CN102512338A - Water-soluble human body lubricant and preparation method thereof - Google Patents

Abstract

The invention provides a water-soluble human body lubricant and a preparation method thereof. The water-soluble human body lubricant comprises the following components in percentage by mass: 5-20 percent of glycerol, 5-20 percent of propylene glycol, 0.1-1.0 percent of polyacrylate and 0.1-1.0 percent of hydroxypropyl methyl cellulose serving as a thickening agent, 0.1-1.0 percent of pH regulator, 0.1-0.5 percent of preservative and the balance of water. The lubricant has similar viscosity and acidity to natural lubricating liquid secreted by vagina, and is easier to accept in sense, nontoxic and non-irritant to skin and mucous membrane of a human body, and easy to clean; and the normal performance of a condom is not reduced.

Description

A kind of water-soluble human body lubricants and preparation method thereof

Technical field

The lubricant technical field that the present invention relates to use on the human body, particularly a kind of water-soluble human body lubricants that contains hypromellose and polyacrylate and preparation method thereof.

Background technology

Vagina drying can betide the women of institute's has age.The reason that causes vagina drying is a lot, and the women crossed after climacteric, because its vagina thins down, gonad secretions is fewer and feweri, the reproductive tract endocrine lacks, and causes vagina drying; Age of sucking, oral contraceptive, menstrual phase and high pressure training also possibly cause vagina drying.Vagina drying can make sexual's penis insert difficulty, and the burning sensation at vagina position, pain and other discomforts have a strong impact on life quality when causing sexual intercourse.For lubricated germinal tissue, the tender and lovely tissue of protection body avoids sexual intercourse not accommodate the destruction of stimulation to vaginal mucosa protection barrier, needs to use human body lubricants to alleviate vagina drying, improves the quality of sexual life.

In the production process of natural emulsion condom; Also often add dimethicone on every condom surface; As interleaving agent; Can avoid practising contraception adhesion between jacket layer and the layer also can be played the effect of lubricant simultaneously, can prevent the friction of condom and human epidermal and the damage of not accommodating of causing and epidermis cell.

Use at present more human body lubricants to be generally the lubricant of oleaginous base, like vaseline and derivant thereof, food oil, mineral wet goods; Research shows, when the lubricant of many oleaginous bases contacts with condom, can damage the security performance of the condom that natural emulsion processes, and makes the intensity decreases of condom, even damaged, causes contraceptive failure.Therefore, natural emulsion condom manufacture commercial city does not recommend consumer to use mineral oil to make lubricant on the condom surface.In addition, the normal juice in the lubricant of oleaginous base and the women's alms bowl is incompatible fully, in use or use greasy feeling is arranged later, be difficult for cleaning, and can pollution clothes.

And existing water-soluble human body lubricants remains in some defectives, and having ignored the excretory natural lubricating fluid of human vagina is faintly acid, the certain antibacterial functions that self has.For example; Various antibiotic, antiinflammatory, antiviral drug have been added in the disclosed human body lubricants of one Chinese patent application CN1279923, CN1319606 and CN1543985; If these lubricants are as prevention and medicine life-time service, because the uncertain meeting of its dosage, interval etc. causes poisoning or drug resistance.Its pH of the disclosed water-soluble human body lubricants of one Chinese patent application CN1225291 is 6～7, is not inconsistent with the weakly acidic environment of vagina, and life-time service can cause the pH value of vagina to raise, and helps the breeding of pathogenic bacteria, causes various gynaecopathias.

Summary of the invention

The present invention provides a kind of water-soluble human body lubricants and preparation method thereof, and the natural lubricating fluid of this lubricant and vaginal secretion has similar viscosity and acidity, and is more acceptant on the sense organ, and is nontoxic, non-stimulated to human body skin, mucosa, is easy to clean; Can not reduce the normal performance of condom.

To achieve these goals, the present invention provides following technical scheme:

A kind of water-soluble human body lubricants, it comprises according to mass percent:

5～20% glycerol, 5～20% propylene glycol, contain 0.1～1.0% polyacrylate and 0.1～1.0% hydroxypropyl methylcellulose as thickening agent, 0.1～1.0% pH regulator agent, 0.1～0.5% antiseptic, all the other are water.Wherein: hydroxypropyl methylcellulose is a white powder; Dissolve in cold water, viscosity changes lessly in very wide pH value scope, and high temperature or boil does not down precipitate; Viscosity increases along with molecular weight; Can with other water-soluble polymers on a large scale, the coexistence of surfactant, salt has good filming performance.Polyacrylate is a white powder, dissolves in cold water, increases viscosity with pH value and becomes big, is used the toughness that can increase lubricant with hydroxypropyl methylcellulose.

The pH value regulator, the pH value and the viscosity that are used for regulating lubricant.

Glycerol, propylene glycol can increase viscosity, and excellent moistening effect is arranged again, can prolong polymer substance in the intravaginal holdup time.Antiseptic can suppress the growth of antibacterial preferably, is beneficial to the storage of lubricant.

Preferably, the range of viscosities of said lubricant is 60～150mPas.

Preferably, comprise that also the pH value that is used for lubricant is adjusted to 3.5～5.5 pH value regulator.

Preferably, said pH value regulator one or more the combination that is citric acid, citric acid, lactic acid and sodium lactate.

Preferably, said antiseptic is one or more the combination in methyl hydroxybenzoate, propylparaben, hibitane, the benzoic acid.

The present invention also provides a kind of water-soluble human body lubricants method for preparing, and it comprises:

Purified water is added in first Agitation Tank, in first Agitation Tank, add hypromellose, polyacrylate fully stirs, and makes its dissolving;

Propylene glycol, glycerol are added in second Agitation Tank, add benzoic acid again and fully stir and make the dissolving of propylene glycol, glycerol;

Liquid in second Agitation Tank added in first Agitation Tank mix, regulate pH value, again aforesaid liquid is heated to 80 ℃, and kept 30 minutes with the pH value regulator; Leave standstill to room temperature fill.

Through implementing above technical scheme; Has following technique effect: water-soluble human body lubricants provided by the invention and preparation method thereof; The natural lubricating fluid of this lubricant and vaginal secretion has similar viscosity and acidity; More acceptant on the sense organ, nontoxic, non-stimulated to human body skin, mucosa, be easy to clean; Can not reduce the normal performance of condom.Can suppress the growth of the harmful pathogenic bacteria (especially fungus, yeast) of intravaginal.And colourless, do not have smell, tasteless, have no greasy feeling, safe in utilization, convenient.

The specific embodiment

Technical scheme is for a better understanding of the present invention described embodiment provided by the invention below in detail.These embodiment are only owing to further specify the present invention, and do not constitute any restriction to protection domain of the present invention.Below used raw material be pharmaceutical grade, water for the self-control purified water.

Embodiment one:

1. fill a prescription

The raw material title	Consumption (%)
		Hypromellose 15KM	0.5
Polyacrylate 7S	0.2
		Glycerol	10.4
Benzoic acid	0.1
		Citric acid	0.6
Propylene glycol	11.5
		Purified water	76.7

2, method for preparing:

Purified water is added among the Agitation Tank A, in Agitation Tank A, add hypromellose, polyacrylate fully stirs, and makes its dissolving; Propylene glycol, glycerol are added among the Agitation Tank B, and the adding benzoic acid fully stirs and makes its dissolving, liquid among the B is added among the A mix, and with 20% Fructus Citri Limoniae acid for adjusting pH value, aforesaid liquid is heated to 80 ℃, and keeps 30 minutes; Leave standstill to room temperature fill.

Testing result:

PH value: 4.16

Viscosity: 120mpas

Embodiment two:

1. fill a prescription

The raw material title	Consumption (%)
		Hypromellose 15KM	0.5
Polyacrylate 7M	0.2
		Glycerol	12.0
Methyl hydroxybenzoate	0.2
		Propylparaben	0.2
Citric acid	0.6
		Propylene glycol	10.5
Purified water	75.8

2, method for preparing:

Purified water is added among the Agitation Tank A, in Agitation Tank A, add hypromellose, polyacrylate fully stirs, and makes its dissolving; Propylene glycol, glycerol are added among the Agitation Tank B, and adding methyl hydroxybenzoate, propylparaben fully stir and make its dissolving, liquid among the B are added among the A mix, and with 20% Fructus Citri Limoniae acid for adjusting pH value, aforesaid liquid are heated to 80 ℃, and keep 30 minutes; Leave standstill to room temperature fill.

Testing result:

PH value: 4.62

Viscosity: 135mPas

Embodiment three:

1. fill a prescription

The raw material title	Consumption (%)
		Hypromellose 15KM	0.5
Polyacrylate 7M	0.2
		Glycerol	11.0
Hibitane	0.3
		Lactic acid	0.4
Sodium lactate	0.2
		Propylene glycol	13.5
Purified water	73.9

2, method for preparing:

Purified water is added in the Agitation Tank, in Agitation Tank, adds hypromellose, polyacrylate fully stirs, make its dissolving after; After adding the hibitane dissolving; Add propylene glycol, glycerol fully stirs, and makes its mix homogeneously, regulates pH value with lactic acid and sodium lactate; Aforesaid liquid is heated to 80 ℃, and kept 30 minutes; Leave standstill to room temperature fill.

Testing result:

PH value: 4.26

Viscosity: 140mPas

Embodiment 4

The human body lubricants of embodiment 1 preparation is carried out skin allergy test, the test of vaginal irritation property and cell toxicity test.The result shows, the negative reaction of human body lubricants skin allergy test; The yet negative reaction of vaginal irritation property test does not have obvious pathology damage through the pathological examination vagina tissue; The basic no cytotoxicity of cell toxicity test.

More than a kind of water-soluble human body lubricants that the embodiment of the invention provided and preparation method thereof has been carried out detailed introduction; For one of ordinary skill in the art; Thought according to the embodiment of the invention; The part that on the specific embodiment and range of application, all can change, in sum, this description should not be construed as limitation of the present invention.

Claims (6)

1. a water-soluble human body lubricants is characterized in that, according to mass percent, comprising:

5～20% glycerol, 5～20% propylene glycol, contain 0.1～1.0% polyacrylate and 0.1～1.0% hydroxypropyl methylcellulose as thickening agent, 0.1～1.0% pH regulator agent, 0.1～0.5% antiseptic, all the other are water.

2. water-soluble human body lubricants according to claim 1 is characterized in that the range of viscosities of said lubricant is 60～150mPas.

3. water-soluble human body lubricants according to claim 1 is characterized in that, comprises that also the pH value that is used for lubricant is adjusted to 3.5～5.5 pH value regulator.

4. like claim 1 or 3 said water-soluble human body lubricants, it is characterized in that the combination of one or more that said pH value regulator is citric acid, citric acid, lactic acid and sodium lactate.

5. water-soluble human body lubricants according to claim 1 is characterized in that, said antiseptic is one or more the combination in methyl hydroxybenzoate, propylparaben, hibitane, the benzoic acid.

6. a water-soluble human body lubricants method for preparing is characterized in that, comprises step:

Purified water is added in first Agitation Tank, in first Agitation Tank, add hypromellose, polyacrylate fully stirs, and makes its dissolving;

Propylene glycol, glycerol are added in second Agitation Tank, add benzoic acid again and fully stir and make the dissolving of propylene glycol, glycerol;

Liquid in second Agitation Tank added in first Agitation Tank mix, regulate pH value, again aforesaid liquid is heated to 80 ℃, and kept 30 minutes with the pH value regulator; Leave standstill to room temperature fill.