CN104225237A - Chinese medicine for treating adult viral myocarditis and preparation method thereof - Google Patents
Chinese medicine for treating adult viral myocarditis and preparation method thereof Download PDFInfo
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Abstract
The invention provides Chinese medicine for treating adult viral myocarditis and a preparation method thereof. The Chinese medicine comprises raw materials of herb of prostrate wedelia, dogbane leaves, valerian roots, bedstraw herb, herb of malay blumea, peruvian groundcherry herb, mountain dragon, oriental stephania roots, rhizome of perny false fairybells, disporopsis longifolia craib, all-grass of thellung pimpinella, herb of cupleaf passionflower, large leaf moss, fennelflower, evergreen mucuna, herb of sibirica walking fern, and root-bark of pittosporumlike nothapodytes. The Chinese medicine is capable of clearing away heat and toxic materials, invigorating spleen and supplementing qi, promoting blood circulation to arrest pain, and tranquilizing mind by nourishing the heart, has an exact curative effect on adult viral myocarditis, and is small in toxic and side effect.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating Chinese medicine of adult diseases viral myocarditis and preparation method thereof.
Background technology
Viral myocarditis refer to by Coxsackie virus, dust can (ECHO), poliomyelitis, adenovirus 40,41, the myocardium limitation that influenza infection causes or diffuse acute inflammatory condition, belong to infectious cardiomyopathy.
Virus function is directly invade thin vessels in cardiac muscle and cardiac muscle to damage in the mode of cardiac muscle.Produce cardiac damage by immunologic mechanism to play an important role in myocarditic morbidity.The direct infringement of virus and immunoreation mediation cause myocardial cell to damage, and make heart systolic and diastolic function obstacle; If pathological changes involves pace-making or the conducting systems such as sinuatrial node, atrioventricular node, bundle branch, then can cause various types of arrhythmia.Western medicine unsatisfactory curative effect and side effect are comparatively large, and easily recur.
Viral myocarditis belongs to the category such as the traditional Chinese medical science " cardiopalmus ", " palpitation with a distress feeling ", " thoracic obstruction ", " temperature poison ", and most scholar thinks that primary disease is Primary Asthenia-Secondary Sthenia Syndrome clinically, and deficiency in origin is mainly deficiency of both QI and YIN, the real evil poison of diseases caused by exogenous pathogenic factor that is mainly of mark, and pathogenesis key is evil drug-pedlar's heart; In pathogenic process, deficiency in origin usually influences each other with mark is real, and the heart invaded by positive QI-insufficiency, evil poison is the key factor causing VMC to occur.Wherein, deficiency of both QI and YIN is this pathogenetic inherent basis, and the evil poison of outer temperature-sensing thermal is then the main exopathogenic factor bringing out and increase the weight of primary disease.Also have scholar to point out, VMC causes for experiencing warm evil poison, and the easiest yin-damaging and Qi consuming of warm evil poison, again because this evil poison violates well the heart, arteries and veins, pathogenic heat refining blood becomes the stasis of blood, and Tianjin blood trouble is stagnant.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of and is used for the treatment of Chinese medicine of adult diseases viral myocarditis and preparation method thereof, Effect of Chinese Medicine Qing thermal detoxification of the present invention, invigorating the spleen and benefiting QI, promoting blood circulation and stopping pain, tranquilizing by nourishing the heart, have definite curative effect to adult diseases viral myocarditis, toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine being used for the treatment of adult diseases viral myocarditis, its raw medicinal material comprises: Herba Wedeliae Prostratae, Herba Apocyni veneti, Rhizoma et radix valerianae, Herba galii veri, Herba Blumeae Lacerae, Fructus Seu Herba Pubescentis, Caulis Arcangelisiae, Rhizoma Polygonati Cirrhifolii, Rhizoma disporopsis pernyi, come into leaves Rhizoma Tupistrae Chinensis, Herba Pimpinellae thellungianae, Herba Passiflorae Cupiformis, Rhodobryum roseum Limpr., Nigella damascena L., Radix Seu Caulis Mucunae Sempervirentis, Herba Camptosori Sibirici and Lysimachia trientaloides Hemsl..
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Wedeliae Prostratae 10 ~ 20 parts, Herba Apocyni veneti 5 ~ 15 parts, Rhizoma et radix valerianae 40 ~ 50 parts, Herba galii veri 10 ~ 20 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Fructus Seu Herba Pubescentis 10 ~ 20 parts, Caulis Arcangelisiae 5 ~ 15 parts, Rhizoma Polygonati Cirrhifolii 5 ~ 15 parts, Rhizoma disporopsis pernyi 15 ~ 25 parts, come into leaves Rhizoma Tupistrae Chinensis 20 ~ 30 parts, Herba Pimpinellae thellungianae 30 ~ 40 parts, Herba Passiflorae Cupiformis 30 ~ 40 parts, Rhodobryum roseum Limpr. 15 ~ 25 parts, Nigella damascena L. 20 ~ 30 parts, Radix Seu Caulis Mucunae Sempervirentis 10 ~ 20 parts, Herba Camptosori Sibirici 15 ~ 25 parts and Lysimachia trientaloides Hemsl. 5 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Wedeliae Prostratae 10 ~ 15 parts, Herba Apocyni veneti 5 ~ 10 parts, Rhizoma et radix valerianae 40 ~ 45 parts, Herba galii veri 10 ~ 15 parts, Herba Blumeae Lacerae 5 ~ 10 parts, Fructus Seu Herba Pubescentis 10 ~ 15 parts, Caulis Arcangelisiae 5 ~ 10 parts, Rhizoma Polygonati Cirrhifolii 5 ~ 10 parts, Rhizoma disporopsis pernyi 15 ~ 20 parts, come into leaves Rhizoma Tupistrae Chinensis 20 ~ 25 parts, Herba Pimpinellae thellungianae 30 ~ 35 parts, Herba Passiflorae Cupiformis 30 ~ 35 parts, Rhodobryum roseum Limpr. 15 ~ 20 parts, Nigella damascena L. 20 ~ 25 parts, Radix Seu Caulis Mucunae Sempervirentis 10 ~ 15 parts, Herba Camptosori Sibirici 15 ~ 20 parts and Lysimachia trientaloides Hemsl. 5 ~ 10 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Wedeliae Prostratae 12 parts, Herba Apocyni veneti 6 parts, Rhizoma et radix valerianae 44 parts, Herba galii veri 14 parts, Herba Blumeae Lacerae 8 parts, Fructus Seu Herba Pubescentis 12 parts, Caulis Arcangelisiae 7 parts, Rhizoma Polygonati Cirrhifolii 8 parts, Rhizoma disporopsis pernyi 16 parts, come into leaves Rhizoma Tupistrae Chinensis 24 parts, Herba Pimpinellae thellungianae 32 parts, Herba Passiflorae Cupiformis 31 parts, Rhodobryum roseum Limpr. 18 parts, Nigella damascena L. 22 parts, Radix Seu Caulis Mucunae Sempervirentis 13 parts, Herba Camptosori Sibirici 17 parts and Lysimachia trientaloides Hemsl. 7 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Wedeliae Prostratae 14 parts, Herba Apocyni veneti 8 parts, Rhizoma et radix valerianae 42 parts, Herba galii veri 11 parts, Herba Blumeae Lacerae 6 parts, Fructus Seu Herba Pubescentis 14 parts, Caulis Arcangelisiae 8 parts, Rhizoma Polygonati Cirrhifolii 6 parts, Rhizoma disporopsis pernyi 18 parts, come into leaves Rhizoma Tupistrae Chinensis 22 parts, Herba Pimpinellae thellungianae 34 parts, Herba Passiflorae Cupiformis 33 parts, Rhodobryum roseum Limpr. 16 parts, Nigella damascena L. 24 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Herba Camptosori Sibirici 18 parts and Lysimachia trientaloides Hemsl. 8 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 85 ~ 95%, reflux 2 ~ 4 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.05 ~ 0.5 times, the starch of 0.2 ~ 0.4 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;
3rd step: add the starch relative to its quality 1 ~ 3 times in the micropowders obtained by second step, mixing, obtains powder.
Beneficial effect of the present invention: Effect of Chinese Medicine Qing thermal detoxification of the present invention, invigorating the spleen and benefiting QI, promoting blood circulation and stopping pain, tranquilizing by nourishing the heart, have definite curative effect to adult diseases viral myocarditis, toxic and side effects is little.
Detailed description of the invention
The invention provides a kind of Chinese medicine being used for the treatment of adult diseases viral myocarditis, its raw medicinal material comprises: Herba Wedeliae Prostratae, Herba Apocyni veneti, Rhizoma et radix valerianae, Herba galii veri, Herba Blumeae Lacerae, Fructus Seu Herba Pubescentis, Caulis Arcangelisiae, Rhizoma Polygonati Cirrhifolii, Rhizoma disporopsis pernyi, come into leaves Rhizoma Tupistrae Chinensis, Herba Pimpinellae thellungianae, Herba Passiflorae Cupiformis, Rhodobryum roseum Limpr., Nigella damascena L., Radix Seu Caulis Mucunae Sempervirentis, Herba Camptosori Sibirici and Lysimachia trientaloides Hemsl..
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Herba Wedeliae Prostratae: acid, sweet, flat.Return liver, spleen channel.Heat clearing away, removing toxic substances.Control throat moth, sore throat, diphtheria, pertussis, dyspnea and cough due to lung-heat, epistaxis, carbuncle, furuncle.
Herba Apocyni veneti: sweet, bitter, cool.Return Liver Channel.Suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema.
Rhizoma et radix valerianae: pungent, sweet, temperature.GUIXIN, Liver Channel.Calm the nerves, regulate the flow of vital energy, pain relieving.For neurasthenia, insomnia, epilepsy, hysteria, stomach abdominal distention and pain, lumbago and skelalgia, traumatic injury." Shaanxi Chinese herbal medicine ": calmness of calming the nerves, wind dispelling spasmolytic, promoting regeneration of the tissue and arresting bleeding, pain relieving.Control hysteria, Keshan disease, heart disease (myocarditis, post partum heart disease, rheumatic heart disease merge heart failure), lumbago and skelalgia, gastrointestinal convulsion, arthritis, traumatic injury, traumatic hemorrhage.
Herba galii veri: micro-pungent, bitter, be slightly cold.Heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, dispelling wind for relieving itching.Main hepatitis, ascites, laryngopharynx swelling and pain, furuncle toxic swelling, traumatic injury, women's amenorrhea, leukorrhagia, venom, urticaria, paddy field dermatitis.
Herba Blumeae Lacerae: bitter, cold.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For tonsillitis, stomatitis, gingival abscess, mumps, infantile pneumonia; Carbuncle pyogenic infections from tumour or sore is controlled in external, skin pruritus.
Fructus Seu Herba Pubescentis: bitter, cool.Heat-clearing and toxic substances removing, antiinflammatory diuretic.Cure mainly cold, fever, parotitis, bronchitis, acute pyelonephritis, orchitis, herpes, scabies, colicky.
Caulis Arcangelisiae: bitter, cold.Clearing away heat-damp and promoting diuresis, removing toxic substances pain relieving.For preventing influenza, leptospirosis, controls acute gastroenteritis, bacillary dysentery, tonsillitis, bronchitis, malaria; Eye conjunctivitis is controlled in external, skin eczema, pustule ulcer, vaginitis.
Rhizoma Polygonati Cirrhifolii: sweet, pungent, flat.Nourishing lung-YIN, invigorating the spleen and benefiting QI, hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control chronic consumptive disease cough, dizzy, lack of appetite, seminal emission, night sweat, bleeding not during menses, puerperal, body lost, and spitted blood, epistaxis, traumatic hemorrhage, laryngopharynx swelling and pain, and skin ulcer swells, scrofula.
Rhizoma disporopsis pernyi: sweet in the mouth, property is put down.Replenishing QI to invigorate the spleen, nourishing YIN and moistening the lung, relaxing muscles and tendons to promote blood circulation.Main puerperal asthenia, infantile malnutrition, cough due to yin deficiency, hyperhidrosis, xerostomia, treating swelling and pain by traumatic injury, rheumatalgia, lumbago.
Come into leaves Rhizoma Tupistrae Chinensis: sweet in the mouth, micro-pungent, and property is put down.QI invigorating, yin nourishing, lung moistening, invigorates blood circulation.Main body is after being ill empty, lung-dryness syndrome due to deficiency of YIN, and cough expectorant sticks, dry throat and mouth, traumatic injury.
Herba Pimpinellae thellungianae: sweet in the mouth, pungent, warm in nature.Invigorating the spleen and benefiting QI, tranquilizing by nourishing the heart, eliminating phlegm and stopping cough.Main Keshan disease, the heart is reconstructed, and breathes hard, cough with asthma.
Herba Passiflorae Cupiformis: sweet in the mouth is micro-puckery, warm in nature.Expelling wind and removing dampness, promoting blood circulation and stopping pain, tranquilizing by nourishing the heart.Cure mainly rheumatic heart disease, hematuria, nebulousurine, hemiplegia, furuncle, traumatic hemorrhage, eruptive disease abdominal distention pain.
Rhodobryum roseum Limpr.: pungent is bitter, flat.Tranquilizing by nourishing the heart, liver heat removing and eyesight improving.For severe palpitation, neurasthenia, conjunctival congestion and swelling pain is controlled in external.
Nigella damascena L.: sweet in the mouth, pungent, warm in nature.GUIXIN, lung meridian.Qi-benefiting and heart-nourishing, dispelling wind stopping cough.Main cardiopalmus, insomnia, body is empty, anemofrigid cold, cough.
Radix Seu Caulis Mucunae Sempervirentis: sweet, temperature.Blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, dredge the meridian passage.For traumatic injury, rheumatalgia, numb, stimulate the menstrual flow, amenorrhea.
Herba Camptosori Sibirici: light is flat.GUIXIN warp.Blood circulation promoting and blood stasis dispelling, hemostasis, removing toxic substances.Main thromboangiitis obliterans, hemiplegia, metrorrhagia, traumatic hemorrhage, neurodermatitis, ulcer of the lower limb.
Lysimachia trientaloides Hemsl.: pungent, warm in nature.Dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain.Main air pain of dampness syndrome, hemiplegia, infantile convulsion, traumatic injury, fracture.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Wedeliae Prostratae 10 ~ 20 parts, Herba Apocyni veneti 5 ~ 15 parts, Rhizoma et radix valerianae 40 ~ 50 parts, Herba galii veri 10 ~ 20 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Fructus Seu Herba Pubescentis 10 ~ 20 parts, Caulis Arcangelisiae 5 ~ 15 parts, Rhizoma Polygonati Cirrhifolii 5 ~ 15 parts, Rhizoma disporopsis pernyi 15 ~ 25 parts, come into leaves Rhizoma Tupistrae Chinensis 20 ~ 30 parts, Herba Pimpinellae thellungianae 30 ~ 40 parts, Herba Passiflorae Cupiformis 30 ~ 40 parts, Rhodobryum roseum Limpr. 15 ~ 25 parts, Nigella damascena L. 20 ~ 30 parts, Radix Seu Caulis Mucunae Sempervirentis 10 ~ 20 parts, Herba Camptosori Sibirici 15 ~ 25 parts and Lysimachia trientaloides Hemsl. 5 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Wedeliae Prostratae 10 ~ 15 parts, Herba Apocyni veneti 5 ~ 10 parts, Rhizoma et radix valerianae 40 ~ 45 parts, Herba galii veri 10 ~ 15 parts, Herba Blumeae Lacerae 5 ~ 10 parts, Fructus Seu Herba Pubescentis 10 ~ 15 parts, Caulis Arcangelisiae 5 ~ 10 parts, Rhizoma Polygonati Cirrhifolii 5 ~ 10 parts, Rhizoma disporopsis pernyi 15 ~ 20 parts, come into leaves Rhizoma Tupistrae Chinensis 20 ~ 25 parts, Herba Pimpinellae thellungianae 30 ~ 35 parts, Herba Passiflorae Cupiformis 30 ~ 35 parts, Rhodobryum roseum Limpr. 15 ~ 20 parts, Nigella damascena L. 20 ~ 25 parts, Radix Seu Caulis Mucunae Sempervirentis 10 ~ 15 parts, Herba Camptosori Sibirici 15 ~ 20 parts and Lysimachia trientaloides Hemsl. 5 ~ 10 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Wedeliae Prostratae 12 parts, Herba Apocyni veneti 6 parts, Rhizoma et radix valerianae 44 parts, Herba galii veri 14 parts, Herba Blumeae Lacerae 8 parts, Fructus Seu Herba Pubescentis 12 parts, Caulis Arcangelisiae 7 parts, Rhizoma Polygonati Cirrhifolii 8 parts, Rhizoma disporopsis pernyi 16 parts, come into leaves Rhizoma Tupistrae Chinensis 24 parts, Herba Pimpinellae thellungianae 32 parts, Herba Passiflorae Cupiformis 31 parts, Rhodobryum roseum Limpr. 18 parts, Nigella damascena L. 22 parts, Radix Seu Caulis Mucunae Sempervirentis 13 parts, Herba Camptosori Sibirici 17 parts and Lysimachia trientaloides Hemsl. 7 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Wedeliae Prostratae 14 parts, Herba Apocyni veneti 8 parts, Rhizoma et radix valerianae 42 parts, Herba galii veri 11 parts, Herba Blumeae Lacerae 6 parts, Fructus Seu Herba Pubescentis 14 parts, Caulis Arcangelisiae 8 parts, Rhizoma Polygonati Cirrhifolii 6 parts, Rhizoma disporopsis pernyi 18 parts, come into leaves Rhizoma Tupistrae Chinensis 22 parts, Herba Pimpinellae thellungianae 34 parts, Herba Passiflorae Cupiformis 33 parts, Rhodobryum roseum Limpr. 16 parts, Nigella damascena L. 24 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Herba Camptosori Sibirici 18 parts and Lysimachia trientaloides Hemsl. 8 parts.
Chinese medicine of the present invention can be prepared into various dosage form as required, is preferably tablet and powder.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 85 ~ 95%, reflux 2 ~ 4 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.05 ~ 0.5 times, the starch of 0.2 ~ 0.4 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;
3rd step: add the starch relative to its quality 1 ~ 3 times in the micropowders obtained by second step, mixing, obtains powder.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1 tablet
Get Herba Wedeliae Prostratae 120g, Herba Apocyni veneti 60g, Rhizoma et radix valerianae 440g, Herba galii veri 140g, Herba Blumeae Lacerae 80g, Fructus Seu Herba Pubescentis 120g, Caulis Arcangelisiae 70g, Rhizoma Polygonati Cirrhifolii 80g, Rhizoma disporopsis pernyi 160g, come into leaves Rhizoma Tupistrae Chinensis 240g, Herba Pimpinellae thellungianae 320g, Herba Passiflorae Cupiformis 310g, Rhodobryum roseum Limpr. 180g, Nigella damascena L. 220g, Radix Seu Caulis Mucunae Sempervirentis 130g, Herba Camptosori Sibirici 170g and Lysimachia trientaloides Hemsl. 70g;
Prepare according to the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, reflux 2 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 times again, reflux 1 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 hour, pulverize and sieve acquisition 200 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 times, the lactose of 0.1 times, the starch of 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, dry, add the magnesium stearate relative to micropowders quality 0.01 times, granulate, tabletting, makes.
Embodiment 2 powder
Get Herba Wedeliae Prostratae 140g, Herba Apocyni veneti 80g, Rhizoma et radix valerianae 420g, Herba galii veri 110g, Herba Blumeae Lacerae 60g, Fructus Seu Herba Pubescentis 140g, Caulis Arcangelisiae 80g, Rhizoma Polygonati Cirrhifolii 60g, Rhizoma disporopsis pernyi 180g, come into leaves Rhizoma Tupistrae Chinensis 220g, Herba Pimpinellae thellungianae 340g, Herba Passiflorae Cupiformis 330g, Rhodobryum roseum Limpr. 160g, Nigella damascena L. 240g, Radix Seu Caulis Mucunae Sempervirentis 110g, Herba Camptosori Sibirici 180g and Lysimachia trientaloides Hemsl. 80g;
Prepare according to the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;
3rd step: add the starch relative to its quality 1 ~ 3 times in the micropowders obtained by second step, mixing, obtains powder.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 25-35g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.24g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 41.2 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>41.2 crude drug/kg, every day, maximum dosage-feeding was 82.4 crude drugs/kg/ day.Chinese medicine composition clinical application amount of the present invention be 7.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.127g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 33g) oral administration gavage Chinese medicine composition of the present invention is 649 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine composition embodiment 1 tablet of the present invention presses 14.75,22.56 and 42.12g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine composition of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 84 routine cases are my Out-patient Department patient in August, 2010 ~ in June, 2013, be divided into treatment group and matched group at random, wherein treatment group 44 people, male 24 people, women 20 people, 18 ~ 50 years old age, average (36 ± 7.5) year, the course of disease 3 ~ 15 days, on average (9.4 ± 2.6) sky, electrocardiogram (ECG) checks: Frequent atrial premature beats secondary 10 example, ventricular premature contraction 27 example, premature nodal contraction 3 example, I Aminophyline 8 example, II degree of I type atrioventricular block 2 example, S-T section moves down >=0.05mmV8 example, and T ripple is inverted 8 examples; Matched group 40 people, male 22 people, women 18 people, 19 ~ 52 years old age, average (38 ± 4.6) year, the course of disease 3 ~ 15 days, on average (9.1 ± 3.5) sky, electrocardiogram (ECG) checks: Frequent atrial premature beats secondary 8 example, ventricular premature contraction 25 example, premature nodal contraction 2 example, I Aminophyline 7 example, II degree of I type atrioventricular block 1 example, S-T section moves down >=0.05mmV7 example, and T ripple is inverted 7 examples.Two groups of ages, sex, the course of disease and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).
Diagnostic criteria: all cases all meet adult's diagnosis of viral myocarditis reference standard that Chinese cardiovascular diseases in 1999 learns to draft.Standard is as follows:
One. medical history and sign
After the viral infection such as upper respiratory tract infection, diarrhoea, there is Cardiac Manifestation in three weeks, as occur can not with severe weak, uncomfortable in chest, dizzy (cardiac output reduce caused by) after the infection explained of reason, apex of the heart first heart sound obviously weaken, DG, pericardial friction rub, cardiac dilatation, congestive heart failure or cardiogenic syncope etc.
Two. newly there is following arrhythmia or ECG change in three weeks after above-mentioned infection
1. sinus tachycardia, atrioventricular block, sino atrial block or bundle-branch block
2. multi-source, in pairs ventricular premature contraction, autonomy room or junctional tachycardia, the tactical deployment of troops or non-paroxysmal ventricular tachycardia, atrium or ventricular flutter or vibration.
3. more than two ST-Segments are that horizontal type or declivity type move down and be more than or equal to that 0.01mV or ST section is abnormal to be raised or occur abnormality Q wave.。
Three. the reference index of myocardial damage
In the course of disease, serum cardiac troponin I or TnT (emphasizing quantitative assay), CK-MB obviously increase, and the ultrasonic cardiography diagram chambers of the heart expands or wall motion exception and (or) nucleic cardiac inspection confirm that left room is shunk or diastolic function weakens.
Four. nosetiology foundation
1. from endocardium, cardiac muscle, pericardium or paracentesis pericardii liquid, detect virus, viral gene fragment or virus protein antigens in acute stage.
2. antiviral antibody: in second part of serum homologous virus antibody (as change of coxsackie b virus neutralizing antibody or influenza virus hemagglutination inhibition antibody etc.) titre comparatively first part of serum raise 4 times (2 parts of serum should be separated by more than 2 weeks) or antibody titer >=640 for positive, 320 be probable positive (as based on 1:32 person then with >=256 for positive, 128 is probable positive, makes a decision according to different experiments room standard).
3. virus-specific IgM: with >=1:320 person for positive (by each laboratory diagnosis standard, need under strict quality control condition).More support that recent virus infects as there being enterovirus positive in blood simultaneously.
To having any binomial in above-mentioned, two (any one in 1,2,3), three simultaneously, after eliminating other reasons cardiomyopathy, diagnosable viral myocarditis clinically.As having 1 person in four simultaneously, viral myocarditis can be made a definite diagnosis from nosetiology; Can only intend examining as acute viral myocarditis in nosetiology as only having 2,3 persons in four.
Therapeutic Method:
Treatment group: the embodiment of the present invention 1 tablet every day 3 times, each 4.1 month course for the treatment of.
Matched group: application western medicine, intravenous drip Energy mixture, intramuscular injection interferon 1,000,000 U, every day 1 time; Oral vitamin C sheet, each 0.2g, every day 3 times, coenzyme-Q _10 tablet, each 10mg, every day 3 times.1 month course for the treatment of.
Curative effect judging standard: cure: clinical symptoms and sign disappear, ECG and myocardial enzymes inspection normal.Effective: clinical symptoms and sign obviously alleviate, ECG and myocardial enzymes inspection substantially recover or obviously improve.Invalid: clinical symptoms, sign, ECG and myocardial enzymes inspection improve not obvious or unchanged, even increase the weight of.
Therapeutic outcome: total effects compares, in table 1.
Table 1 total effects compares
| ? | n | Cure | Effectively | Invalid | Effectively total |
| Treatment group | 44 | 23 | 18 | 3 | 41(93.18％) |
| Matched group | 40 | 15 | 17 | 8 | 32(80.00％) |
Note: compare * P<0.05 with matched group
ECG changes: treatment group ECG recovers normal person 32 example completely, accounts for 72.7%, and matched group ECG recovers normal person 27 example completely, accounts for 67.5%, comparitive study P>0.05 between two groups, no significant difference.
Myocardial enzymes changes, in table 2.
Table 2 myocardial enzymes changes
Concrete case: Lee, male, 35 years old.There is the symptoms such as uncomfortable in chest, weak, dizzy before 5 days in patient, Electrocardioscopy display sinus tachycardia, ST move down, and etiological examination detects virus, is diagnosed as viral myocarditis.Advise patient fully to have a rest, restraint, give easy to digest, be rich in vitamin, protein food, take Chinese medicine embodiment 1 tablet of the present invention every day 3 times, each 4, treat after one month, recovery from illness, follows up a case by regular visits to and does not recur for 1 year.
Claims (9)
1. treat a Chinese medicine for adult diseases viral myocarditis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Wedeliae Prostratae, Herba Apocyni veneti, Rhizoma et radix valerianae, Herba galii veri, Herba Blumeae Lacerae, Fructus Seu Herba Pubescentis, Caulis Arcangelisiae, Rhizoma Polygonati Cirrhifolii, Rhizoma disporopsis pernyi, come into leaves Rhizoma Tupistrae Chinensis, Herba Pimpinellae thellungianae, Herba Passiflorae Cupiformis, Rhodobryum roseum Limpr., Nigella damascena L., Radix Seu Caulis Mucunae Sempervirentis, Herba Camptosori Sibirici and Lysimachia trientaloides Hemsl..
2. Chinese medicine as claimed in claim 1, is characterized in that, Herba Wedeliae Prostratae 10 ~ 20 parts, Herba Apocyni veneti 5 ~ 15 parts, Rhizoma et radix valerianae 40 ~ 50 parts, Herba galii veri 10 ~ 20 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Fructus Seu Herba Pubescentis 10 ~ 20 parts, Caulis Arcangelisiae 5 ~ 15 parts, Rhizoma Polygonati Cirrhifolii 5 ~ 15 parts, Rhizoma disporopsis pernyi 15 ~ 25 parts, come into leaves Rhizoma Tupistrae Chinensis 20 ~ 30 parts, Herba Pimpinellae thellungianae 30 ~ 40 parts, Herba Passiflorae Cupiformis 30 ~ 40 parts, Rhodobryum roseum Limpr. 15 ~ 25 parts, Nigella damascena L. 20 ~ 30 parts, Radix Seu Caulis Mucunae Sempervirentis 10 ~ 20 parts, Herba Camptosori Sibirici 15 ~ 25 parts and Lysimachia trientaloides Hemsl. 5 ~ 15 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Wedeliae Prostratae 10 ~ 15 parts, Herba Apocyni veneti 5 ~ 10 parts, Rhizoma et radix valerianae 40 ~ 45 parts, Herba galii veri 10 ~ 15 parts, Herba Blumeae Lacerae 5 ~ 10 parts, Fructus Seu Herba Pubescentis 10 ~ 15 parts, Caulis Arcangelisiae 5 ~ 10 parts, Rhizoma Polygonati Cirrhifolii 5 ~ 10 parts, Rhizoma disporopsis pernyi 15 ~ 20 parts, come into leaves Rhizoma Tupistrae Chinensis 20 ~ 25 parts, Herba Pimpinellae thellungianae 30 ~ 35 parts, Herba Passiflorae Cupiformis 30 ~ 35 parts, Rhodobryum roseum Limpr. 15 ~ 20 parts, Nigella damascena L. 20 ~ 25 parts, Radix Seu Caulis Mucunae Sempervirentis 10 ~ 15 parts, Herba Camptosori Sibirici 15 ~ 20 parts and Lysimachia trientaloides Hemsl. 5 ~ 10 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Wedeliae Prostratae 12 parts, Herba Apocyni veneti 6 parts, Rhizoma et radix valerianae 44 parts, Herba galii veri 14 parts, Herba Blumeae Lacerae 8 parts, Fructus Seu Herba Pubescentis 12 parts, Caulis Arcangelisiae 7 parts, Rhizoma Polygonati Cirrhifolii 8 parts, Rhizoma disporopsis pernyi 16 parts, come into leaves Rhizoma Tupistrae Chinensis 24 parts, Herba Pimpinellae thellungianae 32 parts, Herba Passiflorae Cupiformis 31 parts, Rhodobryum roseum Limpr. 18 parts, Nigella damascena L. 22 parts, Radix Seu Caulis Mucunae Sempervirentis 13 parts, Herba Camptosori Sibirici 17 parts and Lysimachia trientaloides Hemsl. 7 parts.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Wedeliae Prostratae 14 parts, Herba Apocyni veneti 8 parts, Rhizoma et radix valerianae 42 parts, Herba galii veri 11 parts, Herba Blumeae Lacerae 6 parts, Fructus Seu Herba Pubescentis 14 parts, Caulis Arcangelisiae 8 parts, Rhizoma Polygonati Cirrhifolii 6 parts, Rhizoma disporopsis pernyi 18 parts, come into leaves Rhizoma Tupistrae Chinensis 22 parts, Herba Pimpinellae thellungianae 34 parts, Herba Passiflorae Cupiformis 33 parts, Rhodobryum roseum Limpr. 16 parts, Nigella damascena L. 24 parts, Radix Seu Caulis Mucunae Sempervirentis 11 parts, Herba Camptosori Sibirici 18 parts and Lysimachia trientaloides Hemsl. 8 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 85 ~ 95%, reflux 2 ~ 4 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.05 ~ 0.5 times, the starch of 0.2 ~ 0.4 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;
3rd step: add the starch relative to its quality 1 ~ 3 times in the micropowders obtained by second step, mixing, obtains powder.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 85 ~ 95%, reflux 2 ~ 4 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.05 ~ 0.5 times, the starch of 0.2 ~ 0.4 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;
3rd step: add the starch relative to its quality 1 ~ 3 times in the micropowders obtained by second step, mixing, obtains powder.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940755A (en) * | 2015-06-26 | 2015-09-30 | 吴强 | Medicine composition for treating phlegm stagnation mutual-resisting type viral myocarditis and preparing method of medicine composition |
| CN105031476A (en) * | 2015-08-21 | 2015-11-11 | 王璐 | Beverage for treating anxiety neurosis |
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| CN102961604A (en) * | 2012-11-26 | 2013-03-13 | 姜波 | Traditional Chinese medicine preparation for treating viral myocarditis |
| CN103142849A (en) * | 2013-02-17 | 2013-06-12 | 郭荣杰 | Chinese medicine preparation for treating acute vital myocarditis |
| CN103520443A (en) * | 2013-10-22 | 2014-01-22 | 宋彬 | Traditional Chinese medicinal preparation for treating adult viral myocarditis and preparation method for traditional Chinese medicinal preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961604A (en) * | 2012-11-26 | 2013-03-13 | 姜波 | Traditional Chinese medicine preparation for treating viral myocarditis |
| CN103142849A (en) * | 2013-02-17 | 2013-06-12 | 郭荣杰 | Chinese medicine preparation for treating acute vital myocarditis |
| CN103520443A (en) * | 2013-10-22 | 2014-01-22 | 宋彬 | Traditional Chinese medicinal preparation for treating adult viral myocarditis and preparation method for traditional Chinese medicinal preparation |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940755A (en) * | 2015-06-26 | 2015-09-30 | 吴强 | Medicine composition for treating phlegm stagnation mutual-resisting type viral myocarditis and preparing method of medicine composition |
| CN105031476A (en) * | 2015-08-21 | 2015-11-11 | 王璐 | Beverage for treating anxiety neurosis |
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