CN1178669C - Injection for treating pile and fistula and its preparing process - Google Patents
Injection for treating pile and fistula and its preparing process Download PDFInfo
- Publication number
- CN1178669C CN1178669C CNB021093245A CN02109324A CN1178669C CN 1178669 C CN1178669 C CN 1178669C CN B021093245 A CNB021093245 A CN B021093245A CN 02109324 A CN02109324 A CN 02109324A CN 1178669 C CN1178669 C CN 1178669C
- Authority
- CN
- China
- Prior art keywords
- grams
- milliliters
- injection
- alcoholic solution
- sodium sulfide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002347 injection Methods 0.000 title claims abstract description 28
- 239000007924 injection Substances 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title abstract description 7
- 206010016717 Fistula Diseases 0.000 title abstract 4
- 230000003890 fistula Effects 0.000 title abstract 4
- 239000000243 solution Substances 0.000 claims abstract description 41
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 208000014617 hemorrhoid Diseases 0.000 claims abstract description 23
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229910052979 sodium sulfide Inorganic materials 0.000 claims abstract description 19
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000006184 cosolvent Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000008215 water for injection Substances 0.000 claims abstract description 11
- 230000001476 alcoholic effect Effects 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 24
- 208000004680 Rectal Fistula Diseases 0.000 claims description 20
- 206010002156 anal fistula Diseases 0.000 claims description 20
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000003643 water by type Substances 0.000 claims 1
- 230000036407 pain Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000000857 drug effect Effects 0.000 abstract description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 3
- 229940041616 menthol Drugs 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- 239000003814 drug Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000010923 batch production Methods 0.000 description 3
- 238000011031 large-scale manufacturing process Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 208000020154 Acnes Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to an injection for treating hemorrhoids and fistula and a preparing method thereof. The injection for treating hemorrhoids and fistula has the advantages of good drug effect, capability of reducing pain, easier clinical acceptance by patients and easy industrialized mass production. The injection for treating hemorrhoids and fistula is composed of 30 to 120 grams of sodium sulfide, 5 to 50 grams of menthol, 30 to 150 milliliters of cosolvents, 2 to 100 grams of glycerol, 100 to 800 milliliters of ethanol and water for injection, which is added to 1000 milliliters. The preparing method comprises: the ethanol and the water for injection are prepared into ethanol solution; the 30 to 120 grams of sodium sulfide is dissolved in a proper amount of ethanol solution; the 2 to 100 grams of glycerol is then added and is stirred so that the glycerol is dissolved; a proper amount of ethanol solution and the 30 to 150 milliliters of cosolvents are taken, and the 5 to 50 grams of menthol is added so that the menthol is dissolved; the two kinds of solutions are mixed, and ethanol solution is added to 1000 milliliters; the solutions and the ethanol solution are stirred until the solutions are clear; a pH value and contents are measured, and the solutions are filtered and bottled after being qualified.
Description
Technical field
The present invention relates to a kind of injection liquid for the treatment of hemorrhoid complicated by anal fistula and preparation method thereof.
Background technology
The injection liquid kind of existing treatment hemorrhoid complicated by anal fistula is a lot, wherein is that the quick-acting gangrenosum acnes of principal agent are organized agents for defoliating with sodium sulfide, and it is remarkable to be used for clinical efficacy.For fear of causing the partial pain of patient in use, in this medicine with aether pronarcosi as local anesthetic.Because the purposes of aether pronarcosi in Chinese Pharmacopoeia is the imbedibility general anesthetic.Therefore, be used for the treatment of the injection liquid of hemorrhoid complicated by anal fistula, anaesthetic effect is very undesirable.In the preparation process of above-mentioned injection liquid, another effect of aether pronarcosi is the dissolving Mentholum, but in fact not all dissolving but float over the surface of liquid is not filled in aether pronarcosi and Mentholum in the peace bottle in the process of embedding.In addition, the aether pronarcosi volatility is stronger, and volatilization is more in ingredients and pouring process.Therefore, aether pronarcosi and Mentholum do not play due effect at above-mentioned injection liquid.The injection liquid aether pronarcosi of this treatment hemorrhoid complicated by anal fistula is also very easily burning in process of production, exists serious production unsafe factor, so be not suitable for batch production large-scale production.
Summary of the invention
The objective of the invention is to solve the problem that prior art exists, a kind of good drug efficacy is provided, can reduces pain, the injection liquid and preparation method thereof of the easier treatment hemorrhoid complicated by anal fistula of being accepted and be easy to batch production large-scale production by the patient clinically.
The injection liquid of this treatment hemorrhoid complicated by anal fistula consist of 30～150 milliliters of sodium sulfide 30～120 grams, Mentholum 5～50 grams, medicinal cosolvent, glycerol 2～100 grams, 100～800 milliliters of ethanol and water for injection add to 1000 milliliters.
According to the injection liquid of above-mentioned treatment hemorrhoid complicated by anal fistula, it is characterized in that said medicinal cosolvent is a propylene glycol.
A kind of preparation method of injection liquid of hemorrhoid complicated by anal fistula is that 100～800 milliliters of ethanol and water for injection are made into alcoholic solution for 870～50 milliliters, gets sodium sulfide 30～120 grams and is dissolved in an amount of above-mentioned alcoholic solution that is made into, and adds glycerol 2～100 gram stirrings again and makes it dissolving; Get 30～150 milliliters of an amount of above-mentioned alcoholic solution that is made into and medicinal cosolvents and add Mentholum 5～50 grams, make the Mentholum dissolving, said alcoholic solution addition is dissolved as standard with sodium sulfide, Herba Menthae brain-capacity, above-mentioned two kinds of solution are mixed add surplus alcoholic solution to 1000 milliliter, stirring is until clear and bright, survey pH value, content, qualified after-filtration, embedding.
Advantage of the present invention is:
1, owing to deletes the aether pronarcosi of high volatility in this medicine, the method that employing adds local anesthesia makes that the injection liquid of this treatment hemorrhoid complicated by anal fistula is easier clinically to be accepted by the patient, makes the patient use the pain that is produced behind the injection liquid of this treatment hemorrhoid complicated by anal fistula to be reduced to minimum or not have pain;
2, add medicinal cosolvent hydrotropy Mentholum, make Mentholum all be dissolved in the injection liquid of this treatment hemorrhoid complicated by anal fistula, make the injection liquid better efficacy of this treatment hemorrhoid complicated by anal fistula, more stable;
3, because the aether pronarcosi of deletion high volatility in this medicine, production process safely, be easier to batch production large-scale production.
The preparation method of the injection liquid of this treatment hemorrhoid complicated by anal fistula makes this injection liquid can bring into play drug effect better owing to adopt alcoholic solution to dissolve sodium sulfide, Mentholum and mixing after cure sodium, Mentholum solution respectively.
The specific embodiment
Embodiment 1:
Consist of sodium sulfide 30 grams, Mentholum 5 grams, medicinal cosolvent (propylene glycol or tween 80) 30ml, glycerol 2 grams, ethanol 100ml and the water for injection 870ml of the injection liquid of this treatment hemorrhoid complicated by anal fistula add to 1000ml.
Its preparation process is:
The ethanol 100ml and the water for injection 870ml that get the ingredients amount are made into alcoholic solution, and sodium sulfide is dissolved in an amount of above-mentioned alcoholic solution that is made into, and add the glycerol stirring again and make dissolving.Get the medicinal cosolvent adding of an amount of above-mentioned alcoholic solution that is made into and 30ml Mentholum, make it dissolving, said alcoholic solution addition is dissolved as standard with sodium sulfide, Herba Menthae brain-capacity; Above-mentioned two kinds of solution are mixed add surplus alcoholic solution to 1000 milliliter, stir, survey pH value 6-14, content, refilter embedding until clear and bright.
Embodiment 2:
The injection liquid of this treatment hemorrhoid complicated by anal fistula consist of sodium sulfide 120 gram, Mentholum 50 grams, medicinal cosolvent (propylene glycol or tween 80) 150ml, glycerol 100 grams, ethanol 800ml and water for injection 50ml add to 1000 milliliters.
The ethanol 800ml and the water for injection 50ml that get the ingredients amount are made into alcoholic solution, and sodium sulfide is dissolved in an amount of above-mentioned alcoholic solution that is made into, and add the glycerol stirring again and make dissolving.Get the medicinal cosolvent adding of an amount of above-mentioned alcoholic solution that is made into and 150ml Mentholum, make it dissolving, said alcoholic solution addition is dissolved as standard with sodium sulfide, Herba Menthae brain-capacity; Above-mentioned two kinds of solution are mixed add surplus alcoholic solution to 1000 milliliter, stir, survey pH value 6-14, content, refilter embedding until clear and bright.
Embodiment 3:
Consist of sodium sulfide 100 grams, Mentholum 30 grams, propylene glycol 120ml, glycerol 10 grams, 700 milliliters of ethanol and the water for injection of the injection liquid of this treatment hemorrhoid complicated by anal fistula add to 1000 milliliters for 180 milliliters.
Its preparation process is that the ethanol 700ml and the water for injection 180ml that get the ingredients amount are made into alcoholic solution, and sodium sulfide is dissolved in an amount of above-mentioned alcoholic solution that is made into, and adds the glycerol stirring again and makes dissolving.Get an amount of above-mentioned alcoholic solution that is made into and propylene glycol (medicinal cosolvent) 120ml and add Mentholum, make it dissolving, said alcoholic solution addition is dissolved as standard with sodium sulfide, Herba Menthae brain-capacity; Above-mentioned two kinds of solution are mixed add surplus alcoholic solution to 1000 milliliter, stir, survey pH value 6-14, content, refilter embedding until clear and bright.
Claims (3)
1, a kind of injection liquid for the treatment of hemorrhoid complicated by anal fistula is characterized in that consisting of 30～150 milliliters of sodium sulfide 30～120 grams, Mentholum 5～50 grams, medicinal cosolvent, and glycerol 2～100 grams, 100～800 milliliters of ethanol and water for injection add to 1000 milliliters.
2, the injection liquid of treatment hemorrhoid complicated by anal fistula according to claim 1 is characterized in that said medicinal cosolvent is a propylene glycol.
3, a kind of preparation method for the treatment of the injection liquid of hemorrhoid complicated by anal fistula, it is characterized in that getting 100～800 milliliters of ethanol and 870～50 milliliters of waters for injection are made into alcoholic solution, sodium sulfide 30～120 grams are dissolved in an amount of above-mentioned alcoholic solution that is made into, add glycerol 2～100 grams again and stir, make dissolving; Get an amount of above-mentioned alcoholic solution that is made into and medicinal cosolvent and add Mentholum for 30～150 milliliters, make it dissolving, said alcoholic solution addition is dissolved as standard with sodium sulfide, Herba Menthae brain-capacity; Above-mentioned two kinds of solution are mixed add surplus alcoholic solution to 1000 milliliter, stir, survey pH value, content, refilter embedding until clear and bright.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021093245A CN1178669C (en) | 2002-03-20 | 2002-03-20 | Injection for treating pile and fistula and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021093245A CN1178669C (en) | 2002-03-20 | 2002-03-20 | Injection for treating pile and fistula and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1381238A CN1381238A (en) | 2002-11-27 |
| CN1178669C true CN1178669C (en) | 2004-12-08 |
Family
ID=4740618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021093245A Expired - Lifetime CN1178669C (en) | 2002-03-20 | 2002-03-20 | Injection for treating pile and fistula and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1178669C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773544A (en) * | 2010-03-26 | 2010-07-14 | 史长山 | Medicinal preparation for treating anorectal disease and preparation method thereof |
| CN106983773A (en) * | 2017-04-14 | 2017-07-28 | 绵阳思明科技有限公司 | Application, preparation method and detection device of the sodium sulfide vein injection liquid in the medicine for preparing treatment AIDS virus |
-
2002
- 2002-03-20 CN CNB021093245A patent/CN1178669C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1381238A (en) | 2002-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: ZHANG ZHONGYI Free format text: FORMER OWNER: FENG GUOQING Free format text: FORMER OWNER: GOU DAHUI Effective date: 20050325 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20050325 Address after: 121000 No. 55-46, security center, Guta District, Liaoning, Jinzhou Patentee after: Zhang Zhongyi Address before: 121000 Jinzhou City, Liaoning province Linghe District Yunfei street two No. 40 Co-patentee before: Gou Dahui Patentee before: Feng Guoqing |
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| ASS | Succession or assignment of patent right |
Owner name: GUODI PHARMACEUTICAL CO., LTD., HULUDAO Free format text: FORMER OWNER: ZHANG ZHONGYI Effective date: 20130402 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 121000 JINZHOU, LIAONING PROVINCE TO: 125001 HULUDAO, LIAONING PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20130402 Address after: 125001 Huludao province Liaoning City Nanpiao District Gaoqiao Town Patentee after: Huludao Guodi Pharma Ceutical Co.,Ltd. Address before: 121000 No. 55-46, security center, Guta District, Liaoning, Jinzhou Patentee before: Zhang Zhongyi |
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| CX01 | Expiry of patent term |
Granted publication date: 20041208 |
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| CX01 | Expiry of patent term |