AU2011222531B2 - Nuclear transport modulatiors and uses thereof - Google Patents

Nuclear transport modulatiors and uses thereof Download PDF

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AU2011222531B2
AU2011222531B2 AU2011222531A AU2011222531A AU2011222531B2 AU 2011222531 B2 AU2011222531 B2 AU 2011222531B2 AU 2011222531 A AU2011222531 A AU 2011222531A AU 2011222531 A AU2011222531 A AU 2011222531A AU 2011222531 B2 AU2011222531 B2 AU 2011222531B2
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phenyl
nitrogen
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molecular weight
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AU2011222531A1 (en
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Michael Kauffman
Vincent P. Sandanyaka
Sharon Shacham
Sharon Shechter
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Karyopharm Therapeutics Inc
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Karyopharm Therapeutics Inc
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
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  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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AU2011222531A 2010-03-05 2011-03-05 Nuclear transport modulatiors and uses thereof Active AU2011222531B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31081010P 2010-03-05 2010-03-05
US61/310,810 2010-03-05
US38327510P 2010-09-15 2010-09-15
US61/383,275 2010-09-15
PCT/US2011/027328 WO2011109799A1 (en) 2010-03-05 2011-03-05 Nuclear transport modulatiors and uses thereof

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AU2011222531A1 AU2011222531A1 (en) 2012-10-04
AU2011222531B2 true AU2011222531B2 (en) 2015-03-26

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US (2) US8513230B2 (https=)
EP (1) EP2542089B1 (https=)
JP (1) JP5816635B2 (https=)
CN (1) CN103002742B (https=)
AU (1) AU2011222531B2 (https=)
CA (1) CA2791914C (https=)
WO (1) WO2011109799A1 (https=)

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