CN106178141A - Water soluble medical lubricating jelly and preparation method thereof - Google Patents
Water soluble medical lubricating jelly and preparation method thereof Download PDFInfo
- Publication number
- CN106178141A CN106178141A CN201610676641.8A CN201610676641A CN106178141A CN 106178141 A CN106178141 A CN 106178141A CN 201610676641 A CN201610676641 A CN 201610676641A CN 106178141 A CN106178141 A CN 106178141A
- Authority
- CN
- China
- Prior art keywords
- water
- manufacture method
- lubricating jelly
- emulsifying
- carbomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of water soluble medical lubricating jelly and preparation method thereof, belong to field of medical products.This lubricating jelly is mainly made by following components by weight percentage: carbomer 0.72～0.85%, methyl hydroxybenzoate 0.041～0.056%, repair liquid 0.41～0.54%, triethanolamine 0.77～0.86%, water surplus.Repair liquid is sequentially passed through alkalization by Plant fiber, is etherified, pulverizes, and then mixes with solvent.Solvent includes any one in normal saline, purified water and glucose solution.This lubricating jelly viscosity is low, has preferable lubricant effect, and has preferable water solublity, thus it uses and clears up the most more convenient.Additionally, the acid or alkali environment of its pH value and human body adapts, it is to avoid injury to human body during use.
Description
Technical field
The present invention relates to medical products field, in particular to a kind of water soluble medical lubricating jelly and preparation method thereof.
Background technology
Medical lubricating jelly is used for the lubrication of medical equipment in clinical operation, to reduce when medical equipment is got involved human body
Injury.At present, major part medical lubricant poorly water-soluble, water there will be significantly layering or the phenomenon of precipitation, cause
Its inconvenience used.
Summary of the invention
The first object of the present invention is to provide a kind of water soluble medical lubricating jelly, can improve the water solublity of lubricating jelly,
Improve its convenience used.
The second object of the present invention is to provide the manufacture method of above-mentioned water soluble medical lubricating jelly, by dissolving, mixing,
PH regulator, four steps of emulsifying can make water soluble medical lubricating jelly, and it has the advantage that flow process is simple, be easy to control.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of water soluble medical lubricating jelly, is mainly made by following components by weight percentage:
Carbomer 0.72～0.85%；
Methyl hydroxybenzoate 0.041～0.056%；
Repair liquid 0.41～0.54%；
Triethanolamine 0.77～0.86%；
The water of surplus；
Repair liquid is sequentially passed through alkalization by Plant fiber, is etherified, pulverizes, and then mixes with solvent, and solvent includes raw
Any one in reason saline, purified water and glucose solution.
The manufacture method of a kind of above-mentioned water soluble medical lubricating jelly, comprises the following steps:
Use water dissolution carbomer, obtain swelling solution；By repair liquid, the mixing of methyl hydroxybenzoate use water, obtain mixed liquor；And will
Swelling solution and mixed liquor mixing, and add triethanolamine regulation pH value, emulsifying.
Beneficial effects of the present invention:
1, the water soluble medical lubricating jelly that the present invention provides is colourless, transparent jelly, its stable height, is more convenient for depositing
Storage.
2, the water soluble medical lubricating jelly that the present invention provides has the good tissue compatibility, and pH value is close to human body
Environment, can effectively maintain the acid-base value environment of human body, reduce the stimulation to human body.
3, the viscosity of the water soluble medical lubricating jelly that the present invention provides is less than 25Pa s, has preferable greasy property, energy
Effectively reduce and rub between medical apparatus and instruments and human body skin, tissue, thus reduce the mechanical injuries in operation process.
4, the water soluble medical lubricating jelly that the present invention provides is by irradiation sterilization, can guarantee that the safety of product is with effective
Property, and it is not more than 1 grade, the lightest mucous membrane irritation without sensitization, cytotoxicity.
5, the water soluble medical lubricating jelly that the present invention provides, has preferable water solublity, uses convenient, and make to be finished
It is easier to after one-tenth clean, thus in use patient or medical worker can be offered convenience.
6, the manufacture method of the water soluble medical that the present invention provides is by dissolving, mixing, pH regulator and four steps of emulsifying,
The making of water soluble medical lubricating jelly can be realized.It is simple that this manufacture method has flow process, and efficiency is high a little, it is simple to advise
Draw metaplasia to produce.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will
Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be
Can be by the commercially available conventional products bought and obtain.
Water soluble medical lubricating jelly below for the embodiment of the present invention and preparation method thereof is specifically described:
A kind of water soluble medical lubricating jelly, is mainly made by following components by weight percentage:
Carbomer 0.72～0.85%；
Methyl hydroxybenzoate 0.041～0.056%；
Repair liquid 0.41～0.54%；
Triethanolamine 0.77～0.86%；
Water surplus；
Repair liquid is sequentially passed through alkalization by Plant fiber, is etherified, pulverizes, and then mixes with solvent, described solvent bag
Include any one in normal saline, purified water and D/W.
Carbomer is dissolved in water and forms colloid solution, has advantage pressure, resistant to elevated temperatures, its stable in properties, is conducive to improving
The service life of lubricating jelly.Additionally, the adhesive force between the colloid solution of carbomer and human body skin, mucosal tissue is good, stimulation
Property is low, and can effectively absorb the transudate of tissue.
Methyl hydroxybenzoate can destroy the cell membrane of microorganism and make its intracellular protein generation degeneration, thus play antibacterial,
Antisepsis, and it is respectively provided with fungistatic effect in wider pH value range.
Repair liquid is good with human body affinity, retentiveness is good and non-stimulated to human body.It addition, repair liquid has isolation, lubrication
Effect, can form biological barrier, the biological activity of protection tissue between tissue, the most also have and prevent from oozing
Blood, promotes epithelial tissue and the effect of wound repair.
Triethanolamine aqueous solution is alkalescence, and has hygroscopicity feature.
Carbomer is dissolved in water and forms stable colloid solution, and this colloid solution has acidity, utilizes the triethanolamine can be to it
PH value be adjusted, in order to lubricating jelly adapts with the pH environment of human body.Repair liquid can improve the parent of lubricating jelly and human body
And property, reduce stimulation to human body, strengthen lubricant effect simultaneously, and improve the retentiveness of lubricating jelly, prevent in lubricating jelly
The loss of moisture.Additionally, repair liquid also can improve the mixed performance of various component, make various component be more easy to mixing, thus improve
The uniformity of various lubricating jellies.Methyl hydroxybenzoate then can suppress the microbial growth in lubricating jelly system, the problem of breeding, thus can
Extend the holding time of lubricating jelly.
In a word, the water soluble medical lubricating jelly that the present invention provides with the colloid solution of carbomer as carrier, mixing repair liquid,
Methyl hydroxybenzoate, triethanolamine form homogeneous, the stable jelly with good aqueous solubility, lubrication and bactericidal effect.This is water-soluble
Property medical lubricating jelly use composition multiple soluble in water and good with human compatibility to be made, it is stingless to human body
Swash, owing to having preferable dissolubility in water, thus, it is easier to carry out clearing up from without producing residual, for patient and doctor
The work for the treatment of worker brings convenience.
Preferably, repair liquid is made by the following method:
Plant fiber is soaked in sodium hydrate aqueous solution 1～2 hour, quaternization occurs；
Take out Plant fiber, be dried, be then soaked in monoxone aqueous solution 3.5～6 hours, etherification reaction occurs；Take
Go out after Plant fiber cleans with medical alcohol, dry, pulverize and mix with solvent.
By weight percentage, 23～the sodium hydrate aqueous solution of monoxone aqueous solution, 22～25% of 30%, 6～
The Plant fiber of 10%, the medical alcohol of surplus.In monoxone aqueous solution, chloroacetic mass fraction is 47～54%, hydroxide
The mass fraction 51～57% of sodium hydroxide in sodium water solution, in medical alcohol, the mass fraction of ethanol is 75～96%.Plant
Fiber includes rice husk, wood flour, cotton thread etc., and solvent includes any one in normal saline, purified water and D/W.
A kind of manufacture method of above-mentioned water soluble medical lubricating jelly, including:
Use water dissolution carbomer, obtain swelling solution；By repair liquid, the mixing of methyl hydroxybenzoate use water, obtain mixed liquor；And will
Swelling solution and mixed liquor mixing, and add triethanolamine, emulsifying.
The manufacture method that the present invention provides, by dissolving, mixing, pH regulator and four steps of emulsifying, can realize water solublity
The making of medical lubricating jelly.It is simple that this manufacture method has flow process, the advantage that efficiency is high.
Owing to carbomer can produce certain bubble in swelling process, and its aqueous solution is gel, therefore, wherein
Water soluble medical lubricating jelly in bubble process more bother.In order to reduce bubble in water soluble medical lubricating jelly, improve and produce
The quality of product, is controlled the concentration of carbomer aqueous solution.Preferably, the weight ratio 1～2 of water and carbomer in swelling solution:
100, and when with water dissolution carbomer, slowly carbomer be added to the water and be stirred simultaneously.It is highly preferred that by card ripple
Nurse stands 8～10 hours after dissolving under room temperature (especially 25～35 DEG C) so that it is the most swelling, forms colourless, transparent glue
Shape thing, then mix with mixed liquor, to improve the mixing uniformity between each component, improve the stability of lubricating jelly.
In order to improve methyl hydroxybenzoate dissolubility in water, the water used during by repair liquid, the mixing of methyl hydroxybenzoate water is
The purified water of 60～90 DEG C.It is preferred that the ratio of the volume of the weight of methyl hydroxybenzoate and purified water is 6～16g/L.In purified water
Impurity content is few, can improve the purity of product, reduces impurity content.It addition, improve methyl hydroxybenzoate by the purified water of high temperature
Dissolubility, in order to contact fully between each component, improves mixing uniformity.
Getting involved the field such as operation owing to medical lubricating jelly is used for medical apparatus and instruments, lubricant is directly and human contact, its acid
Basicity has large effect to body cavities, skin etc..It is then desired to the pH value of medical lubricating jelly is adjusted, in order to
Adapt with human body acid-base environment.Preferably, triethanolamine regulation pH value is utilized to make the pH value of lubricating jelly be 6～8.
During using above-mentioned water soluble medical lubricating jelly, owing to the pH value of lubricating jelly adapts with human body, therefore energy
Enough acid or alkali environment balances effectively maintaining human body.In order to improve the pH value regulating effect of triethanolamine further, it is preferable that molten
After swollen liquid and mixed liquor mix 5～10 minutes, add triethanolamine regulation pH value.After swelling solution, mixed liquor are sufficiently mixed, its
In carbomer, repair liquid and methyl hydroxybenzoate the most fully act on, recycling triethanolamine carry out pH value regulation, in order to
The pH value making lubricating jelly is more stable, it is to avoid cause pH value to change greatly due to swelling solution and mixed liquor undercompounding
Problem, thus improve the safety in utilization of lubricating jelly.
In manufacturing process, after the mixing of various components, then by emulsifying, can in lubricating jelly by the swelling mistake of carbomer
The bubble produced in journey is removed, disperses, and also can improve the mixing uniformity of various component further so that obtain
Lubricating jelly character is more homogeneous, stability is higher, the effect of the outward appearance improving product can also be played simultaneously.
In order to obtain preferable emulsifying effectiveness, it is preferable that described emulsifying uses vacuum emulsifying machine to carry out emulsifying, vacuum
The working condition of mulser is: temperature 36～42 DEG C, agitator speed 40～60 revs/min, emulsifying head rotating speed 3200～3700
Rev/min, vacuum 0.07～0.12MPa, emulsification times 20～30 minutes.
Based on the consideration using safety, it is to avoid the microorganism such as breed bacteria in lubricant, it is preferable that after emulsifying also
Including: radiation sterilization.The carrying out of the microorganism in lubricating jelly is killed by the electromagnetic wave that irradiation sterilization utilizes ionizing radiation to produce, and goes out
Bacterium efficiency is high.Radiation sterilizing belongs to contactless sterilizing, the problem that can avoid secondary pollution during sterilizing.
Described in further detail to water soluble medical lubricating jelly of the present invention and preparation method thereof below in conjunction with embodiment.
Embodiment one
Present embodiments provide a kind of water soluble medical lubricating jelly, following components in percentage by weight be made:
Carbomer 0.72%；Methyl hydroxybenzoate 0.041%；Repair liquid 0.41%；Triethanolamine 0.77%；Water surplus.
Repair liquid is made by the following method:
Step S101, cotton thread is soaked in the sodium hydrate aqueous solution 30 minutes of 70 DEG C, then takes out and be dried, system
Become alkalization cotton.
Step S102, alkalization cotton is soaked in the monoxone aqueous solution 40 minutes of 70 DEG C, takes out and also clean with medical alcohol,
Then it is dried, makes etherified cotton.
Step S103, will etherified cotton pulverize after add account for etherified cotton weight 1/3 normal saline mixing.
Wherein, by weight percentage, monoxone aqueous solution 23%, sodium hydrate aqueous solution 22%, Plant fiber 6% with
And medical alcohol 49%.
Plant fiber is cotton thread, and in monoxone aqueous solution, chloroacetic mass fraction is 47～54%, and sodium hydroxide is water-soluble
The mass fraction 51～57% of sodium hydroxide in liquid, in medical alcohol, the mass fraction of ethanol is 95%.
The present embodiment additionally provides the manufacture method of above-mentioned water soluble medical lubricating jelly, comprises the following steps:
Step S201, by 1.4510Kg carbomer with to mix to gross weight with water be 100Kg, and be stirred simultaneously, and
Stand 8 hours at 25 DEG C, make carbomer the most swelling, obtain swelling solution.
Step S202, the 0.0826Kg methyl hydroxybenzoate purified water of 60 DEG C, 10L is dissolved, then adds in repair liquid,
And to add water to gross weight be 100Kg stirring and evenly mixing, obtain mixed liquor；
Step S203, swelling solution and mixed liquor are mixed in the emulsion tank of vacuum emulsifying machine, start vacuum emulsifying machine 5 points
Zhong Hou, adds triethanolamine regulation pH value in emulsion tank and, to 6, starts vacuum emulsifying machine and carry out emulsifying, to obtain final product.
The working procedure of vacuum emulsifying machine is as follows:
Temperature 36 DEG C, agitator speed 40 revs/min, emulsifying head rotating speed 3200 revs/min, vacuum 0.08MPa, emulsifying
28 minutes time.
Under the room temperature of the lubricating jelly that the present embodiment makes, viscosity is 18Pa s, and 30 grams of dissolved solutions of this lubricant are in 100
In gram water and layering, deposited phenomenon do not occur；Medical grade light liquid paraffin oil occurs the phenomenon of layering in normal-temperature water.
Embodiment two
Present embodiments provide a kind of water soluble medical lubricating jelly, following components in percentage by weight be made:
Carbomer 0.76%；Methyl hydroxybenzoate 0.05%；Repair liquid 0.43%；Triethanolamine 0.80%；Water surplus.
Repair liquid is made by the following method:
Step S101, wood flour is soaked in the sodium hydrate aqueous solution 43 minutes of 73 DEG C, then takes out and be dried, system
Become alkalization wood flour.
Step S102, alkalization wood flour is soaked in the monoxone aqueous solution 25 minutes of 68 DEG C, takes out the most clear with medical alcohol
Wash, be then dried, make etherificate wood flour.
Step S103, will etherificate wood flour pulverize after add account for etherificate wood flour weight 1/10 purified water mixing.
Wherein, by weight percentage, Plant fiber 7%, sodium hydrate aqueous solution 23%, monoxone aqueous solution 26%,
Medical alcohol 44%.
Plant fiber is wood flour, and in monoxone aqueous solution, chloroacetic mass fraction is 50%, in sodium hydrate aqueous solution
The mass fraction of sodium hydroxide is 52%, and in medical alcohol, the mass fraction of ethanol is 95%.
The present embodiment additionally provides the manufacture method of above-mentioned water soluble medical lubricating jelly, comprises the following steps:
Step S201, it is slowly added to 1.5320Kg carbomer in water to gross weight be 100Kg, and is stirred simultaneously, and
At 28 DEG C, stand 9 hours, make carbomer the most swelling, obtain swelling solution.
Step S202, the 0.1008Kg methyl hydroxybenzoate purified water of 74 DEG C, 10L is dissolved, then adds in repair liquid,
And to add water to gross weight be 100Kg stirring and evenly mixing, obtain mixed liquor；
Step S203, swelling solution and mixed liquor are mixed in the emulsion tank of vacuum emulsifying machine, start vacuum emulsifying machine 5 points
Zhong Hou, adds triethanolamine regulation pH value in emulsion tank and, to 6.3, starts vacuum emulsifying machine and carry out emulsifying, to obtain final product.
The working procedure of vacuum emulsifying machine is as follows:
Temperature 40 DEG C, agitator speed 50 revs/min, emulsifying head rotating speed 3500 revs/min, vacuum 0.09MPa, emulsifying
25 minutes time.
Under the room temperature of the lubricating jelly that the present embodiment makes, viscosity is 21.7Pa s, 41 grams of dissolved solutions of this lubricant in
In 100 grams of water, be layered, deposited phenomenon；Medical grade light liquid paraffin oil occurs the phenomenon of layering in normal-temperature water.
Embodiment three
Present embodiments provide a kind of water soluble medical lubricating jelly, following components in percentage by weight be made:
Carbomer 0.76%；Methyl hydroxybenzoate 0.051%；Repair liquid 0.52%；Triethanolamine 0.84%；Water surplus.
Repair liquid is made by the following method:
Step S101, rice husk is soaked in 73 DEG C of sodium hydrate aqueous solutions 50 minutes, then takes out and be dried, make
Alkalization rice husk.
Step S102, alkalization rice husk is soaked in 68 DEG C of monoxone aqueous solutions 25 minutes, takes out and also clean with medical alcohol,
Then it is dried, makes etherificate rice husk.
Step S103, will etherificate rice husk pulverize after add account for etherificate rice husk weight 1/5 purified water mixing.
Wherein, by weight percentage, Plant fiber 9%, sodium hydrate aqueous solution 25%, monoxone aqueous solution 30% with
And medical alcohol 36%.Plant fiber is rice husk, in sodium hydrate aqueous solution the mass fraction of sodium hydroxide be 55%, monoxone
In aqueous solution, chloroacetic mass fraction is 50%, and in medical alcohol, the mass fraction of ethanol is 95%.
The present embodiment additionally provides the manufacture method of above-mentioned water soluble medical lubricating jelly, comprises the following steps:
Step S201, it is slowly added to 1.5328Kg carbomer in water to gross weight be 100Kg and be stirred simultaneously, and
Stand 9.6 hours at 31 DEG C, make carbomer the most swelling, obtain swelling solution.
Step S202, the 0.1029Kg methyl hydroxybenzoate purified water of 78 DEG C, 10L is dissolved, then adds in repair liquid,
And to add water to gross weight be that 100Kg stirring and evenly mixing obtains mixed liquor；
Step S203, swelling solution and mixed liquor are mixed in the emulsion tank of vacuum emulsifying machine, start vacuum emulsifying machine 9 points
Zhong Hou, adds triethanolamine regulation pH value in emulsion tank and, to 6.8, starts vacuum emulsifying machine and carry out emulsifying, to obtain final product.
The working procedure of vacuum emulsifying machine is as follows:
Temperature 37 DEG C, agitator speed 60 revs/min, emulsifying head rotating speed 3560 revs/min, vacuum 0.12MPa, emulsifying
30 minutes time.
Under the room temperature of the lubricating jelly that the present embodiment makes, viscosity is 18.3Pa s, 36 grams of dissolved solutions of this lubricant 100
Gram in water, have no layering, deposited phenomenon；Medical grade light liquid paraffin oil occurs the phenomenon of layering in normal-temperature water.
Embodiment four
Present embodiments provide a kind of water soluble medical lubricating jelly, following components in percentage by weight be made:
Carbomer 0.85%；Methyl hydroxybenzoate 0.056%；Repair liquid 0.54%；Triethanolamine 0.86%；Water surplus.
Repair liquid is made by the following method:
Step S101, corn cob is soaked in 73 DEG C of sodium hydrate aqueous solutions 60 minutes, then takes out and be dried, system
Become alkalization corn cob.
Step S102, alkalization corn cob is soaked in 68 DEG C of monoxone aqueous solutions 25 minutes, takes out the most clear with medical alcohol
Wash, be then dried, make etherificate corn cob.
Step S103, will etherificate corn cob pulverize after add account for etherificate corn cob weight 1/3 5% glucose solution mix
Close.
Wherein, by weight percentage, Plant fiber 10%, sodium hydrate aqueous solution 25%, monoxone aqueous solution 30%
And medical alcohol 35%.Plant fiber is corn cob, in sodium hydrate aqueous solution the mass fraction of sodium hydroxide be 57%, chlorine
In acetic acid aqueous solution, chloroacetic mass fraction is 54%, and in medical alcohol, the mass fraction of ethanol is 95%.
The present embodiment additionally provides the manufacture method of above-mentioned water soluble medical lubricating jelly, comprises the following steps:
Step S201, it is slowly added to 1.7147Kg carbomer in water to gross weight be 100Kg and be stirred simultaneously, and
Stand 10 hours at 35 DEG C, make carbomer the most swelling, obtain swelling solution.
Step S202, the 0.1130Kg methyl hydroxybenzoate purified water of 60 DEG C, 10L is dissolved, then adds in repair liquid,
And to add water to gross weight be 100Kg stirring and evenly mixing, obtain mixed liquor；
Step S203, swelling solution and mixed liquor are mixed in the emulsion tank of vacuum emulsifying machine, start vacuum emulsifying machine 5 points
Zhong Hou, adds triethanolamine regulation pH value in emulsion tank and, to 8, starts vacuum emulsifying machine and carry out emulsifying, to obtain final product.
The working procedure of vacuum emulsifying machine is as follows:
Temperature 38 DEG C, agitator speed 50 revs/min, emulsifying head rotating speed 3500 revs/min, vacuum 0.11MPa, emulsifying
22 minutes time.
Under the room temperature of the lubricating jelly that the present embodiment makes, viscosity is 17Pa s, and 44 grams of dissolved solutions of this lubricant are in 100
In gram water, have no layering, deposited phenomenon；Medical grade light liquid paraffin oil occurs the phenomenon of layering in normal-temperature water.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims
Including all such changes and modifications belonged in the scope of the invention.
Claims (10)
1. a water soluble medical lubricating jelly, it is characterised in that be mainly made by following components by weight percentage:
Carbomer 0.72～0.85%；
Methyl hydroxybenzoate 0.041～0.056%；
Repair liquid 0.41～0.54%；
Triethanolamine 0.77～0.86%；
The water of surplus；
Described repair liquid is sequentially passed through alkalization by Plant fiber, is etherified, pulverizes, and then mixes with solvent, described solvent bag
Include any one in normal saline, purified water and glucose solution.
2. the manufacture method of the water soluble medical lubricating jelly described in a claim 1, it is characterised in that including:
Use water dissolution carbomer, obtain swelling solution；By repair liquid, the mixing of methyl hydroxybenzoate use water, obtain mixed liquor；And by described
Swelling solution and the mixing of described mixed liquor, and add triethanolamine regulation pH value, emulsifying.
Manufacture method the most according to claim 2, it is characterised in that in described swelling solution, the weight ratio of water and carbomer is
1～2:100.
Manufacture method the most according to claim 2, it is characterised in that before described swelling solution and the mixing of described mixed liquor,
Described swelling solution stands 8～10 hours in 25～35 DEG C.
Manufacture method the most according to claim 2, it is characterised in that in described mixing step, described water is 60～90 DEG C
Purified water.
Manufacture method the most according to claim 5, it is characterised in that in described mixing step, the weight of described methyl hydroxybenzoate
The ratio of the volume of amount and described purified water is 6～16g:1L.
Manufacture method the most according to claim 2, it is characterised in that described emulsifying uses vacuum emulsifying machine to carry out breast
Changing, the working condition of described vacuum emulsifying machine is:
Temperature 36～42 DEG C, agitator speed 40～60 revs/min, emulsifying head rotating speed 3200～3700 revs/min, vacuum
0.07～0.12MPa, emulsification times 20～30 minutes.
Manufacture method the most according to claim 2, it is characterised in that described regulation pH is 6～8 for regulation to pH.
Manufacture method the most according to claim 2, it is characterised in that the opportunity of described addition triethanolamine is: described molten
After swollen liquid and described mixed liquor mix 5～10 minutes.
10. according to the manufacture method one of claim 2 to 9 Suo Shu, it is characterised in that also include after described emulsifying:
Irradiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610676641.8A CN106178141A (en) | 2016-08-17 | 2016-08-17 | Water soluble medical lubricating jelly and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610676641.8A CN106178141A (en) | 2016-08-17 | 2016-08-17 | Water soluble medical lubricating jelly and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106178141A true CN106178141A (en) | 2016-12-07 |
Family
ID=57522634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610676641.8A Pending CN106178141A (en) | 2016-08-17 | 2016-08-17 | Water soluble medical lubricating jelly and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106178141A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107593211A (en) * | 2017-10-12 | 2018-01-19 | 蚌埠市天网渔需用品有限公司 | A kind of fly net for carrying anthelminthic effect |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544100A (en) * | 2003-11-21 | 2004-11-10 | 武汉杰士邦卫生用品有限公司 | Water-soluble human body lubricant |
| CN101327346A (en) * | 2008-07-24 | 2008-12-24 | 武汉杰士邦卫生用品有限公司 | Water-soluble human body lubricants |
| CN101332317A (en) * | 2008-07-24 | 2008-12-31 | 武汉杰士邦卫生用品有限公司 | Water soluble human lubricant |
| CN101905041A (en) * | 2009-06-08 | 2010-12-08 | 上海市计划生育科学研究所 | Acid vagina lubricant and preparation method and use thereof |
| CN103083733A (en) * | 2013-02-19 | 2013-05-08 | 华熙福瑞达生物医药有限公司 | Medical water-based lubricant for introducing instrument into body cavity |
| CN103203042A (en) * | 2013-04-13 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Water-soluble medical lubricant |
| CN104771791A (en) * | 2014-01-10 | 2015-07-15 | 贵州金玖生物技术有限公司 | Water-soluble aseptic medical multifunctional lubricant and preparation method thereof |
-
2016
- 2016-08-17 CN CN201610676641.8A patent/CN106178141A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544100A (en) * | 2003-11-21 | 2004-11-10 | 武汉杰士邦卫生用品有限公司 | Water-soluble human body lubricant |
| CN101327346A (en) * | 2008-07-24 | 2008-12-24 | 武汉杰士邦卫生用品有限公司 | Water-soluble human body lubricants |
| CN101332317A (en) * | 2008-07-24 | 2008-12-31 | 武汉杰士邦卫生用品有限公司 | Water soluble human lubricant |
| CN101905041A (en) * | 2009-06-08 | 2010-12-08 | 上海市计划生育科学研究所 | Acid vagina lubricant and preparation method and use thereof |
| CN103083733A (en) * | 2013-02-19 | 2013-05-08 | 华熙福瑞达生物医药有限公司 | Medical water-based lubricant for introducing instrument into body cavity |
| CN103203042A (en) * | 2013-04-13 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Water-soluble medical lubricant |
| CN104771791A (en) * | 2014-01-10 | 2015-07-15 | 贵州金玖生物技术有限公司 | Water-soluble aseptic medical multifunctional lubricant and preparation method thereof |
Non-Patent Citations (6)
| Title |
|---|
| 余祥彬等: "《药剂学与药物动力学实验指导》", 31 January 2014, 厦门大学出版社 * |
| 姚静等: "《药用辅料应用指南》", 31 August 2011, 中国医药科技出版社 * |
| 孟胜男等: "《药剂学》", 30 September 2011, 上海科学技术出版社 * |
| 李杰等: "《新型纤维素系止血材料》", 31 October 2015, 中国科学技术出版社 * |
| 董放等: "《无源医疗器械产品与不良事件监测》", 30 September 2013, 中国医药科技出版社 * |
| 高峰等: "《药剂学实验》", 31 March 2015, 华东理工大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107593211A (en) * | 2017-10-12 | 2018-01-19 | 蚌埠市天网渔需用品有限公司 | A kind of fly net for carrying anthelminthic effect |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105209049B (en) | Antimicrobial compositions and its manufacturing method | |
| CN104257639B (en) | A kind of liniment for Wound treating and preparation method thereof | |
| TWI305535B (en) | Chemically modified polyaminosaccharide by a hydrocarbyl sultone compound | |
| CN104208726B (en) | Chitosan quaternary ammonium salt couplant and preparation method thereof | |
| CN102373620B (en) | Preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber | |
| CN102643498B (en) | Preparation method of water-absorbing gel containing animal and plant fibers and inorganic nanoparticles | |
| CN101612408A (en) | B ultrasonic couplant and preparation method | |
| CN110384621A (en) | A kind of disposable hand-wrist bones gel of hydrogen-rich and preparation method thereof | |
| CN107982277B (en) | Composite antibacterial aerosol and preparation method and application thereof | |
| CN108498372A (en) | A kind of disposable hand cleanser and preparation method thereof | |
| CN108904542A (en) | The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation | |
| CN106390179B (en) | A kind of polyurethane sponge dressing and preparation method thereof with the hemostatic function that prevents adhesion | |
| CN102430131A (en) | Antibacterial medical ultrasound compounding agent and preparation method thereof | |
| CN103816560B (en) | Colloidal fluid used for wound restoration and preparation method thereof | |
| CN106178141A (en) | Water soluble medical lubricating jelly and preparation method thereof | |
| KR20210117234A (en) | Nano bio complex film and fabricating method of the same | |
| CN103120642A (en) | Gel used for skin diseases and preparation method thereof | |
| CN1961970A (en) | Medical chitosan dressing and production method thereof | |
| CN109846985A (en) | A kind of nasal cavity disease adjuvant treatment cleaning agent and preparation method thereof | |
| CN103976942B (en) | Canker sore gel and preparation method thereof | |
| CN102218149A (en) | Medical ultrasonic couplant capable of disinfection and sterilization and preparation technology thereof | |
| CN102886061B (en) | Chitosan-iodide biological antibacterial film | |
| CN105664224B (en) | A kind of compound alginic acid dressing of low molecular weight carboxymethyl chitosan and preparation method thereof | |
| CN105568675B (en) | A kind of preparation method of H-type carboxymethyl chitosan fiber | |
| CN114010533B (en) | Natural sanzang gel with alcohol solubility and moisture retention, no-clean disinfection gel and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161207 |