CN103006914A - Isatis root-folium isatidis grain for livestock and preparation method thereof - Google Patents
Isatis root-folium isatidis grain for livestock and preparation method thereof Download PDFInfo
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- CN103006914A CN103006914A CN201210365415XA CN201210365415A CN103006914A CN 103006914 A CN103006914 A CN 103006914A CN 201210365415X A CN201210365415X A CN 201210365415XA CN 201210365415 A CN201210365415 A CN 201210365415A CN 103006914 A CN103006914 A CN 103006914A
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Abstract
The invention relates to the field of Chinese medicine, and in particular relates to an isatis root-folium isatidis grain for livestock and a preparation method thereof. The isatis root-folium isatidis grain for the livestock is prepared from the following ingredients in part by weight: 6 parts of isatis root and 9 parts of folium isatidis. The preparation method comprises the following steps of: adding 120-150 parts of water into the 6 parts of the isatis root and 9 parts of the folium isatidis according to weight part; soaking; carrying out thermal reflex extraction on the mixture; filtering to obtain the filtrate; adding water into the filter residue; carrying out thermal reflex extraction on the mixture; filtering to obtain the filtrate; mixing the two filtrates; concentrating the mixed filtrates; adding a ZTC1+1-II type clarifying agent; standing; filtering and taking the supernatant of the filtrate; centrifuging the supernatant; concentrating the centrifuged liquid till an extract is formed; adding auxiliaries materials, namely, cane sugar and maltodextrin; pelletizing and drying so as to obtain the isatis root-folium isatidis grain. According to the isatis root-folium isatidis grain, the ingredients are simple and effective, and the preparation method has the advantages of small effective Chinese medicine component loss, high clarification efficiency, simplicity in operation, less time consumption, low cost, safety, no toxicity, no residue and the like.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly blue or green granule of a kind of plate for animals and preparation method thereof.
Background technology
The blue or green granule of plate is a kind of pure Chinese medicinal preparation, has the function of heat-clearing and toxic substances removing, removing heat from blood, cures mainly anemopyretic cold, laryngopharynx swelling and pain, calentura and sends out speckle isothermal febrile illness, be 2005 version " Chinese veterinary pharmacopoeia " record kind.The blue or green granule of plate is applicable to swine influenza, circovirus disease, reproductive and respiratory syndrome, and chicken atypical newcastle disease, infectious bursal disease, infectious laryngotracheitis, influenza etc. are specially adapted to torridity summer, the warm property of the animal disease that causes such as hot and humid.
In the production process of Chinese medicine preparation, often need to make with extra care the extracting solution of Chinese crude drug, its main purpose is to remove the effective ingredient that has physiologically active in impurity, the reservation medical material, reduces dose.Widely used process for purification is the water extract-alcohol precipitation method for refining in the preparation technology of the multiple dosage forms such as Chinese medicine granules, oral liquid, injection at present, and it can remove the impurity such as protein in the extracting solution, starch, phlegmatic temperament, oils and fats, fat-soluble pigment, resin, natural gum, part saccharide effectively.But find also that in practice there are many defectives in this method, not easy to operate such as the loss of effective composition, the stability that affects preparation, post-production operation also has in addition that cost is high, the production cycle long, contaminated environment and may cause the problems such as Residual ethanol is higher in the finished product medicament.The flocculate and clarify technology is at Chinese medicine extraction liquid or extracts and to add a kind of absorptive clarificant in the concentrated solution, removes coarse granule in the solution by the mode of absorption, reaches refining and improves a new and high technology of preparation clarity purpose.Have that loss of effective components is few, clarifying efficiency is high, simple to operate, consuming time less, cost is low, the advantages such as safety non-toxic, noresidue.
Summary of the invention:
The purpose of this invention is to provide a kind of blue or green granule of plate for animals for the treatment of the warm property of animal disease medicament, and provide a kind of cost low, efficient is high, pollution-free and keep to greatest extent the method for the blue or green granule of this plate for animals of preparation of Effective Component of Chinese Medicine.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
The blue or green granule of a kind of plate for animals is made by following weight portion raw material: 6 parts of Radix Isatidis, 9 parts of Folium Isatidiss.
The preparation method of the blue or green granule of described a kind of plate for animals, its step be, by weight: add 120-150 part water in 6 parts of Radix Isatidis and 9 portions of Folium Isatidiss, soaks after 0.5-1.5 hour, the mixture hot reflux was extracted 2-2.5 hour, mistake leaching filtrate; In filtering residue, add 90-120 part water, the mixture hot reflux was extracted 1-2 hour, cross leaching filtrate, merge filtrate twice; Filtrate after merging is concentrated into 70-80 part, adds ZTC1+1-II type clarifier, leave standstill, filter and get the filtrate supernatant; The centrifugal supernatant of getting to extractum, adds adjuvant sucrose and maltodextrin with the liquid concentration after centrifugal, granulates, is drying to obtain.
The preparation method of the blue or green granule of described a kind of plate for animals, described ZTC1+1-II type clarifier needs to use in accordance with the following methods: again add distilled water after ZTC1+1-II type clarifier is stirred into pasty state with distilled water, swelling 24 hours is mixed with 1% viscose, and this is for processing 1; With ZTC1+1-II type clarifier 1% acetate dissolution, again add 1% acetic acid after stirring into pasty state, swelling 24 hours is mixed with 1% viscose, this is for processing 2, process 1 with the consumption volume ratio of processing 2 be 1:2; During use, stir the filtrate after concentrating under 50-80 ℃ the condition, the viscose that adds the processing 2 of the 2-4% that concentrates the rear filtrate volume, per 30 minutes between left and right every stirring once, after 2 hours, same processing method adds the viscose of the processing 1 of filtrate volume 1-2%, after stirring, be warming up to 70-80 ℃ of insulation 10-20 minute, then under 2-5 ℃ of environment, left standstill 18-24 hour.
The preparation method of the blue or green granule of described a kind of plate for animals, the density of concentrated rear extractum is 1.25-1.30.
The preparation method of the blue or green granule of described a kind of plate for animals, the weight proportion of its extractum and adjuvant is: extractum 1-2 part, sucrose 2-4 part, maltodextrin 1-2 part.
The present invention has the following advantages: Chinese medicinal components is simply effective, and medicament preparation technology is simple, adopts the flocculate and clarify technology, removes coarse granule in the solution by the mode of using the absorption of ZTC1+1-II type clarifier, reaches the purpose of refining medicament.Have Effective Component of Chinese Medicine loss less, clarifying efficiency is high, simple to operate, consuming time less, cost is low, the advantages such as safety non-toxic, noresidue.By showing after the science calculating, adopting the Effective Component of Chinese Medicine loss rate of the medicament of the present invention program's preparation is 12%-17%, and adopts the Effective Component of Chinese Medicine loss rate in the medicament that decoction and alcohol sedimentation technique prepares in the prior art to be about 37%.
The specific embodiment:
Embodiment 1
Get Radix Isatidis 6kg, Folium Isatidis 9kg, place in the extraction pot, add the 120L purified water and soaked 0.5 hour, then reflux, extract,, reflux, extract, were crossed leaching filtrate after 2 hours, again add purified water 90L in the filtering residue after filter, reflux, extract, 1 hour is crossed leaching filtrate.Twice filtrate is merged, be concentrated into 70kg, add ZTC1+1-II type clarifier precipitation, rear 70 ℃ of insulations 20 minutes stir.Then under 2 ℃ of environment, left standstill 18 hours, filter, get filtrate.Get supernatant centrifugal through tube centrifuge, get centrifugal medicinal liquid, be concentrated into the thick extractum of density to 1.25,1 part of extractum, 2 portions of sucrose, 1 portion of maltodextrin are granulated after mixing, dry, and get final product Effective Component of Chinese Medicine loss rate as calculated: adopt process loss 17% of the present invention, conventional alcohol deposition method loss 37%.
Embodiment 2
Get Radix Isatidis 6kg, Folium Isatidis 9kg, place in the extraction pot, add the 120L purified water and soaked 1 hour, reflux, extract, then, reflux, extract, was crossed leaching filtrate after 2.5 hours, again added purified water 120L, and reflux, extract, 1.5 hours is crossed leaching filtrate.Twice filtrate is merged, be concentrated into 75kg, add ZTC1+1-II type clarifier precipitation, rear 70 ℃ of insulations 20 minutes stir.Then under 3 ℃ of environment, left standstill 24 hours, filter, get filtrate.Get supernatant centrifugal through tube centrifuge, get centrifugal medicinal liquid, be concentrated into the thick extractum of density to 1.25,2 parts of extractum, 2 portions of sucrose, 2 portions of maltodextrins are granulated after mixing, dry, and get final product Effective Component of Chinese Medicine loss rate as calculated: adopt process loss 15% of the present invention, conventional alcohol deposition method loss 37%.
Embodiment 3
Take by weighing Radix Isatidis 6kg, Folium Isatidis 9kg, place in the extraction pot, add the 150L purified water and soaked 1.5 hours, then begin reflux, extract,, reflux, extract, was crossed leaching filtrate after 2 hours, again added purified water 90L, and reflux, extract, 2 hours is crossed leaching filtrate.Twice filtrate is merged, be concentrated into 80kg, add ZTC1+1-II type clarifier precipitation, rear 70 ℃ of insulations 15 minutes stir.Then under 4 ℃ of environment, left standstill 18 hours, filter, get filtrate.Get supernatant centrifugal through tube centrifuge, get centrifugal medicinal liquid, be concentrated into the thick extractum of density to 1.30,2 parts of extractum, 3 portions of sucrose, 2 portions of maltodextrins are granulated after mixing, dry, and get final product Effective Component of Chinese Medicine loss rate as calculated: adopt process loss 13% of the present invention, conventional alcohol deposition method loss 37%.
Embodiment 4
Take by weighing Radix Isatidis 6kg, Folium Isatidis 9kg, place in the extraction pot, add the 150L purified water and soaked 1 hour, then begin reflux, extract,, reflux, extract, was crossed leaching filtrate after 1.5 hours, again added purified water 120L, and reflux, extract, 1.5 hours is crossed leaching filtrate.Twice filtrate is merged, be concentrated into 75kg, add ZTC1+1-II type clarifier precipitation, rear 75 ℃ of insulations 20 minutes stir.Then under 5 ℃ of environment, left standstill 18 hours, filter, get filtrate.Get supernatant centrifugal through tube centrifuge, get centrifugal medicinal liquid, be concentrated into the thick extractum of density to 1.25,1 part of extractum, 4 portions of sucrose, 2 portions of maltodextrins are granulated after mixing, dry, and get final product Effective Component of Chinese Medicine loss rate as calculated: adopt process loss 15% of the present invention, conventional alcohol deposition method loss 37%.
Embodiment 5
Take by weighing Radix Isatidis 6kg, Folium Isatidis 9kg, place in the extraction pot, add the 120L purified water and soaked 1 hour, then begin reflux, extract,, reflux, extract, was crossed leaching filtrate after 2 hours, again added purified water 120L, and reflux, extract, 1.5 hours is crossed leaching filtrate.Twice filtrate is merged, be concentrated into 75kg, add ZTC1+1-II type clarifier precipitation, rear 75 ℃ of insulations 20 minutes stir.Then under 3 ℃ of environment, left standstill 24 hours, filter, get filtrate.Get supernatant centrifugal through tube centrifuge, get centrifugal medicinal liquid, be concentrated into the thick extractum of density to 1.30,2 parts of extractum, 3 portions of sucrose, 1 portion of maltodextrin are granulated after mixing, dry, and get final product Effective Component of Chinese Medicine loss rate as calculated: adopt process loss 13% of the present invention, conventional alcohol deposition method loss 37%.
Embodiment 6
Take by weighing Radix Isatidis 6kg, Folium Isatidis 9kg, place in the extraction pot, add the 150L purified water and soaked 1 hour, then begin reflux, extract,, reflux, extract, was crossed leaching filtrate after 2 hours, again added purified water 120L, and reflux, extract, 2 hours is crossed leaching filtrate.Filtrate is merged, be concentrated into 75kg, add ZTC1+1-II type clarifier precipitation, rear 80 ℃ of insulations 10 minutes stir.Then under 35 ℃ of environment, left standstill 20 hours, filter, get filtrate.Get supernatant centrifugal through tube centrifuge, get centrifugal medicinal liquid, be concentrated into the thick extractum of density to 1.25,2 parts of extractum, 4 portions of sucrose, 1 portion of maltodextrin are granulated after mixing, dry, and get final product Effective Component of Chinese Medicine loss rate as calculated: adopt process loss 12% of the present invention, conventional alcohol deposition method loss 37%.
Claims (5)
1. the blue or green granule of plate for animals is characterized in that, is made by following weight portion raw material: 6 parts of Radix Isatidis, 9 parts of Folium Isatidiss.
2. the preparation method of the blue or green granule of a kind of plate for animals claimed in claim 1, it is characterized in that, by weight: in 6 parts of Radix Isatidis and 9 portions of Folium Isatidiss, add 120-150 part water, soak after 0.5-1.5 hour, the mixture hot reflux was extracted 2-2.5 hour, cross leaching filtrate; In filtering residue, add 90-120 part water, the mixture hot reflux was extracted 1-2 hour, cross leaching filtrate, merge filtrate twice; Filtrate after merging is concentrated into 70-80 part, adds ZTC1+1-II type clarifier, leave standstill, filter and get the filtrate supernatant; The centrifugal supernatant of getting to extractum, adds adjuvant sucrose and maltodextrin with the liquid concentration after centrifugal, granulates, is drying to obtain.
3. the preparation method of the blue or green granule of a kind of plate for animals as claimed in claim 2, it is characterized in that, described ZTC1+1-II type clarifier needs to use in accordance with the following methods: again add distilled water after ZTC1+1-II type clarifier is stirred into pasty state with distilled water, swelling 24 hours, be mixed with 1% viscose, this is for processing 1; With ZTC1+1-II type clarifier 1% acetate dissolution, again add 1% acetic acid after stirring into pasty state, swelling 24 hours is mixed with 1% viscose, this is for processing 2, process 1 with the consumption volume ratio of processing 2 be 1:2; During use, stir the filtrate after concentrating under 50-80 ℃ the condition, the viscose that adds the processing 2 of the 2-4% that concentrates the rear filtrate volume, per 30 minutes between left and right every stirring once, after 2 hours, same processing method adds the viscose of the processing 1 of filtrate volume 1-2%, after stirring, be warming up to 70-80 ℃ of insulation 10-20 minute, then under 2-5 ℃ of environment, left standstill 18-24 hour.
4. the preparation method of the blue or green granule of a kind of plate for animals as claimed in claim 2 is characterized in that, the density of described extractum is 1.25-1.30.
5. the preparation method of the blue or green granule of a kind of plate for animals as claimed in claim 2 is characterized in that, the weight proportion of extractum and adjuvant is: extractum 1-2 part, sucrose 2-4 part, maltodextrin 1-2 part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210365415XA CN103006914A (en) | 2012-09-27 | 2012-09-27 | Isatis root-folium isatidis grain for livestock and preparation method thereof |
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| CN201210365415XA CN103006914A (en) | 2012-09-27 | 2012-09-27 | Isatis root-folium isatidis grain for livestock and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547174A (en) * | 2014-12-30 | 2015-04-29 | 郑州都灵兽药科技有限公司 | Preparation method of anti-virus traditional Chinese medicine granules for livestock and poultry |
| CN105287785A (en) * | 2015-11-11 | 2016-02-03 | 郑州后羿制药有限公司 | Traditional Chinese medicine for treating hyperthermia toxin symptoms of livestock and poultry and preparation method of traditional Chinese medicine |
| CN106890212A (en) * | 2015-12-18 | 2017-06-27 | 洛阳惠中兽药有限公司 | Application of the slender acanthopanax stilbene Chinese medicine composition in prevention and treatment porcine respiratory disease syndrome |
| CN108186706A (en) * | 2018-02-28 | 2018-06-22 | 山东信合生物制药有限公司 | A kind of isatis root-folium isatidis grain for livestock and preparation method thereof |
| CN110624026A (en) * | 2019-10-29 | 2019-12-31 | 河南黑马动物药业有限公司 | Preparation method of veterinary antiviral granules |
| CN113713004A (en) * | 2021-09-16 | 2021-11-30 | 哈尔滨绿达生动物药业有限公司 | Radix isatidis granules and preparation method thereof |
-
2012
- 2012-09-27 CN CN201210365415XA patent/CN103006914A/en active Pending
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| 中国兽药典委员会编: "《中华人民共和国兽药典 2005年版 二部》", 30 April 2006 * |
| 张恒弼等: "《中药现代研究与开发》", 31 January 2010 * |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547174A (en) * | 2014-12-30 | 2015-04-29 | 郑州都灵兽药科技有限公司 | Preparation method of anti-virus traditional Chinese medicine granules for livestock and poultry |
| CN104547174B (en) * | 2014-12-30 | 2017-03-15 | 郑州都灵兽药科技有限公司 | Preparation method of the fowl with anti virus herb granule |
| CN105287785A (en) * | 2015-11-11 | 2016-02-03 | 郑州后羿制药有限公司 | Traditional Chinese medicine for treating hyperthermia toxin symptoms of livestock and poultry and preparation method of traditional Chinese medicine |
| CN106890212A (en) * | 2015-12-18 | 2017-06-27 | 洛阳惠中兽药有限公司 | Application of the slender acanthopanax stilbene Chinese medicine composition in prevention and treatment porcine respiratory disease syndrome |
| CN108186706A (en) * | 2018-02-28 | 2018-06-22 | 山东信合生物制药有限公司 | A kind of isatis root-folium isatidis grain for livestock and preparation method thereof |
| CN110624026A (en) * | 2019-10-29 | 2019-12-31 | 河南黑马动物药业有限公司 | Preparation method of veterinary antiviral granules |
| CN113713004A (en) * | 2021-09-16 | 2021-11-30 | 哈尔滨绿达生动物药业有限公司 | Radix isatidis granules and preparation method thereof |
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Application publication date: 20130403 |