CN102961604B - Traditional Chinese medicine preparation for treating viral myocarditis - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating viral myocarditis. The traditional Chinese medicine believes that the viral myocarditis belongs to the fields of syndromes of 'palpitation' 'severe palpitation' 'chest obstruction''consumptive disease' and the like. Consequently, the traditional Chinese medicine preparation selects the traditional Chinese medicines such as ophiopogon latifolius, herb of flabellate hemipilia, epilobium angustifolium, radix sophorae tonkinensis, berberis dasystachya maxim., berberis thunbergii DC., potentilla anserine, adenophora stricta, finelydivided phtheirospermum, spina date seed, leguminosae, pilose asiabell, semen vaccariae and processed radix glycyrrhizae which clear heat, detoxify, tonify qi and yin, relieve blockage, eliminate pathogen, promote coronary circulation, tonify kidney and soothe heart, so that a traditional Chinese medicine decoction is prepared for patients to take. Through clinical experiments, the total efficiency reaches 96.2%, and the improvement degrees of a treatment group in the syndromes of palpitation, choking sensation in chest, chest pain, shortness of breath, lacking in strength and the like are also better than a control group obviously. Clinical experiments prove that the traditional Chinese medicine preparation is an ideal medicine for treating viral myocarditis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of viral myocarditis.
Background technology
Viral myocarditis is the commonly encountered diseases of internal medicine, and its sickness rate is in rising trend.Its clinical manifestation is: patient often first has the symptoms such as heating, systemic pain, pharyngalgia, asthenia, nausea,vomiting,diarrhea, then occurring cardiopalmus, uncomfortable in chest, chest pain or pareordia dull pain, dizziness, dyspnea, edema, there is heart failure or cardiogenic shock in only a few patient.Cause gradually clinician's attention.Primary disease is by blood circulation, to damage cardiac muscle by virus or its toxin, causes focal or the myocardium interstitial inflammatory exudation of diffusivity and myofibrosis cordis or the necrosis of cardiac muscle, causes the disease of cardiac dysfunction and General Symptoms.There is no at present effective treatment means, conventional therapy adopts cardiac nutrition, arrhythmia class Drug therapy more, but therapeutic effect is undesirable.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of viral myocarditis.Chinese medicine thinks that viral myocarditis belongs to the card categories such as " cardiopalmus " " palpitation with a distress feeling " " thoracic obstruction " " asthenia ", the exopathogenic factor of primary disease is mainly the evil poison of foreign aggression, and how because of physical weakness, deficiency of both QI and YIN, affection due to external wind and heat is evil malicious again, the gas of the deficient vital QI leading to lingering of pathogen damage heart is cloudy, and deficiency of heart-QI is difficult to agitate due to blood vessels.The traditional Chinese medical science take in treatment that heat-clearing and toxic substances removing, supplementing QI and nourishing YIN, blood stasis dispelling are eliminating evil, blood circulation and channel invigorating, kidney calming are the rule for the treatment of.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment viral myocarditis is made by the Chinese medicine of following weight portion: Radix Ophiopogonis Dracaenoidis 10-20 part, Herba Hemipiliae Flabellatae 10-20 part, Radix leontopodii sinensis 7-9 part, Radix Sophorae Tonkinensis 7-9 part, Cortex berberidis dasystachyae 8-10 part, Radix Berberidis Amurensis 9-11 part, Radix potentillae anserinae 6-8 part, Radix Adenophorae 3-5 part, Phtheirospermum tenuisectum Bur.et Franch. 5-7 part, Semen Ziziphi Spinosae 5-7 part, Radix Astragali 7-9 part, Radix Codonopsis 5-7 part, Semen Vaccariae 5-7 part, Radix Glycyrrhizae Preparata 3-5 part.
Preferably, 15 parts of Radix Ophiopogonis Dracaenoidiss, 15 parts of Herba Hemipiliae Flabellataes, 8 parts of Radix leontopodii sinensis, 8 parts of Radix Sophorae Tonkinensiss, 9 parts of Cortex berberidis dasystachyaes, 10 parts of Radix Berberidis Amurensis, 7 parts of Radix potentillae anserinae, 7 parts of Radix Adenophoraes, 6 parts of Phtheirospermum tenuisectum Bur.et Franch.s, 6 parts of Semen Ziziphi Spinosaes, 8 parts of the Radixs Astragali, 6 parts of Radix Codonopsis, 6 parts of Semen Vaccariae, 4 parts of Radix Glycyrrhizae Preparata.
Preparation method is made decoction by above-mentioned Chinese medicine by traditional method.
In side: Radix Ophiopogonis Dracaenoidis feels at ease to calm the nerves, relieving cough and resolving phlegm; Herba Hemipiliae Flabellatae nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst; Radix leontopodii sinensis heat-clearing and toxic substances removing, anti-inflammatory analgetic; Radix Sophorae Tonkinensis heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling; Cortex berberidis dasystachyae heat clearing and damp drying, eliminating fire and detoxication; Radix Berberidis Amurensis heat clearing and damp drying, eliminating fire and detoxication; Radix potentillae anserinae invigorating spleen and reinforcing stomach, promoting the production of body fluid to quench thirst; Radix Adenophorae nourishing YIN and clearing away lung-heat, the QI invigorating of reducing phlegm; Phtheirospermum tenuisectum Bur.et Franch. tranquilizing by nourishing the heart, hemostasis; The Semen Ziziphi Spinosae the liver benefiting that nourishes heart, the arresting sweating of calming the nerves; The raw sun of Radix Astragali QI invigorating, benefit is consolidating superficial resistance, inducing diuresis to remove edema; Radix Codonopsis QI invigorating, promotes the production of body fluid, and nourishes blood; Semen Vaccariae promoting blood circulation to remove obstruction in the collateral, inducing diuresis for treating stranguria syndrome; The sweet temperature of Radix Glycyrrhizae Preparata helps spleen and the merit of invigorating the spleen and replenishing QI stomach function regulating, relieving spasm to stop pain.
Clinical data
1, physical data is selected from June, 2008～2010, the court Inpatients in year July, and totally 160 examples, are divided into treatment group and matched group at random, treatment group 80 examples, and male 34 examples wherein, female's 46 examples, at 18～53 years old age, the mean age is (34.7 ± 6.8) year; The course of disease 5 days～6 weeks, average course of disease is (12.5 ± 8.5) day.Matched group 80 examples, male 33 examples wherein, female's 47 examples; At 19～54 years old age, the mean age is (35.2 ± 6.5) year; The course of disease 7 days～5 weeks, average course of disease is (12.7 ± 9.1) day.Two groups of Genders, age, the course of disease, state of an illness etc. are carried out statistics comparison, and there was no significant difference (P > 0.05), has comparability.
Had palpitation when 2, diagnostic criteria patient falls ill, sensation of oppression over the chest with shortness of breath, dizzy, spiritlessness and weakness, the performances such as abnormal electrocardiographic pattern, all meet after diagnosing diagnosis of viral myocarditis standard in < < internal medicine > >, get rid of severe viral myocarditis and merge the system serious disease patients such as lung, liver, kidney, brain.
3, Therapeutic Method treatment group is taken Chinese medicine preparation of the present invention, take Radix Ophiopogonis Dracaenoidis 15g, Herba Hemipiliae Flabellatae 15g, Radix leontopodii sinensis 8g, Radix Sophorae Tonkinensis 8g, Cortex berberidis dasystachyae 9g, Radix Berberidis Amurensis 10g, Radix potentillae anserinae 7g, Radix Adenophorae 7g, Phtheirospermum tenuisectum Bur.et Franch. 6g, Semen Ziziphi Spinosae 6g, Radix Astragali 8g, Radix Codonopsis 6g, Semen Vaccariae 6g, Radix Glycyrrhizae Preparata 4g make decoction, every day potion, secondary early, late sub-service.Matched group coenzyme A100U, inosine 400mg, vitamin C 3g, 10% potassium chloride 10ml add 10% glucose injection 500ml, intravenous injection once a day.Two groups equal 10 days is a course for the treatment of.
4, criterion of therapeutical effect is cured: clinical symptoms (chest pain, uncomfortable in chest, dizzy, weak etc.), sign are eliminated substantially, and lab testing is normally, and electrocardiogram recovery normally; (2) effective: clinical symptoms (chest pain, uncomfortable in chest, dizzy, weak etc.), sign partly disappear, and lab testing makes moderate progress, and electrocardiogram takes a turn for the better to some extent; (3) invalid: clinical symptoms (chest pain, uncomfortable in chest, dizzy, weak etc.), sign and every coherence check are unchanged.
5, after (1) two group for the treatment of of therapeutic outcome, symptom is improved situation in Table 1.
After two groups of treatments, symptom is improved information slip 1
As can be seen from Table 1, two groups of cardiopalmus, uncomfortable in chest, chest pain, breathe hard, weak, kank, irregularly rapid pulse, slow pulse symptom all have improvement in various degree, but the every symptom for the treatment of group is improved degree and is obviously better than matched group, especially cardiopalmus, uncomfortable in chest, chest pain, breathe hard, the symptom (P < 0.01) of weak, irregularly rapid pulse.
After three courses for the treatment of of (2) two groups of treatments, curative effect is relatively in Table 2.
After three courses for the treatment of of two groups of treatments, curative effect is relatively in Table 2
By table 2, found out, treatment group total effective rate is 96.2%, and matched group total effective rate is 81.3%, and the total effective rate for the treatment of group is significantly higher than matched group, and difference has statistical significance (P < 0.05).
The specific embodiment
Embodiment mono-: take 15 parts of Radix Ophiopogonis Dracaenoidiss, 15 parts of Herba Hemipiliae Flabellataes, 8 parts of Radix leontopodii sinensis, 8 parts of Radix Sophorae Tonkinensiss, 9 parts of Cortex berberidis dasystachyaes, 10 parts of Radix Berberidis Amurensis, 7 parts of Radix potentillae anserinae, 7 parts of Radix Adenophoraes, 6 parts of Phtheirospermum tenuisectum Bur.et Franch.s, 6 parts of Semen Ziziphi Spinosaes, 8 parts of the Radixs Astragali, 6 parts of Radix Codonopsis, 8 parts of Semen Vaccariae, 4 parts of Radix Glycyrrhizae Preparata.By traditional method, decoct into decoction, every day potion, sooner or later sub-service of secondary.
Embodiment bis-: take Radix Ophiopogonis Dracaenoidis 10g, Herba Hemipiliae Flabellatae 20g, Radix leontopodii sinensis 7g, Radix Sophorae Tonkinensis 7g, Cortex berberidis dasystachyae 8g, Radix Berberidis Amurensis 9g, Radix potentillae anserinae 6g, Radix Adenophorae 3g, Phtheirospermum tenuisectum Bur.et Franch. 5g, Semen Ziziphi Spinosae 5g, Radix Astragali 7g, Radix Codonopsis 5g, Semen Vaccariae 7g, Radix Glycyrrhizae Preparata 3g.By traditional method, decoct into decoction, every day potion, secondary early, late sub-service.
Embodiment tri-: take Radix Ophiopogonis Dracaenoidis 20g, Herba Hemipiliae Flabellatae 10g, Radix leontopodii sinensis 9g, Radix Sophorae Tonkinensis 9g, Cortex berberidis dasystachyae 10g, Radix Berberidis Amurensis 11g, Radix potentillae anserinae 8g, Radix Adenophorae 5g, Phtheirospermum tenuisectum Bur.et Franch. 7g, Semen Ziziphi Spinosae 7g, Radix Astragali 9g, Radix Codonopsis 7g, Semen Vaccariae 5g, Radix Glycyrrhizae Preparata 5g.By traditional method, decoct into decoction, every day potion, sooner or later sub-service of secondary.
Claims (2)
1. treat a Chinese medicine preparation for viral myocarditis, it is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Radix Ophiopogonis Dracaenoidis 10-20 part, Herba Hemipiliae Flabellatae 10-20 part, Radix leontopodii sinensis 7-9 part, Radix Sophorae Tonkinensis 7-9 part, Cortex berberidis dasystachyae 8-10 part, Radix Berberidis Amurensis 9-11 part, Radix potentillae anserinae 6-8 part, Radix Adenophorae 3-5 part, Phtheirospermum tenuisectum Bur.et Franch. 5-7 part, Semen Ziziphi Spinosae 5-7 part, Radix Astragali 7-9 part, Radix Codonopsis 5-7 part, Semen Vaccariae 5-7 part, Radix Glycyrrhizae Preparata 3-5 part.
2. a kind of Chinese medicine preparation for the treatment of viral myocarditis according to claim 1, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 15 parts of Radix Ophiopogonis Dracaenoidiss, 15 parts of Herba Hemipiliae Flabellataes, 8 parts of Radix leontopodii sinensis, 8 parts of Radix Sophorae Tonkinensiss, 9 parts of Cortex berberidis dasystachyaes, 10 parts of Radix Berberidis Amurensis, 7 parts of Radix potentillae anserinae, 7 parts of Radix Adenophoraes, 6 parts of Phtheirospermum tenuisectum Bur.et Franch.s, 6 parts of Semen Ziziphi Spinosaes, 8 parts of the Radixs Astragali, 6 parts of Radix Codonopsis, 6 parts of Semen Vaccariae, 4 parts of Radix Glycyrrhizae Preparata.
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