JP2716514B2 - Laminate - Google Patents
LaminateInfo
- Publication number
- JP2716514B2 JP2716514B2 JP1078355A JP7835589A JP2716514B2 JP 2716514 B2 JP2716514 B2 JP 2716514B2 JP 1078355 A JP1078355 A JP 1078355A JP 7835589 A JP7835589 A JP 7835589A JP 2716514 B2 JP2716514 B2 JP 2716514B2
- Authority
- JP
- Japan
- Prior art keywords
- layer
- gas barrier
- laminate
- heat
- barrier properties
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Laminated Bodies (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は柔軟性、ガス遮断性に優れ、且つ、加熱殺菌
処理に耐え得る耐熱性及び耐白化性さらに加熱殺菌処理
後もガスバリア性の低下が起こらない高ガスバリア性輸
液バッグ用の積層体に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention is excellent in flexibility and gas barrier properties, and has heat resistance and whitening resistance enough to withstand heat sterilization, and a decrease in gas barrier properties even after heat sterilization. The present invention relates to a laminate for a high-gas-barrier infusion bag, which does not cause the problem.
食品や医薬品の変質、腐敗の原因となる微生物を完全
に死滅、除去するために従来からレトルト加熱殺菌処理
やオートクレーブ加熱殺菌処理が行なわれている。この
用途に使用される包装材料はガラス又はAl箔を主構成と
する多層フィルムである。しかしAl箔は不透明であり、
加熱処理後の内容物の変化を検査することができなかっ
た。又柔軟性があり、耐熱性や透明性に優れた材料とし
て軟質塩化ビニルが従来輸液バッグに使用されている
が、あくまで常温使用であり、オートクレーブ加熱殺菌
処理を施した場合、可塑剤その他の添加物溶出及び耐白
化性に問題があり、使用に耐える材料は得られていな
い。さらに、ポリプロピレン系材料も種々検討されてい
るが、柔軟性、耐熱性、耐白化性の点で充分満足できる
ものはなかった。医療機関では患者への点滴の際直前に
アミノ酸やビタミン剤などを添加調合するが勤務体制の
合理化等により調合済み点滴剤をメーカー側に要望する
声も強くなっている。その場合は輸液バッグにはガスバ
リア性が必要となる。Conventionally, retort heat sterilization and autoclave heat sterilization have been performed in order to completely kill and remove microorganisms that cause deterioration and spoilage of foods and pharmaceuticals. The packaging material used for this purpose is a multilayer film mainly composed of glass or Al foil. But Al foil is opaque,
The change in the contents after the heat treatment could not be inspected. In addition, soft vinyl chloride is conventionally used for infusion bags as a material that is flexible and has excellent heat resistance and transparency.However, it is only used at room temperature, and if it is subjected to autoclave heat sterilization, plasticizers and other additives are added. There is a problem in elution of substances and whitening resistance, and no material that can be used has been obtained. Further, various studies have been made on polypropylene-based materials, but none of them has been sufficiently satisfactory in terms of flexibility, heat resistance, and whitening resistance. At medical institutions, amino acids and vitamins are added immediately before infusion to patients, but due to streamlining of the work system, there is a growing demand for manufacturers to provide prepared infusions. In that case, the transfusion bag needs to have gas barrier properties.
先記の材料はガスバリア性に劣るため、その点におい
ても単体では満足に使用できるものではない。積層フィ
ルムでは、ポリエステルフィルムやポリプロピレンフィ
ルムとガスバリア性フィルムを組み合わせたものが市販
されているが、柔軟性が全くなく、輸液バッグには使用
不可能であった。Since the above-mentioned materials are inferior in gas barrier properties, they cannot be used satisfactorily alone. As the laminated film, a combination of a polyester film or a polypropylene film and a gas barrier film is commercially available, but has no flexibility and cannot be used for an infusion bag.
本発明は従来の耐熱包装材料では得られなかった柔軟
性に優れ且つガスバリア性、加熱殺菌処理に耐える耐熱
性及び耐白化性、さらに安定したガス遮断性を保持した
高ガスバリア性輸液バック用の包装材料を提供するにあ
る。The present invention provides a highly gas-barrier infusion bag package that has excellent flexibility and gas barrier properties, heat and whitening resistance to heat sterilization, and stable gas barrier properties, which were not obtained with conventional heat-resistant packaging materials. In providing materials.
本発明は、引張弾性率が500〜5000kg f/cm2及びVicat
軟化点が100℃以上である熱可塑性エラストマー層を最
外層とし、エチレンビニルアルコール共重合体層、ポリ
オレフィン系樹脂からなるシール層、さらに接着層で少
くとも構成されることを特徴とする積層体である。The present invention has a tensile modulus of 500 to 5000 kg f / cm 2 and Vicat.
A laminate characterized by having a thermoplastic elastomer layer having a softening point of 100 ° C or higher as an outermost layer, an ethylene-vinyl alcohol copolymer layer, a seal layer made of a polyolefin resin, and at least an adhesive layer. is there.
本発明において用いられる熱可塑性エラストマーは引
張弾性率が500〜5000kg f/cm2及びVicat軟化点が100℃
以上のものである。引張弾性率が500kg f/cm2以下では
柔軟すぎ、シート加工時のトラブルを引き起こす。一
方、5000kg f/cm2以上は輸液バッグに必要な柔軟性が損
われる。又Vicat軟化点が100℃以下のものはオートクレ
ーブ加熱滅菌処理時にバッグ同士が熱融着してしまう。The thermoplastic elastomer used in the present invention has a tensile modulus of 500 to 5000 kg f / cm 2 and a Vicat softening point of 100 ° C.
That's all. If the tensile modulus is less than 500 kg f / cm 2, it is too flexible, which causes trouble during sheet processing. On the other hand, if it is 5000 kg f / cm 2 or more, the flexibility required for an infusion bag is impaired. If the Vicat softening point is 100 ° C. or lower, the bags are heat-sealed during autoclave heat sterilization.
ポリオレフィン系樹脂は、ポリエチレン、ポリプロピ
レン、ポリブテンなどの単独重合体及びその共重合体さ
らにはポリオレフィン系樹脂が主成分である他の樹脂と
の混合組成物である。The polyolefin-based resin is a homopolymer such as polyethylene, polypropylene, and polybutene, a copolymer thereof, and a mixed composition with another resin whose main component is a polyolefin-based resin.
又、接着層は、共押出の場合は接着性樹脂であり、ド
ライラミネートでは接着剤により構成される。The adhesive layer is an adhesive resin in the case of co-extrusion, and is formed of an adhesive in the case of dry lamination.
第１図は本発明による積層体の１具体例の断面図であ
るが、１は最外層の熱可塑性エラストマー層であり、柔
軟性、耐熱性を保持し望ましくは優れた透明性と水蒸気
バリア性もあり、オートクレーブ加熱滅菌処理時にはバ
ッグ同士の熱融着を防止し、さらに水蒸気の侵入を防ぐ
ことにより、ガスバリア性の低下や白化現象を起こさな
い。FIG. 1 is a cross-sectional view of one specific example of a laminate according to the present invention, where 1 is an outermost thermoplastic elastomer layer, which retains flexibility and heat resistance and preferably has excellent transparency and water vapor barrier properties. During the heat sterilization treatment in an autoclave, heat fusion between the bags is prevented, and furthermore, the invasion of water vapor is prevented, so that the gas barrier property does not deteriorate and the whitening phenomenon does not occur.
２はガスバリア層であるエチレンビニルアルコール共
重合体層であり、ポリ塩化ビニリデン系樹脂は、オート
クレーブ加熱滅菌処理時に侵入する水蒸気によりガスバ
リア性の低下が、エチレンビニルアルコール共重合体に
比べて少ないが、押出加工性を改良するために添加する
安定剤等によりバリア性はエチレンビニルアルコール共
重合体に比べ大巾に劣るため、長期の保存性を付与する
ためにはエチレンビニルアルコール共重合体にする必要
がある。2 is an ethylene vinyl alcohol copolymer layer which is a gas barrier layer, and the polyvinylidene chloride-based resin has a lower gas barrier property due to water vapor entering during the autoclave heat sterilization treatment, but is smaller than the ethylene vinyl alcohol copolymer. Barrier properties are greatly inferior to ethylene vinyl alcohol copolymer due to stabilizers added to improve extrudability, so ethylene vinyl alcohol copolymer must be used to provide long-term storage stability There is.
３はシール層でシール性に優れているオレフィン系樹
脂で、４、４′は各層を接着するための接着層である。Reference numeral 3 denotes an olefin resin which is a sealing layer having excellent sealing properties, and reference numerals 4 and 4 'denote bonding layers for bonding the respective layers.
下記の材料を使用し、表−１の様な構成で積層体を作
り高ガスバリア性輸液バッグとしての特性を測定した。
本発明の効果をより明確とするために比較例も示す。The following materials were used to form a laminate with the configuration shown in Table 1, and the characteristics as a high gas barrier infusion bag were measured.
Comparative examples are also shown to clarify the effects of the present invention.
〔発明の効果〕 本発明の積層体を使用することにより、従来では得ら
れなかった優れた耐熱性、柔軟性を保持し、透明性、ガ
スバリア性にも優れた高ガスバリア性輸液バッグが可能
となり医療分野に大きく貢献し得るものである。 [Effects of the Invention] By using the laminate of the present invention, a high gas barrier infusion bag having excellent heat resistance and flexibility, which has not been obtained conventionally, and having excellent transparency and gas barrier properties can be obtained. It can greatly contribute to the medical field.
第１図は本発明による積層体の１実施例の断面図であ
る。FIG. 1 is a sectional view of one embodiment of a laminate according to the present invention.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 // Ａ６１Ｊ 1/10 Ａ６１Ｊ 1/00 ３３１Ｃ ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 6 Identification code Agency reference number FI Technical indication // A61J 1/10 A61J 1/00 331C
Claims (1)
軟化点が100℃以上である熱可塑性エラストマー層を最
外層とし、エチレンビニルアルコール共重合体層、ポリ
オレフィン系樹脂からなるシール層、さらに接着層で少
くとも構成されることを特徴とする積層体。(1) a tensile modulus of 500 to 5000 kg f / cm 2 and Vicat
A laminate comprising, as an outermost layer, a thermoplastic elastomer layer having a softening point of 100 ° C. or higher, and at least an ethylene vinyl alcohol copolymer layer, a seal layer made of a polyolefin resin, and an adhesive layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1078355A JP2716514B2 (en) | 1989-03-31 | 1989-03-31 | Laminate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1078355A JP2716514B2 (en) | 1989-03-31 | 1989-03-31 | Laminate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02258339A JPH02258339A (en) | 1990-10-19 |
| JP2716514B2 true JP2716514B2 (en) | 1998-02-18 |
Family
ID=13659684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1078355A Expired - Fee Related JP2716514B2 (en) | 1989-03-31 | 1989-03-31 | Laminate |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2716514B2 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3297889B2 (en) * | 1993-08-30 | 2002-07-02 | 藤森工業株式会社 | Laminated packaging material |
| JP3297891B2 (en) * | 1993-11-10 | 2002-07-02 | 藤森工業株式会社 | Laminated packaging material |
| JP3397409B2 (en) * | 1993-12-22 | 2003-04-14 | 株式会社フジシール | Packaging bag for chemical solution filling bag, method for producing the same, and package |
| AU691261B2 (en) * | 1994-03-15 | 1998-05-14 | Otsuka Pharmaceutical Factory, Inc. | Contamination-proof sealant film and product fabricated therefrom |
| JPH08217942A (en) * | 1995-02-09 | 1996-08-27 | Kureha Chem Ind Co Ltd | Raw material composition for oxygen-gas barrier laminate and laminate produced therefrom |
| US6271351B1 (en) * | 1995-03-23 | 2001-08-07 | Biopure Corporation | Method for preserving a hemoglobin blood substitute |
| JP2005304911A (en) * | 2004-04-23 | 2005-11-04 | Inter Medic Kk | Multi cell container for medical care and its manufacturing method |
| WO2006118034A1 (en) * | 2005-04-28 | 2006-11-09 | Otsuka Pharmaceutical Factory, Inc. | Housing body for medical liquid container and process for producing the same |
| DK2080501T3 (en) | 2006-10-27 | 2015-08-03 | Otsuka Pharma Co Ltd | Package containing drug solution with reduced dissolved oxygen content |
| CN105270739A (en) * | 2014-07-25 | 2016-01-27 | 张建华 | Repackage antibacterial film |
| JP6898478B2 (en) * | 2014-12-25 | 2021-07-07 | エイワイファーマ株式会社 | Infusion container and its manufacturing method |
| CN107199734A (en) * | 2017-06-06 | 2017-09-26 | 石家庄鹏海制药股份有限公司 | The production technology of big soft infusion bag |
-
1989
- 1989-03-31 JP JP1078355A patent/JP2716514B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02258339A (en) | 1990-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20071107 Year of fee payment: 10 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20081107 Year of fee payment: 11 |
|
| LAPS | Cancellation because of no payment of annual fees |