CN102972424A - Flufiprole acetamiprid complex insecticide - Google Patents
Flufiprole acetamiprid complex insecticide Download PDFInfo
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- CN102972424A CN102972424A CN2012105738802A CN201210573880A CN102972424A CN 102972424 A CN102972424 A CN 102972424A CN 2012105738802 A CN2012105738802 A CN 2012105738802A CN 201210573880 A CN201210573880 A CN 201210573880A CN 102972424 A CN102972424 A CN 102972424A
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Abstract
The invention relates to a flufiprole acetamiprid complex insecticide. The flufiprole acetamiprid complex insecticide comprises active components, auxiliaries and a solvent, wherein the active components account for 1-90wt% of the finished product drug; the active components comprise flufiprole and acetamiprid, and the flufiprole accounts for 1-95wt% of the active components. The flufiprole and acetamiprid are compounded, so that compared with the existing single agent, the flufiprole acetamiprid complex insecticide has the following advantages that the insecticidal activity is greatly improved, the insecticidal spectrum is expanded, the drug resistance of pests is slowed down, and the drug cost is reduced.
Description
Technical field:
The invention belongs to the Recompounded pesticide of control pest, the compounded pesticides that to relate to a kind of effective active composition be butene-fipronil and Acetamiprid.
Background technology:
Enter 21 century, the production of China's agricultural chemicals and use face many new challenges: the one, along with the adjustment of agricultural structure, to kind and the new demand of operation technique proposition of agricultural chemicals; The 2nd, along with the raising of living standards of the people and the enhancing of Food Hygiene, more and more pay close attention to the security performance of agricultural product.Because the unreasonable use of high-toxic pesticide, residue of pesticide exceed standard and cause the event of consumer's acute poisoning to happen occasionally; The 3rd, after the entry into the World Trade Organization, the requirement of the competitiveness in the international market that improves agricultural product is improved day by day.For an urgent demand of various circles of society to agricultural product security, the theory of nuisanceless, green, organic farming and agricultural product is rooted in the hearts of the people, and oneself be the public and government's approval, and agenda has been put in the reduction replacement of high poison, long residual agricultural chemicals.Reasonably carrying out combined use of pesticides, is the effective way that Scientific Usage of Drugs gains mutually, not only can improve control efficiency, also can reduce dosage and reduce cost accounting, and the safety that can improve agricultural product.
China wet crop mainly is paddy rice, and dry crop mainly contains vegetables, wheat class, cotton, corn etc.These crops all can be subject to the pest invasion and attack in various degree such as disease Chinese caterpillar fungus in its process of growth, for output and the quality that guarantees crop, will use agricultural chemicals inevitably.
China rice grub mainly contains: brown planthopper, small brown rice planthopper, white-backed planthopper, striped rice borer, paddy stem borer, rice leaf roller etc.
China's Cruciferous Vegetable Pests mainly contains: diamond-back moth, cabbage caterpillar, prodenia litura, beet armyworm, vegetable aphid etc.
Insect on the wheat class mainly contains: wheat aphid, midge worm, evil mite etc.
For a long time, people mainly rely on chemical pesticide and prevent and treat these crop pests, and main medicament is organophosphorous pesticide, carbamate chemicals for agriculture, pyrethroid pesticide, heterocyclic pesticide etc.Yet single, repeatedly, the use of heavy dose of agricultural chemicals causes generation and the growth of pest resistance to insecticide inevitably.
Butene-fipronil, chemical name: 3-cyano group-5-methylallyl amino-1-(2,6-dichlor-4-trifluoromethyl phenyl)-4-trifluoromethyl sulfinyl pyrazole is the noval chemical compound that Ruize Farm-Chemicals Co., Ltd., Dalian develops on the ethiprole basis.Butene-fipronil has high activity to cabbage caterpillar, diamond-back moth, snout moth's larva, mythimna separata, brown planthopper, many insects such as chrysomelid, particularly the insect on the crops such as paddy rice, vegetables has been presented the activity equal with ethiprole.Simultaneously, since this medicament to the fish low toxicity, for wider space has been opened up in its application on paddy rice, vegetables.
Acetamiprid (acetamiprid, CAS:82657-04-3), chemical name: N-(N-cyano group-ethyleneimine base)-N-methyl-2-chloropyridine-5-methylamine.Acetamiprid belongs to the Nitromethylene heterocycle compound, it is a kind of novel pesticide, act on the nAChR at insect nerve system cynapse position, the neural stimulation conduction of interference insect, cause the nervous system path blockade, cause neurotransmitter acetylcholine in the accumulation at cynapse position, thereby cause the insect paralysis, final dead.Be widely used in the control of the homoptera pest such as aphid, plant hopper on paddy rice, vegetables, fruit tree, the tealeaves and part lepidoptera pest.
Agriculture chemical compounding is raising preventive effect and expanding prevention object, slows down pest resistance to insecticide, reduces a kind of effective ways that pollute, reduce Residual Pesticides in Farm Produce.At present, the compounded pesticides for butene-fipronil and Acetamiprid yet there are no report.
Summary of the invention:
The object of the invention is to: for Acetamiprid and butene-fipronil single dose usage amount are large, use cost is higher, easily pollute and the Practice for Pesticide Residue in Agricultural Products problem such as exceed standard, provide a kind of by butene-fipronil and the composite insecticide of Acetamiprid, thereby reduce the usage amount of agricultural chemicals, improve control efficiency, delay pest resistance to insecticide, reduce the residual level of agricultural chemicals in agricultural product and environment.
The object of the present invention is achieved like this: a kind of butene-fipronil Acetamiprid compounded pesticides, comprise effective active component, auxiliary agent and solvent, it is characterized in that: the percentage by weight that the effective active composition accounts for the finished product medicament is 1 ~ 90%, described effective active composition is comprised of butene-fipronil and Acetamiprid, and the percentage by weight of butene-fipronil in the effective active composition is 1 ~ 95%.
In the compounded pesticides that the present invention relates to: described auxiliary agent, the percentage by weight of solvent in the finished product medicament are: auxiliary agent is 5 ~ 30%; Solvent is 0 ~ 90%.
In the compounded pesticides that the present invention relates to: the formulation of finished product medicament is missible oil, or aqueous suspension agent, or wetting powder, or aqueous emulsion.
The invention has the advantages that: with butene-fipronil and Acetamiprid carry out composite after, use with existing single dose and to compare, greatly improved insecticidal activity, enlarged insecticidal spectrum, slowed down pest resistance to insecticide, reduced drug cost.
Embodiment:
Reagent agent among the embodiment: the former medicine of 95% butene-fipronil (abbreviation butene-fipronil) is provided by Ruize Farm-Chemicals Co., Ltd., Dalian, and the former medicine of 97% Acetamiprid (abbreviation Acetamiprid) is provided by agricultural chemicals Co., Ltd of Gaoyou City, Jiangsu Province Toyota.
Embodiment 1:
Toxicity Determination:
Tested agricultural chemicals: the weight ratio of butene-fipronil and Acetamiprid is 1:1 in the composite mother liquor of butene-fipronil Acetamiprid;
Contrast agricultural chemicals: butene-fipronil mother liquor (by the former medicinal acetone diluted constant volume gained of butene-fipronil), Acetamiprid mother liquor (by the former medicinal acetone diluted constant volume gained of Acetamiprid);
For trying insect: diamond-back moth 2 instar larvaes, striped rice borer 3 instar larvaes, brown planthopper nymph in 3 age and the aptery adult of wheat aphid (the examination worm is the Jiangsu Province Agriculture Science Institute indoor feeding);
Assay method: infusion process.
Tested pesticide mother liquor and contrast pesticide mother liquor are diluted to 5 concentration gradients with the 0.1% Tween-80 aqueous solution, with in the liquid of the vegetable material of fresh and healthy, size appropriateness (diamond-back moth with cabbage leaves, striped rice borer with wild rice stem, brown planthopper with rice straw, wheat aphid wheat seeding) the above-mentioned variable concentrations of immersion 30 seconds, taking-up is dried naturally, put into culture dish or long test tube (brown planthopper is used), access the examination worm (15 of diamond-back moths, 15 of striped rice borer, 20 of brown planthoppers, 30 of wheat aphids) of some, every processing repeats for 4 times again.Process in contrast with corresponding solvent simultaneously.Check the borer population of living after 24 hours, the calculation correction lethality is calculated the lethal concentration of 50 (LC with concentration logarithm value and dead probability value
50).
The LC of toxicity index (TI)=standard medicament
50The LC of value/reagent agent
50Value * 100;
The LC of the actual toxicity index (ATI) of mixture (M)=A medicament
50The LC of value/M medicament
50Value * 100;
B%+ in the TI of A%+B medicament * M medicament in the TI of the theoretical toxicity index (TTI) of mixture (M)=A medicament * M medicament
The co-toxicity coefficient of mixture (CTC)=ATI/TTI * 100;
It is summation action that CTC 〉=120 expressions have synergistic effect, 80＜CTC＜120, and CTC≤80 are antagonism.
After result of the test shows that butene-fipronil and Acetamiprid are mixed, the indoor virulence of diamond-back moth and wheat aphid is obviously improved, show obvious synergistic effect (table 1, table 4), striped rice borer, brown planthopper act as addition (table 2, table 3).
Each medicament of table 1 is to the toxicity test of diamond-back moth
| Medicament | The toxicity regression formula | 95% confidence interval | LC 50（mg a.i./L） | Co-toxicity coefficient |
| Butene-fipronil | y=2.6317x+1.6647(r=0.9918) | 15.77~21.72 | 18.51 | / |
| Acetamiprid | y=2.0662x+0.0068(r=0.9956) | 217.68~312.81 | 260.94 | / |
| The butene-fipronil Acetamiprid | y=1.7251x+2.4850(r=0.9956) | 22.98~35.85 | 28.70 | 120.45 |
Each medicament of table 2 is to the toxicity test of striped rice borer
| Medicament | The toxicity regression formula | 95% confidence interval | LC 50（mg a.i./L） | Co-toxicity coefficient |
| Butene-fipronil | y=2.3041x+2.1148(r=0.9958) | 14.94~21.38 | 17.87 | / |
| Acetamiprid | y=2.4673x-1.4033(r=0.9930) | 335.26~462.60 | 393.82 | / |
| The butene-fipronil Acetamiprid | y=1.5737x+2.9513(r=0.9965) | 15.90~25.26 | 20.04 | 97.55 |
Each medicament of table 3 is to the toxicity test of brown planthopper
| Medicament | The toxicity regression formula | 95% confidence interval | LC 50（mg a.i./L） | Co-toxicity coefficient |
| Butene-fipronil | y=2.0390x+1.2129(r=0.9947) | 60.76~85.33 | 72.01 | / |
| Acetamiprid | y=1.8800x+1.5171(r=0.9934) | 60.15~84.35 | 71.23 | / |
| The butene-fipronil Acetamiprid | y=2.1337x+1.0326(r=0.9967) | 62.08~84.29 | 72.34 | 99.45 |
Each medicament of table 4 is to the toxicity test of wheat aphid
| Medicament | The toxicity regression formula | 95% confidence interval | LC 50（mg a.i./L） | Co-toxicity coefficient |
| Butene-fipronil | y=2.2439x+0.7801(r=0.9946) | 66.99~86.16 | 75.97 | / |
| Acetamiprid | y=2.3560x+1.2613(r=0.9979) | 34.21~43.62 | 38.63 | / |
| The butene-fipronil Acetamiprid | y=2.3016x+1.2583(r=0.9975) | 126.60~193.07 | 42.23 | 121.28 |
Embodiment 2:
Toxicity Determination:
Tested agricultural chemicals: the weight ratio of butene-fipronil and Acetamiprid is respectively 4:1,2:1,1:2,1:4 in the composite mother liquor of butene-fipronil Acetamiprid;
Contrast agricultural chemicals: with embodiment 1;
For trying insect: the aptery adult of wheat aphid (the examination worm is the Jiangsu Province Agriculture Science Institute indoor feeding);
Assay method: infusion process (with embodiment 1).
After result of the test shows that butene-fipronil and Acetamiprid 2:1,1:2,1:4 proportioning are mixed, the indoor virulence of wheat aphid is all shown as synergistic effect, the 4:1 proportioning is mixed is summation action (table 5).
Each medicament of table 5 is to the toxicity test of wheat aphid
| Medicament | The toxicity regression formula | 95% confidence interval | LC 50（mg a.i./L） | Co-toxicity coefficient |
| Butene-fipronil | y=2.2439x+0.7801(r=0.995) | 66.99~86.16 | 75.97 | / |
| Acetamiprid | y=2.3560x+1.2613(r=0.998) | 34.21~43.62 | 38.63 | / |
| Butene-fipronil Acetamiprid (4:1) | y=2.4491x+0.3743(r=0.997) | 68.79~87.08 | 77.40 | 82.25 |
| Butene-fipronil Acetamiprid (2:1) | y=2.2282x+1.2590(r=0.997) | 42.30~53.89 | 47.75 | 120.36 |
| Butene-fipronil Acetamiprid (1:2) | y=2.3981x+1.2582(r=0.998) | 32.14~41.08 | 36.33 | 127.14 |
| Butene-fipronil Acetamiprid (1:4) | y=2.1147x+1.8030(r=0.996) | 28.61~36.91 | 32.49 | 131.86 |
Embodiment 3:
The preparation of 40% butene-fipronil acetamiprid EC (weight ratio of butene-fipronil and Acetamiprid is 1:1 in the active drug composition):
Auxiliary agent is selected: DMF, farming breast 0206, farming breast 2201.
Solvent is selected: toluene.
Each component is got the raw materials ready according to following percentage by weight:
Butene-fipronil: 20%; Acetamiprid: 20%; DMF 5%; The newborn 2201:5% of farming; The newborn 0206:5% of farming; Solvent: toluene adds to 100g.
Preparation process: with the Acetamiprid acetone solution, add successively butene-fipronil, DMF, then farming breast 2201, farming breast 0206 are filled to 100% with toluene again, with said mixture volumetric flask mix 40% butene-fipronil acetamiprid EC.
Embodiment 4:
The preparation of 40% butene-fipronil Acetamiprid aqueous suspension agent (weight ratio of butene-fipronil and Acetamiprid is 1:1 in the active drug composition):
Auxiliary agent is selected: the dispersant sodium lignin sulfonate; Wetting agent OP-10; Thickener CMC; The defoamer organic silicone; Antifreeze glycol.
Solvent is selected: water.
Each component is got the raw materials ready according to following percentage by weight:
Butene-fipronil: 20%; Acetamiprid: 20%; Sodium lignin sulfonate: 5%; OP-10:5%; CMC:1%; Organic silicone: 0.01%; Ethylene glycol: 8%; Water: add to 100g.
Preparation process: with the Acetamiprid acetone solution, add successively again butene-fipronil, sodium lignin sulfonate, OP-10, CMC, organic silicone, ethylene glycol and place according to the above ratio reactor, water adds to 100% and mixes, mixture being introduced again and being milled to fineness of materials in the sand mill is 1 ~ 5 μ m, mix after milling 40% butene-fipronil Acetamiprid aqueous suspension agent.
Embodiment 5:
Field efficacy:
40% butene-fipronil acetamiprid EC (embodiment 3 provides) carries out in the experimental field, Jiangsu Province Agriculture Science Institute the field control effectiveness test of diamond-back moth and wheat aphid.5 processing are established in test altogether, and wherein 1 is contrast, and every processing repeats for 4 times, and every the repetition is a residential quarter, every residential quarter area 20m
2, amounting to 20 residential quarters, district's group is arranged at random.With the conventional dispenser of MATABA manual sprayer, use amount of liquid medicine 50Kg for every mu.5 samplings in every residential quarter, every some fixed point is looked into 3 strains, totally 15 strains, investigation insect population radix before the medicine was investigated residual worm amount, calculation correction preventive effect in 3 days, 7 days behind the medicine.Adopt the poor Duncan method of the new multipole of Deng Kenshi that test data is analyzed.The result shows that 40% butene-fipronil acetamiprid EC is better than 5% butene-fipronil missible oil to the field efficacy of diamond-back moth, or with its quite (table 6); 40% butene-fipronil acetamiprid EC and 40% acetamiprid water dispersible granules are to the field efficacy suitable (table 7) of wheat aphid.
The field test results (2012, the Nanjing) of table 6 40% butene-fipronil acetamiprid EC control diamond-back moth
The field test results (2012, the Nanjing) of table 7 40% butene-fipronil acetamiprid EC control wheat aphid
It should be noted that, the formulation that above EXAMPLE Example relates to and butene-fipronil, the compatibility of Acetamiprid in the effective active composition are only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can make amendment or be equal to replacement technical scheme of the present invention, and not breaking away from the spirit and scope of technical solution of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (3)
1. butene-fipronil Acetamiprid compounded pesticides, comprise effective active component, auxiliary agent and solvent, it is characterized in that: the percentage by weight that the effective active composition accounts for the finished product medicament is 1 ~ 90%, described effective active composition is comprised of butene-fipronil and Acetamiprid, and the percentage by weight of butene-fipronil in the effective active composition is 1 ~ 95%.
2. butene-fipronil Acetamiprid compounded pesticides according to claim 1, it is characterized in that: the percentage by weight of auxiliary agent and solvent is respectively 5 ~ 30% and 0 ~ 90% in the finished product medicament.
3. butene-fipronil Acetamiprid compounded pesticides according to claim 1 and 2, it is characterized in that: the formulation of finished product medicament is missible oil, or aqueous suspension agent, or wetting powder, or aqueous emulsion.
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| CN201210573880.2A CN102972424B (en) | 2012-12-26 | 2012-12-26 | Flufiprole acetamiprid complex insecticide |
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| CN102972424B CN102972424B (en) | 2014-04-02 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102047914A (en) * | 2009-10-29 | 2011-05-11 | 中国中化股份有限公司 | Pesticide composition |
| CN102349502A (en) * | 2011-09-13 | 2012-02-15 | 广西田园生化股份有限公司 | Ultralow-volume solvent containing pleocidin or spinetoram |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102047914A (en) * | 2009-10-29 | 2011-05-11 | 中国中化股份有限公司 | Pesticide composition |
| CN102349502A (en) * | 2011-09-13 | 2012-02-15 | 广西田园生化股份有限公司 | Ultralow-volume solvent containing pleocidin or spinetoram |
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