CN102964256A - 一种4-氨基-n,n-二甲基苄胺的制备方法 - Google Patents
一种4-氨基-n,n-二甲基苄胺的制备方法 Download PDFInfo
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- CN102964256A CN102964256A CN2012105008763A CN201210500876A CN102964256A CN 102964256 A CN102964256 A CN 102964256A CN 2012105008763 A CN2012105008763 A CN 2012105008763A CN 201210500876 A CN201210500876 A CN 201210500876A CN 102964256 A CN102964256 A CN 102964256A
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- dimethyl benzylamine
- amino
- preparation
- nitro
- dimethylamine
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Abstract
Description
单批投料下对硝基苄溴与二甲胺的摩尔百分比 | 杂质A的摩尔浓度 |
20% | 8.5% |
15% | 6.5% |
10% | 5.0% |
9% | 3.0% |
8% | 2.3% |
7% | 1.5% |
6% | 1.0% |
5% | 0.8% |
4% | 0.5% |
3% | 0.4% |
2% | 0.3% |
1% | 0.3% |
Claims (10)
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CN201210500876.3A CN102964256B (zh) | 2012-11-28 | 2012-11-28 | 一种4-氨基-n,n-二甲基苄胺的制备方法 |
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CN102964256A true CN102964256A (zh) | 2013-03-13 |
CN102964256B CN102964256B (zh) | 2014-05-07 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109796349A (zh) * | 2019-03-01 | 2019-05-24 | 西南石油大学 | 一种还原芳香硝基化合物制备芳胺类化合物的方法 |
Citations (7)
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WO2003037346A1 (en) * | 2001-10-31 | 2003-05-08 | Cell Therapeutics, Inc. | 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer |
WO2005097752A1 (en) * | 2004-03-31 | 2005-10-20 | Bayer Pharmaceuticals Corporation | Quinolone carboxylic acid derivatives for treatment of hyperproliferative conditions |
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WO2006123145A1 (en) * | 2005-05-18 | 2006-11-23 | F2G Ltd | Antifungal agents |
WO2007075783A2 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Substituted isoquinoline-1,3(2h,4h)-diones, 1-thioxo-1,4-dihydro-2h-isoquinoline-3-ones and 1,4-dihydro-3(2h)-isoquinolones and use thereof as kinase inhibitor |
WO2007099326A1 (en) * | 2006-03-02 | 2007-09-07 | Astrazeneca Ab | Quinoline derivatives |
CN101735071A (zh) * | 2009-12-04 | 2010-06-16 | 大连凯飞精细化工有限公司 | 一种生产4-n,n-二甲胺基甲基苯胺的方法 |
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2012
- 2012-11-28 CN CN201210500876.3A patent/CN102964256B/zh active Active
Patent Citations (7)
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WO2003037346A1 (en) * | 2001-10-31 | 2003-05-08 | Cell Therapeutics, Inc. | 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer |
WO2005097752A1 (en) * | 2004-03-31 | 2005-10-20 | Bayer Pharmaceuticals Corporation | Quinolone carboxylic acid derivatives for treatment of hyperproliferative conditions |
WO2006040526A1 (en) * | 2004-10-12 | 2006-04-20 | Astrazeneca Ab | Quinazoline derivatives for use against cancer |
WO2006123145A1 (en) * | 2005-05-18 | 2006-11-23 | F2G Ltd | Antifungal agents |
WO2007075783A2 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Substituted isoquinoline-1,3(2h,4h)-diones, 1-thioxo-1,4-dihydro-2h-isoquinoline-3-ones and 1,4-dihydro-3(2h)-isoquinolones and use thereof as kinase inhibitor |
WO2007099326A1 (en) * | 2006-03-02 | 2007-09-07 | Astrazeneca Ab | Quinoline derivatives |
CN101735071A (zh) * | 2009-12-04 | 2010-06-16 | 大连凯飞精细化工有限公司 | 一种生产4-n,n-二甲胺基甲基苯胺的方法 |
Non-Patent Citations (3)
Title |
---|
GERALD J.ROTH 等: "Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)", 《J.MED.CHEM.》, vol. 52, no. 14, 6 December 2009 (2009-12-06), pages 4466 - 4480, XP002582395, DOI: 10.1021/JM900431G * |
KAREL ŠINDELÁř 等: "Potential antidepressants. Synthesis of 6,11-dihydrodibenzo[b,e]thiepin-11-yl (dimethylaminomethyl)phenyl ethers, sulfides, amines and some related compounds", 《COLLECT.CZECH.CHEM.COMMUN.》, vol. 55, no. 1, 31 December 1990 (1990-12-31), pages 287 - 288, XP009176408 * |
吴江 等: "N,N-二甲基苄胺的制备", 《天津化工》, no. 1, 20 February 2001 (2001-02-20), pages 28 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109796349A (zh) * | 2019-03-01 | 2019-05-24 | 西南石油大学 | 一种还原芳香硝基化合物制备芳胺类化合物的方法 |
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Denomination of invention: A preparation method of 4-amino-n, n-dimethylbenzylamine Effective date of registration: 20210520 Granted publication date: 20140507 Pledgee: Industrial Commercial Bank of China Ltd. Taizhou Jiaojiang branch Pledgor: ZHEJIANG HISOAR PHARMACEUTICAL Co.,Ltd. Registration number: Y2021330000425 |
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Date of cancellation: 20211223 Granted publication date: 20140507 Pledgee: Industrial Commercial Bank of China Ltd. Taizhou Jiaojiang branch Pledgor: ZHEJIANG HISOAR PHARMACEUTICAL Co.,Ltd. Registration number: Y2021330000425 |
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Denomination of invention: A preparation method of 4-amino-n, n-dimethylbenzylamine Effective date of registration: 20220607 Granted publication date: 20140507 Pledgee: China Co. truction Bank Corp Taizhou Jiaojiang branch Pledgor: ZHEJIANG HISOAR PHARMACEUTICAL Co.,Ltd. Registration number: Y2022330000871 |