CN1029729C - Injection for internal hemorrhoid - Google Patents
Injection for internal hemorrhoid Download PDFInfo
- Publication number
- CN1029729C CN1029729C CN 93106092 CN93106092A CN1029729C CN 1029729 C CN1029729 C CN 1029729C CN 93106092 CN93106092 CN 93106092 CN 93106092 A CN93106092 A CN 93106092A CN 1029729 C CN1029729 C CN 1029729C
- Authority
- CN
- China
- Prior art keywords
- grams
- injection
- present
- milliliters
- chlorobutanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to an injection for treating internal hemorrhoids, which is formed by mixing six kinds of substances, namely, alum, sodium citrate, chlorobutanol, procaine hydrochloride, glycerol and distilled water. The present invention has the advantages of simple preparing technology, no need of extracting tannic acid from Chinese gall of traditional Chinese medicine and wide sources of raw materials, and is suitable for industrialized production. When the present invention is injected, other medicine does not need to be additional matched, and the present invention can be directly injected with a good treatment effect and a small side effect.
Description
The present invention relates to treat the injection of internal hemorrhoid.
State's internal therapy internal hemorrhoid extensively adopts " xiaozhiling injection " that Beijing the 4th pharmaceutical factory produces at present, and therapeutic effect is no doubt fine.The Hunan Province association of traditional Chinese medicine causes side effect such as massive hemorrhage, hemorrhoid necrosis and perianal abscess after congratulating and holding luxuriant report " xiaozhiling injection " injection according to " whole nation is the academic meeting material of anorectal for the third time ".To be made into the injection of 2: 1 or 1: 1 when using " xiaozhiling injection " with procaine hydrochloride, inconvenience during use.Also have from the Chinese medicine Galla Chinensis and extract tannic acid technology.
The objective of the invention is provides a kind of technology simple, easy to use to the public, and therapeutic effect is good, the injection that side effect is little.
The present invention is mixed by the solution of following six kinds of materials:
1. Alumen (aluminium potassium sulfate) KAL(SO
4)
212H
2O ALUMEN
2. sodium citrate C
6H
5Na
3O
72H
2O NaTRIICITRAS
3. chlorobutanol C
4H
7Cl
3O 1/2 H
2O CHLOROBU
TANOLUM
4. procaine hydrochloride C
13H
20N
2O
2HCl PROCAINI HYDROCHLORIDI
5. glycerol CH
2(OH) CH CH(OH)
2OH GLYCERINUM
6. distilled water H
2O STERILIS
Containing the above-mentioned substance deal in per 1000 milliliters injection is respectively:
1. Alumen: 22 grams are to 26 grams,
2. sodium citrate: 8 grams are to 10 grams,
3. chlorobutanol: 3 grams are to 5 grams,
4. procaine hydrochloride: 5 grams are preferably 7.5 grams to 7.5.
5. glycerol: 60 milliliters, be preferably 60 milliliters.
6. distilled water: surplus is a distilled water.
Preparation method of the present invention is: chlorobutanol is dissolved in the glycerol, is heated to 50 degree Celsius to 100 degree at water-bath, chlorobutanol is dissolved fully; Alumen, sodium citrate, procaine hydrochloride are dissolved in 500 milliliters of the distilled water.Two kinds of solution mixing are poured in the graduated container.Adding distil water makes solution to 1000 milliliter.With sodium hydroxide acid adjustment basicity (pH value) to 3.Cross sintered glass filter (Tianjin Injector Factory's product).Again by microporous filter membrane (Red Star chemical plant, Haining, Zhejiang Province county product).Per 10 milliliters are sub-packed in the ampoule bottle.Flowing steam 100 sterilization 30 minutes.The transparent free from admixture of lamp inspection is promptly available.
Advantage of the present invention: reparation technology is simple, does not extract tannic acid from Galla Chinensis.Raw material sources are extensive, are suitable for suitability for industrialized production.The thing that need not make up a prescription in addition during injection can directly be used for injection, good effect, and side effect is little, as following table:
Post-operative complication
Title example number remarks
Downright bad massive hemorrhage abscess anal stenosis anal fistula
Postoperative 3-14
Xiaozhiling injection did not wait out in 10,395 3,366 42 15 20 days
Blood volume 300-
13,036 228 0101 1500 milliliters of the present invention
Embodiment 1: gets 60 milliliters of glycerol, chlorobutanol 3 grams put in the glycerol, and in water-bath 80 degree heating for dissolving Celsius, with Alumen 24 grams, sodium citrate 9 grams, procaine hydrochloride 7.5 grams are dissolved in 500 ml distilled waters.Two kinds of solution are poured in the graduated cylinder, and adding distil water makes solution to 1000 milliliter.The solution pH value is transferred to 3.Solution is crossed sintered glass filter, after microporous filter membrane.10 milliliters of per ampoules are through flowing steam 100 sterilization 30 minutes, the transparent free from admixture of lamp inspection.It promptly is injection.
Embodiment 2: get chlorobutanol 4 grams, put into 60 ml containers are housed, 50 degree heating Celsius are dissolved chlorobutanol fully in water-bath; Get Alumen 22 grams, sodium citrate 8 grams, procaine hydrochloride 5 grams are dissolved in 500 ml distilled waters.Two kinds of solution groups are poured in the graduated graduated cylinder adding distil water to 1000 milliliter.Transfer pH value to 3.Solution is crossed sintered glass filter, after microporous filter membrane, and 10 milliliters of packing per ampoules.The flowing steam 100 was sterilized 30 minutes down, and lamp inspection liquid-transparent free from admixture promptly is an injection.
Embodiment 3: get chlorobutanol 5 grams, be dissolved in the container that 60 milliliters of glycerol are housed, the 100 heating is dissolved chlorobutanol fully in water-bath; Get Alumen 26 grams, sodium citrate 10 grams, procaine hydrochloride 6 grams are dissolved in 500 ml containers.Two kinds of solution are mixed, pour in the graduated container, adding distil water to 1000 milliliter.Transfer pH value to 3.Solution is crossed sintered glass filter, after microporous filter membrane, and the 10 milliliters of ampoules of packing into, sterilization is 30 minutes under the flowing steam 100, and lamp inspection liquid-transparent free from admixture gets final product.
Claims (2)
1, the injection of treatment internal hemorrhoid is characterized in that per 1000 milliliters of solution by following six kinds of materials mix:
A. Alumen (aluminium potassium sulfate) KAL (SO
4)
212H
2O 22 grams are to 26 grams
B. sodium citrate C
6H
5Na
3O
72H
2O 8 grams are to 10 grams
C. chlorobutanol C
4H
7Cl
3O 1/2 H
2O 3 grams are to 5 grams
D. procaine hydrochloride C
13H
2ON
2O
2HCl 5 grams are to 7.5 grams
E. glycerol CH
2(OH) CH (OH) CH
260 milliliters of OH
F. surplus is distilled water H
2O
2, according to the injection of the described treatment internal hemorrhoid of claim 1., it is characterized in that each component optimum amount is: the solution by following substances in per 1000 milliliters mixes,
A. Alumen (aluminium potassium sulfate) KAL(SO
4)
212H
2O 24 grams
B. sodium citrate C
6H
5Na
3O
72H
2O 9 grams
C. chlorobutanol C
4H
7Cl
3O 1/2 H
2O 3 grams
D. procaine hydrochloride C
13H
20N
2O
2HCl 7.5 grams
E. glycerol CH
2(OH) CH CH(OH)
260 milliliters of OH
F. surplus is distilled water H
2O
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93106092 CN1029729C (en) | 1993-05-18 | 1993-05-18 | Injection for internal hemorrhoid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93106092 CN1029729C (en) | 1993-05-18 | 1993-05-18 | Injection for internal hemorrhoid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1081880A CN1081880A (en) | 1994-02-16 |
| CN1029729C true CN1029729C (en) | 1995-09-13 |
Family
ID=4986070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93106092 Expired - Fee Related CN1029729C (en) | 1993-05-18 | 1993-05-18 | Injection for internal hemorrhoid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1029729C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008506A (en) * | 2010-11-29 | 2011-04-13 | 王其军 | Formula of injection for convergence and hemostasis of internal hemorrhoid hemorrhage and preparation method thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2303832T3 (en) * | 2000-06-06 | 2008-09-01 | Lequio Pharma Co., Ltd. | MEDICAL COMPOSITION KIT TO TREAT INJURED ABNORMAL FABRIC. |
| CN110151781A (en) * | 2019-05-05 | 2019-08-23 | 张广田 | A kind of medical fluid and preparation method thereof for treating hemorrhoid |
-
1993
- 1993-05-18 CN CN 93106092 patent/CN1029729C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008506A (en) * | 2010-11-29 | 2011-04-13 | 王其军 | Formula of injection for convergence and hemostasis of internal hemorrhoid hemorrhage and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1081880A (en) | 1994-02-16 |
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|---|---|---|---|
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |