CN102988838A - Chinese medicinal composition for treating hyperlipidemia - Google Patents
Chinese medicinal composition for treating hyperlipidemia Download PDFInfo
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- CN102988838A CN102988838A CN2012105470470A CN201210547047A CN102988838A CN 102988838 A CN102988838 A CN 102988838A CN 2012105470470 A CN2012105470470 A CN 2012105470470A CN 201210547047 A CN201210547047 A CN 201210547047A CN 102988838 A CN102988838 A CN 102988838A
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Abstract
The invention relates to a Chinese medicinal composition for treating hyperlipidemia, which is prepared from the following natural plants (raw materials) by weight: 69g of bitter melon, 45g of Chinese wolfberry fruit, 48g of pueraria, 30g of honeysuckle, 25g of pumpkin flower, 10g of raw hawthorn, 15g of raw wheat germ, 15g of salvia miltiorrhiza, 10g of poria, 10g of alisma, 10g of red ginseng, 15g of polygonum multiflorum and 10g of radix polygonati officinalis. All the raw materials are natural plants, so the Chinese medicinal composition is wide in sources, simple in component and easy to prepare.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese medicine composition for the treatment of hyperlipidemia and preparation method thereof that can be used for.
Background technology
Hyperlipidemia is a kind of common and multiple metabolic disease, is the important risk factor that causes cardiovascular and cerebrovascular disease.Hyperlipidemia is common in middle-aged and elderly people, but along with the raising of national life level, the change of dietary structure, the hyperlipidemia prevalence of adolescence is also increasing year by year." Chinese residents nutrition in 2004 and Health Situation " investigation report points out that China adult blood fat abnormality prevalence rate is 18.6%, and national dyslipidemia is now suffered from number 1.6 hundred million, and the middle-aged and elderly people prevalence is close, and differentials between town and country are little.Develop safe and efficient antihyperlipidemic product become current in the urgent need to.
At present, hypolipidemic clinically is take chemical drugs (being mainly at present the Statins Western medicine preparation) as main, though instant effect, side effect is large, and general patient is difficult to accept; And the common drug effect of chemical drugs is difficult to need long-term taking lastingly, and toxic and side effects is more remarkable, and severe patient can produce Cardiovascular Toxicity and liver toxicity, and therefore, exploitation auxiliary antilipemic product has important practical significance from Chinese medicine or in the food.
Think on the Chinese medicine that hyperlipidemia is deficiency in origin and excess in superficiality, belong to blood stasis, the turbid category of expectorant, its disease is sent out in taste at blood, and root is in kidney.Clinical syndrome differentiation is attributed to caused by liver and kidney deficiency, turbid, the qi depression to blood stasis of insufficiency of the spleen expectorant more, mostly adopts the medicine of liver and kidney tonifying, invigorating the spleen and benefiting QI, nourishing YIN and benefiting blood, blood circulation promoting and blood stasis dispelling, clearing away heat and promoting digestion during treatment.From the modern medicine viewpoint, the effect for reducing fat of Chinese medicine mainly embodies from absorption, adjusting blood lipid metabolism, the promotion Cholesterol Excretion that suppresses cholesterol.
Make a general survey of present research situation to hyperlipidemia, the research of Chinese medicine single medicine and compound preparation is many, but general effect is not satisfactory.Perhaps, although some Chinese medicine formula has been obtained reasonable therapeutic effect, prescription is complicated, on the one hand, complicated process of preparation, cost is higher; On the other hand, the composition of prescription fails very clearly to determine that safety can't effectively be guaranteed.
Summary of the invention
Technical problem to be solved by this invention overcomes the deficiencies in the prior art, and a kind of Chinese medicine composition that is used for the treatment of hyperlipidemia is provided, and this Chinese medicine composition is evident in efficacy, and its composition is simple, preparation method is easy.
The present invention also will provide a kind of preparation method that is used for the treatment of the Chinese medicine composition of hyperlipidemia simultaneously, and the method is simple, and cost is low, and the traditional Chinese medicine composition for treating effect that obtains is remarkable.
For solving above technical problem, a kind of technical scheme that the present invention takes is as follows:
A kind of Chinese medicine composition that is used for the treatment of hyperlipidemia, its natural plant raw material by following weight portion is prepared from: bright and beautiful Fructus Litchi 69 grams, Fructus Lycii 45 grams, Radix Puerariae 48 grams, Flos Lonicerae 30 grams, Flos Cucurbitae 25 grams, Fructus Crataegi 10 grams, Fructus Hordei Germinatus 15 grams, Radix Salviae Miltiorrhizae 15 grams, Poria 10 grams, Rhizoma Alismatis 10 grams, Radix Ginseng Rubra 10 grams, Radix Polygoni Multiflori 15 grams, Rhizoma Polygonati Odorati 10 grams.
According to the present invention, all raw materials all are known, and the research of comparative maturity is arranged, and are specific as follows:
The brocade Fructus Litchi is the Fructus Momordicae charantiae of southern Jiangsu real estate, and bitter in the mouth is cold in nature, returns spleen channel.The pharmacological evaluation prompting, bright and beautiful Fructus Litchi aqueous extract can reduce TC, TG in the hyperlipidemia mice serum, LDL index, the HDL that slightly raises, the fat drop quantity of minimizing hyperlipidemia mouse liver cell is improved hepatic pathology and is changed, and has preferably effect for reducing blood fat;
Radix Puerariae, sweet in the mouth, suffering, property is flat, returns the taste warp, and contained isoflavonoid has effect for reducing blood fat in the Radix Puerariae; The Chinese patent medicine painstaking effort of making take Radix Puerariae extract as primary raw material are peaceful, the XINANNING sheet all has preferably lipid-lowering effect; The kudzu root oral liquid apoA-I in the ethanol hyperlipidemia rats blood that can raise reduces TC, TG.
Fructus Lycii, sweet in the mouth, property is flat, returns liver, kidney channel.Tool nourishing the liver nourishing kidney effect is used for caused by liver and kidney deficiency.Fructus Lycii has blood fat reducing and protects the liver, lipotropy, not only triglyceride reducing but also cholesterol reducing.The fat regulating tablet that lengthens one's life take Fructus Lycii as primary raw material, the fat recovery capsule can significantly be regulated the blood lipid level of hyperlipidemia rats.Fructus Lycii liquid then has the effect of serum total cholesterol (TC) in the obvious reduction blood, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and the effect that reduces TC, TG in the liver;
Flos Lonicerae, sweet in the mouth, cold in nature.Return the stomach warp.The tool heat-clearing toxin-expelling functions.Flos Lonicerae is the good medicine of heat-clearing and toxic substances removing, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, also kind removing summer-heat blood poison.Zoopery shows that Flos Lonicerae can reduce the enteral cholesterol absorption, reduces the content of cholesterol in the blood plasma, triglyceride reducing.Flos Lonicerae extract can make hyperlipemia in mice, rat blood serum and hepatic tissue TG level obviously reduce, and certain effect for reducing blood fat is arranged;
Flos Cucurbitae, sweet in the mouth, cool in nature, tool clearing away damp-heat, the malicious effect of subsiding a swelling.
Fructus Crataegi " long-pending, the dissipating blood stasis blood that helps digestion is controlled the long-pending lump in the abdomen of meat, phlegm retention ", " Removing Blood Stasis and do not hinder fresh blood, dissipating depression of QI gas and do not hinder healthy energy ", thus vertical be monarch.
Fructus Hordei Germinatus " help digestion, expectorant drink, broken lump in the abdomen ".
Radix Salviae Miltiorrhizae " blood circulation promoting and blood stasis dispelling ", this three flavor is minister, auxiliary monarch drug increases its consumer product dredge stasis, the power of blood circulation promoting and blood stasis dispelling altogether.
Poria " strengthening the spleen stomach function regulating, eliminating dampness and diuresis " also is minister, altogether the principal drug assistance eliminating dampness and resolving phlegm.
After middle age, body constitution becomes to declining, so assistant is got Radix Ginseng Rubra and strengthened the spleen and stomach with the product of Radix Ginseng Rubra, Radix Polygoni Multiflori, beautiful product, makes the strong fortune of temper, and sputum is not given birth to, Radix Polygoni Multiflori nourishing the liver and kidney, Rhizoma Polygonati Odorati yin nourishing profit body.
The another technical scheme that the present invention takes is: a kind of preparation method of the above-mentioned Chinese medicine composition that is used for the treatment of hyperlipidemia, as follows: as to take by weighing in proportion whole described raw materials, water decocts 2 ~ 3 times, collecting decoction, concentrate to get concentrated solution, the spray-dried method of concentrated solution obtains powder or graininess extract, is the Chinese medicine composition that is used for the treatment of hyperlipidemia.
Preferably, water decocts 2 times.
Owing to take above technical scheme, the present invention compared with prior art has following advantage:
The present invention fills a prescription and merges the Chinese and western medical theory, and compound compatibility can suppress absorption, adjusting blood lipid metabolism, the promotion Cholesterol Excretion of cholesterol, thereby reach extraordinary therapeutic effect.In addition, whole raw materials of the present invention are natural plant raw material, wide material sources, and recipe ingredient is simple, prepares easy.
The specific embodiment
The present invention will be further described in detail below in conjunction with specific embodiment, but the invention is not restricted to following examples.
Embodiment 1
A kind of Chinese medicine composition that is used for the treatment of hyperlipidemia, its composition of raw materials is as follows: bright and beautiful Fructus Litchi 69 grams, Fructus Lycii 45 grams, Radix Puerariae 48 grams, Flos Lonicerae 30 grams, Flos Cucurbitae 25 grams, Fructus Crataegi 10 grams, Fructus Hordei Germinatus 15 grams, Radix Salviae Miltiorrhizae 15 grams, Poria 10 grams, Rhizoma Alismatis 10 grams, Radix Ginseng Rubra 10 grams, Radix Polygoni Multiflori 15 grams, Rhizoma Polygonati Odorati 10 grams.
The preparation process of Chinese medicine composition is as follows: take by weighing in proportion whole raw materials, and whole raw materials are divided into equiponderant two parts, a part of water wherein decocts collecting decoction 2 times, concentrate to get concentrated solution, the spray-dried method of concentrated solution obtains Powdered extract; Another part is directly pulverized, and excessively behind 60 mesh sieves, with the powder extracts mix homogeneously, namely gets the Chinese medicine composition for the treatment hyperlipidemia.
Embodiment 2
A kind of Chinese medicine composition that is used for the treatment of hyperlipidemia, its composition of raw materials are with embodiment 1, but preparation method is different.Specifically, Chinese medicine composition adopts conventional water extraction method preparation in this example, and is specific as follows: as to take by weighing in proportion whole raw materials, water decocts 2 times, and collecting decoction concentrates to get concentrated solution, the spray-dried method of concentrated solution obtains Powdered extract, is this routine described Chinese medicine composition.
Comparative Examples 1
This Comparative Examples provides a kind of Chinese medicine composition that is used for the treatment of hyperlipidemia, and its composition of raw materials is as follows: 40 parts of bright and beautiful Fructus Litchi, 25 parts of Fructus Lycii, 20 parts of Radix Puerariaes, 15 parts of Flos Loniceraes.This routine Chinese medicine composition is according to the method preparation identical with embodiment 1.
Comparative Examples 2
This Comparative Examples provides a kind of Chinese medicine composition that is used for the treatment of hyperlipidemia, and its composition of raw materials is as follows: 35 parts of bright and beautiful Fructus Litchi, 25 parts of Fructus Lycii, 25 parts of Radix Puerariaes, 15 parts of Flos Cucurbitaes.
Comparative Examples 3
This Comparative Examples provides a kind of Chinese medicine composition that is used for the treatment of hyperlipidemia, and its composition of raw materials is as follows: 40 parts of bright and beautiful Fructus Litchi, 30 parts of Fructus Lycii, 30 parts of Radix Puerariaes.
Chinese medicine composition of the present invention is used for the treatment of the effect of hyperlipidemia
Chinese medicine composition provided by the present invention be the inventor through long-term practice, research and sum up gained.The inventor is surprised to find that in long-term practice the Chinese medicine composition that these five kinds of raw material reasonable compatibilities of bright and beautiful Fructus Litchi, Fructus Lycii, Radix Puerariae, Flos Lonicerae and Flos Cucurbitae are prepared has showed for the outstanding therapeutic effect for the treatment of hyperlipidemia symptom.All have the effect that reduces fat that studies confirm that although consist of each raw material of compositions, they then are that inventor's accident in long-term practice is found and summary obtains according to the obtained curing protrusion effect of special ratios combination.
Application has capsule or Granules in Treating hyperlipidemia 240 examples that the Chinese medicine composition of embodiment 1 described prescription is made, have capsule or the granule that the Chinese medicine composition of embodiment 2 ~ 6 described prescriptions makes and treat respectively hyperlipidemia 12 examples, it is about 96%, 98% and 72% that the total effective rate that reduces TC, TG and rising HDL-C is respectively, without any side effects.Use respectively capsule or Granules in Treating hyperlipidemia 20 examples that the Chinese medicine composition of Comparative Examples 1 ~ 3 is made, it is about 65%, 60% and 35% that the total effective rate that reduces TC, TG and rising HDL-C is respectively, without any side effects.
Most of patients is taken and is got final product a course for the treatment of.Find for same patient, hyperlipidemia symptom person is arranged obviously particularly in the practice, the capsule of taking the Chinese medicine composition that comprises embodiment 1 is better than the therapeutic effect of the capsule of taking the Chinese medicine composition that comprises embodiment 2.
,, adopt No. 0 or No. 1 capsule in the practice as example take capsule (hereinafter referred to as brocade flower complex capsule), in the capsule, the content of Chinese medicine composition is 0.35～0.40g/ grain.For general hyperlipidemia symptom person, oral, every twice-daily, each 2; Or once a day, each four, taking one month is a course for the treatment of; For obvious hyperlipidemia symptom person is arranged, recommending consumption is every day three times, and each 3, taking one month is a course for the treatment of, and long-term taking is without ill effect.
Claims (1)
1. Chinese medicine composition that is used for the treatment of hyperlipidemia, it is characterized in that: described Chinese medicine composition is prepared from by the natural plant raw material of following weight portion: bright and beautiful Fructus Litchi 69 grams, Fructus Lycii 45 grams, Radix Puerariae 48 grams, Flos Lonicerae 30 grams, Flos Cucurbitae 25 grams, Fructus Crataegi 10 grams, Fructus Hordei Germinatus 15 grams, Radix Salviae Miltiorrhizae 15 grams, Poria 10 grams, Rhizoma Alismatis 10 grams, Radix Ginseng Rubra 10 grams, Radix Polygoni Multiflori 15 grams, Rhizoma Polygonati Odorati 10 grams.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012105470470A CN102988838A (en) | 2012-12-17 | 2012-12-17 | Chinese medicinal composition for treating hyperlipidemia |
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| CN2012105470470A CN102988838A (en) | 2012-12-17 | 2012-12-17 | Chinese medicinal composition for treating hyperlipidemia |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176820A (en) * | 1997-09-26 | 1998-03-25 | 操瑞明 | Red ginseng and hawthorn fruit health-care wine |
| CN102755444A (en) * | 2012-08-06 | 2012-10-31 | 苏州神良生物科技有限公司 | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof |
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- 2012-12-17 CN CN2012105470470A patent/CN102988838A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176820A (en) * | 1997-09-26 | 1998-03-25 | 操瑞明 | Red ginseng and hawthorn fruit health-care wine |
| CN102755444A (en) * | 2012-08-06 | 2012-10-31 | 苏州神良生物科技有限公司 | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof |
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Application publication date: 20130327 |