CN1265820C - Compound solanum lyratum injection agent for animal - Google Patents
Compound solanum lyratum injection agent for animal Download PDFInfo
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- CN1265820C CN1265820C CN 03124790 CN03124790A CN1265820C CN 1265820 C CN1265820 C CN 1265820C CN 03124790 CN03124790 CN 03124790 CN 03124790 A CN03124790 A CN 03124790A CN 1265820 C CN1265820 C CN 1265820C
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Abstract
The present invention relates to a compound solanum lyratum thunb injection agent for livestock, which is prepared from raw materials of the following proportion by weight: 30 to 40% of solanum lyratum thunb, 20 to 25% of isatis roots, 15 to 20% of taraxacum herbs, 12 to 18% of coptis roots and 8 to 12% of white atractylodes rhizome. The medicinal herbs are roughly crushed and mixed and then made into the injection agent with a conventional improved water ethanol method according to injection agent preparing requirements. The preparation can be directly used for bacterium resistance and virus resistance and can enhance antibody immunity and the immunogenicity of inactivated vaccine, and the cure rate of bacterial disease of the livestock and fowl can reach 93.4%. The present invention is prepared from pure traditional Chinese medicine and has no medicine residue and adverse reaction nearly so as to effectively protect human health and prevent environmental pollution.
Description
Technical field
The present invention relates to a kind of is the Chinese herbal compound preparation for animals of monarch drug with the Herba Solani Lyrati.
Background technology
Along with the development of scale and the adjustment of aquaculture structure are cultured by China; breaking out with popular of zoosis originality disease also presented new characteristics; the popular trend that rising is arranged of zoonosis particularly; to the pathogenicity treatment of diseases mainly is the method for taking immunity inoculation at present; but, cause immune effect not satisfactory owing to reasons such as immunoprotection phase weak points.The medicine of treatment pathogenicity disease mainly is chemical synthetic drug and antibiotics at present, though poultry specific yield and animal products quantity are increased substantially, obtains comparatively considerable economic, has certain toxic and side effects.Scientific research in recent years proves, the antibiotic in human common cancer, distortion, Drug resistance and some intoxicating phenomenon and meat, egg, the milk, hormone and other synthetic drugs residual closely related.Therefore must study a class can improve immunity function of animal, can prevent and treat the medicine of pathogenicity disease again.The applicating history of Chinese herbal medicine in animal medicine, animal science is long, and it is extremely low to have Drug resistance, and residual quantity is few, almost has no adverse reaction and non-environmental-pollution, does not cause characteristics such as drug-induced disease, and extremely everybody pays close attention to.But the reasonable compatibility of Chinese herbal medicine and correct the use have deep theoretical foundation and scientific basis.
Summary of the invention
The technical problem to be solved in the present invention is, at the deficiencies in the prior art, develop and a kind ofly can improve immunity function of animal, performance immunological adjuvant usefulness, again can directly antibiotic, antiviral pure Chinese herbal compound preparation, be animal compound Herba Solani Lyrati injection, to solve untoward reaction and the drug residue problem that chemical synthetic drug and antibiotic bring.
Technical scheme of the present invention is that described animal compound Herba Solani Lyrati injection adopts following bulk drugs material to make:
Herba Solani Lyrati 30-40%,
Radix Isatidis 20-25%,
Herba Taraxaci 15-20%,
Rhizoma Coptidis 12-18%,
Rhizoma Atractylodis Macrocephalae 8-12%;
To mix after the above drug storage coarse crushing, adopt conventional improvement water alcohol method and injection preparation to require to make.Injection concentration can be that to contain crude drug concentration be 0.8-1.1 gram to every milliliter of injection.
Below the present invention made further specify.
A kind of embodiment preparation method of the present invention is, in the aforementioned proportion scope, get a certain amount of all medicines, mix after the coarse crushing, press 1Kg mixing medical material and soak 3.5-4.5h with the 8000-10000ml distilled water, heated and boiled 0.8-1.2h, its filtering residue of filtration back adds distilled water 2000ml～4000ml and boils 0.4～0.6h, filters, merge secondary filtrate, filtrate is concentrated into 900-1100ml; Concentrated solution is adopted three precipitate with ethanol, make that determining alcohol is respectively 58-62% in the mixed liquor, 68-72% and 78-82%, determining alcohol of every increase makes mixed liquor cold preservation 46-50h, its determining alcohol is controlled with the alcoholic degree meter, and the standardize solution medicinal liquid is 1000ml behind the recovery ethanol, and transferring Ph is between the 5-5.5, it is refining to make requirement by injection, can use behind the circulation steam disinfection.
Development person of the present invention is ministerial drug through years of researches and test with Herba Taraxaci, Radix Isatidis, is the compound preparation that messenger drug has been developed pure Chinese herbal medicine with Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae---compound recipe Herba Solani Lyrati injection.Herba Solani Lyrati is a plant of Solanaceae, and its major function composition is the beta-hydroxy steroid alkaloid, and main pharmacological is antitumor, antiallergic, antiinflammatory, sterilization and immunological enhancement, and major function is heat-clearing and toxic substances removing, expelling wind and removing dampness and blood stasis dispelling.Herba Taraxaci is a feverfew, and its major function composition is a taraxasterol, alkaloid and polysaccharide, and main pharmacological is antibiotic, antiviral and immunologic enhancement, major function are heat-clearing and toxic substances removing, the removing heat from blood detumescence.Radix Isatidis is a crucifer, and its major function composition is indigo glycoside and organic acid, and main pharmacological is antibiotic, antiviral and enhance immunity effect, and main pharmacological is anti-inflammation and immunostimulant, and major function is a heat-clearing and toxic substances removing.The Rhizoma Atractylodis Macrocephalae is a feverfew, and its major function composition is atractylone and atractylodes lactone, and its main pharmacological is invigorating the spleen and benefiting QI, dampness diuresis and immunological enhancement.
Injection of the present invention is according to Chinese veterinarian's " monarch, minister, make, help " and " treating both the principal and secondary aspects of a disease " principle, with the Herba Solani Lyrati is monarch drug, with Herba Taraxaci, Radix Isatidis is ministerial drug, with Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae is a messenger drug, form according to a certain percentage, adopt the preparation of pure method of improvement and injection to require refining forming, its concentration is that to contain crude drug concentration be 0.8-1.1g to every ml injection.
Simultaneously, the present invention finds that by nearly 5 years development test the said preparation compatibility has reasonability, science and practicality; Preparation technology is easy, and strong operability has reduced many intermediate links of herbal injection preparation, has reduced the pure consumption in the water alcohol method, the production cost that saved medicine greatly.
Part clinical practice situation division of the present invention is as follows.
Clinical practice example 1: preparation of the present invention in the Hunan, Guangdong, Guangxi is used for the treatment of the streptococcicosis of pig, treat 1971 altogether, in the course of treatment (3d), cure several 1932, cure rate is 98%, obviously is better than the therapeutic effect (its cure rate is 67.7%) of antibiotic (penicillin, lincomycin).Cooperate pig hammer inactivated vaccine that 3450 pigs are prevented epidemic, pig streptococcicosis takes place in none pig, and its epidemic prevention rate is 100%, suffers from colibacillary sick pig to 1810 and treats, and cures 1760 in the time altogether at 3d, and its cure rate is 96.7%.
Clinical practice example 2: preparation of the present invention in the Hunan, Jiangxi is applied to prevent and treat porcine pseudorabies, treat 480 altogether, curing a number in 3 days is 360, and its cure rate is 74.8%, the reproductive and respiratory syndrome of prevention pig, prevent 240 altogether, 173 end morbidities in the epidemic prevention phase, its epidemic prevention rate is 72.3%, cooperate the swine fever inactivated vaccine to use together, prevent epidemic 24011 altogether, the morbidity of none pig is 100% to the epidemic prevention rate of swine fever.
Clinical practice example 3: preparation of the present invention is applied to prevent and treat mammitis of cow in the Hunan, treats 1200 altogether, cures 1080 in the 6d, and cure rate is 90%.Treatment milk cattle metritis is treated 600 altogether, cures 532 in the 6d altogether, and its cure rate is 87.2%.
As known from the above, the present invention is an animal compound Herba Solani Lyrati injection, said preparation pharmacological action uniqueness, and being mainly reflected in this injection can directly antibiotic, antiviral, and its effect is better than chemical synthetic drug and antibiotic; The energy enhancing body's immunological function has significant immunopharmacological effect; Can strengthen the immunogenicity of inactivated vaccine, be a kind of good immunological adjuvant; The said preparation clinical efficacy is good, is 93.4% to the control rate of fowl bacterial disease, and the control rate of animal viral disease is reached 72.3%, has solved a great problem of poultry pathogenicity diseases prevention and treatment.Said preparation is pure Chinese herbal and crude drugs preparations, and almost drug residue free and untoward reaction is to protecting human health and preventing the pollution of the environment significant.Therefore, said preparation is with a wide range of applications.
The specific embodiment
Get Herba Solani Lyrati 40%, Radix Isatidis 20%, Herba Taraxaci 15%, Rhizoma Coptidis 15%, the Rhizoma Atractylodis Macrocephalae 10% by weight, mix after the coarse crushing, mix medicinal 10000ml distilled water by 1Kg and soak 4h, heated and boiled 1h, filter its filtering residue of back and add distilled water 2000-4000ml, boil 0.5h, filter, merge secondary filtrate, filtrate is concentrated into 1000ml; Concentrated solution is adopted three precipitate with ethanol, make that determining alcohol is respectively 60%, 70%, 80% in the mixed liquor, determining alcohol of every increase makes mixed liquor cold preservation 48h (refrigerated storage temperature 0-10 ℃), and its determining alcohol is controlled with the alcoholic degree meter, the standardize solution medicinal liquid is 1000ml behind the recovery ethanol, and accent PH is 5-5.5.
Claims (1)
1, a kind of animal compound Herba Solani Lyrati injection is characterized in that, it adopts following weight portion raw medicinal material to make:
Herba Solani Lyrati 30-40%,
Radix Isatidis 20-25%,
Herba Taraxaci 15-20%,
Rhizoma Coptidis 12-18%,
Rhizoma Atractylodis Macrocephalae 8-12%;
To mix after above-mentioned all medicine coarse crushings, adopt conventional improvement water alcohol method and injection preparation to require to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03124790 CN1265820C (en) | 2003-09-03 | 2003-09-03 | Compound solanum lyratum injection agent for animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03124790 CN1265820C (en) | 2003-09-03 | 2003-09-03 | Compound solanum lyratum injection agent for animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1589815A CN1589815A (en) | 2005-03-09 |
| CN1265820C true CN1265820C (en) | 2006-07-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03124790 Expired - Fee Related CN1265820C (en) | 2003-09-03 | 2003-09-03 | Compound solanum lyratum injection agent for animal |
Country Status (1)
| Country | Link |
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| CN (1) | CN1265820C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2201957B1 (en) | 2007-09-21 | 2013-08-07 | Pharmabrand S.A. | Anti-aids, anti-tumour, immune-system-stimulating herbal composition and production method therefor |
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2003
- 2003-09-03 CN CN 03124790 patent/CN1265820C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1589815A (en) | 2005-03-09 |
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