CN102975948A - Polytrifluorochloroethylene blister packaging film - Google Patents
Polytrifluorochloroethylene blister packaging film Download PDFInfo
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- CN102975948A CN102975948A CN2012105666984A CN201210566698A CN102975948A CN 102975948 A CN102975948 A CN 102975948A CN 2012105666984 A CN2012105666984 A CN 2012105666984A CN 201210566698 A CN201210566698 A CN 201210566698A CN 102975948 A CN102975948 A CN 102975948A
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- polychlorotrifluoroethylene
- blister package
- package film
- bubble
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Abstract
The invention discloses a polytrifluorochloroethylene blister packaging film, which comprises a blister cover film (1) and a blister bottom film (2), wherein the blister cover film (1) has a multi-layer structure and comprises a resin layer (7) and a blocking layer (5); the resin layer (7) is made from an ethylene acrylic acid modified polyethylene material; the blocking layer (5) is made of a metal foil material and bonded together with the resin layer (7) through a first bonding layer (6); the blister bottom film (2) has a multi-layer structure and comprises a fluorine polymer layer (3) and a supporting layer (1); the fluorine polymer layer (3) is adjacent to the blocking layer (5); the supporting layer (1) is bonded together with the fluorine polymer layer (3) through a second bonding layer (2); the supporting layer (1) is positioned on the bottom surface of a blister; the resin layer (7) is positioned on the top surface of the blister; the blocking layer (5) is bonded to the fluorine polymer layer (3) through a third bonding layer (4); the third bonding layer (4) is a hollow structure; and the blocking layer (5) and the fluorine polymer layer (3) after being bonded with each other form a hollow space (8) for placing drugs.
Description
Technical field
The present invention relates to a kind of blister package film of polychlorotrifluoroethylene, the medicine packing bubble-cap that particularly higher, the moistureproof barrier property of a kind of safety is stronger.
Background technology
Fluoropolymer film is widely used in the medical packaging field because it has good stability.In the existing Blister Package field, relatively poor because of fluoropolymer polymer and other polymer bonding, even there is intermediate adhesion layer also like this, thereby restricted the structure of bubble-cap.Business-like fluoropolymer polymer kind is a lot of at present, and wherein polychlorotrifluoroethylene (PCTFE) enjoys favor because moisture resistance is splendid.In the typical blister configuration, PCTFE is normal to be compounded to form medicine bubble-cap counterdie with polyvinylchloride (PVC), and wherein the aluminium foil of PVC face and medicine bubble-cap epiphragma finally forms blister container by bonding way, for the placement medicine.The bubble-cap that forms like this, the PVC face will directly contact medicine, and contain vinyl chloride monomer among the PVC, vinyl chloride monomer is unfavorable for health, secondly, PVC need add plasticizer in process of production, and wherein phthalate is one of common plasticizers, it is a kind of objectionable impurities, can cause Development of Reproductive System bad etc.
In addition, the medicine bubble-cap is 200～300 μ m with PVC thickness, and its water vapor barrier property is far smaller than the PCTFE film, and steam can slowly infiltrate blister package inside by the PVC film edge that exposes in the external environment, and then the whole water vapor barrier property of bubble-cap is descended.
Up to now, prior art also fails to address the above problem.And causing degradation problem under the bubble-cap barrier for drug safety deficiency, the infiltration of steam side, the exploitation of new structure bubble-cap is with necessary.
Summary of the invention
For overcoming deficiency of the prior art, the present invention will be by changing blister configuration, introducing drug safety and water vapor barrier property that moisture barrier material improves bubble-cap.
The invention provides a kind of blister package film of polychlorotrifluoroethylene, comprising: 1) bubble-cap epiphragma, formed by multiple-structure, comprise, resin bed 7 is the ethylene acrylic modified polyethylene material; Barrier layer 5 adopts metal foil material, bonds together by the first adhesive linkage 6 with described resin bed; 2) the bubble-cap counterdie is comprised of multiple-structure, comprise, fluoroplymer layer 3 is adjacent with described barrier layer 5; Supporting layer 1 bonds together by the second adhesive linkage 2 with described fluoroplymer layer 3; Wherein, described supporting layer 1 is positioned at described bubble-cap bottom surface, described resin bed 7 is positioned at the end face of described bubble-cap, described barrier layer 5 bonds on the described fluoroplymer layer 3 by the 3rd adhesive linkage 4, described the 3rd adhesive linkage 4 is hollow structure, and bonding rear described barrier layer 5 forms a hollow space 8 with described fluoropolymer polymer and is used for placing medicine.
Preferably, the blister package film of described a kind of polychlorotrifluoroethylene, ethene and ethylene acrylic proportioning are 50-100:0-50 in the wherein said ethylene acrylic modified polyethylene material.
Preferably, the blister package film of described a kind of polychlorotrifluoroethylene, wherein said ethylene acrylic modified polyethylene material are to make by ethene and acetate acrylic resin blending extrusion or blend blowing.
Preferably, the blister package film of described a kind of polychlorotrifluoroethylene, wherein said barrier layer 5 usefulness metal foil materials are aluminium foil, its thickness is 15～30 μ m.
Preferably, the blister package film of described a kind of polychlorotrifluoroethylene, wherein said fluoroplymer layer 3 is comprised of polychlorotrifluoroehomopolymer homopolymer or copolymer.
Preferably, the blister package film of described a kind of polychlorotrifluoroethylene, wherein said supporting layer 1 material is polyvinylchloride.
Preferably, the blister package film of described a kind of polychlorotrifluoroethylene, wherein said the first tack coat material therefor is polyacrylic resin.
Preferably, the blister package film of described a kind of polychlorotrifluoroethylene, wherein said the second tack coat is polyurethane.
Preferably, the blister package film of described a kind of polychlorotrifluoroethylene, wherein the 3rd tack coat comprises 3) and 4) blend, wherein: 3) a kind ofly be selected from the following olefin polymer that contains: at least a functionalised polyolefin, at least a by ethene be selected from the copolymer that at least a comonomer of acrylic acid, alkyl acrylic, acrylate and alkyl acrylate consists of, and their blend; And 4) styrene-ethylene-butylene-styrene block copolymer.
The blister package film of a kind of polychlorotrifluoroethylene disclosed by the invention directly contacts fluoroplymer layer 3, barrier layer 5 with medicine by design, and described blister medication package security is significantly improved; Adopt the ethylene acrylic modified polyethylene material then further to improve the whole water vapor barrier property of bubble-cap as barrier layer 5.
Above-mentioned explanation only is the general introduction of technical solution of the present invention, for can clearer understanding skill of the present invention
The art means, and can be implemented according to the content of specification sheets, below will enumerate specific embodiments of the invention and cooperate accompanying drawing to be elaborated.
Description of drawings
Fig. 1 is that medicine of the present invention is packed with scheme drawing behind the bubble-cap involution;
Fig. 2 is the medicine packing of the present invention front scheme drawing of bubble-cap involution.
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing, can implement according to this with reference to the specification sheets literal to make those skilled in the art.
Embodiment 1:
Referring to Fig. 1, shown in Figure 2, a kind of blister package film of polychlorotrifluoroethylene comprises: 1) bubble-cap epiphragma, formed by multiple-structure, and comprise, resin bed 7 is the ethylene acrylic modified polyethylene material; Barrier layer 5 adopts metal foil material, bonds together by the first adhesive linkage 6 with described resin bed; 2) the bubble-cap counterdie is comprised of multiple-structure, comprise, fluoroplymer layer 3 is adjacent with described barrier layer 5; Supporting layer 1 bonds together by the second adhesive linkage 2 with described fluoroplymer layer 3; Wherein, described supporting layer 1 is positioned at described bubble-cap bottom surface, described resin bed 7 is positioned at the end face of described bubble-cap, described barrier layer 5 bonds on the described fluoroplymer layer 3 by the 3rd adhesive linkage 4, described the 3rd adhesive linkage 4 is hollow structure, and bonding rear described barrier layer 5 forms a hollow space 8 with described fluoropolymer polymer and is used for placing medicine.Ethene and ethylene acrylic proportioning are 50:50 in the wherein said ethylene acrylic modified polyethylene material.Described ethylene acrylic modified polyethylene material is to make by ethene and acetate acrylic resin blend blowing.Described barrier layer 5 usefulness metal foil materials are aluminium foil, and its thickness is 20 μ m.Described fluoroplymer layer 3 is comprised of polychlorotrifluoroehomopolymer homopolymer.Described supporting layer 1 material is polyvinylchloride.Described the first tack coat material therefor is polyacrylic resin.Described the second tack coat is polyurethane.The 3rd tack coat comprises the blend of (1) and (2), wherein: (1) ethylene acrylic acid co polymer; (2) styrene-ethylene-butylene-styrene block copolymer.Sealing strength 〉=8N/15mm after the described bubble-cap moulding.Described moulding bubble-cap vapor transfer rate＜2g/ (m
224h).
Embodiment 2:
Referring to shown in Figure 1, a kind of blister package film of polychlorotrifluoroethylene comprises: 1) bubble-cap epiphragma,
Be comprised of multiple-structure, comprise, resin bed 7 is the ethylene acrylic modified polyethylene material; Barrier layer 5 adopts metal foil material, bonds together by the first adhesive linkage 6 with described resin bed; 2) the bubble-cap counterdie is comprised of multiple-structure, comprise, fluoroplymer layer 3 is adjacent with described barrier layer 5; Supporting layer 1 bonds together by the second adhesive linkage 2 with described fluoroplymer layer 3; Wherein, described supporting layer 1 is positioned at described bubble-cap bottom surface, described resin bed 7 is positioned at the end face of described bubble-cap, described barrier layer 5 bonds on the described fluoroplymer layer 3 by the 3rd adhesive linkage 4, described the 3rd adhesive linkage 4 is hollow structure, and bonding rear described barrier layer 5 forms a hollow space 8 with described fluoropolymer polymer and is used for placing medicine.Ethene and ethylene acrylic proportioning are 75:25 in the wherein said ethylene acrylic modified polyethylene material.Described ethylene acrylic modified polyethylene material is to make by ethene and the calendering of acetate acrylic resin blending extrusion.Described barrier layer 5 usefulness metal foil materials are aluminium foil, and its thickness is 15～30 μ m.Described fluoroplymer layer 3 is comprised of the polychlorotrifluoroethylene copolymer.Described supporting layer 1 material is polyvinylchloride.Described the first tack coat material therefor is polyacrylic resin.Described the second tack coat is polyurethane.The 3rd tack coat comprises 3) and 4) blend, wherein: 3) vinyl alkyl acrylic copolymer; 4) styrene-ethylene-butylene-styrene block copolymer.Described resin bed 7 sealing strengths 〉=8N/15mm.Described moulding bubble-cap vapor transfer rate＜2g/ (m
224h).
Medicine packing disclosed by the invention is used for placing medicine with the described hollow space 8 that fluoroplymer layer 3 described in the blister configuration and described barrier layer 5 form, because described fluoroplymer layer 3 used polychlorotrifluoroethylene copolymer stable chemical performance, thereby described blister medication package security is improved; Adopt the ethylene acrylic modified polyethylene material then to greatly reduce the vapor transfer rate of moulding bubble-cap as barrier layer 5.
Although embodiment of the present invention are open as above, but it is not restricted to listed utilization in specification sheets and the embodiment, it can be applied to various suitable the field of the invention fully, for those skilled in the art, can easily realize other modification, therefore do not deviating under the universal that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend of describing.
Claims (9)
1. the blister package film of a polychlorotrifluoroethylene is characterized in that, comprising:
1) the bubble-cap epiphragma is comprised of multiple-structure, comprise,
Resin bed (7) is the ethylene acrylic modified polyethylene material;
Barrier layer (5) adopts metal foil material, bonds together by the first adhesive linkage (6) with described resin bed;
2) the bubble-cap counterdie is comprised of multiple-structure, comprise,
Fluoroplymer layer (3) is adjacent with described barrier layer (5);
Supporting layer (1) bonds together by the second adhesive linkage (2) with described fluoroplymer layer (3);
Wherein, described supporting layer (1) is positioned at described bubble-cap bottom surface, described resin bed (7) is positioned at the end face of described bubble-cap, described barrier layer (5) bonds on the described fluoroplymer layer (3) by the 3rd adhesive linkage (4), described the 3rd adhesive linkage (4) is hollow structure, and bonding rear described barrier layer (5) forms a hollow space (8) with described fluoroplymer layer (3) and is used for placing medicine.
2. the blister package film of a kind of polychlorotrifluoroethylene according to claim 1 is characterized in that, ethene and ethylene acrylic proportioning are 50-100:0-50 in the wherein said ethylene acrylic modified polyethylene material.
3. the blister package film of a kind of polychlorotrifluoroethylene according to claim 2 is characterized in that, wherein said ethylene acrylic modified polyethylene material is to make by ethene and acetate acrylic resin blending extrusion or blend blowing.
4. the blister package film of a kind of polychlorotrifluoroethylene according to claim 1 is characterized in that, wherein said barrier layer (5) is aluminium foil with metal foil material, and its thickness is 15～30 μ m.
5. the blister package film of a kind of polychlorotrifluoroethylene according to claim 1 is characterized in that, wherein said fluoroplymer layer (3) is comprised of polychlorotrifluoroehomopolymer homopolymer or copolymer.
6. the blister package film of a kind of polychlorotrifluoroethylene according to claim 1 is characterized in that, wherein said supporting layer (1) material is polyvinylchloride.
7. the blister package film of a kind of polychlorotrifluoroethylene according to claim 1 is characterized in that, wherein said the first tack coat material therefor is polyacrylic resin.
8. the blister package film of a kind of polychlorotrifluoroethylene according to claim 1 is characterized in that, wherein said the second tack coat is polyurethane.
9. the blister package film of a kind of polychlorotrifluoroethylene according to claim 1, it is characterized in that, wherein the 3rd tack coat comprises 3) and 4) blend, wherein: 3) a kind ofly be selected from the following olefin polymer that contains: at least a functionalised polyolefin, at least a by ethene be selected from the copolymer that at least a comonomer of acrylic acid, alkyl acrylic, acrylate and alkyl acrylate consists of, and their blend; And 4) styrene-ethylene-butylene-styrene block copolymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210566698.4A CN102975948B (en) | 2012-12-24 | 2012-12-24 | Polytrifluorochloroethylene blister packaging film |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210566698.4A CN102975948B (en) | 2012-12-24 | 2012-12-24 | Polytrifluorochloroethylene blister packaging film |
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| CN102975948A true CN102975948A (en) | 2013-03-20 |
| CN102975948B CN102975948B (en) | 2015-04-29 |
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| CN201210566698.4A Active CN102975948B (en) | 2012-12-24 | 2012-12-24 | Polytrifluorochloroethylene blister packaging film |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105189110A (en) * | 2013-05-06 | 2015-12-23 | 爱克发-格法特公司 | Novel blister pack for pharmaceuticals |
| CN106189916A (en) * | 2016-07-08 | 2016-12-07 | 姚华鹏 | Long-acting damp-proof blister packaging materials |
| WO2018205748A1 (en) * | 2017-05-08 | 2018-11-15 | 霍尼韦尔国际公司 | Composite film, and packaging article |
| CN112874067A (en) * | 2021-01-11 | 2021-06-01 | 安徽和美瑞医用包装材料有限公司 | Medical blister film suitable for bubble cap of packing |
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| US4595613A (en) * | 1983-12-30 | 1986-06-17 | Colgate-Palmolive Company | Laminated fluoropolymer containing substrate and collapsible dispensing container |
| EP0598822B1 (en) * | 1991-08-12 | 1997-10-08 | AlliedSignal Inc. | Multilayer film constructions |
| CN1662372A (en) * | 2002-04-25 | 2005-08-31 | 霍尼韦尔国际公司 | Blister package |
| CN101291807A (en) * | 2005-10-18 | 2008-10-22 | 艾尔坎技术及管理有限公司 | Cold-workable laminate for blister bottom parts |
| CN101508369A (en) * | 2008-02-15 | 2009-08-19 | 艾尔坎技术及管理有限公司 | Cold-forming laminated material for bubble-cap basis parts |
| CN101624111A (en) * | 2008-07-08 | 2010-01-13 | 上海海顺包装材料有限公司 | Open-type aluminum-plastic bubble cap packaging coverage film |
| CN102202986A (en) * | 2008-11-06 | 2011-09-28 | 克勒克纳彭塔普拉斯特有限及两合公司 | Multi-layer film |
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2012
- 2012-12-24 CN CN201210566698.4A patent/CN102975948B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595613A (en) * | 1983-12-30 | 1986-06-17 | Colgate-Palmolive Company | Laminated fluoropolymer containing substrate and collapsible dispensing container |
| EP0598822B1 (en) * | 1991-08-12 | 1997-10-08 | AlliedSignal Inc. | Multilayer film constructions |
| CN1662372A (en) * | 2002-04-25 | 2005-08-31 | 霍尼韦尔国际公司 | Blister package |
| CN101291807A (en) * | 2005-10-18 | 2008-10-22 | 艾尔坎技术及管理有限公司 | Cold-workable laminate for blister bottom parts |
| CN101508369A (en) * | 2008-02-15 | 2009-08-19 | 艾尔坎技术及管理有限公司 | Cold-forming laminated material for bubble-cap basis parts |
| CN101624111A (en) * | 2008-07-08 | 2010-01-13 | 上海海顺包装材料有限公司 | Open-type aluminum-plastic bubble cap packaging coverage film |
| CN102202986A (en) * | 2008-11-06 | 2011-09-28 | 克勒克纳彭塔普拉斯特有限及两合公司 | Multi-layer film |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105189110A (en) * | 2013-05-06 | 2015-12-23 | 爱克发-格法特公司 | Novel blister pack for pharmaceuticals |
| CN106189916A (en) * | 2016-07-08 | 2016-12-07 | 姚华鹏 | Long-acting damp-proof blister packaging materials |
| WO2018205748A1 (en) * | 2017-05-08 | 2018-11-15 | 霍尼韦尔国际公司 | Composite film, and packaging article |
| CN112874067A (en) * | 2021-01-11 | 2021-06-01 | 安徽和美瑞医用包装材料有限公司 | Medical blister film suitable for bubble cap of packing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102975948B (en) | 2015-04-29 |
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Owner name: SHANGHAI HAISHUN NEW MEDICINAL PACKING MATERIALS C Effective date: 20150312 |
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Effective date of registration: 20150312 Address after: 215211 Wujiang City, Suzhou province Fen town to show Road No. 8 Applicant after: Suzhou Haishun Packaging Material Co., Ltd. Applicant after: Shanghai Haishun New Pharmaceutical Packaging Co., Ltd. Address before: 215211 Wujiang City, Suzhou province Fen town to show Road No. 8 Applicant before: Suzhou Haishun Packaging Material Co., Ltd. |
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