CN103002742B - 核转运调节剂及其应用 - Google Patents

核转运调节剂及其应用 Download PDF

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CN103002742B
CN103002742B CN201180022653.4A CN201180022653A CN103002742B CN 103002742 B CN103002742 B CN 103002742B CN 201180022653 A CN201180022653 A CN 201180022653A CN 103002742 B CN103002742 B CN 103002742B
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compound
certain embodiments
alkyl
pharmaceutically acceptable
ethyl acetate
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CN103002742A (zh
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S·沙查姆
M·考夫曼
V·P·桑丹雅卡
S·谢克特尔
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Karyopharm Therapeutics Inc
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CN201180022653.4A 2010-03-05 2011-03-05 核转运调节剂及其应用 Active CN103002742B (zh)

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Application Number Priority Date Filing Date Title
US31081010P 2010-03-05 2010-03-05
US61/310,810 2010-03-05
US38327510P 2010-09-15 2010-09-15
US61/383,275 2010-09-15
PCT/US2011/027328 WO2011109799A1 (en) 2010-03-05 2011-03-05 Nuclear transport modulatiors and uses thereof

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CN103002742B true CN103002742B (zh) 2016-07-13

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EP (1) EP2542089B1 (https=)
JP (1) JP5816635B2 (https=)
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AU (1) AU2011222531B2 (https=)
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