pleasure for users, providing more fun for the sex life. The sense of hotness is more obvious by tootling the coating parts.
Description
Technical field
The present invention relates to a kind of lubricant, particularly relate to a kind of water-soluble human body lubricants.
Background technology
Many men and wives in sexual life, for the quality that improves sexual life on the genitals coated lubricant.The women carries out the transition to the old stage from the childbearing age, ovarian function is faded, decrease in estrogen, the human secretory ability goes down thereupon, vagina is dry and astringent gradually, follow the string, particularly the women is after having spent climacteric, because its vagina thins down, gonad secretions is fewer and feweri, reproductive tract are endocrine to be lacked, and makes sexual's penis insert difficulty, has a strong impact on the quality of sexual life, therefore when sexual life, need to use human body lubricants more, to alleviate and to improve the vaginal dryness symptom.
Enter in the process of tract at medical apparatus and instruments (diagnostors such as endoscope, colposcope, cervical clamps, medical catheter), often need coat proper amount of lubricating agent on the surface of medical apparatus and instruments, to reduce the damage of apparatus, also using the light liquid paraffin oil as lubricant at most existing hospital-based outpatient obstetrical clinic, in-patient department to tissue.Liquid paraffin oil is difficult to clean, and tissues such as vagina is had certain zest, and grow mycete easily, is badly in need of wanting a kind of fine soluble oil to be replaced.
In the production process of rubber condoms, generally drip the dimethyl siloxane (being commonly called as silicone oil) of about 0.2～0.35 gram on every condom surface, as interleaving agent, can avoid practising contraception adhesion between jacket layer and the layer, also can play simultaneously the effect of lubricant, can prevent the friction of condom and human epidermal and the damage that does not accommodate epidermis cell that causes.
These above-mentioned lubricants should or not change the character of the material of medical apparatus and instruments and condom in human body untoward reaction being arranged, should not reduce the normal performance of medical apparatus and instruments and condom.
Present widely used human body lubricants is generally the lubricant of oleaginous base, as vaseline and derivant thereof, edible oil, mineral wet goods.Have much and studies show that, the lubricant of many oleaginous bases is with medical apparatus and instruments, when condom contacts, the security performance of the condom that meeting damage natural emulsion is made, medical glove etc., such as mineral oil contact with condom be as short as for 60 seconds after, the intensity decreases of condom is about 90%, so all rubber condoms production commercial cities do not recommend consumer to use mineral oil to make lubricant on the surface of condom.In addition, the intravital normal juice of the lubricant of oleaginous base and women is immiscible fully, in use or use greasy feeling, not easy cleaning are arranged later.
Summary of the invention
The technical problem to be solved in the present invention is intended to overcome the deficiency of above-mentioned prior art, and a kind of water-soluble human body lubricants is provided, and is applicable to the shortage of vagina secretions in the sexual life, effectively alleviates and improve the vaginal dryness symptom, improves life quality; And the lubricant when checking as diagnostor in the tract, the lubricant when also can be used as massage and the lubricant that on condom, uses or the like.This lubricant is inviscid soluble oil of character gentleness, dissolves each other with women's juice, and colorless and odorless is convenient to cleaning.In the process of using this product, can make user produce slight scorching hot sensation, strengthen the excitement and the pleasant sensation degree of user simultaneously, for sexual life brings more susceptible interest.Featheriness scribbles the position of this water-soluble human body lubricants, and sensation will be more obvious.
Water-soluble human body lubricants involved in the present invention comprises the component of following weight proportion: 25～35 parts of glycerol, 1,1～6 part of 2-propylene glycol, 20～45 parts of Polyethylene Glycol, 0.1～1.5 part of viscosifier, 0.11～0.13 part of antiseptic, 15～30 parts of deionized waters, the mean molecule quantity of described Polyethylene Glycol is between 200～800.
The glycerol that comprises in component of the present invention and 1, the 2-propylene glycol can increase viscosity, and excellent moistening effect is also arranged.Glycerol and 1, the lubricant effect of preserving moisture of the mixture of 2-propylene glycol is better than simple glycerol.
Glycerol (glycerol) has another name called glycerol, is the simplest trihydroxy alcohol, molecular formula HOCH
2CH (OH) CH
2OH mainly extensively is formed in the bodies of aminal and plant with the form of glyceride at occurring in nature glycerol, contains a small amount of glycerol in Petiolus Trachycarpi oil and other only a few oils and fatss.Glycerol is a kind of colourless viscous liquid, odorlessness, warm sweet taste is arranged, the energy moisture absorption, 182 ℃ of boiling points (2.7KPa), relative density 1.2613 (20/4 ℃), water absorption is very strong, can be miscible in alcohol, and dissolve in acetone, trichloroethylene and ether-pure mixed liquor, can be miscible with water, be insoluble to chloroform, ether, oils.Glycerol is the by-product of soap industry, and also available extraordinary culture propagation molasses make, and can propylene be the raw material synthetic glycerine also.Glycerol as industrial chemicals, is used to make synthetic resin, plastics, paint, nitroglycerin, oils and fats and Cera Flava etc. in a large number, also is used for industry such as pharmacy, spice, cosmetics, hygienic article.
The molecular formula of 1,2 propylene glycol (1,2-Propylene glycol) is HOCH
2CH
2CH
2OH is the stable water absorption liquid of colourless thickness, tasteless odorless, and it is sweet slightly to distinguish the flavor of, have draw moist, inflammable, nontoxic, with water, ethanol and multiple immiscible organic solvent, 187.3 ℃ of boiling points, relative density 1.035～1.037 (25 ℃), surface tension 38mN/m (20 ℃), viscosity 60.5mPas (20 ℃).Many raw materials as resin, plasticizer, surfactant, emulsifying agent and demulsifier also can be used as antifreezing agent and heat carrier.1, the viscosity of 2-propylene glycol and good hygroscopicity, and nontoxic, thereby in food, medicine and cosmetics industry, be widely used as hygroscopic agent, antifreeze, lubricant and solvent, be fit to the use of human body low dose, slight sensitization.
Polyethylene Glycol (PEG) is to be HOCH to structure
2CH
2OH or H[OCH
2CH
2]
nOH, mean molecule quantity is in the general name of about 200 to 6000 ethylene glycol high polymer.PEG is neutral, nontoxic and has unique physicochemical property and the high molecular polymer of good biocompatibility, also is one of synthetic polymer that injection drug is used in the only a few of FDA approval can be as body.PEG has the hydrophilic of height, bigger hydrodynamics volume is arranged in aqueous solution, and do not have immunogenicity.Because PEG has good water solublity, the compatibility, lubricity, moisture retention, cementability and heat stability.Thereby PEG is as lubricant, wetting agent, dispersant, bonding agent etc., in the substrate of industry such as medicine and cosmetics as ointment, suppository, and the carrier of pill, tablet, the solvent of forming agent and injection etc. all have very widely and use.Along with the difference of mean molecule quantity, character is also variant.Mainly act as solvent and water-soluble base in the pharmacy.Stable in properties has no side effect, and a lot of medicines are had solubilising, increase stability and prolongation of effect effect.PEG 200～400 Chang Zuowei injection solvents many are combined into the double solvent use with ethanol, propylene glycol, glycerol and so on.PEG1000～1500th, as the ointment water-soluble base, this product is non-stimulated to skin, and easily eccysis is difficult for mould losing.PEG 4000 and 6000 commonly used carries out different proportion and regulates the ointment denseness, to adapt to the needs of Various Seasonal, temperature.PEG 4000,6000 can also be used as on tablet, the powder as assosting effect.Hygroscopicity and the ethylene glycol of low-molecular-weight PEG are similar, but the very fast reduction of its hygroscopicity when molecular weight increases, the hygroscopicity of PEG4000 and PEG6000 is very low, but still very sensitive to temperature.In order to obtain hygroscopicity widely, can be by mixing or PEG and 1 between PEG, the mixing of 2-propylene glycol and obtaining.
In the present invention, the mixture of one or more among the low-molecular-weight preferably PEG-200～PEG-800 of employing hygroscopicity is as the component of water-soluble human body lubricants of the present invention.
In component of the present invention, also comprise hydroxyethyl-cellulose (HEC) as viscosifier.Hydroxyethyl-cellulose is a kind of white or little yellow, does not have and smell tasteless, runny powder that apparent density is 0.35～0.61g/mL; Softening temperature is 135～140 ℃; Decomposition temperature is 205～210 ℃; Burning velocity is slower; PH value viscosity in 2～12 scopes changes less, but surpasses this scope viscosity degradation.HEC is as a kind of non-ionic water-soluble polymer, except that having thickening, suspension, bonding, floatingization, film forming, dispersion, water conservation and providing the protective colloid action, also has following character:
(1) HEC dissolves in hot water or cold water, and dissolution velocity raises with temperature and speed, and high temperature or boil does not precipitate, and is insoluble in most of organic solvents generally speaking, makes it have large-scale dissolubility and viscosity characteristics, and non-hot gelation;
(2) nonionic own can coexist with other water-soluble polymers, surfactant, the salt on a large scale, is a kind of good colloid thickening agent that contains the high concentration electrolyte solution;
(3) water holding capacity exceeds one times than methylcellulose, has flow adjustment preferably;
(4) to compare dispersibility the poorest for the dispersibility of HEC and methylcellulose of generally acknowledging and hydroxypropyl emthylcellulose, but the protecting colloid ability is the strongest.
Carbomer as viscosifier is a kind of moist very strong white bulky powder that draws.Because have a large amount of hydroxy-acid groups in the molecule, this product and polyacrylic acid have closely similar physicochemical property, faint cross-bond makes it to have the suction phenomenon similar to cross-linked sodium polyacrylate again in the structure simultaneously.Carbomer rapid swelling in water, but do not dissolve, when with in the alkali and the time, carbomer is dissolving gradually in water, pure and mild glycerol, forms clear and bright solution when low concentration, concentration forms translucent gels when big, gel has certain intensity and elasticity.Hydroxy-acid group makes its aqueous dispersions be acid, and the pH value of 1% aqueous dispersions is about 3.11, and viscosity is lower.When with in the alkali and the time, along with macromole dissolves gradually, viscosity also increases, in pH6～11 o'clock viscosity and denseness maximum.Carbomer is a kind of novel medicinal high polymer adjuvant, has been widely used in preparation, can prepare hydrogel adhesive, can make suspending agent, coemulsifier etc.Carbomer is to be produced by U.S. Goodrich chemical company the earliest, and ProductName Carbopol has the specification kind of different molecular weights such as Carbopol 940, Carbopol 934, Carbopol 941.The similar kind of domestic existing pharmaceutical grade and cosmetics-stage is divided into 3 grades by the viscosity size, i.e. high viscosity, medium viscosity, low viscosity, and molecular weight is 4 * 10
6, 3 * 10
6, 1 * 10
6, corresponding with above-mentioned external carbomer specification respectively.Acritamer 940 is fit to do the hydrophilic gel substrate of ointment, cream, has the characteristics of water-soluble base, and putting on the skin has special fine and smooth smooth feeling on skin, and is splendid with the skin coupling effect; Carbomer 934 is fit to do suspending agent or coemulsifier; Carbopol 941 then is used for the tackify of for oral administration or liquid preparation for external use, also is current unique pharmaceutical grade adjuvant of taking in being considered to do.
Also comprise antiseptic in component of the present invention, antiseptic can have the effect of killing preferably and suppressing to anaerobe, is beneficial to the preservation of lubricant.
Nipagin ester is a p-Hydroxybenzoate, is the antiseptic safely and effectively that adopts in the world, is widely used in industries such as food, cosmetics and medicine.Nipagin ester is colourless tiny crystallization or crystalline powder, and astringent taste is arranged slightly, and almost odorless is stable to photo-thermal, is slightly soluble in water, is soluble in ethanol.Nipagin ester is compared with traditional benzoic acid, sorbic acid antiseptic, and its antiseptic effect is difficult for changing with the variation of pH, and simultaneously, they also have low toxicity, efficient, characteristics such as consumption is few, antimicrobial spectrum is wide.Nipagin ester series as antiseptic has: methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, and they are to food, and cosmetics all have good preventing and ferment, suppress bacterial multiplication and sterilizing ability.Because parabens all is insoluble in water, so normally they are dissolved in sodium hydroxide earlier, acetic acid in the ethanol, uses then.Be better performance antisepsis, preferably two kinds of nipalgins or two or more parabenses mixed use.Nipalgin has broad-spectrum bactericidal action, and to Gram-positive, negative bacterium, yeast and mycete have very strong killing action; Nipalgin is chemically belonging to inert substance, easy and all cpds compatibility.
Chlorhexidine gluconate is all very low safe disinfection agent of a kind of toxicity, corrosivity and zest, to skin, mucosa nonirritant, is widely used in the sterilization of skin mucosa, wound surface and urinary organs, and its sterilization and bacteriostasis are good, and stable in properties is easy to use.
Two imidazolidinyl urea (Diazolidinyl Urea), molecular formula: C
8H
14N
4O
7, the mobile easily moisture absorption powder (moisture absorption does not influence bacteriostatic activity) of off-white color, little band formaldehyde odor, very easily water-soluble, easy deliquescence, dissolubility is very low in oil, to the skin avirulence, there is not allergy, nonirritant, good water solubility, compatibility good (not can by other raw material passivation), its antiseptic action principle is a slow release formaldehyde, to removing from office blue formula positive bacteria, the blue formula negative bacterium of leather, comprise that pseudomonas has fungistatic effect, share good antibiotic potentiation with Nipagin ester (benzoates).
In water-soluble human body lubricants of the present invention, also added the pH value regulator, the pH value of water-soluble human body lubricants has been adjusted to 6～7.
Water-soluble human body lubricants of the present invention has following good effect: 1. as lubricated main body, its lubricity obviously improves than the lubricant of oleaginous bases such as silicone oil water-soluble human body lubricants of the present invention with water-soluble material; 2. soluble oil of the present invention all adopts water-soluble material formulated, mixes with the normal juice of female body, does not have oily sensation, is easy to clean, and sensuously is easier to accept, and human body is had no adverse reaction; 3. can not change the character of the material of medical apparatus and instruments and condom, reduce the fracture phenomena that takes place in the use of condom; 4. can not reduce the normal performance of medical apparatus and instruments and condom; 5. in the process of using water-soluble human body lubricants of the present invention, moisture around water-soluble human body lubricants can absorb, discharge heat simultaneously in the process of absorption moisture, make and be coated with the position and feel certain temperature, strengthen the excitement and the pleasant sensation degree of user simultaneously, for sexual life brings more susceptible interest.When the user featheriness scribbled the position of this water-soluble human body lubricants, expiration will produce more moisture, and institute is so that moisture absorption is faster, and the heat of release is also more, and the hotness at coated position is more obvious.
The specific embodiment
The component and the weight proportion thereof of specific embodiments 1～6 of the present invention see the following form:
In above-mentioned embodiment, used glycerol, Polyethylene Glycol, 1,2-propylene glycol, hydroxyethyl-cellulose are medical grade, and used deionized water is a redistilled water.
In the present invention, adopt the composition of the low-molecular-weight preferably PEG of hygroscopicity as water-soluble human body lubricants of the present invention.Polyethylene Glycol in the embodiment 1～6 is PEG-200, PEG-400, PEG-600, the mixing of one or more among the PEG-800.
In embodiment 1～6 1, the 2-propylene glycol, existing moisture-keeping function is again a kind of penetrating agent, can promote simultaneously the dissolving of antiseptic.
In embodiments of the invention 1～6, also added the pH value regulator, the pH value of water-soluble human body lubricants is adjusted to 6～7.The pH value regulator that uses in the embodiment 1～3 is acetic acid, and the pH value regulator that uses in the embodiment 4～6 is citric acid.PH value regulator used in the present invention can also be the pH value regulator that pH value can be adjusted to other kinds of 6～7.
The preparation method of above-mentioned specific embodiments of the present invention is:
In the deionized water under the stirring at low speed, add hydroxyethyl-cellulose, it is drenched fully to be stirred to all hydroxyethyl-celluloses, after treating that hydroxyethyl-cellulose dissolves fully, add glycerol and the Polyethylene Glycol, 1 that has prepared again, the mixed liquor of 2 propylene glycol (containing antiseptic), after continuing to stir mixed liquor put into 10 minutes (120 ℃ of temperature) of high-pressure sterilizing pot sterilization, adding pH value regulator is adjusted to 6～7 with pH value after taking out natural cooling, can obtain water-soluble human body lubricants of the present invention.
The principle of using water-soluble human body lubricants of the present invention can make user produce hotness is: the moisture around the Polyethylene Glycol that contains in water-soluble human body lubricants of the present invention can absorb, and in the process that absorbs moisture, discharge heat simultaneously, make and be coated with the position and feel certain temperature, make user produce slight scorching hot sensation, strengthen the excitement and the pleasant sensation degree of user simultaneously, for sexual life brings more susceptible interest.When the user featheriness scribbled the position of lubricant, expiration will produce more moisture, and institute is so that moisture absorption is faster, and the heat of release is also more, and hotness is more obvious.
Water-soluble human body lubricants to embodiment of the present invention 1～6 is estimated, nasil, determines it is the water white transparency thick liquid, does not have precipitation; No abnormal abnormal smells from the patient and foreign body.
The physical and chemical inspection index is: viscosity (25 ℃) mPas 1500-2000
Relative density g/mL＞1.0
Acidity-basicity ph 6.0-7.0
Skin and mucosa there are not bad stimulation and anaphylaxis.
Claims (9)
1, a kind of water-soluble human body lubricants, it is characterized in that described water-soluble human body lubricants comprises the component of following weight proportion: 25～35 parts of glycerol, 1,1～6 part of 2-propylene glycol, 20～45 parts of Polyethylene Glycol, 0.1～1.5 part of viscosifier, 0.11～0.13 part of antiseptic, 15～30 parts of deionized waters, the mean molecule quantity of described Polyethylene Glycol is between 200～800.
2, water-soluble human body lubricants as claimed in claim 1 is characterized in that: described Polyethylene Glycol is one or more combination of the Polyethylene Glycol of mean molecule quantity 200～800.
3, as any described water-soluble human body lubricants in claim 1 or 2, it is characterized in that: described water-soluble human body lubricants comprises that also the pH value that is used for described water-soluble human body lubricants is adjusted to 6～7 pH value regulator.
4, water-soluble human body lubricants as claimed in claim 3 is characterized in that: described pH value regulator is acetic acid or citric acid.
5, as any described water-soluble human body lubricants in claim 1 or 2, it is characterized in that: described viscosifier are a kind of or its combination in hydroxyethyl-cellulose, the carbomer 934.
6, as any described water-soluble human body lubricants in claim 1 or 2, it is characterized in that: described antiseptic is a kind of or its combination in methyl hydroxybenzoate, the ethyl hydroxybenzoate.
7, as any described water-soluble human body lubricants in claim 1 or 2, it is characterized in that: described antiseptic is any one or a few the combination in methyl hydroxybenzoate, ethyl hydroxybenzoate, the propylparaben.
8. as any described water-soluble human body lubricants in claim 1 or 2, it is characterized in that: described antiseptic is any one or a few the combination in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, the chlorhexidine gluconate.
9. as any described water-soluble human body lubricants in claim 1 or 2, it is characterized in that: described antiseptic is any one or several combination in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, chlorhexidine gluconate, the two imidazolidinyl urea.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101322986A CN101327346A (en) | 2008-07-24 | 2008-07-24 | Water-soluble human body lubricants |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101322986A CN101327346A (en) | 2008-07-24 | 2008-07-24 | Water-soluble human body lubricants |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642590B (en) * | 2009-07-24 | 2012-12-12 | 上海名邦橡胶制品有限公司 | High-lubricity compound silicone oil for condom |
| CN102872156A (en) * | 2012-10-09 | 2013-01-16 | 姜志银 | Lubricant containing hyaluronic acid |
| CN102920615A (en) * | 2011-08-08 | 2013-02-13 | 陈明智 | Gum composition for external use on skin |
| CN103203042A (en) * | 2013-04-13 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Water-soluble medical lubricant |
| CN103785068A (en) * | 2014-02-19 | 2014-05-14 | 江苏苏云医疗器材有限公司 | Water soluble lubricant and preparation method thereof |
| CN104941010A (en) * | 2015-07-27 | 2015-09-30 | 广西信业生物技术有限公司 | Medical vagina lubricating fluid and preparation method thereof |
| CN106137514A (en) * | 2016-07-26 | 2016-11-23 | 广东诺丝科技股份有限公司 | A kind of novel decorative pattern condom of tatooing |
| CN106178141A (en) * | 2016-08-17 | 2016-12-07 | 贵州金玖生物技术有限公司 | Water soluble medical lubricating jelly and preparation method thereof |
| CN107376034A (en) * | 2017-09-04 | 2017-11-24 | 中国热带农业科学院热带作物品种资源研究所 | Plant polypeptide soluble oil and preparation method thereof |
| CN107626001A (en) * | 2016-07-18 | 2018-01-26 | 常州瑞尔康医疗器械有限公司 | A kind of medical sterilization lubricant and preparation method thereof |
| CN111773437A (en) * | 2020-07-13 | 2020-10-16 | 广州奇龙生物科技有限公司 | Lubricated condom and preparation method thereof |
| CN112121236A (en) * | 2020-08-28 | 2020-12-25 | 浙江优亿医疗器械股份有限公司 | Medical sterile water-soluble lubricant and preparation method thereof |
| CN114767948A (en) * | 2022-05-20 | 2022-07-22 | 吉林省人民医院 | Water-soluble lubricant and application thereof |
-
2008
- 2008-07-24 CN CNA2008101322986A patent/CN101327346A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642590B (en) * | 2009-07-24 | 2012-12-12 | 上海名邦橡胶制品有限公司 | High-lubricity compound silicone oil for condom |
| CN102920615A (en) * | 2011-08-08 | 2013-02-13 | 陈明智 | Gum composition for external use on skin |
| CN102872156A (en) * | 2012-10-09 | 2013-01-16 | 姜志银 | Lubricant containing hyaluronic acid |
| CN102872156B (en) * | 2012-10-09 | 2015-04-01 | 姜志银 | Lubricant containing hyaluronic acid |
| CN103203042A (en) * | 2013-04-13 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Water-soluble medical lubricant |
| CN103785068A (en) * | 2014-02-19 | 2014-05-14 | 江苏苏云医疗器材有限公司 | Water soluble lubricant and preparation method thereof |
| CN104941010A (en) * | 2015-07-27 | 2015-09-30 | 广西信业生物技术有限公司 | Medical vagina lubricating fluid and preparation method thereof |
| CN107626001A (en) * | 2016-07-18 | 2018-01-26 | 常州瑞尔康医疗器械有限公司 | A kind of medical sterilization lubricant and preparation method thereof |
| CN106137514A (en) * | 2016-07-26 | 2016-11-23 | 广东诺丝科技股份有限公司 | A kind of novel decorative pattern condom of tatooing |
| CN106178141A (en) * | 2016-08-17 | 2016-12-07 | 贵州金玖生物技术有限公司 | Water soluble medical lubricating jelly and preparation method thereof |
| CN107376034A (en) * | 2017-09-04 | 2017-11-24 | 中国热带农业科学院热带作物品种资源研究所 | Plant polypeptide soluble oil and preparation method thereof |
| CN111773437A (en) * | 2020-07-13 | 2020-10-16 | 广州奇龙生物科技有限公司 | Lubricated condom and preparation method thereof |
| CN111773437B (en) * | 2020-07-13 | 2021-04-02 | 广州奇龙生物科技有限公司 | Lubricated condom and preparation method thereof |
| CN112121236A (en) * | 2020-08-28 | 2020-12-25 | 浙江优亿医疗器械股份有限公司 | Medical sterile water-soluble lubricant and preparation method thereof |
| CN114767948A (en) * | 2022-05-20 | 2022-07-22 | 吉林省人民医院 | Water-soluble lubricant and application thereof |
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Application publication date: 20081224 |