CN102977102A - 美罗培南三水合物晶体的制备方法 - Google Patents
美罗培南三水合物晶体的制备方法 Download PDFInfo
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- CN102977102A CN102977102A CN2012105620745A CN201210562074A CN102977102A CN 102977102 A CN102977102 A CN 102977102A CN 2012105620745 A CN2012105620745 A CN 2012105620745A CN 201210562074 A CN201210562074 A CN 201210562074A CN 102977102 A CN102977102 A CN 102977102A
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- Prior art keywords
- meropenem
- solution
- add
- acid
- crude product
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
Abstract
Description
Claims (6)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012105620745A CN102977102A (zh) | 2012-12-21 | 2012-12-21 | 美罗培南三水合物晶体的制备方法 |
PCT/CN2013/090169 WO2014094659A1 (zh) | 2012-12-21 | 2013-12-20 | 一种美罗培南三水合物晶体的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012105620745A CN102977102A (zh) | 2012-12-21 | 2012-12-21 | 美罗培南三水合物晶体的制备方法 |
Publications (1)
Publication Number | Publication Date |
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CN102977102A true CN102977102A (zh) | 2013-03-20 |
Family
ID=47851493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2012105620745A Pending CN102977102A (zh) | 2012-12-21 | 2012-12-21 | 美罗培南三水合物晶体的制备方法 |
Country Status (2)
Country | Link |
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CN (1) | CN102977102A (zh) |
WO (1) | WO2014094659A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014094659A1 (zh) * | 2012-12-21 | 2014-06-26 | 浙江海正药业股份有限公司 | 一种美罗培南三水合物晶体的制备方法 |
CN107459520A (zh) * | 2016-06-02 | 2017-12-12 | 重庆圣华曦药业股份有限公司 | 一种新的高纯度美罗培南三水合物制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101914098A (zh) * | 2010-07-20 | 2010-12-15 | 深圳市海滨制药有限公司 | 美罗培南三水合物结晶的制备方法 |
CN102267997A (zh) * | 2011-07-15 | 2011-12-07 | 海南美兰史克制药有限公司 | 一种美罗培南化合物及其制法 |
CN102336757A (zh) * | 2011-08-02 | 2012-02-01 | 天津市嵩锐医药科技有限公司 | 一种稳定晶型的美罗培南化合物 |
WO2012160576A2 (en) * | 2011-05-26 | 2012-11-29 | Sequent Anti Biotics Private Limited | A process for preparation of meropenem |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102977102A (zh) * | 2012-12-21 | 2013-03-20 | 卫宏远 | 美罗培南三水合物晶体的制备方法 |
-
2012
- 2012-12-21 CN CN2012105620745A patent/CN102977102A/zh active Pending
-
2013
- 2013-12-20 WO PCT/CN2013/090169 patent/WO2014094659A1/zh active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101914098A (zh) * | 2010-07-20 | 2010-12-15 | 深圳市海滨制药有限公司 | 美罗培南三水合物结晶的制备方法 |
WO2012160576A2 (en) * | 2011-05-26 | 2012-11-29 | Sequent Anti Biotics Private Limited | A process for preparation of meropenem |
CN102267997A (zh) * | 2011-07-15 | 2011-12-07 | 海南美兰史克制药有限公司 | 一种美罗培南化合物及其制法 |
CN102336757A (zh) * | 2011-08-02 | 2012-02-01 | 天津市嵩锐医药科技有限公司 | 一种稳定晶型的美罗培南化合物 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014094659A1 (zh) * | 2012-12-21 | 2014-06-26 | 浙江海正药业股份有限公司 | 一种美罗培南三水合物晶体的制备方法 |
CN107459520A (zh) * | 2016-06-02 | 2017-12-12 | 重庆圣华曦药业股份有限公司 | 一种新的高纯度美罗培南三水合物制备方法 |
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Publication number | Publication date |
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WO2014094659A1 (zh) | 2014-06-26 |
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Owner name: HAIZHENG MEDICINE CO., LTD., ZHEJIANG PROV. Free format text: FORMER OWNER: WEI HONGYUAN Effective date: 20130913 Owner name: WEI HONGYUAN Effective date: 20130913 |
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Free format text: CORRECT: ADDRESS; FROM: 300192 NANKAI, TIANJIN TO: 318000 TAIZHOU, ZHEJIANG PROVINCE |
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TA01 | Transfer of patent application right |
Effective date of registration: 20130913 Address after: Jiaojiang District of Taizhou City, Zhejiang province 318000 road outside No. 46 Applicant after: Zhejiang Hisun Pharmaceutical Co., Ltd. Applicant after: Wei Hongyuan Address before: 300192 Tianjin City, Nankai District Anshan West Road trade era Residence Internazionale room 1703 Applicant before: Wei Hongyuan |
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