CN102319283A - Preparation method for veterinary licorice root particles - Google Patents
Preparation method for veterinary licorice root particles Download PDFInfo
- Publication number
- CN102319283A CN102319283A CN201110277755A CN201110277755A CN102319283A CN 102319283 A CN102319283 A CN 102319283A CN 201110277755 A CN201110277755 A CN 201110277755A CN 201110277755 A CN201110277755 A CN 201110277755A CN 102319283 A CN102319283 A CN 102319283A
- Authority
- CN
- China
- Prior art keywords
- hours
- purified water
- licorice root
- carrying
- extracting solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method for veterinary licorice root particles. The method comprises: placing a licorice root medicinal material in an extraction tank; adding purified water to the material and carrying out warm immersing for 2 hours, wherein the adding amount of the purified water is 8-10 times amount of the licorice root medicinal material; carrying out heat reflux extraction for 1.5-2 hours, and collecting an extracting solution; adding purified water to the material, wherein the adding amount of the purified water is 6-8 times amount of the licorice root medicinal material; carrying out heat reflux extraction for 1.5-2 hours, and collecting an extracting solution; mixing the extracting solutions from the steps; concentrating the resulting mixture to a ratio of the licorice root medicinal material to the water of 1:5; precipitating the concentrated mixture through a ZTC1+1-II type cleaning agent; carrying out filtration, and collecting the supernatant; centrifuging the supernatant; collecting the centrifuged drug liquid, and concentrating the drug liquid into a thick paste; adding an assistant material to the thick paste, uniformly mixing and pelletizing, and then carrying out drying. With the preparation method for the veterinary licorice root particles, the active ingredients in the traditional Chinese drug can be maintained maximally, the operation process is simple, the production cost is reduced and the production period is shortened.
Description
Technical field
The present invention relates to the particulate method for preparing of a kind of Radix Glycyrrhizae for animals.
Background technology
Radix Glycyrrhizae has similar adrenocortical hormone effect, and the gastroxia that histamine is caused has inhibitory action, and effect antiacid and alleviation gastrointestinal smooth muscle spasm is arranged, and expectorant effect is obvious.In addition, also have antiinflammatory, anti-allergic effects, can protect the throat and the tunica mucosa tracheae of inflammation.The Radix Glycyrrhizae granule is a kind of pure Chinese medicinal preparation; Has the expelling phlegm for arresting cough function; Curative effect is very good when treating animal breath road class disease, is applicable to swine influenza, circovirus disease, reproductive and respiratory syndrome, transmissible gastroenteritis, epidemic diarrhea, infectious bursal disease, infectious laryngotracheitis, infectious bronchitis, fowl pox, influenza and various accompanying infections etc.
In the production process of Chinese medicine preparation, often need make with extra care the extracting solution of Chinese crude drug, its main purpose is to remove the effective ingredient that has physiologically active in impurity, the reservation medical material.At present; Widely used process for purification is the water extract-alcohol precipitation method for refining among the preparation technology of multiple dosage forms such as Chinese medicine granules, oral liquid, injection, and it can remove impurity such as protein in the extracting solution, starch, phlegmatic temperament, oils and fats, fat-soluble pigment, resin, natural gum, part saccharide effectively.But find also in the practical operation that there are many defectives in it, many like loss of effective components, the post-production operation is not easy to operate, cost is high, the production cycle is long, in the finished product ethanol residual quantity than problems such as height.
Summary of the invention
The purpose of this invention is to provide the particulate method for preparing of a kind of Radix Glycyrrhizae for animals, this method is simple to operate, cost is low, the cycle is short.
To achieve these goals, technical scheme of the present invention is: the particulate method for preparing of a kind of Radix Glycyrrhizae for animals, and the extracting liquorice medical material places extraction pot, adds 8～10 times of medical material amount purified water warm macerating 2 hours, and hot reflux was extracted 1.5～2 hours; Collect extracting solution, in medical material, add 6～8 times of medical material amount purified water, hot reflux was extracted 1.5～2 hours once more, collected extracting solution; Merge extractive liquid, is concentrated into liquid medicine than being 1:5, with ZTC1+1-II type clarifier deposition, filters; Get supernatant, supernatant is centrifugal, get centrifugal medicinal liquid, be condensed into thick paste; Add adjuvant, mix homogeneously is processed granule, drying.
Said thick paste relative density is between 1.25～1.30.
Described adjuvant is sucrose and maltodextrin.
Per 1～2 part of medical material thick paste adds 2～4 portions of sucrose and 1～2 portion of maltodextrin.
ZTC1+1-II type clarifier layoutprocedure is following:
Elder generation joins in the A component with a small amount of distilled water and stirs into pasty state, adds the distilled water of requirement then, and swelling 24 hours stirs, and is mixed with 1% viscose.Elder generation is with a small amount of 1% acetate dissolution B component and stir into pasty state, adds 1% acetic acid of q.s then, and swelling 24 hours stirs, and is mixed with 1% viscose.
A component viscose and B component viscose are pressed the 1:2 proportioning and are used, and add B component viscose during use earlier and add A component viscose again.Wherein the addition of A component viscose is 1～2% of a medicine liquid volume, and the addition of B component viscose is 2～4% of a medicine liquid volume.
ZTC1+1-II type clarifier method for using is: when 50～80 ℃ of extracting solution temperature; Stirring adds the B component viscose of medicine liquid volume 2～4% down, and per 30 minutes between left and right at a distance from stirring once, after 2 hours; The A component viscose that adds medicine liquid volume 1～2% with quadrat method; After stirring, be warming up to 70～80 ℃ of insulations 10～20 minutes again, under 2～5 ℃ of environment, left standstill 18～24 hours then.
Adopt the particulate method for preparing of above-mentioned Radix Glycyrrhizae, can keep to greatest extent effective ingredient in the Chinese medicine, operating process simple, reduce production costs, shorten the production cycle.
The specific embodiment
Embodiment 1:
Take by weighing licorice medicinal materials 8 kg and place in the extraction pot, added 80L purified water warm macerating 2 hours, hot reflux was extracted 1.5 hours, collected extracting solution, added purified water 64L once more, and reflux, extract, 2 hours is collected extracting solution.Extracted twice liquid is merged, concentrate volume to 40L, with ZTC1+1-II type clarifier deposition, back 80 ℃ of insulations 20 minutes stir.Under 2～5 ℃ of environment, left standstill 18 hours then, filter, must filtrate.It is centrifugal to get supernatant, gets centrifugal medicinal liquid, and the thick paste of simmer down to relative density 1.30 and adjuvant sucrose, maltodextrin mix the back granulates, and drying is processed 8kg Radix Glycyrrhizae granule.
Embodiment 2:
Take by weighing licorice medicinal materials 8 kg and place in the extraction pot, added 64L purified water warm macerating 2 hours, hot reflux was extracted 2 hours, collected extracting solution, added purified water 48L once more, and reflux, extract, 2 hours is collected extracting solution.Extracted twice liquid is merged, concentrate volume to 40L, with ZTC1+1-II type clarifier deposition, back 75 ℃ of insulations 15 minutes stir.Under 2～5 ℃ of environment, left standstill 24 hours then, filter, must filtrate.It is centrifugal to get supernatant, gets centrifugal medicinal liquid, and the thick paste of simmer down to relative density 1.25 and adjuvant sucrose, maltodextrin mix the back granulates, and drying is processed 8kg Radix Glycyrrhizae granule.
Embodiment 3:
Take by weighing licorice medicinal materials 8 kg and place in the extraction pot, added 72L purified water warm macerating 2 hours, hot reflux was extracted 1.5 hours, collected extracting solution, added purified water 56L once more, and reflux, extract, 1.5 hours is collected extracting solution.Extracted twice liquid is merged, concentrate volume to 40L, with ZTC1+1-II type clarifier deposition, back 70 ℃ of insulations 10 minutes stir.Under 2～5 ℃ of environment, left standstill 24 hours then, filter, must filtrate.It is centrifugal to get supernatant, gets centrifugal medicinal liquid, and the thick paste of simmer down to relative density 1.27 and adjuvant sucrose, maltodextrin mix the back granulates, and drying is processed 8kg Radix Glycyrrhizae granule.
Embodiment 4:
Take by weighing licorice medicinal materials 10 kg and place in the extraction pot, added 100L purified water warm macerating 2 hours, hot reflux was extracted 2 hours, collected extracting solution, added purified water 80L once more, and reflux, extract, 1.5 hours is collected extracting solution.Extracted twice liquid is merged, concentrate volume to 50L, with ZTC1+1-II type clarifier deposition, back 75 ℃ of insulations 15 minutes stir.Under 2～5 ℃ of environment, left standstill 20 hours then, filter, must filtrate.It is centrifugal to get supernatant, gets centrifugal medicinal liquid, and the thick paste of simmer down to relative density 1.30 and adjuvant sucrose, maltodextrin mix the back granulates, and drying is processed 10kg Radix Glycyrrhizae granule.
Embodiment 5:
Take by weighing licorice medicinal materials 10 kg and place in the extraction pot, added 80L purified water warm macerating 2 hours, hot reflux was extracted 2 hours, collected extracting solution, added purified water 60L once more, and reflux, extract, 2 hours is collected extracting solution.Extracted twice liquid is merged, concentrate volume to 50L, with ZTC1+1-II type clarifier deposition, back 80 ℃ of insulations 10 minutes stir.Under 2～5 ℃ of environment, left standstill 18 hours then, filter, must filtrate.It is centrifugal to get supernatant, gets centrifugal medicinal liquid, and the thick paste of simmer down to relative density 1.25 and adjuvant sucrose, maltodextrin mix the back granulates, and drying is processed 10kg Radix Glycyrrhizae granule.
Embodiment 6:
Take by weighing licorice medicinal materials 10 kg and place in the extraction pot, added 90L purified water warm macerating 2 hours, hot reflux was extracted 1.5 hours, collected extracting solution, added purified water 70L once more, and reflux, extract, 1.5 hours is collected extracting solution.Extracted twice liquid is merged, concentrate volume to 50L, with ZTC1+1-II type clarifier deposition, back 70 ℃ of insulations 20 minutes stir.Under 2～5 ℃ of environment, left standstill 20 hours then, filter, must filtrate.It is centrifugal to get supernatant, gets centrifugal medicinal liquid, and the thick paste of simmer down to relative density 1.27 and adjuvant sucrose, maltodextrin mix the back granulates, and drying is processed 10kg Radix Glycyrrhizae granule.
Claims (4)
1. particulate method for preparing of Radix Glycyrrhizae for animals, it is characterized in that: the extracting liquorice medical material places extraction pot, adds 8～10 times of medical material amount purified water warm macerating 2 hours, and hot reflux was extracted 1.5～2 hours; Collect extracting solution, in medical material, add 6～8 times of medical material amount purified water, hot reflux was extracted 1.5～2 hours once more, collected extracting solution; Merge extractive liquid, is concentrated into liquid medicine than being 1:5, with ZTC1+1-II type clarifier deposition, filters; Get supernatant, supernatant is centrifugal, get centrifugal medicinal liquid, be condensed into thick paste; Add adjuvant, mix homogeneously is processed granule, drying.
2. the particulate method for preparing of Radix Glycyrrhizae for animals as claimed in claim 1 is characterized in that: said thick paste relative density is between 1.25～1.30.
3. the particulate method for preparing of Radix Glycyrrhizae for animals as claimed in claim 1 is characterized in that: described adjuvant is sucrose and maltodextrin.
4. like claim 1 or the particulate method for preparing of 2 or 3 described Radix Glycyrrhizaes for animals, it is characterized in that: per 1～2 part of medical material thick paste adds 2～4 portions of sucrose and 1～2 portion of maltodextrin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110277755A CN102319283A (en) | 2011-09-19 | 2011-09-19 | Preparation method for veterinary licorice root particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110277755A CN102319283A (en) | 2011-09-19 | 2011-09-19 | Preparation method for veterinary licorice root particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102319283A true CN102319283A (en) | 2012-01-18 |
Family
ID=45447209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110277755A Pending CN102319283A (en) | 2011-09-19 | 2011-09-19 | Preparation method for veterinary licorice root particles |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102319283A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727569A (en) * | 2012-06-30 | 2012-10-17 | 郑州百瑞动物药业有限公司 | Preparation method of licorice particles for livestock and poultry |
| CN103565909A (en) * | 2012-08-09 | 2014-02-12 | 洛阳惠中兽药有限公司 | Liquorice particles and preparation method thereof |
| CN103610739A (en) * | 2013-12-05 | 2014-03-05 | 江苏恒丰强生物技术有限公司 | Liquorice pellet pill |
| CN105998165A (en) * | 2016-07-20 | 2016-10-12 | 四川康而好动物药业有限公司 | Preparation method of licorice granules |
| CN109576715A (en) * | 2018-12-29 | 2019-04-05 | 福建金源泉科技发展有限公司 | Anti-mildew stainless steel cleaning compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101607980A (en) * | 2009-06-15 | 2009-12-23 | 北京九草堂药物研究院有限公司 | A kind of preparation of licorice extract of bulk drug for livestock |
-
2011
- 2011-09-19 CN CN201110277755A patent/CN102319283A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101607980A (en) * | 2009-06-15 | 2009-12-23 | 北京九草堂药物研究院有限公司 | A kind of preparation of licorice extract of bulk drug for livestock |
Non-Patent Citations (3)
| Title |
|---|
| 中国兽药典委员会: "《中华人民共和国兽药典2000年版第二部》", 30 November 2000, article "甘草颗粒" * |
| 张萍等: "ZTC1+1-Ⅱ澄清剂用于中药水提液澄清", 《中国中药杂志》, vol. 32, no. 02, 20 January 2007 (2007-01-20) * |
| 颜红: "天然澄清剂在中药水提液澄清工艺中的应用", 《湖南中医药导报》, vol. 11, no. 01, 28 January 2005 (2005-01-28) * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727569A (en) * | 2012-06-30 | 2012-10-17 | 郑州百瑞动物药业有限公司 | Preparation method of licorice particles for livestock and poultry |
| CN102727569B (en) * | 2012-06-30 | 2014-07-09 | 郑州百瑞动物药业有限公司 | Preparation method of licorice particles for livestock and poultry |
| CN103565909A (en) * | 2012-08-09 | 2014-02-12 | 洛阳惠中兽药有限公司 | Liquorice particles and preparation method thereof |
| CN103565909B (en) * | 2012-08-09 | 2016-02-03 | 洛阳惠中兽药有限公司 | A kind of licorice root particles and preparation method thereof |
| CN103610739A (en) * | 2013-12-05 | 2014-03-05 | 江苏恒丰强生物技术有限公司 | Liquorice pellet pill |
| CN105998165A (en) * | 2016-07-20 | 2016-10-12 | 四川康而好动物药业有限公司 | Preparation method of licorice granules |
| CN109576715A (en) * | 2018-12-29 | 2019-04-05 | 福建金源泉科技发展有限公司 | Anti-mildew stainless steel cleaning compositions |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102319283A (en) | Preparation method for veterinary licorice root particles | |
| CN102552670B (en) | Preparation method for oral liquid capable of clearing heat and removing toxicity | |
| CN103006914A (en) | Isatis root-folium isatidis grain for livestock and preparation method thereof | |
| CN103933116A (en) | Preparation process of herba leonuri paste | |
| CN101543594B (en) | Mulberry-chrysanthemum oral liquid | |
| CN1301103C (en) | Kelu drip pill used for phlegm transforming cough suppressing and its preparation method | |
| CN103961613A (en) | Novel preparation method of high-quality loquat syrup | |
| CN104739726B (en) | A kind of Chinese medicine toothpaste and preparation method thereof | |
| CN102755431B (en) | Traditional Chinese medicine preparation for treating porcine respiratory disease syndrome and preparation method thereof | |
| CN102895317A (en) | Preparation method of Shuanghuanglian oral liquid for veterinary use | |
| CN107693565A (en) | It is a kind of to improve the method for not having medicament extracting solution thickening efficiency and being spray-dried yield | |
| CN102614457B (en) | Preparation method of breast recovering tablet | |
| CN103405504A (en) | Traditional Chinese medicine granules for treating respiratory bovine infectious rhinotracheitis and preparation method thereof | |
| CN104398896A (en) | Traditional Chinese medicinal oral liquid for treating bovine viral diarrhea and preparation method for traditional Chinese medicinal oral liquid | |
| CN1294903C (en) | Loquat drip pill for treating cough and its preparation method | |
| CN102895386B (en) | Method for performing extraction on angelica dahurica, common cnidium fruit, Chinese red pepper and elecampane inula root and pharmaceutical application | |
| CN105395893A (en) | Oral solution for clearing heat from throat and preparation method thereof | |
| CN101732561B (en) | Health-care medicine used for preventing and treating chronic pharyngitis and preparation method thereof | |
| CN103816513B (en) | A kind of preparation method of SHEDAN CHENPI KOUFUYE | |
| CN1322854C (en) | Cold drop pills of mulberry and ginger in use for eliminating draft, clearing away heat, and preparing method | |
| CN102988451A (en) | Preparation method of sugar-free banlangen granules | |
| CN102552419A (en) | Tanreqing dropping pills and preparation method thereof | |
| CN102106968A (en) | Process for carrying out impurity removal on syrup technical extract for nourishing yin to clear away lung-heat by flocculation and subsequent separation | |
| CN102309628A (en) | Traditional Chinese medicinal particle for treating dog tonsillopathy and preparation method thereof | |
| CN103800884B (en) | Method for preparing snake gall and dried tangerine peel oral solution |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120118 |