CN102872156B - Lubricant containing hyaluronic acid - Google Patents
Lubricant containing hyaluronic acid Download PDFInfo
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- CN102872156B CN102872156B CN201210382952.5A CN201210382952A CN102872156B CN 102872156 B CN102872156 B CN 102872156B CN 201210382952 A CN201210382952 A CN 201210382952A CN 102872156 B CN102872156 B CN 102872156B
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- chitosan
- polyethylene glycol
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- hyaluronic acid
- hyaluronic
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Abstract
Lubricant containing hyaluronic acid comprises 0.4-3.2 parts of hyaluronic acid, 0.4-2.2 parts of polyethylene glycol, auxiliary materials and 100 parts of purified water by weight, wherein the auxiliary materials include carbomer, and viscosity of the additive amount of the carbomer can be controlled within the range of 1000-500000 Pa.s. The molecular weight of the hyaluronic acid is 10000-20000, and the molecular weight of the polyethylene glycol is 200-800. 0.1-3.5 parts of chitosan is added, and the molecular weight of the chitosan is 20000-25000. The lubricant does not change the environment in vagina, is high in safety, causes no hormone effect and can be used in the gynaecology and obstetrics and the like.
Description
Technical field
The present invention relates to containing hyaluronic human body with lubricator.
Background technology
CN200410035940 provides a kind of containing soybean extract and hyaluronic human body lubricants.The main component of lubricant of the present invention is soybean extract and hyaluronic acid, and basic comprising is soybean extract, hyaluronic acid, conventional pharmaceutical necessities and purified water.Lubricant of the present invention can be directly used in the control of colpoxerosis that a variety of causes causes and pudendal pruritus, leukoplakia vulvae; Also antimicrobial drug, antibiotic medicine, antifungal agent, antiviral agents, antiallergic agent, Promotive union medicine, remission medicine, other wetting agents or the pharmacological active substance such as lubricant, Effective Component of Chinese Medicine can be added in human body lubricants, by soybean lecithin and hyaluronic acid, improve medicine fat-soluble, increase the viscosity of medicinal liquid, prolong drug is in the retention time on surface, improve the bioavailability of medicine, reduce the toxic and side effects of medicine.Existing lubricant is more with glycerol and formula in adult shop.
Summary of the invention
The present invention seeks to propose a kind of hyaluronic human body lubricants.Lubricant of the present invention can be directly used in the colpoxerosis that a variety of causes causes.Utilize the hemostasis biological agent of chitosan and antibacterial simultaneously, improve the curative effect of physical action further.
Technical scheme of the present invention is: containing hyaluronic lubricant, main component comprises: hyaluronic acid and Polyethylene Glycol, another containing adjuvant and purified water.Adjuvant is carbomer, and by weight, hyaluronic acid is 0.4-3.5 part, Polyethylene Glycol is 0.4-2.2 part, and purified water is 100 parts.Separately can add antibacterial, and make pH value control at 5.8-7.4, the number that carbomer adds is 0.5-3 part, controls the scope of viscosity at 1000-500000Pa.s.
Hyaluronic acid (comprising its potassium salt or sodium salt) is more and more is applied to moisturizing, and as the endogenous allied substances of people, they can not cause the immunoreation of body, but in vivo the half-life short, to be easily hydrolyzed by enzyme effect in vivo, the shortcoming such as degeneration.For improving above-mentioned undesirable feature, the present invention, by the miscible and covering of a kind of Polyethylene Glycol PEG, changes the hyaluronic acid shortcomings such as effect duration is short in vivo.The Polyethylene Glycol (PEG) that the present invention uses refers to low-molecular-weight Polyethylene Glycol, is often referred to purer oligomer, comparatively has a monodispersity; Polyethylene Glycol is water-soluble, it be combined with hydrophobic molecule after product can be used as non-ionic surface active agent.
Further, increase chitosan, weight portion is 0.1-3.5, especially 0.5-2 part, and its molecular weight is 20000-40000.Especially 20000-25000.
Adjuvant is carbomer; Separately can add sodium hydroxide (potassium) and other antibacterial, adjust ph is to 5.8-7.4,1000-500000Pa.s viscosity.
Appropriate antibacterial is benzoic acid, sorbic acid or methyl hydroxybenzoate.Carbomer addition is for controlling viscosity to 1000-500000Pa.s.Hyaluronic molecular weight is 10000-20000, and molecular weight polyethylene glycol is 200-800.
The invention has the beneficial effects as follows, be applicable to the vagina drying that a variety of causes causes, especially propose the product of the auxiliary of a kind of vagina drying or supplement therapy: the present invention is the reparation product that moistens of non-hormone, vagina especially.Its effect is respectively: moisturizing-maintenance, reparation-and without inflammatory reaction, aqueous lubricating-have no side effect.The women of vaginitis patient, Long-term Oral contraceptive, often with vaginal dryness, habitual abortion symptom; Postpartum breastfeeding phase, caesarean women, the also normal symptom with vaginal dryness; In addition, to middle and aged women, effectively vaginal dryness can be alleviated.
The present invention is applicable to the maintenance of postoperative gynecological tumor patients; Cervix uteri (squama) cancer is postoperative; Part hysteromyoma is postoperative; Ovarian cancer post operation; Carcinoma of endometrium is postoperative, and above is all estrogen contraindication, just in time uses this product.This product does not change intravaginal environment, and safety is high, does not have hormonal action, on endometrium and hormone system without impact.Can be used for menopause outpatient service (gynecological endocrine): climacteric, menopause, senile vaginitis; Oncology, postoperative gynecological tumor patients; Cervical cancer, ovarian cancer, hysteromyoma etc.; OPD of Obs & Gyn; Long-term Oral contraceptive, senile vaginitis, puerperal women and Out-patient Clinic of Department of Gynecology etc.
The present invention shows that adding Polyethylene Glycol makes hyaluronic acid Water-saving effect increase.The present invention also adopts natural (ocean) bio-extract chitosan, is particularly also prepared into gel, have antibacterial, detumescence, hemostasis, repair mucosa, have the effect of Synergistic with hyaluronic acid and Polyethylene Glycol, moistening effect is better.Utilize chitosan itself to have antibacterial action, can effectively regulate acid-base balance in human body, immunologic facilitation immunity moderation, regulate pH value, endocrine regulation, suppress old and feeble, promote wound recovery from illness, regulate human physiological functions; Chitosan is necessary 6th vital principle of human body after protein, fat, sugar, vitamin, the large Major Nutrient key element of mineral five.
Experiment shows, Polyethylene Glycol (PEG) is fairly obvious with the synergism of chitosan gel rubber, utilize chitosan can strengthen the activity of phagocyte, natural killer cell (NK cell), cytokine activation cell (LAK cell), promote IL-1RA, II generation, increase the content of serum hemolysin.Regulate human acid-base balance, the non-health acidic physique of human body is adjusted to alkalescence health status.Regulating plant nervous system and hormonal system, promote the secretion of estrogen, thus enhancing body vigor, renew one's youth, slow down aging.Assist three rows: get rid of bad cholesterol, get rid of heavy metal, get rid of vivotoxin, the toxin in energy adsorbate and harmful heavy metal ion excrete with metabolism.
Accompanying drawing explanation
Fig. 1 illustrates the curve chart adding Polyethylene Glycol and hyaluronic acid Water-saving effect is increased.Wherein abscissa representing time, vertical coordinate represents dehydration number.Experimental group represents the Polyethylene Glycol that with the addition of 1% mass parts, and only adds compared with the hyaluronic dehydration number of equal parts.
Detailed description of the invention
Polyethylene Glycol adds carbomer, and carbomer is containing the crosslinked acrylate copolymer of polyalkenyl polyether.These resins are in faintly acid, are weaker than acetic acid, but are easy to reaction and generate salt, and its pH value in water, with the difference of resin concentration, between the scope of pH2.8-3.2.Concentration higher carboxyl concentration is also higher, and therefore pH value is just lower, therefore needs to adopt potassium hydroxide adjust ph.The large pillar of skin moisture-keeping two: water conservation skeleton+hyaluronic acid (water); Polyethylene Glycol (polyvinyl alcohol) adds carbomer and forms better water conservation skeleton.
Typical formula:
Above raw material adopts warm water, and homogeneous (chitosan glue can be prepared separately and admixes, if powder dissolution is in aqueous solutions of organic acids, pH value controls at 3-5, and adopt the organic acid that acetic acid etc. is commonly used, described organic acid also can be lactic acid, citric acid, tartaric acid, succinic acid, ascorbic acid).Carbomer (carbopol), is divided into 934,940,941 etc. by viscosity, in and thickening, usually by card ripple and salify, make the thickening because electric repulsion opens of curling molecule, sodium hydroxide and triethanolamine are conventional nertralizers, and this is also the reason place of carbomer to ion-sensitive.Carbopol 940: short rheological characteristic, high viscosity, high clarity, low resistance to ionic and endurance of cutting, be applicable in gel and cream frost, Carbopol941: long rheological characteristic, low viscosity, high clarity, medium resistance to ionic and resistant to shearing, be applicable to gel and emulsion, the present invention adopts 940 or 941, without significant difference.Can also adopt Carbopol ETD 2020: acrylate/C10-30 alkyl acrylate interlinkage copolymer, long rheological characteristic, low viscosity, high clarity, high resistance to ionic and endurance of cutting, be suitable for limpid gel.Acrylate/C10-30 alkyl acrylate interlinkage copolymer; Acrylate/C10-30 alkyl acrylate interlinkage copolymer etc.
Containing hyaluronic lubricant, prepare chitosan under these conditions.Preferential composition: hyaluronic acid is 2 parts, Polyethylene Glycol is 0.5 part, chitosan (deacetylation more than 90%) is 2 parts, and purified water is 100 parts, chitosan 2 parts.The number that carbomer adds is about 2.5 parts, controls the scope of viscosity at 15000-20000Pa.s.The preferred hexamethylene of antibacterial is 0.1 part.
The hyaluronic acid HA(that the present invention adopts microorganism Bacillus bacillus to produce comprises its potassium salt or sodium salt), phosphate can be adopted as buffer.
Antibacterial is as benzoic acid, sorbic acid or antibacterium Performance Ratio benzoic acid, methyl hydroxybenzoate (methyl parahydroxybenzoate) that sorbic acid is all strong.
Hyaluronic molecular weight is 10000-20000, and molecular weight polyethylene glycol is the product of 200-800(nominal about 750 is selected in embodiment).Hyaluronic acid adds chitosan.Chitosan adopts as well low-molecular-weight, 20000-25000.It is raw material with it again that chitosan is first prepared into after gel, with glutaraldehyde as cross-linking agent, at formic acid or acetic acid, (other organic acid also can, as citric acid, tartaric acid) generating chitosan hydrogel in solution, when chitosan mass concentration be 2%, glutaraldehyde concentration is 1-3%, gelling temp is 30-55 DEG C time obtained hydrogel, there is good swelling behavior degree. aquagel has good biocompatibility.PH value is 3-5.The gel being carbomer with hyaluronic acid, Polyethylene Glycol, conventional pharmaceutical necessities again mixes.
Claims (2)
1., containing hyaluronic lubricant, it is characterized in that being applicable to human body with lubricator, comprise hyaluronic acid and Polyethylene Glycol, antibacterial, adjuvant and purified water; Adjuvant is carbomer, and by weight, hyaluronic acid 0.4-3.2 part, Polyethylene Glycol are 0.4-2.2 part, and purified water is 100 parts; Carbomer addition controls the scope of viscosity at 1000-500000Pa.s; Antibacterial is benzoic acid, sorbic acid or methyl hydroxybenzoate; PH value is 5.8-7.4; Hyaluronic molecular weight is 10000-20000, and molecular weight polyethylene glycol is 200-800; And adding chitosan, weight portion is 2 parts, and its molecular weight is 20000-40000; Chitosan glutaraldehyde is as cross-linking agent, generating chitosan hydrogel in pH value is 3-5 formic acid or acetum: chitosan mass concentration is 2%, glutaraldehyde concentration is 1-3%, gelling temp obtains aquagel when being 30-55 DEG C, then mixes with the gel of hyaluronic acid, Polyethylene Glycol, carbomer.
2. according to claim 1 containing hyaluronic lubricant, it is characterized in that chitosan molecule amount is 20000-25000.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210382952.5A CN102872156B (en) | 2012-10-09 | 2012-10-09 | Lubricant containing hyaluronic acid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210382952.5A CN102872156B (en) | 2012-10-09 | 2012-10-09 | Lubricant containing hyaluronic acid |
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| CN102872156A CN102872156A (en) | 2013-01-16 |
| CN102872156B true CN102872156B (en) | 2015-04-01 |
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| CN201210382952.5A Expired - Fee Related CN102872156B (en) | 2012-10-09 | 2012-10-09 | Lubricant containing hyaluronic acid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103083733A (en) * | 2013-02-19 | 2013-05-08 | 华熙福瑞达生物医药有限公司 | Medical water-based lubricant for introducing instrument into body cavity |
| CN106215246B (en) * | 2016-08-01 | 2019-12-24 | 西安交通大学 | Chitosan/polyethylene glycol lubricating sol and preparation method and application thereof |
| CN111773241A (en) * | 2020-07-21 | 2020-10-16 | 贵州威克斯医疗科技有限公司 | Composition containing PHMB for preventing and relieving diaper eczema |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101327346A (en) * | 2008-07-24 | 2008-12-24 | 武汉杰士邦卫生用品有限公司 | Water-soluble human body lubricants |
| CN101773513A (en) * | 2009-01-14 | 2010-07-14 | 邢建慧 | Water soluble body lubricant with natural antibacterial components and with pH value consistence with pH value of vagina |
| CN101861154A (en) * | 2007-11-19 | 2010-10-13 | 博迪卡生物有限公司 | Vaginal lubricant containing hyaluronic acid |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101861154A (en) * | 2007-11-19 | 2010-10-13 | 博迪卡生物有限公司 | Vaginal lubricant containing hyaluronic acid |
| CN101327346A (en) * | 2008-07-24 | 2008-12-24 | 武汉杰士邦卫生用品有限公司 | Water-soluble human body lubricants |
| CN101773513A (en) * | 2009-01-14 | 2010-07-14 | 邢建慧 | Water soluble body lubricant with natural antibacterial components and with pH value consistence with pH value of vagina |
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Address after: Toward the road in Taizhou City Industrial Park, 225400 No. 18 in Jiangsu Province Patentee after: Jiang Zhiyin Address before: 321000 Zhejiang city of Jinhua province Xian No. 398 North Street Patentee before: Jiang Zhiyin |
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