CN102972420A - Bactericidal composition containing prothioconazole - Google Patents
Bactericidal composition containing prothioconazole Download PDFInfo
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- CN102972420A CN102972420A CN2012105513279A CN201210551327A CN102972420A CN 102972420 A CN102972420 A CN 102972420A CN 2012105513279 A CN2012105513279 A CN 2012105513279A CN 201210551327 A CN201210551327 A CN 201210551327A CN 102972420 A CN102972420 A CN 102972420A
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- orysastrobin
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Abstract
The invention discloses a bactericidal composition containing prothioconazole, which is composed of an effective ingredient, an auxiliary and an excipient, wherein the effective ingredient is composed of an active constituent A and an active constituent B, the active constituent A is prothioconazole, and the active constituent B is any one selected from pyraclostrobin, picoxystrobin, kresoxim-methyl, dimoxystrobin, metominostrobin or orysastrobin; the effective ingredient accounts for 1-90% of the composition in percentage by weight, and the weight ratio of the active constituent A to the active constituent B is 0: 1 to 1: 60; and the composition is prepared into one of wettable powder, water dispersible granules, a suspending agent, a micro-capsule suspending agent, granules or an aqueous emulsion. The bactericidal composition containing prothioconazole disclosed by the invention is obvious in synergistic effect, capable of overcoming the defects of high medicament dosage, serious pollution to environment and fast pathogenic bacteria resistance generation speed existing in prevention and treatment adopting a single bactericidal agent, realizing reduction for medicament dosage while ensuring the optimal prevention and treatment effect, thus reducing cost and harm to environment, and beneficial to delaying the generation of pathogenic bacteria resistance to medicine.
Description
Technical field
The invention belongs to technical field of pesticide preparations, relate to composition pesticide, specifically a kind of bactericidal composition that contains prothioconazoles.
Background technology
In the whole process of growth of crop, be faced with the threat of numerous pests such as disease, worm, grass, disease wherein, especially fungal disease,, complicated symptoms of a great variety because of it, propagation are rapidly, harm is serious and the characteristics such as plyability generation strengthen its difficulty of prevention and cure, and crop yield and quality are consisted of grave danger.In agricultural production process, in order to reduce the loss that causes because of fungal disease, chemical control is present one of comparatively significant means, but because for a long time, unicity, continuity and repeatability etc. not Scientific Usage of Drugs means have caused many pathogens to the medicament generation resistance in various degree of current use, and it is reported, because this unscientific medication means, the resistance generation time of various medicaments shortens year by year, causes the significantly increase of cost accounting, Environmental costs, medicament R﹠D costs.Based on this present situation, improve effect of drugs for addressing the above problem comparatively cost-effective means on existing basis.
Prothioconazoles, English name Prothioconazole is a kind of New-type wide-spectrum triazolinthione series bactericidal agent of Beyer Co., Ltd's development, the numerous diseases that are mainly used in preventing and treating cereal, wheat class legume crop, its structural formula is as follows:
Prothioconazoles toxicity is low, and the mechanism of action is the demethylation effect on 14 of the precursor-lanosterol of sterol in the Antifungi or 2, the 4-methylene lanostenols, i.e. demethylation inhibitor (DMIs).Not only have good systemic activity, excellent protection, treat and root out activity, and the lasting period is long.By a large amount of field control effectiveness tests, the result shows that prothioconazoles not only has good safety to crop, and preventing disease theraping effect is good, and volume increase is obvious, compares with triazole bactericidal agent, and prothioconazoles has the more bactericidal activity of wide spectrum.Prothioconazoles is mainly used in preventing and treating numerous diseases of cereal crop such as wheat, barley, rape, peanut, paddy rice and legume crop.Almost all wheat class diseases there is good control efficiency, such as the powdery mildew of Wheat and barley, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc.Can also prevent and treat the soil-borne disease of rape and peanut, such as stalk break, and main foliage disease, such as gray mold, black spot, brown spot, balck shank, stalk break and rust etc.
Methoxy acrylic bactericide is a class low toxicity, efficient, wide spectrum, systemic fungicide; have protection, treatment and eradicant action; its mechanism of action is to act on the cytochrome compound; the electron transfer process of blocking-up germ mitochondrial respiratory chain; suppress the supply of germ cellular energy, it is dead to make the germ cell lack energy.This series bactericidal agent comprises pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126, orysastrobin etc., the germs such as Ascomycetes, Basidiomycetes, deuteromycetes and Oomycete are all had good activity, can prevent and treat the disease such as powdery mildew, rust, downy mildew, epidemic disease, anthracnose of various crop.To crop, people and animals and beneficial organism safety, and with other bactericide commonly used without cross resistance.But because action site is single, easily develop immunity to drugs, existing powdery mildew is to the report of the generation resistances such as Fluoxastrobin in Europe.
Pyraclostrobin, English name Pyraclostrobin is the New-type wide-spectrum bactericide by the BASF research and development, has protection, treatment and blade face infiltration conduction and interior absorption, to crop safeties such as cereal, vegetables, fruit trees.
ZEN 90160, English name Picoxystrobinl is Syngenta Co.,Ltd's exploitation, and it is fast that this product has infiltration rate, and systemic activity is compared with existing methoxy acrylate bactericide, and wheat leaf blight, net blotch and moire disease are had stronger result for the treatment of.Be mainly used in preventing and treating wheat rust, powdery mildew, leaf rust of barley etc., increase yield significantly.
Kresoxim-methyl; English name kresoxim-methyl; a kind of efficient, wide spectrum, the strobilurin fungicide by BASF Aktiengesellschaft exploitation; have protection, treat, root out, infiltration, systemic activity; have good inhibition spore germination effect, the lasting period is long, with other bactericide commonly used without cross resistance; to crop, people and animals and beneficial organism safety, substantially pollution-free to environment.
Dimoxystrobin, English name Dimoxystrobin also is a kind of methoxy acrylic bactericide of very wide spectrum.
SSF 126; English name Metominostrobin; it is the methoxy acrylic broad-spectrum germicide of the wild adopted company of Japanese salt exploitation; have protection, root out, infiltration and therapeutic action; be mainly used in preventing and treating the diseases such as rice blast, powdery mildew, downy mildew, before disease occurs or the emergence period use.Suitable crop is paddy rice, wheat, fruit tree and vegetables etc.Using dosage: 1.5-1.8kg/hm
21998 in Japan's registration listing.
Orysastrobin, English name orysastrobin is that BASF was researched and developed in nineteen ninety-five, is mainly used at present preventing and treating rice blast and banded sclerotial blight.Moderate toxicity is to rice safety.
Because the popularization of single dose product, so that germ strengthens just gradually to the active component pesticide resistance, single dose is prevented and treated crop pest and is not reached expected effect.For the bacteria-treating that easily produces resistance on the agricultural, what the main way that adopts was exploitation and existing kind without between the new component of cross resistance or the existing pesticide species is composite, the former is because required development cost is high, the cycle is long, and at present development rate far away less than the speed of germ pesticide resistance generation.Therefore, being mixed for the different existing pesticide species of the mechanism of action is best selection, Synergistic bactericidal composition not only can improve preventive effect greatly, reduce dosage, reduce cost, can also avoid simultaneously phytopathogen to produce the generation speed of resistance and delaying drug resistance, be a kind of effective means that solves current agricultural chemicals resistance and Cost Problems when alone.Therefore, exploitation has the bactericidal composition of synergistic effect significant to fungal disease.
Summary of the invention
The objective of the invention is the problem for above-mentioned use single-activity ingredients for preventing and treating crop pest existence, a kind of bactericidal composition that contains prothioconazoles is provided, it is large to overcome the dosing that single bactericidal agent for preventing and treating exists, and the serious and germ resistance of environmental pollution produces fireballing defective; Be implemented in the usage amount that guarantees to reduce under the optimum preventive effect medicament, reduce cost, reduce the harm to environment, and be of value to and delay the drug-fast generation of germ.
The present invention realizes that the technical scheme that above-mentioned purpose is taked is: a kind of bactericidal composition that contains prothioconazoles, formed by active ingredient, auxiliary agent and excipient, active ingredient is comprised of active component A and active component B, active component A is prothioconazoles, and active component B is selected from any one in pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126 or the orysastrobin; The percentage by weight that active ingredient accounts for composition is 1 ~ 90%, and the weight ratio of active component A and active component B is 80:1～1:60;
The described bactericidal composition that contains prothioconazoles is prepared into a kind of in wetting powder, water dispersible granules, suspending agent, microcapsule suspending agent, granule or the aqueous emulsion.
Further, the weight ratio of described active component A and active component B is preferably 20:1～1:40.
Further, the described active ingredient percentage by weight that accounts for composition is preferably 10 ~ 60%.
The auxiliary agent that uses in the bactericidal composition of prothioconazoles that contains of the present invention is and is of value to the active ingredient material that those skilled in the art stable and the drug effect performance can be known in preparation.
The bactericidal composition that contains prothioconazoles of the present invention directly is mixed into preparation; Perhaps with the combination of single dose form, in bucket or tank, mix first before using, be diluted to again required concentration.
The application crop that contains the bactericidal composition of prothioconazoles of the present invention comprises paddy rice, wheat, fruit and vegetables, and the disease that can prevent and treat comprises rice blast, banded sclerotial blight, false smut, powdery mildew, rust, downy mildew, leaf spot, scab, early blight, gray mold, anthracnose and late blight.
The bactericidal composition that contains prothioconazoles of the present invention is used by common method, and such as cast, spraying or distribution, its amount of application is with weather condition or crop state variation.
The present invention possesses following beneficial effect:
1, the present invention compares with single dose, and target fungus is had obvious synergistic effect, can significantly improve control efficiency, simultaneously also is conducive to overcome and delays the drug-fast generation of germ.
2, the present invention can reduce dosage, thereby reduces cost, alleviates the pollution to environment, and safety is good, meets the security requirement of pesticidal preparations.
Specific embodiment
The combination of active principles of different agricultural chemicals is made the mixed pesticide product, is a kind of effectively and efficiently mode of the upper resistance germ of present development novel pesticide and control agricultural.The agricultural chemicals of different cultivars shows three kinds of type of action: summation action, synergistic effect and antagonism after mixing usually.Compound synergic is well filled a prescription, and can obviously improve actual control efficiency, and reduce the usage amount of agricultural chemicals, thereby delay widely the drug-fast generation speed of germ, be the important means of integrated control disease.
The inventor is by a large amount of screening tests, find that prothioconazoles and methoxy acrylic bactericide combination antagonism Pyricularia oryzae, banded sclerotial blight germ and false smut germ have significant synergistic function, and be not only the simple addition of two kinds of medicaments, this can know from following biologicall test example and find out.
Biologicall test example 1
Arbitrary composite Toxicity Determination to rice blast fungus in prothioconazoles and pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126, the orysastrobin
Subjects: the rice blast fungus that picks up from the field
Test method: with reference to " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) ", pot-culture method.Choose the consistent rice seedlings in tri-leaf period of growth potential, every basin 2 young plants, each processing selects 5 basins for the examination rice seedling.Pyricularia oryzae is cultivated at tomato oat agar medium, washed spore with sterile water behind the product spore, make 1 * 10
5The suspension of individual spore/mL, spray inoculation puts the moisturizing of black plastic bag and cultivates 24h in for trying on the rice seedling after the inoculation uniformly.Behind the inoculation 24h, carry out chemicals treatment, each medicament arranges 5 concentration gradients, sprays the about 5ml of every basin under 50PSI pressure with the Potter spray tower.Behind the spray medicine, rice seedling is placed about 25 ℃, cultivates under the condition of relative moisture 〉=90%, investigate the disease index of whole strain blade behind the 7d according to the morbidity grade scale of rice blast, and calculate control efficiency.
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, calculates concentration EC in virulence equation and the inhibition with method of least squares
50, according to toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in the percentage composition of A+B medicament toxicity index * mixture in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
Toxicity test the results are shown in following table:
The composite Toxicity Determination result to rice blast fungus of table 1 prothioconazoles and pyraclostrobin
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.067 | 100.0 | ? | ? |
| Pyraclostrobin | 0.057 | 117.5 | ? | ? |
| Prothioconazoles 100: pyraclostrobin 1 | 0.059 | 113.6 | 100.2 | 113.4 |
| Prothioconazoles 80: pyraclostrobin 1 | 0.055 | 121.8 | 100.2 | 121.6 |
| Prothioconazoles 60: pyraclostrobin 1 | 0.054 | 124.1 | 100.3 | 123.7 |
| Prothioconazoles 40: pyraclostrobin 1 | 0.046 | 145.7 | 100.4 | 145.0 |
| Prothioconazoles 20: pyraclostrobin 1 | 0.047 | 142.6 | 100.8 | 141.4 |
| Prothioconazoles 10: pyraclostrobin 1 | 0.052 | 128.8 | 101.6 | 126.8 |
| Prothioconazoles 1: pyraclostrobin 1 | 0.042 | 159.5 | 108.8 | 146.7 |
| Prothioconazoles 1: pyraclostrobin 10 | 0.040 | 167.5 | 115.9 | 144.5 |
| Prothioconazoles 1: pyraclostrobin 20 | 0.043 | 155.8 | 116.7 | 133.5 |
| Prothioconazoles 1: pyraclostrobin 40 | 0.042 | 159.5 | 117.1 | 136.2 |
| Prothioconazoles 1: pyraclostrobin 60 | 0.047 | 142.6 | 117.3 | 121.6 |
| Prothioconazoles 1: pyraclostrobin 80 | 0.052 | 128.8 | 117.3 | 109.8 |
The composite Toxicity Determination result to rice blast fungus of table 2 prothioconazoles and ZEN 90160
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.067 | 100.0 | ? | ? |
| ZEN 90160 | 0.042 | 159.5 | ? | ? |
| Prothioconazoles 100: ZEN 90160 1 | 0.056 | 119.6 | 100.6 | 118.9 |
| Prothioconazoles 80: ZEN 90160 1 | 0.054 | 124.1 | 100.7 | 123.2 |
| Prothioconazoles 60: ZEN 90160 1 | 0.054 | 124.1 | 101.0 | 122.9 |
| Prothioconazoles 40: ZEN 90160 1 | 0.046 | 145.7 | 101.5 | 143.6 |
| Prothioconazoles 20: ZEN 90160 1 | 0.047 | 142.6 | 102.8 | 138.6 |
| Prothioconazoles 10: ZEN 90160 1 | 0.032 | 209.4 | 105.4 | 198.6 |
| Prothioconazoles 1: ZEN 90160 1 | 0.033 | 203.0 | 129.8 | 156.5 |
| Prothioconazoles 1: ZEN 90160 10 | 0.030 | 223.3 | 154.1 | 144.9 |
| Prothioconazoles 1: ZEN 90160 20 | 0.023 | 291.3 | 156.7 | 185.9 |
| Prothioconazoles 1: ZEN 90160 40 | 0.034 | 197.1 | 158.1 | 124.7 |
| Prothioconazoles 1: ZEN 90160 60 | 0.035 | 191.4 | 158.5 | 120.7 |
| Prothioconazoles 1: ZEN 90160 80 | 0.044 | 152.3 | 158.8 | 95.9 |
The composite Toxicity Determination result to rice blast fungus of table 3 prothioconazoles and kresoxim-methyl
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.067 | 100.0 | ? | ? |
| Kresoxim-methyl | 0.092 | 72.8 | ? | ? |
| Prothioconazoles 100: kresoxim-methyl 1 | 0.067 | 100.0 | 99.7 | 100.3 |
| Prothioconazoles 80: kresoxim-methyl 1 | 0.055 | 121.8 | 99.7 | 122.2 |
| Prothioconazoles 60: kresoxim-methyl 1 | 0.058 | 115.5 | 99.6 | 116.0 |
| Prothioconazoles 40: kresoxim-methyl 1 | 0.042 | 159.5 | 99.3 | 160.6 |
| Prothioconazoles 20: kresoxim-methyl 1 | 0.047 | 142.6 | 98.7 | 144.4 |
| Prothioconazoles 10: kresoxim-methyl 1 | 0.055 | 121.8 | 97.5 | 124.9 |
| Prothioconazoles 1: kresoxim-methyl 1 | 0.045 | 148.9 | 86.4 | 172.3 |
| Prothioconazoles 1: kresoxim-methyl 10 | 0.057 | 117.5 | 75.3 | 156.1 |
| Prothioconazoles 1: kresoxim-methyl 20 | 0.067 | 100.0 | 74.1 | 134.9 |
| Prothioconazoles 1: kresoxim-methyl 40 | 0.071 | 94.4 | 73.5 | 128.4 |
| Prothioconazoles 1: kresoxim-methyl 60 | 0.064 | 104.7 | 73.3 | 142.9 |
| Prothioconazoles 1: kresoxim-methyl 80 | 0.082 | 81.7 | 73.2 | 111.7 |
The composite Toxicity Determination result to rice blast fungus of table 4 prothioconazoles and dimoxystrobin
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.067 | 100.0 | ? | ? |
| Dimoxystrobin | 0.085 | 78.8 | ? | ? |
| Prothioconazoles 100: dimoxystrobin 1 | 0.057 | 117.5 | 99.8 | 117.8 |
| Prothioconazoles 80: dimoxystrobin 1 | 0.054 | 124.1 | 99.7 | 124.4 |
| Prothioconazoles 60: dimoxystrobin 1 | 0.055 | 121.8 | 99.7 | 122.2 |
| Prothioconazoles 40: dimoxystrobin 1 | 0.049 | 136.7 | 99.5 | 137.4 |
| Prothioconazoles 20: dimoxystrobin 1 | 0.042 | 159.5 | 99.0 | 161.1 |
| Prothioconazoles 10: dimoxystrobin 1 | 0.050 | 134.0 | 98.1 | 136.6 |
| Prothioconazoles 1: dimoxystrobin 1 | 0.044 | 152.3 | 89.4 | 170.3 |
| Prothioconazoles 1: dimoxystrobin 10 | 0.046 | 145.7 | 80.7 | 180.4 |
| Prothioconazoles 1: dimoxystrobin 20 | 0.052 | 128.8 | 79.8 | 161.4 |
| Prothioconazoles 1: dimoxystrobin 40 | 0.056 | 119.6 | 79.3 | 150.8 |
| Prothioconazoles 1: dimoxystrobin 60 | 0.061 | 109.8 | 79.2 | 138.7 |
| Prothioconazoles 1: dimoxystrobin 80 | 0.075 | 89.3 | 79.1 | 113.0 |
The composite Toxicity Determination result to rice blast fungus of table 5 prothioconazoles and SSF 126
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.067 | 100.0 | ? | ? |
| SSF 126 | 0.081 | 82.7 | ? | ? |
| Prothioconazoles 100: SSF 126 1 | 0.067 | 100.0 | 99.8 | 100.2 |
| Prothioconazoles 80: SSF 126 1 | 0.055 | 121.8 | 99.8 | 122.1 |
| Prothioconazoles 60: SSF 126 1 | 0.05 | 134.0 | 99.7 | 134.4 |
| Prothioconazoles 40: SSF 126 1 | 0.048 | 139.6 | 99.6 | 140.2 |
| Prothioconazoles 20: SSF 126 1 | 0.044 | 152.3 | 99.2 | 153.5 |
| Prothioconazoles 10: SSF 126 1 | 0.042 | 159.5 | 98.4 | 162.1 |
| Prothioconazoles 1: SSF 126 1 | 0.045 | 148.9 | 91.4 | 163.0 |
| Prothioconazoles 1: SSF 126 10 | 0.043 | 155.8 | 84.3 | 184.9 |
| Prothioconazoles 1: SSF 126 20 | 0.055 | 121.8 | 83.5 | 145.8 |
| Prothioconazoles 1: SSF 126 40 | 0.056 | 119.6 | 83.1 | 143.9 |
| Prothioconazoles 1: SSF 126 60 | 0.062 | 108.1 | 83.0 | 130.2 |
| Prothioconazoles 1: SSF 126 80 | 0.073 | 91.8 | 82.9 | 110.7 |
The composite Toxicity Determination result to rice blast fungus of table 6 prothioconazoles and orysastrobin amine
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.067 | 100.0 | ? | ? |
| Orysastrobin | 0.074 | 90.5 | ? | ? |
| Prothioconazoles 100: orysastrobin 1 | 0.073 | 91.8 | 99.9 | 91.9 |
| Prothioconazoles 80: orysastrobin 1 | 0.051 | 131.4 | 99.9 | 131.5 |
| Prothioconazoles 60: orysastrobin 1 | 0.045 | 148.9 | 99.8 | 149.1 |
| Prothioconazoles 40: orysastrobin 1 | 0.049 | 136.7 | 99.8 | 137.1 |
| Prothioconazoles 20: orysastrobin 1 | 0.041 | 163.4 | 99.5 | 164.2 |
| Prothioconazoles 10: orysastrobin 1 | 0.041 | 163.4 | 99.1 | 164.8 |
| Prothioconazoles 1: orysastrobin 1 | 0.047 | 142.6 | 95.3 | 149.6 |
| Prothioconazoles 1: orysastrobin 10 | 0.045 | 148.9 | 91.4 | 162.9 |
| Prothioconazoles 1: orysastrobin 20 | 0.053 | 126.4 | 91.0 | 138.9 |
| Prothioconazoles 1: orysastrobin 40 | 0.057 | 117.5 | 90.8 | 129.5 |
| Prothioconazoles 1: orysastrobin 60 | 0.056 | 119.6 | 90.7 | 131.9 |
| Prothioconazoles 1: orysastrobin 80 | 0.066 | 101.5 | 90.7 | 112.0 |
The result of Toxicity Determination shows that any in prothioconazoles and pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126 or the orysastrobin is mixed, and ratio is synergistic effect when being 80:1～1:60.
Biologicall test example 2
Arbitrary composite Toxicity Determination to Rhizoctonia solani Kuhn in prothioconazoles and pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126, the orysastrobin
Subjects: the Rhizoctonia solani Kuhn that picks up from the field
Test method: with reference to " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) ", the Detached Vicia faba Leaves method.With Rhizoctonia solani Kuhn PDA medium culture, when treating that bacterium colony has just covered with culture dish, be that the card punch of 5mm punches from the edge with internal diameter, the mycelia piece that breaks into is as inoculum.Choose the consistent Broad Bean Leaves in leaf position, 10 of every processing are immersed in 10min in the liquid for preparing, and taking-up is dried, and puts into the culture dish that is covered with moisture retention paper, and each medicament arranges 5 concentration gradients.At last the mycelia piece is inverted in blade central authorities, and in 28 ℃ of constant incubators, cultivates, after contrasting abundant morbidity, measure the scab diameter with the right-angled intersection method, and calculate control efficiency.
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, calculates concentration EC in virulence equation and the inhibition with method of least squares
50, according to toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Toxicity test the results are shown in following table
The composite Toxicity Determination result to Rhizoctonia solani Kuhn of table 7 prothioconazoles and pyraclostrobin
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.043 | 100.0 | ? | ? |
| Pyraclostrobin | 0.082 | 52.4 | ? | ? |
| Prothioconazoles 100: pyraclostrobin 1 | 0.043 | 100.0 | 99.5 | 100.5 |
| Prothioconazoles 80: pyraclostrobin 1 | 0.035 | 122.9 | 99.4 | 123.6 |
| Prothioconazoles 60: pyraclostrobin 1 | 0.033 | 130.3 | 99.2 | 131.3 |
| Prothioconazoles 40: pyraclostrobin 1 | 0.025 | 172.0 | 98.8 | 174.0 |
| Prothioconazoles 20: pyraclostrobin 1 | 0.022 | 195.5 | 97.7 | 200.0 |
| Prothioconazoles 10: pyraclostrobin 1 | 0.023 | 187.0 | 95.7 | 195.4 |
| Prothioconazoles 1: pyraclostrobin 1 | 0.021 | 204.8 | 76.2 | 268.6 |
| Prothioconazoles 1: pyraclostrobin 10 | 0.029 | 148.3 | 56.8 | 261.2 |
| Prothioconazoles 1: pyraclostrobin 20 | 0.033 | 130.3 | 54.7 | 238.2 |
| Prothioconazoles 1: pyraclostrobin 40 | 0.038 | 113.2 | 53.6 | 211.1 |
| Prothioconazoles 1: pyraclostrobin 60 | 0.057 | 75.4 | 53.2 | 141.8 |
| Prothioconazoles 1: pyraclostrobin 80 | 0.070 | 61.4 | 53.0 | 115.8 |
The composite Toxicity Determination result to Rhizoctonia solani Kuhn of table 8 prothioconazoles and ZEN 90160
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.043 | 100.0 | ? | ? |
| ZEN 90160 | 0.051 | 84.3 | ? | ? |
| Prothioconazoles 100: ZEN 90160 1 | 0.044 | 97.7 | 99.8 | 97.9 |
| Prothioconazoles 80: ZEN 90160 1 | 0.035 | 122.9 | 99.8 | 123.1 |
| Prothioconazoles 60: ZEN 90160 1 | 0.031 | 138.7 | 99.7 | 139.1 |
| Prothioconazoles 40: ZEN 90160 1 | 0.029 | 148.3 | 99.6 | 148.8 |
| Prothioconazoles 20: ZEN 90160 1 | 0.027 | 159.3 | 99.3 | 160.5 |
| Prothioconazoles 10: ZEN 90160 1 | 0.027 | 159.3 | 98.6 | 161.6 |
| Prothioconazoles 1: ZEN 90160 1 | 0.026 | 165.4 | 92.2 | 179.5 |
| Prothioconazoles 1: ZEN 90160 10 | 0.031 | 138.7 | 85.7 | 161.8 |
| Prothioconazoles 1: ZEN 90160 20 | 0.033 | 130.3 | 85.1 | 153.2 |
| Prothioconazoles 1: ZEN 90160 40 | 0.035 | 122.9 | 84.7 | 145.1 |
| Prothioconazoles 1: ZEN 90160 60 | 0.041 | 104.9 | 84.6 | 124.0 |
| Prothioconazoles 1: ZEN 90160 80 | 0.047 | 91.5 | 84.5 | 108.3 |
The composite Toxicity Determination result to Rhizoctonia solani Kuhn of table 9 prothioconazoles and kresoxim-methyl
| Process | EC 50（μg/ml) | ATI | TTI | CTC |
| Prothioconazoles | 0.043 | 100.0 | ? | ? |
| Kresoxim-methyl | 0.089 | 48.3 | ? | ? |
| Prothioconazoles 100: kresoxim-methyl 1 | 0.046 | 93.5 | 99.5 | 94.0 |
| Prothioconazoles 80: kresoxim-methyl 1 | 0.034 | 126.5 | 99.4 | 127.3 |
| Prothioconazoles 60: kresoxim-methyl 1 | 0.034 | 126.5 | 99.2 | 127.6 |
| Prothioconazoles 40: kresoxim-methyl 1 | 0.032 | 134.4 | 98.7 | 136.1 |
| Prothioconazoles 20: kresoxim-methyl 1 | 0.035 | 122.9 | 97.5 | 126.0 |
| Prothioconazoles 10: kresoxim-methyl 1 | 0.031 | 138.7 | 95.3 | 145.5 |
| Prothioconazoles 1: kresoxim-methyl 1 | 0.029 | 148.3 | 74.2 | 199.9 |
| Prothioconazoles 1: kresoxim-methyl 10 | 0.038 | 113.2 | 53.0 | 213.5 |
| Prothioconazoles 1: kresoxim-methyl 20 | 0.049 | 87.8 | 50.8 | 172.8 |
| Prothioconazoles 1: kresoxim-methyl 40 | 0.054 | 79.6 | 49.6 | 160.6 |
| Prothioconazoles 1: kresoxim-methyl 60 | 0.066 | 65.2 | 49.2 | 132.5 |
| Prothioconazoles 1: kresoxim-methyl 80 | 0.075 | 57.3 | 49.0 | 117.1 |
The composite Toxicity Determination result to Rhizoctonia solani Kuhn of table 10 prothioconazoles and dimoxystrobin
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.043 | 100.0 | ? | ? |
| Dimoxystrobin | 0.092 | 46.7 | ? | ? |
| Prothioconazoles 100: dimoxystrobin 1 | 0.037 | 116.2 | 99.5 | 116.8 |
| Prothioconazoles 80: dimoxystrobin 1 | 0.031 | 138.7 | 99.3 | 139.6 |
| Prothioconazoles 60: dimoxystrobin 1 | 0.035 | 122.9 | 99.1 | 123.9 |
| Prothioconazoles 40: dimoxystrobin 1 | 0.036 | 119.4 | 98.7 | 121.0 |
| Prothioconazoles 20: dimoxystrobin 1 | 0.03 | 143.3 | 97.5 | 147.1 |
| Prothioconazoles 10: dimoxystrobin 1 | 0.031 | 138.7 | 95.2 | 145.8 |
| Prothioconazoles 1: dimoxystrobin 1 | 0.035 | 122.9 | 73.4 | 167.4 |
| Prothioconazoles 1: dimoxystrobin 10 | 0.040 | 107.5 | 51.6 | 208.4 |
| Prothioconazoles 1: dimoxystrobin 20 | 0.041 | 104.9 | 49.3 | 212.8 |
| Prothioconazoles 1: dimoxystrobin 40 | 0.058 | 74.1 | 48.0 | 154.3 |
| Prothioconazoles 1: dimoxystrobin 60 | 0.070 | 61.4 | 47.6 | 129.0 |
| Prothioconazoles 1: dimoxystrobin 80 | 0.082 | 52.4 | 47.4 | 110.6 |
The composite Toxicity Determination result to Rhizoctonia solani Kuhn of table 11 prothioconazoles and SSF 126
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.043 | 100.0 | ? | ? |
| SSF 126 | 0.091 | 47.3 | ? | ? |
| Prothioconazoles 100: SSF 126 1 | 0.041 | 104.9 | 99.5 | 105.4 |
| Prothioconazoles 80: SSF 126 1 | 0.034 | 126.5 | 99.3 | 127.3 |
| Prothioconazoles 60: SSF 126 1 | 0.035 | 122.9 | 99.1 | 123.9 |
| Prothioconazoles 40: SSF 126 1 | 0.034 | 126.5 | 98.7 | 128.1 |
| Prothioconazoles 20: SSF 126 1 | 0.03 | 143.3 | 97.5 | 147.0 |
| Prothioconazoles 10: SSF 126 1 | 0.032 | 134.4 | 95.2 | 141.1 |
| Prothioconazoles 1: SSF 126 1 | 0.037 | 116.2 | 73.6 | 157.8 |
| Prothioconazoles 1: SSF 126 10 | 0.044 | 97.7 | 52.0 | 187.8 |
| Prothioconazoles 1: SSF 126 20 | 0.056 | 76.8 | 49.8 | 154.3 |
| Prothioconazoles 1: SSF 126 40 | 0.062 | 69.4 | 48.5 | 142.9 |
| Prothioconazoles 1: SSF 126 60 | 0.073 | 58.9 | 48.1 | 122.4 |
| Prothioconazoles 1: SSF 126 80 | 0.085 | 50.6 | 47.9 | 105.6 |
The composite Toxicity Determination result to Rhizoctonia solani Kuhn of table 12 prothioconazoles and orysastrobin amine
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.043 | 100.0 | ? | ? |
| Orysastrobin | 0.085 | 50.6 | ? | ? |
| Prothioconazoles 100: orysastrobin 1 | 0.042 | 102.4 | 99.5 | 102.9 |
| Prothioconazoles 80: orysastrobin 1 | 0.033 | 130.3 | 99.4 | 131.1 |
| Prothioconazoles 60: orysastrobin 1 | 0.034 | 126.5 | 99.2 | 127.5 |
| Prothioconazoles 40: orysastrobin 1 | 0.031 | 138.7 | 98.8 | 140.4 |
| Prothioconazoles 20: orysastrobin 1 | 0.032 | 134.4 | 97.6 | 137.6 |
| Prothioconazoles 10: orysastrobin 1 | 0.032 | 134.4 | 95.5 | 140.7 |
| Prothioconazoles 1: orysastrobin 1 | 0.034 | 126.5 | 75.3 | 168.0 |
| Prothioconazoles 1: orysastrobin 10 | 0.042 | 102.4 | 55.1 | 185.9 |
| Prothioconazoles 1: orysastrobin 20 | 0.060 | 71.7 | 52.9 | 135.4 |
| Prothioconazoles 1: orysastrobin 40 | 0.062 | 69.4 | 51.8 | 133.9 |
| Prothioconazoles 1: orysastrobin 60 | 0.063 | 68.3 | 51.4 | 132.8 |
| Prothioconazoles 1: orysastrobin 80 | 0.071 | 60.6 | 51.2 | 118.3 |
The result of Toxicity Determination shows that any in prothioconazoles and pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126, the orysastrobin is mixed, and ratio is synergistic effect when being 80:1～1:60.
Biologicall test example 3
Arbitrary composite Toxicity Determination to Ustilaginoidea virens in prothioconazoles and pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126, the orysastrobin
Subjects: the Ustilaginoidea virens that picks up from the field
Test method: with reference to " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) ", the mycelial growth rate method.With Ustilaginoidea virens PDA medium culture, when treating that bacterium colony has just covered with culture dish, be that the card punch of 7mm punches from the edge with internal diameter, the mycelia piece that breaks into is as inoculum.Get respectively the liquid 5ml and the 75ml sterilising medium that prepare and mix, make 4 and contain the liquid flat board, be mixed into contrast with equivalent sterile water and medium.The inversion of mycelia piece is connected to dull and stereotyped central authorities, and in 28 ℃ of incubators, cultivates.Behind the 7d, measure colony diameter with the right-angled intersection method, calculate and respectively process mycelia net growth, mycelial growth inhibition rate.
Mycelia net growth (mm)=measurement colony diameter-7
The mycelial growth rate conversion is become probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, calculates concentration EC in virulence equation and the inhibition with method of least squares
50, according to toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament, toxicity test the results are shown in following table.
The composite Toxicity Determination result to Ustilaginoidea virens of table 13 prothioconazoles and pyraclostrobin
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.089 | 100.0 | ? | ? |
| Pyraclostrobin | 0.135 | 65.9 | ? | ? |
| Prothioconazoles 100: pyraclostrobin 1 | 0.085 | 104.7 | 99.7 | 105.1 |
| Prothioconazoles 80: pyraclostrobin 1 | 0.073 | 121.9 | 99.6 | 122.4 |
| Prothioconazoles 60: pyraclostrobin 1 | 0.065 | 136.9 | 99.4 | 137.7 |
| Prothioconazoles 40: pyraclostrobin 1 | 0.062 | 143.5 | 99.2 | 144.8 |
| Prothioconazoles 20: pyraclostrobin 1 | 0.054 | 164.8 | 98.4 | 167.5 |
| Prothioconazoles 10: pyraclostrobin 1 | 0.052 | 171.2 | 96.9 | 176.6 |
| Prothioconazoles 1: pyraclostrobin 1 | 0.049 | 181.6 | 83.0 | 218.9 |
| Prothioconazoles 1: pyraclostrobin 10 | 0.053 | 167.9 | 69.0 | 243.3 |
| Prothioconazoles 1: pyraclostrobin 20 | 0.069 | 129.0 | 67.5 | 191.0 |
| Prothioconazoles 1: pyraclostrobin 40 | 0.088 | 101.1 | 66.8 | 151.5 |
| Prothioconazoles 1: pyraclostrobin 60 | 0.094 | 94.7 | 66.5 | 142.4 |
| Prothioconazoles 1: pyraclostrobin 80 | 0.112 | 79.5 | 66.3 | 119.8 |
The composite Toxicity Determination result to Ustilaginoidea virens of table 14 prothioconazoles and ZEN 90160
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.089 | 100.0 | ? | ? |
| ZEN 90160 | 0.069 | 129.0 | ? | ? |
| Prothioconazoles 100: ZEN 90160 1 | 0.081 | 109.9 | 100.3 | 109.6 |
| Prothioconazoles 80: ZEN 90160 1 | 0.071 | 125.4 | 100.4 | 124.9 |
| Prothioconazoles 60: ZEN 90160 1 | 0.066 | 134.8 | 100.5 | 134.2 |
| Prothioconazoles 40: ZEN 90160 1 | 0.065 | 136.9 | 100.7 | 136.0 |
| Prothioconazoles 20: ZEN 90160 1 | 0.059 | 150.8 | 101.4 | 148.8 |
| Prothioconazoles 10: ZEN 90160 1 | 0.055 | 161.8 | 102.6 | 157.7 |
| Prothioconazoles 1: ZEN 90160 1 | 0.056 | 158.9 | 114.5 | 138.8 |
| Prothioconazoles 1: ZEN 90160 10 | 0.055 | 161.8 | 126.4 | 128.1 |
| Prothioconazoles 1: ZEN 90160 20 | 0.047 | 189.4 | 127.6 | 148.4 |
| Prothioconazoles 1: ZEN 90160 40 | 0.054 | 164.8 | 128.3 | 128.5 |
| Prothioconazoles 1: ZEN 90160 60 | 0.052 | 171.2 | 128.5 | 133.2 |
| Prothioconazoles 1: ZEN 90160 80 | 0.067 | 132.4 | 128.6 | 103.0 |
The composite Toxicity Determination result to Ustilaginoidea virens of table 15 prothioconazoles and kresoxim-methyl
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.089 | 100.0 | ? | ? |
| Kresoxim-methyl | 0.154 | 57.8 | ? | ? |
| Prothioconazoles 100: kresoxim-methyl 1 | 0.092 | 96.7 | 99.6 | 97.1 |
| Prothioconazoles 80: kresoxim-methyl 1 | 0.068 | 130.9 | 99.5 | 131.6 |
| Prothioconazoles 60: kresoxim-methyl 1 | 0.059 | 150.8 | 99.3 | 151.9 |
| Prothioconazoles 40: kresoxim-methyl 1 | 0.06 | 148.3 | 99.0 | 149.9 |
| Prothioconazoles 20: kresoxim-methyl 1 | 0.061 | 145.9 | 98.0 | 148.9 |
| Prothioconazoles 10: kresoxim-methyl 1 | 0.058 | 153.4 | 96.2 | 159.6 |
| Prothioconazoles 1: kresoxim-methyl 1 | 0.063 | 141.3 | 78.9 | 179.1 |
| Prothioconazoles 1: kresoxim-methyl 10 | 0.072 | 123.6 | 61.6 | 200.6 |
| Prothioconazoles 1: kresoxim-methyl 20 | 0.084 | 106.0 | 59.8 | 177.2 |
| Prothioconazoles 1: kresoxim-methyl 40 | 0.099 | 89.9 | 58.8 | 152.8 |
| Prothioconazoles 1: kresoxim-methyl 60 | 0.106 | 84.0 | 58.5 | 143.6 |
| Prothioconazoles 1: kresoxim-methyl 80 | 0.136 | 65.4 | 58.3 | 112.2 |
The composite Toxicity Determination result to Ustilaginoidea virens of table 16 prothioconazoles and dimoxystrobin
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.089 | 100.0 | ? | ? |
| Dimoxystrobin | 0.125 | 71.2 | ? | ? |
| Prothioconazoles 100: dimoxystrobin 1 | 0.078 | 114.1 | 99.7 | 114.4 |
| Prothioconazoles 80: dimoxystrobin 1 | 0.064 | 139.1 | 99.6 | 139.6 |
| Prothioconazoles 60: dimoxystrobin 1 | 0.053 | 167.9 | 99.5 | 168.7 |
| Prothioconazoles 40: dimoxystrobin 1 | 0.062 | 143.5 | 99.3 | 144.6 |
| Prothioconazoles 20: dimoxystrobin 1 | 0.055 | 161.8 | 98.6 | 164.1 |
| Prothioconazoles 10: dimoxystrobin 1 | 0.052 | 171.2 | 97.4 | 175.8 |
| Prothioconazoles 1: dimoxystrobin 1 | 0.053 | 167.9 | 85.6 | 196.2 |
| Prothioconazoles 1: dimoxystrobin 10 | 0.068 | 130.9 | 73.8 | 177.3 |
| Prothioconazoles 1: dimoxystrobin 20 | 0.076 | 117.1 | 72.6 | 161.4 |
| Prothioconazoles 1: dimoxystrobin 40 | 0.085 | 104.7 | 71.9 | 145.6 |
| Prothioconazoles 1: dimoxystrobin 60 | 0.099 | 89.9 | 71.7 | 125.4 |
| Prothioconazoles 1: dimoxystrobin 80 | 0.111 | 80.0 | 71.6 | 111.8 |
The composite Toxicity Determination result to Ustilaginoidea virens of table 17 prothioconazoles and SSF 126
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.089 | 100.0 | ? | ? |
| SSF 126 | 0.144 | 61.8 | ? | ? |
| Prothioconazoles 100: SSF 126 1 | 0.077 | 115.6 | 99.6 | 116.0 |
| Prothioconazoles 80: SSF 126 1 | 0.065 | 136.9 | 99.5 | 137.6 |
| Prothioconazoles 60: SSF 126 1 | 0.058 | 153.4 | 99.4 | 154.4 |
| Prothioconazoles 40: SSF 126 1 | 0.052 | 171.2 | 99.1 | 172.8 |
| Prothioconazoles 20: SSF 126 1 | 0.057 | 156.1 | 98.2 | 159.0 |
| Prothioconazoles 10: SSF 126 1 | 0.061 | 145.9 | 96.5 | 151.1 |
| Prothioconazoles 1: SSF 126 1 | 0.064 | 139.1 | 80.9 | 171.9 |
| Prothioconazoles 1: SSF 126 10 | 0.077 | 115.6 | 65.3 | 177.1 |
| Prothioconazoles 1: SSF 126 20 | 0.083 | 107.2 | 63.6 | 168.5 |
| Prothioconazoles 1: SSF 126 40 | 0.092 | 96.7 | 62.7 | 154.2 |
| Prothioconazoles 1: SSF 126 60 | 0.107 | 83.2 | 62.4 | 133.2 |
| Prothioconazoles 1: SSF 126 80 | 0.128 | 69.5 | 62.3 | 111.6 |
The composite Toxicity Determination result to Ustilaginoidea virens of table 18 prothioconazoles and orysastrobin amine
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Prothioconazoles | 0.089 | 100.0 | ? | ? |
| Orysastrobin | 0.141 | 63.1 | ? | ? |
| Prothioconazoles 100: orysastrobin 1 | 0.079 | 112.7 | 99.6 | 113.1 |
| Prothioconazoles 80: orysastrobin 1 | 0.067 | 132.8 | 99.5 | 133.4 |
| Prothioconazoles 60: orysastrobin 1 | 0.053 | 167.9 | 99.4 | 168.9 |
| Prothioconazoles 40: orysastrobin 1 | 0.062 | 143.5 | 99.1 | 144.9 |
| Prothioconazoles 20: orysastrobin 1 | 0.059 | 150.8 | 98.2 | 153.5 |
| Prothioconazoles 10: orysastrobin 1 | 0.067 | 132.8 | 96.6 | 137.4 |
| Prothioconazoles 1: orysastrobin 1 | 0.071 | 125.4 | 81.6 | 153.7 |
| Prothioconazoles 1: orysastrobin 10 | 0.089 | 100.0 | 66.5 | 150.4 |
| Prothioconazoles 1: orysastrobin 20 | 0.094 | 94.7 | 64.9 | 145.9 |
| Prothioconazoles 1: orysastrobin 40 | 0.103 | 86.4 | 64.0 | 135.0 |
| Prothioconazoles 1: orysastrobin 60 | 0.116 | 76.7 | 63.7 | 120.4 |
| Prothioconazoles 1: orysastrobin 80 | 0.131 | 67.9 | 63.6 | 106.9 |
The result of Toxicity Determination shows that any in prothioconazoles and pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126, the orysastrobin is mixed, and ratio is synergistic effect when being 80:1～1:60.
Fungicidal composition of the present invention can be prepared into known method any one formulation that is fit to agricultural use, and reasonable formulation is wetting powder, water dispersible granules, suspending agent, microcapsule suspending agent, granule or aqueous emulsion.
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to absolutely not these examples.The following stated only is preferably embodiment of the present invention, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of making within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Percentage all is weight percentage in all prescriptions.The processing technology of each preparation of the present composition is prior art, can change to some extent according to different situations.
Embodiment 1:1% Bing sulphur Jun Zuo ﹒ pyraclostrobin granule
In prothioconazoles and pyraclostrobin, add DMF, then they are fully stirred, they are dissolved fully; Under agitation, in system, slowly add propane diols, fully stirred 30 minutes, they are dissolved fully, form stable solution.
First 12 ~ 60 purpose zeolites are added in the mixer, the solution with aforementioned stable adds wherein again, mixes 30 minutes, can obtain 1% Bing sulphur Jun Zuo ﹒ pyraclostrobin granule after screening, detection are qualified.
This embodiment is applied to prevent and treat rice blast.1% Bing sulphur Jun Zuo ﹒ pyraclostrobin granule spreads fertilizer over the fields according to 200g a.i./ha, and 10 days control efficiency is 82.5% behind the medicine.40% prothioconazoles wetting powder is mixed soil and is spread fertilizer over the fields according to 200g a.i./ha, and 25% pyraclostrobin missible oil is mixed soil according to 200g a.i./ha and spread fertilizer over the fields, and 10 days control efficiency is respectively 80.1% and 79.3% behind the medicine.The composite rear synergistic effect of prothioconazoles and pyraclostrobin is obvious, to the control efficiency of rice blast significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 2:10% Bing sulphur Jun Zuo ﹒ ZEN 90160 microcapsule suspending agent
With rosickyite bacterium ester 2%, ZEN 90160 8% is dissolved in 5% dimethylbenzene, the suction tributyl phosphate 0.3% again, carboxymethyl cellulose 2.4%, sodium alginate 2.7% was sheared 30 minutes in high shear still high speed, add 20% urea resin prepolymer, heat up under 2000 rev/mins of stirrings and solidified 60 minutes, add afterwards deionized water, 4.5% dinaphthyl methane-disulfonic acid sodium, 1.8% bentonite, stirring gets final product to get 10% prothioconazoles ZEN 90160 microcapsule suspending agent.
This embodiment is applied to prevent and treat rice blast.10% Bing sulphur Jun Zuo ﹒ ZEN 90160 microcapsule suspending agent is according to the spraying of 300g a.i./ha thin up, and 10 days control efficiency is 84.4% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 25% ZEN 90160 suspending agent is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 80.1% and 81.1% behind the medicine.The composite rear synergistic effect of prothioconazoles and ZEN 90160 is obvious, to the control efficiency of rice blast significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 3:16% Bing sulphur Jun Zuo ﹒ kresoxim-methyl aqueous emulsion
Above-mentioned prescription Central Plains medicine, solvent, cosolvent emulsifiers dissolve are become even oil phase; The insecticides adjuvants such as part water, antifreezing agent, defoamer are mixed the uniform water of formation, and oil phase adds water and carry out high speed shear in clipper, and adds remaining water, shears 30 minutes, mixes.Namely make 16% Bing sulphur Jun Zuo ﹒ kresoxim-methyl aqueous emulsion.
This embodiment is applied to prevent and treat rice blast.16% Bing sulphur Jun Zuo ﹒ kresoxim-methyl aqueous emulsion is according to the spraying of 200g a.i./ha thin up, and 10 days control efficiency is 83.7% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 30% kresoxim-methyl wetting powder is according to 200g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 80.1% and 82.2% behind the medicine.The composite rear synergistic effect of prothioconazoles and kresoxim-methyl is obvious, to the control efficiency of rice blast significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 4:21% Bing sulphur Jun Zuo ﹒ dimoxystrobin suspending agent
The ratio of said components in prescription mixed, after high speed shear, obtain 21% Bing sulphur Jun Zuo ﹒ dimoxystrobin suspending agent.
This embodiment is applied to prevent and treat rice blast.21% Bing sulphur Jun Zuo ﹒ dimoxystrobin suspending agent is according to the spraying of 300g a.i./ha thin up, and 10 days control efficiency is 85.4% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 25% dimoxystrobin missible oil is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 80.1% and 83.3% behind the medicine.The composite rear synergistic effect of prothioconazoles and dimoxystrobin is obvious, to the control efficiency of rice blast significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 5:60% Bing sulphur Jun Zuo ﹒ SSF 126 wetting powder
The ratio of said components in prescription mixed, behind ultra-fine pulverizer disintegrating, obtain 60% Bing sulphur Jun Zuo ﹒ SSF 126 wetting powder.
This embodiment is applied to prevent and treat rice blast.60% Bing sulphur Jun Zuo ﹒ SSF 126 wetting powder is according to the spraying of 300g a.i./ha thin up, and 10 days control efficiency is 85.1% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 20% SSF 126 wetting powder is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 80.1% and 83.1% behind the medicine.The composite rear synergistic effect of prothioconazoles and SSF 126 is obvious, to the control efficiency of rice blast significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 6:90% Bing sulphur Jun Zuo ﹒ orysastrobin water dispersible granules
The ratio of said components in prescription mixed, behind air-flow crushing, obtain wetting powder, add again a certain amount of water mixing extruder grain, obtain 90% Bing sulphur Jun Zuo ﹒ orysastrobin water dispersible granules after the drying screening.
This embodiment is applied to prevent and treat rice sheath blight disease.90% Bing sulphur Jun Zuo ﹒ orysastrobin water dispersible granules is according to the spray of 300g a.i./ha thin up, and 10 days control efficiency is 83.3% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 20% orysastrobin wetting powder is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 83.4% and 80.3% behind the medicine.The composite rear synergistic effect of prothioconazoles and orysastrobin is obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 7:55% Bing sulphur Jun Zuo ﹒ pyraclostrobin wetting powder
The ratio of said components in prescription mixed, behind ultra-fine pulverizer disintegrating, obtain 55% Bing sulphur Jun Zuo ﹒ pyraclostrobin wetting powder.
This embodiment is applied to prevent and treat rice sheath blight disease.55% Bing sulphur Jun Zuo ﹒ pyraclostrobin wetting powder is according to the spraying of 200g a.i./ha thin up, and 10 days control efficiency is 86.5% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 25% pyraclostrobin missible oil is according to 200g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 83.4% and 81.3% behind the medicine.The composite rear synergistic effect of prothioconazoles and pyraclostrobin is obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 8:21% Bing sulphur Jun Zuo ﹒ ZEN 90160 microcapsule suspending agent
With rosickyite bacterium ester 20%, ZEN 90160 1% is dissolved in 5% dimethylbenzene, the suction tributyl phosphate 0.3% again, carboxymethyl cellulose 2.4%, sodium alginate 2.7% was sheared 30 minutes in high shear still high speed, add 20% urea resin prepolymer, heat up under 2000 rev/mins of stirrings and solidified 60 minutes, add afterwards deionized water, 4.5% dinaphthyl methane-disulfonic acid sodium, 1.8% bentonite, stirring gets final product to get 21% prothioconazoles ZEN 90160 microcapsule suspending agent.
This embodiment is applied to prevent and treat rice sheath blight disease.21% Bing sulphur Jun Zuo ﹒ ZEN 90160 microcapsule suspending agent is according to the spraying of 300g a.i./ha thin up, and 10 days control efficiency is 84.7% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 25% ZEN 90160 suspending agent is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 83.4% and 82.7% behind the medicine.The composite rear synergistic effect of prothioconazoles and ZEN 90160 is obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 9:41% Bing sulphur Jun Zuo ﹒ water dispersion granules agent of Kresoxim
The ratio of said components in prescription mixed, behind air-flow crushing, obtain wetting powder, add again a certain amount of water mixing extruder grain, obtain 41% Bing sulphur Jun Zuo ﹒ water dispersion granules agent of Kresoxim after the drying screening.
This embodiment is applied to prevent and treat rice sheath blight disease.41% Bing sulphur Jun Zuo ﹒ water dispersion granules agent of Kresoxim is according to the spraying of 200g a.i./ha thin up, and 10 days control efficiency is 84.2% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 30% kresoxim-methyl wetting powder is according to 200g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 83.4% and 73.1% behind the medicine.The composite rear synergistic effect of prothioconazoles and kresoxim-methyl is obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 10:61% Bing sulphur Jun Zuo ﹒ dimoxystrobin water dispersible granules
The ratio of said components in prescription mixed, behind air-flow crushing, obtain wetting powder, add again a certain amount of water mixing extruder grain, obtain 61% Bing sulphur Jun Zuo ﹒ dimoxystrobin water dispersible granules after the drying screening.
This embodiment is applied to prevent and treat rice sheath blight disease.61% Bing sulphur Jun Zuo ﹒ dimoxystrobin water dispersible granules is according to the spraying of 300g a.i./ha thin up, and 10 days control efficiency is 83.7% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 25% dimoxystrobin missible oil is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 83.4% and 74.3% behind the medicine.The composite rear synergistic effect of prothioconazoles and dimoxystrobin is obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 11:81% Bing sulphur Jun Zuo ﹒ SSF 126 wetting powder
The ratio of said components in prescription mixed, behind ultra-fine pulverizer disintegrating, obtain 81% Bing sulphur Jun Zuo ﹒ SSF 126 wetting powder.
This embodiment is applied to prevent and treat rice green smut.81% Bing sulphur Jun Zuo ﹒ SSF 126 wetting powder is according to the spraying of 300g a.i./ha thin up, and 10 days control efficiency is 84.7% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 20% SSF 126 wetting powder is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 77.2% and 72.8% behind the medicine.The composite rear synergistic effect of prothioconazoles and SSF 126 is obvious, to the control efficiency of rice green smut significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 12:6% Bing sulphur Jun Zuo ﹒ orysastrobin granule
In prothioconazoles and orysastrobin, add DMF, then they are fully stirred, they are dissolved fully; Under agitation, in system, slowly add propane diols, fully stirred 30 minutes, they are dissolved fully, form stable solution.
First 12 ~ 60 purpose zeolites are added in the mixer, the solution with aforementioned stable adds wherein again, mixes 30 minutes, can obtain 6% Bing sulphur Jun Zuo ﹒ orysastrobin granule after screening, detection are qualified
This embodiment is applied to prevent and treat rice green smut.6% Bing sulphur Jun Zuo ﹒ orysastrobin granule spreads fertilizer over the fields according to 300g a.i./ha, and 10 days control efficiency is 81.8% behind the medicine.40% prothioconazoles wetting powder is mixed soil according to 200g a.i./ha and is spread fertilizer over the fields, and 20% orysastrobin wetting powder is mixed soil according to 300g a.i./ha and spread fertilizer over the fields, and 10 days control efficiency is respectively 77.2% and 77.8% behind the medicine.The composite rear synergistic effect of prothioconazoles and orysastrobin is obvious, to the control efficiency of rice green smut significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 13:70% Bing sulphur Jun Zuo ﹒ pyraclostrobin water dispersible granules
The ratio of said components in prescription mixed, behind air-flow crushing, obtain wetting powder, add again a certain amount of water mixing extruder grain, obtain 70% Bing sulphur Jun Zuo ﹒ pyraclostrobin water dispersible granules after the drying screening.
This embodiment is applied to prevent and treat rice green smut.70% Bing sulphur Jun Zuo ﹒ pyraclostrobin water dispersible granules is according to the spraying of 200g a.i./ha thin up, and 10 days control efficiency is 82.4% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 25% pyraclostrobin emulsifiable concentrate is according to 200g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 77.2% and 75.3% behind the medicine.The composite rear synergistic effect of prothioconazoles and pyraclostrobin is obvious, to the control efficiency of rice green smut significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 14:30% Bing sulphur Jun Zuo ﹒ ZEN 90160 suspending agent
The ratio of said components in prescription mixed, after high speed shear, obtain 30% Bing sulphur Jun Zuo ﹒ ZEN 90160 suspending agent.
This embodiment is applied to prevent and treat rice green smut.30% Bing sulphur Jun Zuo ﹒ ZEN 90160 suspending agent is according to the spraying of 300g a.i./ha thin up, and 10 days control efficiency is 82.1% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 25% ZEN 90160 suspending agent is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 77.2% and 80.5% behind the medicine.The composite rear synergistic effect of prothioconazoles and ZEN 90160 is obvious, to the control efficiency of rice green smut significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Embodiment 15:25% Bing sulphur Jun Zuo ﹒ SSF 126 aqueous emulsion
Above-mentioned prescription Central Plains medicine, solvent, cosolvent emulsifiers dissolve are become even oil phase; The insecticides adjuvants such as part water, antifreezing agent, defoamer are mixed the uniform water of formation, and oil phase adds water and carry out high speed shear in clipper, and adds remaining water, shears 30 minutes, mixes.Namely make 25% Bing sulphur Jun Zuo ﹒ SSF 126 aqueous emulsion.
This embodiment is applied to prevent and treat rice green smut.25% Bing sulphur Jun Zuo ﹒ SSF 126 aqueous emulsion is according to the spraying of 300g a.i./ha thin up, and 10 days control efficiency is 82.1% behind the medicine.40% prothioconazoles wetting powder is according to 200g a.i./ha, and 20% SSF 126 wetting powder is according to 300g a.i./ha, and thin up is sprayed, and 10 days control efficiency is respectively 77.2% and 72.8% behind the medicine.The composite rear synergistic effect of prothioconazoles and SSF 126 is obvious, to the control efficiency of rice green smut significantly better than single dose; Because the pharmacy effect raising obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby also alleviated the pollution to environment.
Claims (3)
1. bactericidal composition that contains prothioconazoles, formed by active ingredient, auxiliary agent and excipient, it is characterized in that, active ingredient is comprised of active component A and active component B, active component A is prothioconazoles, and active component B is selected from any one in pyraclostrobin, ZEN 90160, kresoxim-methyl, dimoxystrobin, SSF 126 or the orysastrobin; The percentage by weight that active ingredient accounts for composition is 1 ~ 90%, and the weight ratio of active component A and active component B is 80:1～1:60;
The described bactericidal composition that contains prothioconazoles is prepared into a kind of in wetting powder, water dispersible granules, suspending agent, microcapsule suspending agent, granule or the aqueous emulsion.
2. the bactericidal composition that contains prothioconazoles according to claim 1 is characterized in that, the weight ratio of described active component A and active component B is 20:1～1:40.
3. the bactericidal composition that contains prothioconazoles according to claim 1 and 2 is characterized in that, the percentage by weight that described active ingredient accounts for composition is 10 ~ 60%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104621132A (en) * | 2013-11-15 | 2015-05-20 | 南京华洲药业有限公司 | Sterilization composition containing prothioconazole and cyproconazole and application thereof |
| CN104621131A (en) * | 2013-11-15 | 2015-05-20 | 南京华洲药业有限公司 | Sterilization composition containing prothioconazole and famoxadone and application thereof |
| CN104642333A (en) * | 2013-11-15 | 2015-05-27 | 南京华洲药业有限公司 | Prothioconazole and kresoxim-methyl-containing sterilization composition and application thereof |
| CN106719620A (en) * | 2016-12-30 | 2017-05-31 | 江苏扬农化工股份有限公司 | A kind of pyraclostrobin and prothioconazoles compounding suspending agent and application thereof |
| CN107593742A (en) * | 2017-09-11 | 2018-01-19 | 江苏禾业农化有限公司 | Prothioconazoles and the aqueous suspension agent formula of pyraclostrobin 30% |
| CN107771817A (en) * | 2016-08-29 | 2018-03-09 | 南京华洲药业有限公司 | A kind of bactericidal composition and its application containing ZEN 90160 and prothioconazoles |
| CN108782580A (en) * | 2018-09-21 | 2018-11-13 | 贵州道元生物技术有限公司 | A kind of bactericidal composition and application thereof of the rosickyite azoles and SSF 126 of prevention rice blast |
| CN110876381A (en) * | 2019-10-31 | 2020-03-13 | 浙江中山化工集团股份有限公司 | Bactericide composition containing picoxystrobin and prothioconazole and preparation method thereof |
| CN114403152A (en) * | 2022-01-20 | 2022-04-29 | 溧阳中南化工有限公司 | Prothioconazole-kresoxim-methyl bactericidal suspending agent and preparation method thereof |
| EP4014738A1 (en) * | 2013-11-26 | 2022-06-22 | UPL Ltd | A method for controlling rust |
| CN115067326A (en) * | 2022-06-17 | 2022-09-20 | 安徽久易农业股份有限公司 | Seed treatment suspending agent containing prothioconazole and pyraclostrobin and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104621132A (en) * | 2013-11-15 | 2015-05-20 | 南京华洲药业有限公司 | Sterilization composition containing prothioconazole and cyproconazole and application thereof |
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| CN108782580A (en) * | 2018-09-21 | 2018-11-13 | 贵州道元生物技术有限公司 | A kind of bactericidal composition and application thereof of the rosickyite azoles and SSF 126 of prevention rice blast |
| CN110876381A (en) * | 2019-10-31 | 2020-03-13 | 浙江中山化工集团股份有限公司 | Bactericide composition containing picoxystrobin and prothioconazole and preparation method thereof |
| CN114403152A (en) * | 2022-01-20 | 2022-04-29 | 溧阳中南化工有限公司 | Prothioconazole-kresoxim-methyl bactericidal suspending agent and preparation method thereof |
| CN115067326A (en) * | 2022-06-17 | 2022-09-20 | 安徽久易农业股份有限公司 | Seed treatment suspending agent containing prothioconazole and pyraclostrobin and preparation method and application thereof |
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Application publication date: 20130320 |